| Probe |
Symbol |
Description |
Chromosome |
Chromosome Location |
GenBank |
Gene |
PubMed |
Gene Ontology |
Pathway |
| TC0500003731.mm.2 |
Gbp4 |
guanylate binding protein 4 |
5 |
-105115766 |
NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 |
17472 |
11 |
negative regulation of transcription by RNA polymerase II negative regulation of protein phosphorylation GTPase activity protein binding GTP binding negative regulation of protein ubiquitination cytoplasmic vesicle negative regulation of interferon-alpha production negative regulation of protein import into nucleus defense response to protozoan regulation of defense response to virus defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC1900001418.mm.2 |
Ch25h |
cholesterol 25-hydroxylase |
19 |
-34473783 |
NM_009890, BC039919 NM_009890, BC039919 |
12642 |
45 |
C-4 methylsterol oxidase activity cholesterol 25-hydroxylase activity monooxygenase activity iron ion binding endoplasmic reticulum endoplasmic reticulum membrane lipid metabolic process steroid biosynthetic process steroid metabolic process cholesterol metabolic process cholesterol metabolic process steroid hydroxylase activity steroid hydroxylase activity lipid biosynthetic process membrane integral component of membrane sterol biosynthetic process oxidoreductase activity B cell chemotaxis metal ion binding |
00120 |
| TC1000001994.mm.2 |
Calhm6 |
calcium homeostasis modulator family member 6 |
10 |
-34126066 |
NM_175449, BC095946 NM_175449, BC095946 |
215900 |
16 |
cation channel activity integral component of plasma membrane ion transport membrane integral component of membrane |
|
| TC0200004396.mm.2 |
Rasgrp1 |
RAS guanyl releasing protein 1 |
2 |
-117279983 |
NM_011246, BC057120, BC057341 NM_011246, BC057120, BC057341 NM_011246, BC057120, BC057341 |
19419 |
77 |
cytokine production positive regulation of protein phosphorylation inflammatory response to antigenic stimulus guanyl-nucleotide exchange factor activity calcium ion binding intracellular anatomical structure cytoplasm endoplasmic reticulum Golgi apparatus cytosol cytosol plasma membrane plasma membrane small GTPase mediated signal transduction zinc ion binding regulation of phosphatidylinositol 3-kinase signaling membrane diacylglycerol binding natural killer cell activation cell differentiation phosphatidylcholine binding secretory granule localization positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation positive regulation of natural killer cell differentiation positive regulation of T cell differentiation in thymus intracellular signal transduction T cell proliferation B cell proliferation T cell activation B cell activation identical protein binding mast cell degranulation positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of natural killer cell mediated cytotoxicity positive regulation of JNK cascade positive regulation of Ras protein signal transduction metal ion binding vesicle transport along microtubule regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade activation of GTPase activity activation of GTPase activity |
04010 04660 |
| TC0500002755.mm.2 |
Cxcl9 |
chemokine (C-X-C motif) ligand 9 |
5 |
-92321330 |
NM_008599, BC003343 NM_008599, BC003343 |
17329 |
118 |
cytokine activity extracellular region extracellular space extracellular space chemotaxis defense response inflammatory response immune response chemokine activity response to bacterium external side of plasma membrane neutrophil chemotaxis CXCR chemokine receptor binding positive regulation of myoblast differentiation defense response to virus antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of myoblast fusion |
04060 04062 04620 |
| TC1600002148.mm.2 |
Mx1 |
MX dynamin-like GTPase 1 |
16 |
-97447036, -97447034 |
NM_010846, NR_003520, BC011113 NM_010846, NR_003520, BC011113 NM_010846, NR_003520, BC011113 |
17857 |
108 |
mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission GTPase activity nucleus cytoplasm plasma membrane microtubule binding postsynaptic density microtubule cytoskeleton membrane synaptic vesicle budding from presynaptic endocytic zone membrane axon cytoplasmic vesicle receptor internalization mitochondrial membrane dendritic spine head regulation of synapse structure or activity membrane fusion postsynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization |
|
| TC0100003591.mm.2 |
Ifi213 |
interferon activated gene 213 |
1 |
-173591956, -173580356, -173573955, -173566282 |
NM_001177349, NM_001177350 NM_001177349, NM_001177350 |
623121 |
10 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding |
|
| TC1100001171.mm.2 |
Nos2 |
nitric oxide synthase 2, inducible |
11 |
78925290, 78920786, 78924739 |
NM_010927, BC062378 NM_010927, BC062378 |
18126 |
1387 |
response to hypoxia actin binding nitric-oxide synthase activity nitric-oxide synthase activity nitric-oxide synthase activity protein binding calmodulin binding extracellular space nucleus nucleus cytoplasm cytoplasm peroxisome cytosol cytosol cytosol plasma membrane arginine catabolic process arginine catabolic process arginine catabolic process superoxide metabolic process nitric oxide biosynthetic process nitric oxide biosynthetic process nitric oxide biosynthetic process inflammatory response inflammatory response nitric oxide mediated signal transduction circadian rhythm beta-catenin binding cAMP-dependent protein kinase regulator activity response to bacterium response to hormone FMN binding FMN binding negative regulation of gene expression negative regulation of gene expression vesicle membrane vesicle membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen peptidyl-cysteine S-nitrosylation protein kinase binding heme binding cortical cytoskeleton positive regulation of guanylate cyclase activity prostaglandin secretion response to lipopolysaccharide response to lipopolysaccharide interleukin-6 production interleukin-8 production tetrahydrobiopterin binding arginine binding cellular response to drug regulation of cell population proliferation negative regulation of protein catabolic process defense response to bacterium defense response to bacterium defense response to bacterium identical protein binding protein homodimerization activity cadherin binding negative regulation of blood pressure metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm flavin adenine dinucleotide binding flavin adenine dinucleotide binding NADP binding regulation of insulin secretion nitric-oxide synthase binding positive regulation of killing of cells of other organism Hsp90 protein binding cellular response to lipopolysaccharide cellular response to cytokine stimulus cellular response to interferon-gamma cellular response to organic cyclic compound regulation of cytokine production involved in inflammatory response |
00330 01100 04020 04146 05140 05142 05145 05146 05200 05222 |
| TC0300001444.mm.2 |
|
|
|
|
NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 |
|
|
nucleotide binding immune system process GTPase activity protein binding GTP binding extracellular region cytoplasm Golgi apparatus Golgi apparatus cytosol plasma membrane inflammatory response response to bacterium membrane hydrolase activity GMP binding symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle interleukin-1 beta production interleukin-1 beta production interleukin-18 production protein localization to Golgi apparatus cellular response to interferon-beta identical protein binding protein homodimerization activity defense response to protozoan defense response to protozoan adhesion of symbiont to host positive regulation of innate immune response perinuclear region of cytoplasm defense response to Gram-positive bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium protein homotetramerization defense response to virus cellular response to interferon-gamma cellular response to interferon-gamma positive regulation of cytokine production involved in inflammatory response positive regulation of NLRP3 inflammasome complex assembly |
|
| TC1800000610.mm.2 |
Iigp1 |
interferon inducible GTPase 1 |
18 |
60376028, 60373615 |
NM_001146275, NM_021792, BC004649 NM_001146275, NM_021792, BC004649 NM_001146275, NM_021792, BC004649 |
60440 |
44 |
nucleotide binding immune system process GTPase activity GTPase activity GTPase activity protein binding GTP binding nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane Golgi apparatus defense response response to bacterium regulation of autophagy membrane hydrolase activity GDP binding cytokine-mediated signaling pathway symbiont-containing vacuole membrane cellular response to interferon-beta cellular response to interferon-beta identical protein binding identical protein binding defense response to protozoan innate immune response defense response to Gram-negative bacterium |
|
| TC0300003133.mm.2 |
Ifi44 |
interferon-induced protein 44 |
3 |
-151730922 |
NM_133871, BC111882 NM_133871, BC111882 |
99899 |
16 |
molecular_function cytoplasm immune response response to bacterium |
|
| TC0500002623.mm.2 |
Kdr |
kinase insert domain protein receptor |
5 |
-75957364, -75932826 |
NM_010612, BC020530 NM_010612, BC020530 |
16542 |
1021 |
nucleotide binding angiogenesis ovarian follicle development branching involved in blood vessel morphogenesis vasculogenesis response to hypoxia positive regulation of protein phosphorylation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lymph vessel development cell migration involved in sprouting angiogenesis positive regulation of mesenchymal cell proliferation hematopoietic progenitor cell differentiation endocardium development endothelium development endochondral bone growth protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding extracellular region nucleus cytoplasm cytoplasm endosome early endosome endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cytosolic calcium ion concentration multicellular organism development positive regulation of cell population proliferation regulation of cell shape male gonad development external side of plasma membrane cell surface positive regulation of endothelial cell migration positive regulation of endothelial cell migration negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane positive regulation of macroautophagy kinase activity phosphorylation cell migration cell migration transferase activity peptidyl-tyrosine phosphorylation growth factor binding growth factor binding cell junction hemopoiesis cell differentiation lung development positive regulation of cell migration positive regulation of BMP signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway cytoplasmic vesicle positive regulation of TOR signaling positive regulation of kinase activity embryonic hemopoiesis calcium-mediated signaling using intracellular calcium source cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-2 signaling pathway positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine autophosphorylation vascular endothelial growth factor signaling pathway vascular endothelial growth factor binding response to drug identical protein binding neuron projection neuronal cell body negative regulation of apoptotic process surfactant homeostasis receptor complex positive regulation of MAPK cascade protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration membrane raft cell fate commitment cadherin binding endothelial cell differentiation endothelial cell differentiation endothelial cell differentiation endothelial cell differentiation positive regulation of angiogenesis positive regulation of angiogenesis positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway positive regulation of long-term neuronal synaptic plasticity lung alveolus development cell maturation post-embryonic camera-type eye morphogenesis branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of calcium-mediated signaling positive regulation of positive chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of focal adhesion assembly positive regulation of mitochondrial depolarization calcium ion homeostasis blood vessel endothelial cell differentiation vascular wound healing ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cell periphery positive regulation of cell migration involved in sprouting angiogenesis positive regulation of mitochondrial fission sorting endosome regulation of hematopoietic progenitor cell differentiation regulation of bone development cellular response to hydrogen sulfide negative regulation of endothelial cell apoptotic process positive regulation of vasculogenesis |
04060 04144 04370 04510 |
| TC0500001240.mm.2 |
Oasl1 |
2'-5' oligoadenylate synthetase-like 1 |
5 |
114923239 |
NM_145209, BC032152 NM_145209, BC032152 |
231655 |
23 |
immune system process DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm nucleoplasm nucleolus cytoplasm cytosol cytosol immune response response to virus membrane transferase activity negative regulation of viral genome replication negative regulation of viral genome replication innate immune response defense response to virus defense response to virus regulation of ribonuclease activity |
|
| TC1700002816.mm.2 |
Cfb |
complement factor B |
17 |
-34856373 |
NM_001142706, NM_008198, BC005451 NM_001142706, NM_008198, BC005451 NM_001142706, NM_008198, BC005451 |
14962 |
166 |
immune system process serine-type endopeptidase activity extracellular region extracellular space proteolysis complement activation complement activation, alternative pathway complement activation, alternative pathway complement activation, alternative pathway peptidase activity serine-type peptidase activity cell population proliferation hydrolase activity innate immune response response to thyroid hormone |
04610 05150 |
| TC1100001241.mm.2 |
Slfn4 |
schlafen 4 |
11 |
83175185 |
NM_011410, BC044865, BC150770 NM_011410, BC044865, BC150770 NM_011410, BC044865, BC150770 |
20558 |
22 |
molecular_function cellular_component response to bacterium |
|
| TC1100003396.mm.2 |
Ccl5 |
chemokine (C-C motif) ligand 5 |
11 |
-83525778 |
NM_013653, BC033508 NM_013653, BC033508 |
20304 |
216 |
MAPK cascade positive regulation of defense response to virus by host monocyte chemotaxis phosphatidylinositol phospholipase C activity protein kinase activity cytokine activity protein binding extracellular region extracellular space extracellular space extracellular space cytoplasm calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response inflammatory response inflammatory response immune response leukocyte cell-cell adhesion G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cell-cell signaling chemokine activity chemokine activity heparin binding response to toxic substance positive regulation of gene expression positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis positive regulation of T cell chemotaxis positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration phospholipase activator activity receptor signaling protein tyrosine kinase activator activity positive regulation of cell migration neutrophil chemotaxis pseudopodium assembly positive regulation of cellular biosynthetic process activation of phospholipase D activity positive regulation of fever generation lipopolysaccharide-mediated signaling pathway CCR1 chemokine receptor binding CCR1 chemokine receptor binding CCR5 chemokine receptor binding positive regulation of cell-cell adhesion mediated by integrin response to cytokine positive regulation of homotypic cell-cell adhesion response to interferon-gamma response to tumor necrosis factor T-helper 1 cell diapedesis chemoattractant activity positive regulation of T cell proliferation neutrophil activation positive regulation of phosphorylation chemokine receptor binding positive regulation of tyrosine phosphorylation of STAT protein identical protein binding protein homodimerization activity protein kinase B signaling positive regulation of GTPase activity protein self-association negative regulation by host of viral transcription negative regulation of viral genome replication positive regulation of neuron differentiation positive regulation of osteoclast differentiation negative regulation of G protein-coupled receptor signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion chemokine receptor antagonist activity CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis lymphocyte chemotaxis positive regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation regulation of insulin secretion regulation of T cell activation positive regulation of calcium ion transport negative regulation of cell death positive regulation of mast cell chemotaxis chemokine-mediated signaling pathway chemokine-mediated signaling pathway negative regulation of T cell apoptotic process positive regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of monocyte chemotaxis positive regulation of monocyte chemotaxis regulation of neuron death negative regulation of neuron death negative regulation of macrophage apoptotic process positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of T cell migration positive regulation of natural killer cell chemotaxis |
04060 04062 04620 04621 04623 05020 05142 05323 |
| TC0600001369.mm.2 |
Usp18 |
ubiquitin specific peptidase 18 |
6 |
121245905 |
NM_011909, BC138562, BC138577 NM_011909, BC138562, BC138577 NM_011909, BC138562, BC138577 |
24110 |
69 |
cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleus cytosol cytosol ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity response to bacterium protein deubiquitination hydrolase activity ISG15-specific protease activity response to stilbenoid intracellular membrane-bounded organelle regulation of inflammatory response |
|
| TC1100001239.mm.2 |
Slfn1 |
schlafen 1 |
11 |
83116819 |
NM_011407, BC052869 NM_011407, BC052869 |
20555 |
22 |
negative regulation of transcription by RNA polymerase II negative regulation of protein phosphorylation protein binding nucleus cytoplasm cell cycle arrest negative regulation of cell population proliferation negative regulation of T cell proliferation negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter negative regulation of G1/S transition of mitotic cell cycle negative regulation of G1/S transition of mitotic cell cycle |
|
| TC0600002641.mm.2 |
Mxd1 |
MAX dimerization protein 1 |
6 |
-86647044 |
NM_010751, BC034860 NM_010751, BC034860 |
17119 |
48 |
negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding protein binding nucleus nucleoplasm mitochondrion cytosol regulation of transcription by RNA polymerase II protein dimerization activity |
|
| TC0200002544.mm.2 |
Cd40 |
CD40 antigen |
2 |
165055635 |
NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 |
21939 |
573 |
positive regulation of protein phosphorylation immune system process regulation of immunoglobulin production immune response-regulating cell surface receptor signaling pathway immune response-regulating cell surface receptor signaling pathway antigen binding antigen binding protein binding extracellular region extracellular space cytoplasm plasma membrane cellular calcium ion homeostasis cellular calcium ion homeostasis inflammatory response inflammatory response external side of plasma membrane external side of plasma membrane cell surface cell surface membrane integral component of membrane enzyme binding protein domain specific binding CD40 signaling pathway CD40 signaling pathway positive regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of B cell proliferation ubiquitin protein ligase binding positive regulation of interleukin-12 production positive regulation of interleukin-12 production response to interferon-gamma CD40 receptor complex CD40 receptor complex TRIF-dependent toll-like receptor signaling pathway signaling receptor activity B cell activation B cell activation B cell activation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein defense response to protozoan defense response to protozoan neuronal cell body positive regulation of I-kappaB kinase/NF-kappaB signaling varicosity intracellular membrane-bounded organelle positive regulation of MAP kinase activity protein kinase B signaling positive regulation of blood vessel endothelial cell migration positive regulation of blood vessel endothelial cell migration positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of angiogenesis positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of isotype switching to IgG isotypes positive regulation of isotype switching to IgG isotypes regulation of immune response positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity defense response to virus defense response to virus cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of protein kinase C signaling positive regulation of endothelial cell apoptotic process positive regulation of endothelial cell apoptotic process |
04060 04514 04620 04672 05144 05145 05310 05320 05322 05330 05340 05416 |
| TC0300002802.mm.2 |
Vcam1 |
vascular cell adhesion molecule 1 |
3 |
-116110019 |
NM_011693, BC011159, BC029823 NM_011693, BC011159, BC029823 NM_011693, BC011159, BC029823 |
22329 |
334 |
podosome integrin binding integrin binding extracellular space early endosome endoplasmic reticulum Golgi apparatus plasma membrane integral component of plasma membrane microvillus cell adhesion cell adhesion cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion heart development primary amine oxidase activity amine metabolic process external side of plasma membrane cell surface membrane integral component of membrane viral process filopodium anchored component of membrane heterotypic cell-cell adhesion calcium-mediated signaling using intracellular calcium source positive regulation of T cell proliferation sarcolemma apical part of cell cell adhesion molecule binding leukocyte tethering or rolling cell chemotaxis innervation embryonic placenta morphogenesis chorio-allantoic fusion cardiac neuron differentiation visceral serous pericardium development alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex cellular response to glucose stimulus cell periphery cell-cell adhesion cell-cell adhesion in response to extracellular stimulus cellular response to amyloid-beta |
04514 04670 05143 05144 |
| TC1500001728.mm.2 |
Ly6a |
lymphocyte antigen 6 complex, locus A |
15 |
-74994876 |
NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 |
110454 |
177 |
protein binding intracellular anatomical structure plasma membrane response to bacterium external side of plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway |
|
| TC1100001222.mm.2 |
Ccl12 |
chemokine (C-C motif) ligand 12 |
11 |
82101844 |
NM_011331, BC027520 NM_011331, BC027520 |
20293 |
33 |
MAPK cascade angiogenesis monocyte chemotaxis monocyte chemotaxis monocyte chemotaxis positive regulation of leukocyte migration cytokine activity extracellular region extracellular space chemotaxis inflammatory response inflammatory response inflammatory response immune response cytoskeleton organization G protein-coupled receptor signaling pathway chemokine activity regulation of cell shape cytokine-mediated signaling pathway neutrophil chemotaxis lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding negative regulation of glial cell apoptotic process protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration CCR chemokine receptor binding eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of leukocyte proliferation cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of calcium ion import negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process negative regulation of natural killer cell chemotaxis |
04060 04062 |
| TC0300001446.mm.2 |
Gbp3 |
guanylate binding protein 3 |
3 |
142560355, 142560043 |
NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 |
55932 |
23 |
nucleotide binding GTPase activity GTPase activity GTP binding nucleus cytoplasm Golgi apparatus cytosol cytosol plasma membrane membrane hydrolase activity symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle cellular response to interferon-beta protein homodimerization activity defense response to protozoan defense response to protozoan adhesion of symbiont to host perinuclear region of cytoplasm defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC1400002162.mm.2 |
Phf11b |
PHD finger protein 11B |
14 |
-59320963 |
NM_001164327 |
236451 |
3 |
molecular_function nucleus nucleoplasm biological_process nuclear membrane |
|
| TC1100002643.mm.2 |
|
|
|
|
NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 |
|
|
GTPase activity GTPase activity GTP binding endoplasmic reticulum membrane defense response immune response response to virus response to bacterium response to interferon-gamma response to interferon-alpha cellular response to interferon-beta cellular response to interferon-beta |
|
| TC1400002869.mm.2 |
Phf11d |
PHD finger protein 11D |
14 |
-59347406 |
NM_199015, BC030186, BC145673 NM_199015, BC030186, BC145673 NM_199015, BC030186, BC145673 |
219132 |
18 |
molecular_function nucleus nucleoplasm biological_process nuclear membrane metal ion binding |
|
| TC1100002649.mm.2 |
|
|
|
|
NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 |
|
|
GTPase activity GTPase activity GTP binding endoplasmic reticulum membrane defense response immune response response to virus response to bacterium response to interferon-gamma response to interferon-alpha cellular response to interferon-beta cellular response to interferon-beta |
|
| TC1400002160.mm.2 |
Phf11 |
PHD finger protein 11 |
14 |
|
NM_001164329 |
628693 |
3 |
|
|
| TC1100000681.mm.2 |
Gm12250 |
predicted gene 12250 |
11 |
58183842 |
NM_001135115 |
631323 |
9 |
|
|
| TC0900003125.mm.2 |
Ccrl2 |
chemokine (C-C motif) receptor-like 2 |
9 |
-111054833, -111054833, -111054833 |
NM_017466, BC038631 NM_017466, BC038631 |
54199 |
35 |
G protein-coupled receptor activity chemokine receptor activity cytoplasm plasma membrane integral component of plasma membrane chemotaxis inflammatory response inflammatory response immune response signal transduction G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration external side of plasma membrane membrane integral component of membrane C-C chemokine receptor activity C-C chemokine receptor activity calcium-mediated signaling C-C chemokine binding chemokine receptor binding chemokine receptor binding CCR chemokine receptor binding cell chemotaxis |
|
| TC0600002425.mm.2 |
Il23r |
interleukin 23 receptor |
6 |
-67422931 |
NM_144548, BC112425 NM_144548, BC112425 |
209590 |
93 |
positive regulation of defense response to virus by host immune system process leukocyte mediated immunity positive regulation of T-helper 1 type immune response cytokine receptor activity interleukin-12 receptor binding interleukin-12 receptor binding plasma membrane plasma membrane integral component of plasma membrane inflammatory response receptor signaling pathway via JAK-STAT external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine binding response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of interferon-gamma production positive regulation of interleukin-12 production response to interferon-gamma interleukin-23 binding interleukin-23 binding interleukin-23 receptor activity receptor complex receptor complex innate immune response interleukin-23 receptor complex interleukin-23 receptor complex |
04060 04630 |
| TC1900000102.mm.2 |
Batf2 |
basic leucine zipper transcription factor, ATF-like 2 |
19 |
6164438 |
NM_028967, BC024521 NM_028967, BC024521 |
74481 |
28 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cell differentiation defense response to protozoan myeloid dendritic cell differentiation |
|
| TC1900001422.mm.2 |
Ifit1bl1 |
interferon induced protein with tetratricpeptide repeats 1B like 1 |
19 |
-34592887, -34592887 |
NM_001101605, NM_001110517 NM_001101605, NM_001110517 |
667373 |
13 |
RNA binding RNA binding cytoplasm cytosol cytosol defense response to virus |
05160 |
| TC0500002757.mm.2 |
Cxcl11 |
chemokine (C-X-C motif) ligand 11 |
5 |
-92359544, -92359544 |
NM_019494, NR_038116, BC025903 NM_019494, NR_038116, BC025903 NM_019494, NR_038116, BC025903 |
56066 |
38 |
extracellular space inflammatory response chemokine activity neutrophil chemotaxis CXCR chemokine receptor binding antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide |
04060 04062 04620 |
| TC1900001423.mm.2 |
Ifit1bl2 |
interferon induced protein with tetratricopeptide repeats 1B like 2 |
19 |
-34617048, -34617048 |
NM_053217, BC138202 NM_053217, BC138202 |
112419 |
14 |
RNA binding RNA binding cytoplasm cytosol cytosol defense response to virus |
|
| TC0400002737.mm.2 |
Lpar1 |
lysophosphatidic acid receptor 1 |
4 |
-58435251, -58435251, -58435251 |
NM_010336, NM_172989, BC025425 NM_010336, NM_172989, BC025425 NM_010336, NM_172989, BC025425 |
14745 |
150 |
activation of MAPK activity G-protein alpha-subunit binding G protein-coupled receptor activity protein binding phospholipid binding cytoplasm cytoplasm endosome plasma membrane plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway activation of phospholipase C activity activation of phospholipase C activity regulation of cell shape regulation of cell shape cell surface positive regulation of cell death negative regulation of neuron projection development negative regulation of neuron projection development negative regulation of neuron projection development membrane integral component of membrane regulation of metabolic process neurogenesis endocytic vesicle PDZ domain binding bleb assembly positive regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction lysophosphatidic acid binding neuron projection neuronal cell body positive regulation of apoptotic process dendritic spine dendritic shaft positive regulation of MAPK cascade negative regulation of cAMP-mediated signaling positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of stress fiber assembly cell chemotaxis positive regulation of dendritic spine development lysophosphatidic acid receptor activity lysophosphatidic acid receptor activity lysophosphatidic acid receptor activity positive regulation of smooth muscle cell chemotaxis cellular response to 1-oleoyl-sn-glycerol 3-phosphate |
04080 04540 |
| TC0200001854.mm.2 |
|
|
|
|
NM_001004174, NR_030547, BC049633 NM_001004174, NR_030547, BC049633 NM_001004174, NR_030547, BC049633 |
|
|
molecular_function cytochrome-c oxidase activity cellular_component nucleus mitochondrion mitochondrial respiratory chain complex IV response to bacterium BMP signaling pathway negative regulation of inflammatory response cellular response to lipopolysaccharide |
|
| TC0600003229.mm.2 |
Cd69 |
CD69 antigen |
6 |
-129267323 |
NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 |
12515 |
114 |
calcium ion binding external side of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane carbohydrate binding protein-containing complex cellular response to drug identical protein binding |
|
| TC1700002352.mm.2 |
C3 |
complement component 3 |
17 |
-57203966 |
NM_009778, BC043338 NM_009778, BC043338 |
12266 |
585 |
positive regulation of type IIa hypersensitivity positive regulation of protein phosphorylation positive regulation of activation of membrane attack complex immune system process endopeptidase inhibitor activity protein binding extracellular region extracellular space extracellular space extracellular space extracellular space lipid metabolic process fatty acid metabolic process inflammatory response complement activation complement activation complement activation complement activation complement activation, alternative pathway complement activation, classical pathway blood coagulation lipid binding response to bacterium cell surface positive regulation of vascular endothelial growth factor production positive regulation of glucose transmembrane transport regulation of triglyceride biosynthetic process positive regulation of lipid storage neuron remodeling C5L2 anaphylatoxin chemotactic receptor binding protein-containing complex oviduct epithelium development vascular associated smooth muscle cell differentiation innate immune response positive regulation of G protein-coupled receptor signaling pathway positive regulation of angiogenesis positive regulation of receptor-mediated endocytosis positive regulation of receptor-mediated endocytosis positive regulation of developmental growth positive regulation of phagocytosis retina development in camera-type eye positive regulation of phagocytosis, engulfment positive regulation of phagocytosis, engulfment positive regulation of ERK1 and ERK2 cascade amyloid-beta clearance amyloid-beta clearance complement-dependent cytotoxicity complement-mediated synapse pruning vertebrate eye-specific patterning cell surface receptor signaling pathway involved in cell-cell signaling positive regulation of apoptotic cell clearance |
04145 04610 05140 05142 05150 05322 |
| TC1900000504.mm.2 |
Ifit1 |
interferon-induced protein with tetratricopeptide repeats 1 |
19 |
34640888 |
NM_008331, BC003768 NM_008331, BC003768 |
15957 |
59 |
immune system process RNA binding protein binding cytoplasm cytosol response to virus response to bacterium cellular response to interferon-alpha cellular response to interferon-beta innate immune response defense response to virus |
05160 |
| TC1700002781.mm.2 |
H2-Ab1 |
histocompatibility 2, class II antigen A, beta 1 |
17 |
34263226 |
NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 |
14961 |
780 |
adaptive immune response B cell affinity maturation immune system process immunoglobulin production involved in immunoglobulin-mediated immune response humoral immune response mediated by circulating immunoglobulin antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of antigen processing and presentation positive regulation of T-helper 1 type immune response protein binding intracellular anatomical structure early endosome multivesicular body Golgi apparatus plasma membrane immune response transcription factor binding external side of plasma membrane cell surface toxic substance binding membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II ubiquitin protein ligase binding negative regulation of T cell proliferation peptide antigen binding MHC class II protein complex protein-containing complex binding positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell activation antigen processing and presentation of peptide antigen T cell receptor signaling pathway cellular response to interferon-gamma protein antigen binding |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1400002161.mm.2 |
Phf11a |
PHD finger protein 11A |
14 |
-59276912 |
NM_172603, BC116758, BC116760 NM_172603, BC116758, BC116760 NM_172603, BC116758, BC116760 |
219131 |
13 |
molecular_function nucleus nucleoplasm nuclear membrane metal ion binding regulation of immune response |
|
| TC0700003517.mm.2 |
Slco3a1 |
solute carrier organic anion transporter family, member 3a1 |
7 |
-74275417, -74281915 |
NM_001038643, NM_023908, BC025059 NM_001038643, NM_023908, BC025059 NM_001038643, NM_023908, BC025059 |
108116 |
23 |
positive regulation of protein phosphorylation transporter activity plasma membrane integral component of plasma membrane integral component of plasma membrane ion transport oligopeptide transport organic anion transmembrane transporter activity basal plasma membrane cell surface sodium-independent organic anion transmembrane transporter activity organic anion transport prostaglandin transport prostaglandin transport membrane integral component of membrane apical plasma membrane oligopeptide transmembrane transporter activity sodium-independent organic anion transport positive regulation of NF-kappaB transcription factor activity transmembrane transport |
|
| TC0500002896.mm.2 |
Gbp11 |
guanylate binding protein 11 |
5 |
-105323025, -105323025 |
NM_001039647, BC111039 NM_001039647, BC111039 |
634650 |
3 |
GTPase activity GTP binding cytoplasmic vesicle defense response to protozoan defense response to Gram-positive bacterium cellular response to interferon-gamma |
|
| TC0400004171.mm.2 |
Isg15 |
ISG15 ubiquitin-like modifier |
4 |
-156199423 |
NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 |
100038882 |
94 |
integrin binding protein binding extracellular region nucleus cytoplasm integrin-mediated signaling pathway response to bacterium modification-dependent protein catabolic process modification-dependent protein catabolic process cytosolic small ribosomal subunit positive regulation of bone mineralization protein tag protein tag negative regulation of protein ubiquitination ubiquitin protein ligase binding ISG15-protein conjugation ISG15-protein conjugation ISG15-protein conjugation interferon-gamma production interleukin-10 production regulation of interferon-gamma production response to type I interferon defense response to bacterium defense response to bacterium negative regulation of viral genome replication positive regulation of erythrocyte differentiation defense response to virus defense response to virus |
04622 |
| TC0700003039.mm.2 |
Saa3 |
serum amyloid A 3 |
7 |
-46711997 |
NM_011315, BC055885 NM_011315, BC055885 |
20210 |
76 |
extracellular region extracellular space acute-phase response I-kappaB phosphorylation response to bacterium high-density lipoprotein particle response to stilbenoid Toll-like receptor 4 binding chemoattractant activity cell chemotaxis cellular response to interleukin-1 |
|
| TC0200005438.mm.2 |
Helz2 |
helicase with zinc finger 2, transcriptional coactivator |
2 |
-181227614 |
NM_183162 |
229003 |
19 |
nucleotide binding nuclear-transcribed mRNA catabolic process, nonsense-mediated decay DNA binding RNA binding RNA helicase activity helicase activity ribonuclease activity ATP binding nucleus nucleoplasm cytoplasm hydrolase activity nuclear receptor coactivator activity positive regulation of transcription by RNA polymerase II metal ion binding |
|
| TC0100001634.mm.2 |
Ifi208 |
interferon activated gene 208 |
1 |
173673664, 173673664 |
NM_001162938 |
100033459 |
63 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding |
|
| TC0200000933.mm.2 |
Gca |
grancalcin |
2 |
62664326 |
NM_145523, BC021450 NM_145523, BC021450 |
227960 |
17 |
calcium ion binding cytoplasm cytosol cytosol plasma membrane membrane protein homodimerization activity metal ion binding protein heterodimerization activity |
|
| TC0400001543.mm.2 |
Fabp3 |
fatty acid binding protein 3, muscle and heart |
4 |
130308737 |
NM_010174, BC002082, BC089542 NM_010174, BC002082, BC089542 NM_010174, BC002082, BC089542 |
14077 |
90 |
long-chain fatty acid transporter activity fatty acid binding extracellular space extracellular space cytoplasm cytosol cytosol cytoskeletal protein binding lipid binding long-chain fatty acid transport long-chain fatty acid transport long-chain fatty acid transport sarcoplasm intracellular lipid transport long-chain fatty acid binding cholesterol homeostasis regulation of fatty acid oxidation icosatetraenoic acid binding brown fat cell differentiation phospholipid homeostasis oleic acid binding positive regulation of phospholipid biosynthetic process positive regulation of long-chain fatty acid import into cell positive regulation of long-chain fatty acid import into cell regulation of phosphatidylcholine biosynthetic process |
03320 |
| TC1600001092.mm.2 |
Mx2 |
MX dynamin-like GTPase 2 |
16 |
97536080, 97536082 |
NM_013606, NR_003508, BC007127 NM_013606, NR_003508, BC007127 NM_013606, NR_003508, BC007127 |
17858 |
25 |
mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission GTPase activity nucleus cytoplasm plasma membrane microtubule binding postsynaptic density microtubule cytoskeleton membrane synaptic vesicle budding from presynaptic endocytic zone membrane axon cytoplasmic vesicle receptor internalization mitochondrial membrane dendritic spine head regulation of synapse structure or activity membrane fusion postsynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization |
|
| TC0200002374.mm.2 |
Procr |
protein C receptor, endothelial |
2 |
155751216 |
NM_011171, BC028755 NM_011171, BC028755 |
19124 |
78 |
extracellular space extracellular space centrosome blood coagulation hemostasis protein C-terminus binding membrane integral component of membrane signaling receptor activity perinuclear region of cytoplasm negative regulation of coagulation negative regulation of coagulation negative regulation of coagulation |
|
| TC0500003729.mm.2 |
Gbp8 |
guanylate-binding protein 8 |
5 |
-105014152 |
NM_029509, BC031475 NM_029509, BC031475 |
76074 |
11 |
GTPase activity GTP binding cytoplasmic vesicle defense response to protozoan defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC1700000835.mm.2 |
Pla2g7 |
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) |
17 |
43568450 |
NM_013737, BC010726 NM_013737, BC010726 |
27226 |
49 |
1-alkyl-2-acetylglycerophosphocholine esterase activity 1-alkyl-2-acetylglycerophosphocholine esterase activity phospholipid binding extracellular region extracellular space cytoplasm lipid metabolic process inflammatory response phospholipid catabolic process lipid catabolic process hydrolase activity low-density lipoprotein particle high-density lipoprotein particle low-density lipoprotein particle remodeling lipid oxidation plasma lipoprotein particle oxidation phosphatidylcholine catabolic process platelet activating factor metabolic process calcium-independent phospholipase A2 activity platelet activating factor catabolic process positive regulation of monocyte chemotaxis |
00565 01100 |
| TC1900000502.mm.2 |
Ifit3b |
interferon-induced protein with tetratricopeptide repeats 3B |
19 |
34607956 |
NM_001005858 |
667370 |
10 |
RNA binding cytoplasm mitochondrion cytosol cytosol identical protein binding defense response to virus |
|
| TC1000002380.mm.2 |
Susd2 |
sushi domain containing 2 |
10 |
-75636618 |
NM_001162913, NM_027890, BC026837 NM_001162913, NM_027890, BC026837 NM_001162913, NM_027890, BC026837 |
71733 |
18 |
molecular_function scavenger receptor activity extracellular space plasma membrane immune response membrane integral component of membrane polysaccharide binding negative regulation of cell division negative regulation of cell cycle G1/S phase transition |
|
| TC1300000364.mm.2 |
Serpinb9 |
serine (or cysteine) peptidase inhibitor, clade B, member 9 |
13 |
33004540 |
NM_009256, BC029900 NM_009256, BC029900 |
20723 |
40 |
T cell mediated cytotoxicity protease binding acute inflammatory response to antigenic stimulus serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding extracellular space extracellular space nucleus nucleoplasm cytoplasm cytoplasm cytoplasm Golgi apparatus cytosol immune response response to bacterium positive regulation of gene expression negative regulation of endopeptidase activity negative regulation of endopeptidase activity negative regulation by symbiont of host apoptotic process protection from natural killer cell mediated cytotoxicity defense response to bacterium cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process collagen-containing extracellular matrix negative regulation of T cell apoptotic process |
05146 |
| TC0500002895.mm.2 |
|
|
|
|
NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 |
|
|
GTPase activity GTP binding response to bacterium symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle cellular response to interferon-beta defense response to protozoan defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC1400001182.mm.2 |
Acod1 |
aconitate decarboxylase 1 |
14 |
103047011 |
NM_008392 |
16365 |
38 |
immune system process positive regulation of antimicrobial humoral response positive regulation of antimicrobial humoral response mitochondrion mitochondrion defense response defense response defense response inflammatory response embryo implantation response to bacterium lyase activity negative regulation of NF-kappaB transcription factor activity negative regulation of type I interferon production response to lipopolysaccharide negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 4 signaling pathway cellular response to interferon-beta innate immune response negative regulation of innate immune response aconitate decarboxylase activity aconitate decarboxylase activity aconitate decarboxylase activity aconitate decarboxylase activity negative regulation of inflammatory response defense response to virus cellular response to molecule of bacterial origin cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to progesterone stimulus tolerance induction to lipopolysaccharide tolerance induction to lipopolysaccharide positive regulation of reactive oxygen species metabolic process |
|
| TC1700000077.mm.2 |
Tagap |
T cell activation Rho GTPase activating protein |
17 |
7925999 |
NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 |
72536 |
28 |
guanyl-nucleotide exchange factor activity GTPase activator activity signal transduction defense response to virus |
|
| TC0500000171.mm.2 |
Fgl2 |
fibrinogen-like protein 2 |
5 |
21372672 |
NM_008013, BC028893 NM_008013, BC028893 |
14190 |
70 |
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell immunoglobulin production involved in immunoglobulin-mediated immune response negative regulation of dendritic cell antigen processing and presentation negative regulation of macrophage antigen processing and presentation signaling receptor binding extracellular region extracellular space peptidase activity cytolysis negative regulation of memory T cell differentiation negative regulation of defense response to virus collagen-containing extracellular matrix |
|
| TC1200002525.mm.2 |
Serpina3g |
serine (or cysteine) peptidase inhibitor, clade A, member 3G |
12 |
104236146, 104214453 |
NM_009251 |
20715 |
30 |
adaptive immune response immune system process serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular space nucleus cytoplasm apoptotic process negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine response to peptide hormone |
|
| TC0700004530.mm.2 |
Irf7 |
interferon regulatory factor 7 |
7 |
-141263182 |
NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 |
54123 |
230 |
transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding immune system process regulation of adaptive immune response DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of gene expression immunoglobulin mediated immune response positive regulation of type I interferon production type I interferon production interferon-alpha production interferon-beta production positive regulation of interferon-alpha production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production regulation of MyD88-dependent toll-like receptor signaling pathway regulation of MyD88-independent toll-like receptor signaling pathway innate immune response regulation of innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II defense response to virus defense response to virus type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway sequence-specific double-stranded DNA binding |
04620 04622 04623 05160 |
| TC1700000846.mm.2 |
Clic5 |
chloride intracellular channel 5 |
17 |
44188571 |
NM_172621, BC064037 NM_172621, BC064037 |
224796 |
31 |
response to dietary excess diet induced thermogenesis voltage-gated ion channel activity chloride channel activity chloride channel activity nucleus cytoplasm Golgi apparatus cytoskeleton plasma membrane ion transport chloride transport visual perception sensory perception of sound sensory perception of sound sensory perception of sound protein localization actin cytoskeleton membrane integral component of membrane stereocilium stereocilium bundle chloride channel complex regulation of ion transmembrane transport neuromuscular process controlling balance response to stimulus auditory receptor cell stereocilium organization auditory receptor cell stereocilium organization |
|
| TC1100001223.mm.2 |
Ccl8 |
chemokine (C-C motif) ligand 8 |
11 |
82115184 |
NM_021443, BC117101, BC117103 NM_021443, BC117101, BC117103 NM_021443, BC117101, BC117103 |
20307 |
40 |
monocyte chemotaxis cytokine activity extracellular region extracellular space extracellular space chemotaxis inflammatory response immune response G protein-coupled receptor signaling pathway chemokine activity heparin binding neutrophil chemotaxis positive regulation of GTPase activity positive regulation of myoblast differentiation CCR chemokine receptor binding eosinophil chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of myoblast fusion |
04060 04062 |
| TC1900001123.mm.2 |
AW112010 |
expressed sequence AW112010 |
19 |
-11047611 |
NR_102366, NM_001177351 NR_102366, NM_001177351 |
107350 |
10 |
molecular_function cellular_component biological_process |
|
| TC0200000551.mm.2 |
|
|
|
|
NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 |
|
|
urea cycle urea cycle citrulline metabolic process argininosuccinate metabolic process argininosuccinate metabolic process nucleotide binding argininosuccinate synthase activity argininosuccinate synthase activity protein binding ATP binding nucleus cytoplasm cytoplasm mitochondrion mitochondrial outer membrane lysosome endoplasmic reticulum cytosol arginine biosynthetic process arginine biosynthetic process aspartate metabolic process circadian rhythm circadian rhythm cellular amino acid biosynthetic process response to zinc ion response to mycotoxin toxic substance binding amino acid binding ligase activity identical protein binding neuron projection neuronal cell body perikaryon myelin sheath positive regulation of nitric oxide biosynthetic process response to glucocorticoid cell body fiber cellular response to laminar fluid shear stress negative regulation of leukocyte cell-cell adhesion |
|
| TC0800001118.mm.2 |
Ccl22 |
chemokine (C-C motif) ligand 22 |
8 |
94745683 |
NM_009137, BC012658 NM_009137, BC012658 |
20299 |
54 |
monocyte chemotaxis cytokine activity extracellular region extracellular space extracellular space chemotaxis inflammatory response immune response G protein-coupled receptor signaling pathway chemokine activity neutrophil chemotaxis killing of cells of other organism positive regulation of GTPase activity CCR chemokine receptor binding lymphocyte chemotaxis cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor |
04060 04062 |
| TC0300001447.mm.2 |
Gbp2 |
guanylate binding protein 2 |
3 |
142620662 |
NM_010260, BC011336, BC032882 NM_010260, BC011336, BC032882 NM_010260, BC011336, BC032882 |
14469 |
54 |
nucleotide binding GTPase activity GTPase activity GTP binding nucleus nucleoplasm cytoplasm Golgi apparatus cytosol response to bacterium membrane hydrolase activity symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle protein localization to nucleus cellular response to interferon-beta protein homodimerization activity defense response to protozoan defense response to protozoan adhesion of symbiont to host perinuclear region of cytoplasm defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC0100000039.mm.2 |
Adhfe1 |
alcohol dehydrogenase, iron containing, 1 |
1 |
9547947 |
NM_175236, NR_027664, BC026584 NM_175236, NR_027664, BC026584 NM_175236, NR_027664, BC026584 |
76187 |
17 |
alcohol dehydrogenase (NAD+) activity mitochondrion mitochondrion glutamate catabolic process via 2-oxoglutarate oxidoreductase activity metal ion binding hydroxyacid-oxoacid transhydrogenase activity |
|
| TC0700002128.mm.2 |
Tarm1 |
T cell-interacting, activating receptor on myeloid cells 1 |
7 |
-3486499, -3489068 |
NM_177363 |
245126 |
10 |
adaptive immune response immune system process plasma membrane plasma membrane membrane integral component of membrane immunoglobulin receptor binding innate immune response positive regulation of cytokine production involved in inflammatory response negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell proliferation |
|
| TC1800001396.mm.2 |
Gm4841 |
predicted gene 4841 |
18 |
-60268300 |
NM_001034859, BC150900 NM_001034859, BC150900 |
225594 |
9 |
GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta |
|
| TC1800000606.mm.2 |
Gm4951 |
predicted gene 4951 |
18 |
60212076 |
NM_001033767, BC139145, BC139147 NM_001033767, BC139145, BC139147 NM_001033767, BC139145, BC139147 |
240327 |
12 |
GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta cellular response to interferon-beta |
|
| TC1500001727.mm.2 |
Ly6i |
lymphocyte antigen 6 complex, locus I |
15 |
-74979533 |
NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 |
57248 |
13 |
plasma membrane plasma membrane membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway |
|
| TC0700003942.mm.2 |
|
|
|
|
XM_485980 |
|
|
|
|
| TC1700001952.mm.2 |
Aif1 |
allograft inflammatory factor 1 |
17 |
-35170985 |
NM_019467, BC021539 NM_019467, BC021539 |
11629 |
177 |
ruffle microglial cell activation phagocytic cup positive regulation of protein phosphorylation actin binding calcium ion binding calcium ion binding protein binding nucleus nucleus cytoplasm cytoplasm cytosol cytoskeleton actin filament actin filament actin filament plasma membrane phagocytosis, engulfment positive regulation of cell population proliferation negative regulation of gene expression positive regulation of muscle hyperplasia membrane Rac protein signal transduction lamellipodium lamellipodium actin filament polymerization parallel actin filament bundle assembly positive regulation of cell migration ruffle membrane ruffle membrane ruffle membrane positive regulation of chemokine production positive regulation of interleukin-6 production cellular response to oxidative stress positive regulation of T cell proliferation cell projection negative regulation of apoptotic process perikaryon positive regulation of nitric oxide biosynthetic process metal ion binding perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation positive regulation of chemotaxis actin filament binding actin filament binding actin filament binding actin filament bundle assembly actin filament bundle assembly actin filament bundle assembly actin crosslink formation negative regulation of smooth muscle cell chemotaxis positive regulation of smooth muscle cell chemotaxis positive regulation of mononuclear cell migration positive regulation of monocyte chemotaxis positive regulation of fibroblast growth factor production ruffle assembly ruffle assembly ruffle assembly positive regulation of G1/S transition of mitotic cell cycle positive regulation of T cell migration |
|
| TC1700002823.mm.2 |
H2-T10 |
histocompatibility 2, T region locus 10 |
17 |
-36115875, -36115870 |
NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 |
15024 |
23 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| TC0200003209.mm.2 |
Slc2a6 |
solute carrier family 2 (facilitated glucose transporter), member 6 |
2 |
-27021364, -27021366 |
NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 |
227659 |
20 |
transporter activity lysosome lysosomal membrane regulation of glycolytic process regulation of glycolytic process carbohydrate transport membrane integral component of membrane transmembrane transporter activity transmembrane transport |
|
| TC1500002347.mm.2 |
Parp10 |
poly (ADP-ribose) polymerase family, member 10 |
15 |
-76232994 |
NM_001163575, NM_001163576 NM_001163575, NM_001163576 |
671535 |
16 |
transcription corepressor activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity nucleus nucleus nucleolus cytoplasm cytoplasm Golgi apparatus cytosol DNA repair protein ADP-ribosylation cellular response to DNA damage stimulus negative regulation of gene expression negative regulation of gene expression regulation of chromatin assembly transferase activity transferase activity, transferring glycosyl groups translesion synthesis negative regulation of NF-kappaB transcription factor activity negative regulation of viral genome replication negative regulation of fibroblast proliferation protein poly-ADP-ribosylation protein poly-ADP-ribosylation protein auto-ADP-ribosylation K63-linked polyubiquitin modification-dependent protein binding protein mono-ADP-ribosylation protein mono-ADP-ribosylation negative regulation of protein K63-linked ubiquitination protein ADP-ribosylase activity protein ADP-ribosylase activity |
|
| TC1900000141.mm.2 |
Plaat3 |
phospholipase A and acyltransferase 3 |
19 |
7557458, 7557484 |
NM_139269, BC024581 NM_139269, BC024581 |
225845 |
28 |
phospholipase A2 activity phospholipase A2 activity phospholipase A2 activity cytoplasm cytoplasm peroxisome endoplasmic reticulum plasma membrane lipid metabolic process triglyceride metabolic process phospholipid metabolic process peroxisome organization phospholipid biosynthetic process phospholipase A1 activity phospholipase A1 activity phospholipase A1 activity response to bacterium membrane integral component of membrane lipid catabolic process N-acyltransferase activity N-acyltransferase activity transferase activity hydrolase activity negative regulation of cell cycle ether lipid metabolic process perinuclear region of cytoplasm phosphatidylserine 1-acylhydrolase activity 1-acyl-2-lysophosphatidylserine acylhydrolase activity N-acylphosphatidylethanolamine metabolic process N-acylphosphatidylethanolamine metabolic process regulation of adipose tissue development |
|
| TC0200003355.mm.2 |
Traf1 |
TNF receptor-associated factor 1 |
2 |
-34941749 |
NM_009421, BC096595 NM_009421, BC096595 |
22029 |
63 |
tumor necrosis factor receptor binding tumor necrosis factor receptor binding protein binding cytoplasm apoptotic process signal transduction zinc ion binding cytoplasmic side of plasma membrane ubiquitin protein ligase binding ubiquitin protein ligase binding thioesterase binding tumor necrosis factor-mediated signaling pathway identical protein binding regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade positive regulation of NF-kappaB transcription factor activity protein K63-linked ubiquitination plasma membrane signaling receptor complex regulation of extrinsic apoptotic signaling pathway |
05200 05222 |
| TC1900000501.mm.2 |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
19 |
34583528 |
NM_010501, BC003804, BC089563 NM_010501, BC003804, BC089563 NM_010501, BC003804, BC089563 |
15959 |
31 |
immune system process RNA binding protein binding cytoplasm mitochondrion cytosol cytosol response to bacterium cellular response to interferon-alpha cellular response to interferon-beta response to stilbenoid identical protein binding innate immune response defense response to virus |
|
| TC1100000989.mm.2 |
Xaf1 |
XIAP associated factor 1 |
11 |
72301628 |
NM_001037713, BC153050 NM_001037713, BC153050 |
327959 |
16 |
nucleus nucleoplasm cytoplasm mitochondrion apoptotic process negative regulation of protein-containing complex assembly response to interferon-beta metal ion binding |
|
| TC0500003629.mm.2 |
Flt1 |
FMS-like tyrosine kinase 1 |
5 |
-147635159, -147561603 |
NM_010228, BC029674 NM_010228, BC029674 |
14254 |
432 |
nucleotide binding angiogenesis angiogenesis branching involved in blood vessel morphogenesis response to hypoxia sprouting angiogenesis hematopoietic progenitor cell differentiation monocyte chemotaxis protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding extracellular space nucleus endosome plasma membrane integral component of plasma membrane integral component of plasma membrane protein phosphorylation chemotaxis transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development positive regulation of phospholipase C activity positive regulation of phosphatidylinositol 3-kinase signaling actin cytoskeleton membrane integral component of membrane kinase activity phosphorylation cell migration cell migration cell migration cell migration transferase activity peptidyl-tyrosine phosphorylation growth factor binding cell differentiation positive regulation of cell migration positive regulation of kinase activity cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-1 signaling pathway placental growth factor-activated receptor activity identical protein binding receptor complex receptor complex positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity positive regulation of angiogenesis positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway blood vessel morphogenesis post-embryonic camera-type eye morphogenesis embryonic morphogenesis positive regulation of hematopoietic progenitor cell differentiation negative regulation of vascular endothelial cell proliferation hyaloid vascular plexus regression |
04060 04144 04510 05323 |
| TC0900001339.mm.2 |
Tlr9 |
toll-like receptor 9 |
9 |
106222597 |
NM_031178, BC172644 NM_031178, BC172644 |
81897 |
855 |
microglial cell activation regulation of cytokine production positive regulation of cytokine production regulation of protein phosphorylation activation of innate immune response toll-like receptor signaling pathway toll-like receptor signaling pathway response to molecule of bacterial origin immune system process positive regulation of immunoglobulin production regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway transmembrane signaling receptor activity interleukin-1 receptor binding protein binding cytoplasm lysosome endosome endoplasmic reticulum plasma membrane plasma membrane plasma membrane plasma membrane inflammatory response immune response immune response signal transduction I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation response to virus positive regulation of autophagy positive regulation of gene expression membrane integral component of membrane basolateral plasma membrane apical plasma membrane maintenance of gastrointestinal epithelium positive regulation of B cell proliferation cytoplasmic vesicle early phagosome negative regulation of NF-kappaB transcription factor activity tumor necrosis factor production tumor necrosis factor production negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 9 signaling pathway regulation of toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 9 signaling pathway siRNA binding endolysosome endolysosome endolysosome pattern recognition receptor activity positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of JUN kinase activity innate immune response unmethylated CpG binding phagocytic vesicle regulation of B cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity defense response to virus defense response to virus defense response to virus positive regulation of nitric-oxide synthase biosynthetic process positive regulation of NIK/NF-kappaB signaling negative regulation of ATPase-coupled calcium transmembrane transporter activity cellular response to chloroquine |
04620 05142 05143 05144 |
| TC1700002071.mm.2 |
H2-M2 |
histocompatibility 2, M region locus 2 |
17 |
-37480850 |
NM_008204, BC150676 NM_008204, BC150676 |
14990 |
17 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane cell surface peptide antigen binding |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| TC0500003180.mm.2 |
Oas1g |
2'-5' oligoadenylate synthetase 1G |
5 |
-120876141 |
NM_011852, BC018470, BC043339 NM_011852, BC018470, BC043339 NM_011852, BC018470, BC043339 |
23960 |
17 |
2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol membrane negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity |
|
| TC0700001913.mm.2 |
Htra1 |
HtrA serine peptidase 1 |
7 |
130936202 |
NM_019564, BC013516 NM_019564, BC013516 |
56213 |
71 |
placenta development serine-type endopeptidase activity protein binding insulin-like growth factor binding extracellular region cytoplasm plasma membrane proteolysis peptidase activity serine-type peptidase activity membrane hydrolase activity growth factor binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway identical protein binding positive regulation of epithelial cell proliferation negative regulation of defense response to virus chorionic trophoblast cell differentiation collagen-containing extracellular matrix collagen-containing extracellular matrix |
|
| TC0500002756.mm.2 |
Cxcl10 |
chemokine (C-X-C motif) ligand 10 |
5 |
-92346638 |
NM_021274, BC030067 NM_021274, BC030067 |
15945 |
278 |
positive regulation of leukocyte chemotaxis cytokine activity extracellular region extracellular space extracellular space extracellular space chemotaxis defense response inflammatory response immune response G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway chemokine activity chemokine activity heparin binding positive regulation of cell population proliferation response to bacterium external side of plasma membrane T cell chemotaxis regulation of T cell chemotaxis negative regulation of angiogenesis positive regulation of cell migration neutrophil chemotaxis killing of cells of other organism chemoattractant activity endothelial cell activation regulation of cell population proliferation regulation of apoptotic process CXCR chemokine receptor binding negative regulation of myoblast differentiation CXCR3 chemokine receptor binding positive regulation of release of sequestered calcium ion into cytosol defense response to virus antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to lipopolysaccharide positive regulation of monocyte chemotaxis regulation of endothelial tube morphogenesis negative regulation of myoblast fusion positive regulation of T cell migration |
04060 04062 04620 04622 04623 |
| TC1900000441.mm.2 |
Cd274 |
CD274 antigen |
19 |
29367437 |
NM_021893, BC066841, CD274 NM_021893, BC066841, CD274 NM_021893, BC066841, CD274 |
60533 |
389 |
adaptive immune response immune system process positive regulation of tolerance induction to tumor cell protein binding nucleoplasm endosome plasma membrane immune response immune response signal transduction cell surface receptor signaling pathway cell surface receptor signaling pathway external side of plasma membrane external side of plasma membrane cell surface actin cytoskeleton membrane integral component of membrane positive regulation of cell migration T cell costimulation T cell costimulation early endosome membrane negative regulation of interferon-gamma production negative regulation of interleukin-10 production positive regulation of interleukin-10 production response to cytokine positive regulation of T cell proliferation positive regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of T cell proliferation negative regulation of activated T cell proliferation recycling endosome membrane extracellular exosome cellular response to lipopolysaccharide toxin transport negative regulation of tumor necrosis factor superfamily cytokine production positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD8-positive, alpha-beta T cell activation |
04514 |
| TC1400000574.mm.2 |
Pnp |
purine-nucleoside phosphorylase |
14 |
50944302 |
NM_013632, BC003788, BC052679 NM_013632, BC003788, BC052679 NM_013632, BC003788, BC052679 |
18950 |
86 |
nucleoside binding positive regulation of T cell mediated cytotoxicity purine nucleobase binding catalytic activity purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity extracellular region nucleus cytoplasm cytoplasm cytosol cytosol cytoskeleton nucleobase-containing compound metabolic process inosine catabolic process inosine catabolic process inosine catabolic process deoxyinosine catabolic process adenosine catabolic process adenosine catabolic process deoxyguanosine catabolic process GTP biosynthetic process AMP catabolic process AMP catabolic process IMP catabolic process IMP catabolic process intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes nucleoside metabolic process response to gamma radiation transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups urate biosynthetic process urate biosynthetic process positive regulation of T cell proliferation positive regulation of T cell proliferation purine nucleoside metabolic process purine nucleoside metabolic process purine nucleoside metabolic process phosphate ion binding identical protein binding positive regulation of B cell differentiation positive regulation of DNA repair GMP catabolic process GMP catabolic process dGMP catabolic process dGMP catabolic process dAMP catabolic process dAMP catabolic process dGTP metabolic process guanosine catabolic process positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell differentiation negative regulation of T cell apoptotic process |
00230 00240 00760 01100 |
| TC0100001615.mm.2 |
Slamf9 |
SLAM family member 9 |
1 |
172475359 |
NM_029612, BC019477 NM_029612, BC019477 |
98365 |
21 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC0600003139.mm.2 |
Tapbpl |
TAP binding protein-like |
6 |
-125224211 |
NM_145391, BC017613 NM_145391, BC017613 |
213233 |
5 |
immune system process peptide antigen assembly with MHC class I protein complex negative regulation of antigen processing and presentation of peptide antigen via MHC class I endoplasmic reticulum Golgi apparatus plasma membrane membrane integral component of membrane MHC class I protein complex binding intracellular membrane-bounded organelle |
|
| TC0900001900.mm.2 |
Acp5 |
acid phosphatase 5, tartrate resistant |
9 |
-22126726, -22126726, -22126726 |
NM_001102404, NM_001102405, NM_007388, BC012911, BC019160, BC029644 NM_001102404, NM_001102405, NM_007388, BC012911, BC019160, BC029644 NM_001102404, NM_001102405, NM_007388, BC012911, BC019160, BC029644 NM_001102404, NM_001102405, NM_007388, BC012911, BC019160, BC029644 NM_001102404, NM_001102405, NM_007388, BC012911, BC019160, BC029644 NM_001102404, NM_001102405, NM_007388, BC012911, BC019160, BC029644 |
11433 |
105 |
ossification acid phosphatase activity acid phosphatase activity acid phosphatase activity lysosome lysosome ferrous iron binding ferric iron binding dephosphorylation hydrolase activity response to lipopolysaccharide negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production negative regulation of tumor necrosis factor production negative regulation of superoxide anion generation response to cytokine negative regulation of nitric oxide biosynthetic process bone resorption bone resorption metal ion binding negative regulation of inflammatory response defense response to Gram-positive bacterium bone morphogenesis |
00740 04142 04380 05323 |
| TC1700000684.mm.2 |
H2-Q4 |
histocompatibility 2, Q region locus 4 |
17 |
35379616 |
NM_001143689, BC010602 NM_001143689, BC010602 |
15015 |
32 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface beta-2-microglobulin binding peptide binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding TAP complex binding endoplasmic reticulum exit site |
|
| TC0700002644.mm.2 |
Axl |
AXL receptor tyrosine kinase |
7 |
-25756499 |
NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 |
26362 |
152 |
nucleotide binding virus receptor activity neuron migration neuron migration natural killer cell differentiation natural killer cell differentiation phosphatidylserine binding negative regulation of cytokine production positive regulation of cytokine-mediated signaling pathway blood vessel remodeling immune system process protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein binding ATP binding extracellular space plasma membrane integral component of plasma membrane protein phosphorylation phagocytosis phagocytosis phagocytosis inflammatory response enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development spermatogenesis nervous system development cell surface actin cytoskeleton membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity forebrain cell migration cell differentiation platelet activation platelet activation cellular response to extracellular stimulus myosin heavy chain binding negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of natural killer cell differentiation secretion by cell positive regulation of kinase activity erythrocyte homeostasis erythrocyte homeostasis substrate adhesion-dependent cell spreading cellular response to interferon-alpha ovulation cycle negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle receptor complex apoptotic cell clearance apoptotic cell clearance protein kinase B signaling protein kinase B signaling negative regulation of neuron apoptotic process negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding innate immune response viral entry into host cell positive regulation of pinocytosis negative regulation of lymphocyte activation positive regulation of protein kinase B signaling positive regulation of protein kinase B signaling vagina development cellular response to hydrogen peroxide cellular response to lipopolysaccharide neutrophil clearance positive regulation of viral life cycle negative regulation of dendritic cell apoptotic process |
|
| TC1700002822.mm.2 |
|
|
|
|
NM_010397, NM_010399, BC003819 NM_010397, NM_010399, BC003819 NM_010397, NM_010399, BC003819 |
|
|
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding |
|
| TC0800001110.mm.2 |
|
|
|
|
NM_001033207, NR_106040 NM_001033207, NR_106040 |
|
|
nucleotide binding RNA polymerase II cis-regulatory region sequence-specific DNA binding immune system process ATP binding nucleus nucleus nucleus cytoplasm centrosome cytosol cytosol response to bacterium negative regulation of NF-kappaB transcription factor activity negative regulation of NF-kappaB transcription factor activity intracellular signal transduction regulation of kinase activity innate immune response innate immune response positive regulation of MHC class I biosynthetic process positive regulation of MHC class I biosynthetic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway |
|
| TC0500003176.mm.2 |
Oas3 |
2'-5' oligoadenylate synthetase 3 |
5 |
-120753097 |
NM_145226, BC141055 NM_145226, BC141055 |
246727 |
19 |
nucleotide binding 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol plasma membrane immune response response to virus membrane transferase activity nucleotidyltransferase activity negative regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus defense response to virus regulation of ribonuclease activity regulation of ribonuclease activity |
05160 |
| TC0700004288.mm.2 |
Nupr1 |
nuclear protein transcription regulator 1 |
7 |
-126623245 |
NM_019738, BC002109 NM_019738, BC002109 |
56312 |
64 |
acute inflammatory response DNA binding chromatin binding transcription coactivator activity protein binding nucleus nucleus nucleoplasm cytoplasm protein acetylation negative regulation of cell population proliferation male gonad development response to toxic substance negative regulation of autophagy negative regulation of autophagy negative regulation of cardiac muscle cell apoptotic process acetyltransferase activator activity positive regulation of protein modification process protein-DNA complex skeletal muscle cell differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of DNA-binding transcription factor activity intercellular bridge negative regulation of cell cycle negative regulation of cell cycle negative regulation of cell cycle positive regulation of cell cycle negative regulation of glycolytic process negative regulation of fibroblast proliferation perinuclear region of cytoplasm negative regulation of epithelial cell proliferation negative regulation of programmed necrotic cell death protein-containing complex assembly positive regulation of neuroinflammatory response positive regulation of proteasomal protein catabolic process negative regulation of autophagosome assembly positive regulation of oxidative phosphorylation negative regulation of epithelial cell apoptotic process negative regulation of type B pancreatic cell proliferation regulation of response to endoplasmic reticulum stress regulation of female gonad development positive regulation of intrinsic apoptotic signaling pathway |
|
| TC0200002223.mm.2 |
Cst7 |
cystatin F (leukocystatin) |
2 |
150570414 |
NM_009977, BC117047, BC117049 NM_009977, BC117047, BC117049 NM_009977, BC117047, BC117049 |
13011 |
25 |
cysteine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity extracellular region extracellular space extracellular space extracellular space cytoplasm lysosome lysosome lysosome endosome late endosome late endosome multivesicular body endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum Golgi apparatus Golgi apparatus Golgi apparatus negative regulation of peptidase activity negative regulation of peptidase activity peptidase inhibitor activity peptidase inhibitor activity cytoplasmic vesicle cytoplasmic vesicle positive regulation of myelination positive regulation of myelination protein homodimerization activity inhibition of cysteine-type endopeptidase activity inhibition of cysteine-type endopeptidase activity negative regulation of microglial cell activation negative regulation of microglial cell activation |
|
| TC0700003941.mm.2 |
Trim30b |
tripartite motif-containing 30B |
7 |
-104355397 |
NM_175648 |
244183 |
14 |
protein polyubiquitination nucleoplasm cytoplasm cytosol regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell positive regulation of NF-kappaB transcription factor activity ubiquitin protein ligase activity |
|
| TC0100003575.mm.2 |
Slamf8 |
SLAM family member 8 |
1 |
-172581376 |
NM_029084, BC024587 NM_029084, BC024587 |
74748 |
14 |
leukocyte chemotaxis involved in inflammatory response B-1 B cell lineage commitment negative regulation of macrophage chemotaxis membrane integral component of membrane regulation of NAD(P)H oxidase activity cellular response to drug signaling receptor activity defense response to bacterium identical protein binding regulation of kinase activity regulation of B cell differentiation negative regulation of respiratory burst involved in inflammatory response negative regulation of monocyte chemotaxis phagosome acidification negative regulation of neutrophil migration negative regulation of dendritic cell chemotaxis |
|
| TC0100000758.mm.2 |
|
|
|
|
XM_979370 |
|
|
|
|
| TC0100003589.mm.2 |
|
|
|
|
XM_136331 |
|
|
|
|
| TC0200004599.mm.2 |
Il1a |
interleukin 1 alpha |
2 |
-129299609 |
NM_010554, BC003727 NM_010554, BC003727 |
16175 |
389 |
fever generation positive regulation of cytokine production connective tissue replacement involved in inflammatory response wound healing cytokine activity cytokine activity interleukin-1 receptor binding copper ion binding extracellular region extracellular space extracellular space extracellular space cytoplasm cytosol plasma membrane cellular sodium ion homeostasis inflammatory response inflammatory response immune response negative regulation of cell population proliferation cell surface positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression positive regulation of steroid biosynthetic process cytokine-mediated signaling pathway cytokine-mediated signaling pathway keratinization positive regulation of prostaglandin secretion positive regulation of interleukin-2 production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade regulation of actin cytoskeleton organization positive regulation of immature T cell proliferation in thymus cellular response to heat ectopic germ cell programmed cell death positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of angiogenesis positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade response to copper ion positive regulation of protein secretion regulation of nitric-oxide synthase activity positive regulation of cell division regulation of sensory perception of pain positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of monocyte chemotactic protein-1 production extrinsic apoptotic signaling pathway in absence of ligand positive regulation of neutrophil migration negative regulation of establishment of Sertoli cell barrier positive regulation of neutrophil extravasation |
04010 04060 04210 04380 04640 04940 05020 05140 05323 05332 |
| TC0700004287.mm.2 |
Il27 |
interleukin 27 |
7 |
-126589008 |
NM_145636, BC119402 NM_145636, BC119402 |
246779 |
199 |
positive regulation of defense response to virus by host positive regulation of defense response to virus by host immune system process signaling receptor binding cytokine activity protein binding extracellular region extracellular region extracellular space extracellular space cytosol inflammatory response positive regulation of interferon-gamma production regulation of T cell proliferation regulation of T cell proliferation innate immune response interleukin-27 receptor binding interleukin-27 receptor binding regulation of T-helper 1 cell differentiation regulation of T-helper 1 cell differentiation |
|
| TC1100003115.mm.2 |
Scimp |
SLP adaptor and CSK interacting membrane protein |
11 |
-70790931 |
NM_001045526, BC147177, BC147178 NM_001045526, BC147177, BC147178 NM_001045526, BC147177, BC147178 |
327957 |
16 |
ruffle immunological synapse immunological synapse cytokine production involved in immune response positive regulation of dendritic cell cytokine production protein binding plasma membrane membrane integral component of membrane filopodium leading edge membrane uropod membrane cytoplasmic vesicle positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of stress-activated MAPK cascade toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor 7 signaling pathway toll-like receptor TLR1:TLR2 signaling pathway cell projection receptor complex phagocytic vesicle molecular adaptor activity positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to molecule of fungal origin tetraspanin-enriched microdomain |
|
| TC0300001445.mm.2 |
Gbp7 |
guanylate binding protein 7 |
3 |
142530335 |
NM_001083312, NM_145545, BC010229 NM_001083312, NM_145545, BC010229 NM_001083312, NM_145545, BC010229 |
229900 |
15 |
GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle defense response to protozoan defense response to protozoan defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC0200000222.mm.2 |
Il15ra |
interleukin 15 receptor, alpha chain |
2 |
11705711, 11705292 |
NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 |
16169 |
143 |
extracellular region nucleus plasma membrane plasma membrane plasma membrane receptor signaling pathway via JAK-STAT cell surface negative regulation of neuron projection development membrane integral component of membrane protein kinase binding cytoplasmic vesicle positive regulation of natural killer cell differentiation interleukin-15-mediated signaling pathway interleukin-15-mediated signaling pathway interleukin-15 receptor activity interleukin-15 receptor activity positive regulation of phagocytosis |
04060 04630 04672 |
| TC1400000745.mm.2 |
Mmp14 |
matrix metallopeptidase 14 (membrane-inserted) |
14 |
54431597 |
NM_008608, BC076638 NM_008608, BC076638 |
17387 |
211 |
skeletal system development ossification endochondral ossification endopeptidase activity metalloendopeptidase activity metalloendopeptidase activity metalloendopeptidase activity integrin binding extracellular space nucleus cytoplasm cytosol plasma membrane proteolysis peptidase activity metallopeptidase activity zinc ion binding response to hormone positive regulation of myotube differentiation positive regulation of protein processing membrane integral component of membrane cell migration hydrolase activity extracellular matrix organization positive regulation of cell growth lung development positive regulation of cell migration collagen catabolic process collagen catabolic process extracellular matrix cytoplasmic vesicle zymogen activation zymogen activation zymogen activation chondrocyte proliferation macropinosome intermediate filament cytoskeleton positive regulation of B cell differentiation negative regulation of Notch signaling pathway metal ion binding embryonic cranial skeleton morphogenesis branching morphogenesis of an epithelial tube tissue remodeling negative regulation of focal adhesion assembly head development bone development metalloaminopeptidase activity craniofacial suture morphogenesis regulation of protein localization to plasma membrane positive regulation of macrophage migration |
04912 |
| TC0200002542.mm.2 |
Mmp9 |
matrix metallopeptidase 9 |
2 |
164948218 |
NM_013599, BC046991 NM_013599, BC046991 |
17395 |
1041 |
skeletal system development skeletal system development positive regulation of protein phosphorylation fibronectin binding positive regulation of leukocyte migration endopeptidase activity metalloendopeptidase activity metalloendopeptidase activity metalloendopeptidase activity serine-type endopeptidase activity extracellular region extracellular space proteolysis response to oxidative stress heart development embryo implantation aging peptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity transformation of host cell by virus extracellular matrix organization extracellular matrix organization extracellular matrix organization positive regulation of cell migration collagen catabolic process collagen catabolic process collagen catabolic process extracellular matrix positive regulation of synaptic plasticity protein-containing complex cellular response to reactive oxygen species response to drug identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of DNA binding protein-containing complex binding positive regulation of epidermal growth factor receptor signaling pathway positive regulation of angiogenesis metal ion binding negative regulation of fibroblast proliferation tissue remodeling positive regulation of keratinocyte migration collagen-containing extracellular matrix cellular response to cadmium ion cellular response to cell-matrix adhesion cellular response to UV-A positive regulation of release of cytochrome c from mitochondria positive regulation of receptor binding response to amyloid-beta positive regulation of vascular associated smooth muscle cell proliferation negative regulation of epithelial cell differentiation involved in kidney development negative regulation of intrinsic apoptotic signaling pathway negative regulation of cation channel activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
04670 05200 05219 |
| TC1700000600.mm.2 |
Daxx |
Fas death domain-associated protein |
17 |
33909497, 33909600, 33909444 |
NM_001199733, NM_007829, BC128373 NM_001199733, NM_007829, BC128373 NM_001199733, NM_007829, BC128373 |
13163 |
100 |
negative regulation of transcription by RNA polymerase II mitotic cytokinesis chromosome, centromeric region heterochromatin XY body positive regulation of protein phosphorylation p53 binding transcription coactivator activity transcription coactivator activity transcription corepressor activity transcription corepressor activity transcription corepressor activity protein binding nucleus nucleus nucleoplasm chromosome cytoplasm cytosol microtubule cell cortex chromatin organization nucleosome assembly nucleosome assembly nucleosome assembly chromatin remodeling regulation of transcription, DNA-templated apoptotic process transcription factor binding transcription factor binding JUN kinase binding negative regulation of myotube differentiation nuclear body PML body PML body PML body kinesin binding enzyme binding protein kinase binding protein kinase activator activity androgen receptor signaling pathway PML body organization regulation of protein ubiquitination ubiquitin protein ligase binding positive regulation of histone phosphorylation cellular response to heat cellular response to unfolded protein regulation of multicellular organism growth histone binding histone binding histone binding protein homodimerization activity regulation of apoptotic process neuron projection positive regulation of apoptotic process negative regulation of apoptotic process cell body positive regulation of protein kinase activity negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein N-terminus binding androgen receptor binding protein localization to chromatin cellular response to cadmium ion cellular response to copper ion cellular response to diamide apoptotic signaling pathway sumo-dependent protein binding transcription regulator inhibitor activity positive regulation of neuron death cellular response to sodium arsenite positive regulation of apoptotic signaling pathway positive regulation of apoptotic signaling pathway |
04010 05014 |
| TC0500003181.mm.2 |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
5 |
-120896256 |
NM_145211, BC013715, BC057878 NM_145211, BC013715, BC057878 NM_145211, BC013715, BC057878 |
246730 |
33 |
2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding protein binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol purine nucleotide biosynthetic process response to virus membrane negative regulation of viral genome replication negative regulation of viral process defense response to virus regulation of ribonuclease activity |
05160 |
| TC1100000119.mm.2 |
Upp1 |
uridine phosphorylase 1 |
11 |
9118007, 9118102, 9118506 |
NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 |
22271 |
43 |
catalytic activity uridine phosphorylase activity uridine phosphorylase activity nucleoplasm cytoplasm cytosol uridine catabolic process uridine catabolic process pyrimidine nucleotide metabolic process CMP catabolic process dCMP catabolic process dCMP catabolic process thymidine phosphorylase activity nucleoside metabolic process nucleotide catabolic process transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups identical protein binding UMP catabolic process dTMP catabolic process dUMP catabolic process uridine metabolic process deoxyuridine phosphorylase activity |
00240 00983 01100 |
| TC1000001596.mm.2 |
Stat2 |
signal transducer and activator of transcription 2 |
10 |
128270497 |
NM_019963, BC167243 NM_019963, BC167243 |
20847 |
120 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific regulation of protein phosphorylation DNA binding DNA-binding transcription factor activity protein binding nucleus cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II defense response signal transduction receptor signaling pathway via JAK-STAT cytokine-mediated signaling pathway regulation of cell population proliferation identical protein binding response to peptide hormone ubiquitin-like protein ligase binding defense response to virus type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway regulation of mitochondrial fission |
04062 04380 04630 05160 |
| TC0400002808.mm.2 |
Tnfsf15 |
tumor necrosis factor (ligand) superfamily, member 15 |
4 |
-63724599 |
NM_177371, BC096494, BC138207, BC138208 NM_177371, BC096494, BC138207, BC138208 NM_177371, BC096494, BC138207, BC138208 NM_177371, BC096494, BC138207, BC138208 |
326623 |
49 |
cytokine production positive regulation of cytokine production death receptor binding cytokine activity tumor necrosis factor receptor binding extracellular region extracellular space plasma membrane apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process immune response signal transduction activation of NF-kappaB-inducing kinase activity membrane integral component of membrane |
04060 |
| TC0800001833.mm.2 |
Gm15056 |
predicted gene 15056 |
8 |
-20900605 |
NM_001177471 |
100504014 |
2 |
|
|
| TC0100001632.mm.2 |
Ifi209 |
interferon activated gene 209 |
1 |
173630858 |
NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 |
236312 |
17 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta cellular response to interferon-beta identical protein binding |
|
| TC1100004265.mm.2 |
Igtp |
interferon gamma induced GTPase |
11 |
58199555 |
NM_018738, BC132557, BC138607 NM_018738, BC132557, BC138607 NM_018738, BC132557, BC138607 |
16145 |
50 |
GTPase activity GTPase activity endoplasmic reticulum membrane cytosol defense response cellular response to interferon-beta cellular response to interferon-beta |
05145 |
| TC0500001724.mm.2 |
Fscn1 |
fascin actin-bundling protein 1 |
5 |
142960354 |
NM_007984, BC052408 NM_007984, BC052408 |
14086 |
66 |
stress fiber ruffle ruffle podosome actin binding protein binding cytoplasm cytoplasm cytosol cytoskeleton plasma membrane microvillus microvillus cell-cell junction actin filament organization cell-cell junction assembly establishment or maintenance of cell polarity drug binding drug binding positive regulation of lamellipodium assembly actin cytoskeleton actin cytoskeleton cell migration cell migration cell migration lamellipodium lamellipodium lamellipodium microspike assembly actin cytoskeleton organization parallel actin filament bundle assembly cell junction filopodium filopodium filopodium dendrite growth cone growth cone growth cone protein-macromolecule adaptor activity cell projection membrane cell projection membrane regulation of microvillus assembly regulation of actin cytoskeleton organization establishment of apical/basal cell polarity cell projection myelin sheath microspike cell motility actin filament binding actin filament binding actin filament binding actin filament bundle assembly actin filament bundle assembly actin filament bundle assembly positive regulation of filopodium assembly positive regulation of filopodium assembly positive regulation of podosome assembly positive regulation of extracellular matrix disassembly |
|
| TC0500001239.mm.2 |
Oasl2 |
2'-5' oligoadenylate synthetase-like 2 |
5 |
114896933 |
NM_011854, BC034361 NM_011854, BC034361 |
23962 |
21 |
nucleotide binding 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleoplasm cytosol purine nucleotide biosynthetic process immune response response to virus membrane transferase activity nucleotidyltransferase activity negative regulation of viral genome replication innate immune response metal ion binding defense response to virus regulation of ribonuclease activity |
|
| TC0200005290.mm.2 |
Zbp1 |
Z-DNA binding protein 1 |
2 |
-173206611, -173213735 |
NM_001139519, NM_021394, BC020033 NM_001139519, NM_021394, BC020033 NM_001139519, NM_021394, BC020033 |
58203 |
62 |
activation of innate immune response immune system process DNA binding DNA binding DNA binding left-handed Z-DNA binding RNA binding double-stranded RNA binding protein binding nucleus nucleus nucleus cytoplasm cytoplasm cytosol cytosol apoptotic process programmed cell death viral process identical protein binding positive regulation of apoptotic process positive regulation of apoptotic process innate immune response regulation of inflammatory response positive regulation of inflammatory response defense response to virus defense response to virus defense response to virus positive regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway positive regulation of necroptotic process positive regulation of necroptotic process positive regulation of necroptotic process pyroptosis regulation of interleukin-1-mediated signaling pathway |
04623 |
| TC1200002524.mm.2 |
Serpina3f |
serine (or cysteine) peptidase inhibitor, clade A, member 3F |
12 |
104214543, 104214632 |
NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 |
238393 |
19 |
serine-type endopeptidase inhibitor activity extracellular space response to bacterium negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity response to cytokine response to peptide hormone |
|
| TC0500001896.mm.2 |
Fzd1 |
frizzled class receptor 1 |
5 |
-4753838 |
NM_021457, BC053010 NM_021457, BC053010 |
14362 |
86 |
positive regulation of protein phosphorylation membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis transmembrane signaling receptor activity G protein-coupled receptor activity signaling receptor binding frizzled binding plasma membrane plasma membrane signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway cell-cell signaling cell-cell signaling multicellular organism development cell surface positive regulation of neuron projection development membrane integral component of membrane Wnt signaling pathway Wnt-protein binding Wnt-protein binding Wnt-protein binding PDZ domain binding negative regulation of BMP signaling pathway epithelial cell differentiation epithelial cell differentiation autocrine signaling non-canonical Wnt signaling pathway astrocyte-dopaminergic neuron signaling response to drug identical protein binding protein homodimerization activity Wnt-activated receptor activity Wnt-activated receptor activity neuron projection canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein heterodimerization activity positive regulation of DNA-binding transcription factor activity hard palate development canonical Wnt signaling pathway canonical Wnt signaling pathway canonical Wnt signaling pathway canonical Wnt signaling pathway ventricular septum morphogenesis negative regulation of canonical Wnt signaling pathway planar cell polarity pathway involved in neural tube closure negative regulation of oxidative stress-induced neuron death regulation of presynapse assembly regulation of presynapse assembly |
04310 04916 05200 05217 |
| TC1800000617.mm.2 |
|
|
|
|
NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) |
|
|
activation of MAPK activity prostaglandin biosynthetic process amyloid-beta binding positive regulation of protein phosphorylation positive regulation of cytokine-mediated signaling pathway positive regulation of cytokine-mediated signaling pathway positive regulation of cytokine-mediated signaling pathway adaptive immune response T cell activation involved in immune response immune system process positive regulation of dendritic cell antigen processing and presentation negative regulation of peptide secretion positive regulation of adaptive immune response positive regulation of type 2 immune response positive regulation of type 2 immune response negative regulation of mature B cell apoptotic process cytokine receptor activity cytokine receptor activity cytokine receptor activity protein binding extracellular space nucleus cytoplasm cytoplasm lysosome endosome late endosome multivesicular body vacuole endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane plasma membrane integral component of plasma membrane intracellular protein transport intracellular protein transport defense response immune response cell population proliferation external side of plasma membrane cell surface cell surface positive regulation of gene expression membrane integral component of membrane immunoglobulin mediated immune response antigen processing and presentation antigen processing and presentation antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II cytokine binding cytokine binding MHC class II protein complex binding negative regulation of cell migration positive regulation of B cell proliferation positive regulation of prostaglandin biosynthetic process positive regulation of chemokine production positive regulation of interleukin-6 production positive regulation of interleukin-8 production protein-containing complex positive regulation of kinase activity positive regulation of kinase activity response to interferon-gamma response to interferon-gamma macrophage migration inhibitory factor signaling pathway macrophage migration inhibitory factor receptor complex macrophage migration inhibitory factor receptor complex NOS2-CD74 complex macrophage migration inhibitory factor binding macrophage migration inhibitory factor binding MHC class II protein binding MHC class II protein binding CD4 receptor binding MHC class II protein complex MHC class II protein complex MHC class II protein binding, via antigen binding groove negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator protein folding chaperone positive thymic T cell selection negative thymic T cell selection positive regulation of innate immune response negative regulation of T cell differentiation positive regulation of T cell differentiation positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated negative regulation of viral entry into host cell positive regulation of viral entry into host cell positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation protein stabilization nitric-oxide synthase binding chaperone cofactor-dependent protein refolding chaperone cofactor-dependent protein refolding positive regulation of macrophage cytokine production positive regulation of macrophage cytokine production protein-containing complex assembly protein trimerization positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of macrophage migration inhibitory factor signaling pathway |
|
| TC1800000609.mm.2 |
F830016B08Rik |
RIKEN cDNA F830016B08 gene |
18 |
60293379 |
NM_001101475 |
240328 |
9 |
GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta |
|
| TC1400001086.mm.2 |
Epsti1 |
epithelial stromal interaction 1 (breast) |
14 |
77904238, 77904238 |
NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 |
108670 |
13 |
molecular_function cellular_component biological_process |
|
| TC1700000621.mm.2 |
Tap1 |
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
17 |
34187555 |
NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 |
21354 |
256 |
nucleotide binding adaptive immune response immune system process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ATP binding mitochondrion endoplasmic reticulum defense response protein transport ABC-type peptide antigen transporter activity ABC-type peptide antigen transporter activity ABC-type peptide antigen transporter activity ABC-type peptide transporter activity peptide transport peptide transport membrane integral component of membrane integral component of membrane ATPase activity antigen processing and presentation of endogenous peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I MHC class Ib protein binding integral component of endoplasmic reticulum membrane phagocytic vesicle membrane centriolar satellite protection from natural killer cell mediated cytotoxicity MHC protein binding MHC class I protein binding MHC class I protein binding peptide antigen binding ATPase-coupled transmembrane transporter activity protein homodimerization activity MHC class I peptide loading complex MHC class I peptide loading complex TAP complex intracellular membrane-bounded organelle ADP binding protein-containing complex binding cytosol to endoplasmic reticulum transport TAP1 binding TAP1 binding TAP2 binding tapasin binding transmembrane transport peptide transmembrane transporter activity |
02010 04145 04612 05340 |
| TC0500002945.mm.2 |
Mfsd7a |
major facilitator superfamily domain containing 7A |
5 |
-108441053 |
NM_172883, BC094512 NM_172883, BC094512 |
243197 |
13 |
cellular_component membrane integral component of membrane transmembrane transport |
|
| TC0100001338.mm.2 |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
1 |
150100030 |
NM_011198, BC052900 NM_011198, BC052900 |
19225 |
998 |
prostaglandin biosynthetic process prostaglandin biosynthetic process angiogenesis peroxidase activity prostaglandin-endoperoxide synthase activity prostaglandin-endoperoxide synthase activity protein binding nuclear inner membrane nuclear inner membrane nuclear outer membrane nuclear outer membrane cytoplasm cytoplasm cytoplasm endoplasmic reticulum caveola lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process inflammatory response response to oxidative stress embryo implantation embryo implantation learning memory regulation of blood pressure positive regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of vascular endothelial growth factor production positive regulation of cell death membrane oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen sensory perception of pain cyclooxygenase pathway cyclooxygenase pathway enzyme binding heme binding keratinocyte differentiation bone mineralization ovulation positive regulation of prostaglandin biosynthetic process positive regulation of fever generation positive regulation of fever generation positive regulation of synaptic plasticity negative regulation of synaptic transmission, dopaminergic response to lipopolysaccharide protein-containing complex positive regulation of peptidyl-serine phosphorylation response to cytokine maintenance of blood-brain barrier regulation of cell population proliferation positive regulation of protein import into nucleus anagen protein homodimerization activity neuron projection neuron projection positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intracellular membrane-bounded organelle positive regulation of nitric oxide biosynthetic process negative regulation of cell cycle positive regulation of vasoconstriction negative regulation of smooth muscle contraction positive regulation of smooth muscle contraction decidualization decidualization metal ion binding positive regulation of smooth muscle cell proliferation brown fat cell differentiation dioxygenase activity negative regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic cellular response to non-ionic osmotic stress cellular response to fluid shear stress positive regulation of transforming growth factor beta production positive regulation of cell migration involved in sprouting angiogenesis positive regulation of fibroblast growth factor production positive regulation of brown fat cell differentiation positive regulation of platelet-derived growth factor production regulation of neuroinflammatory response negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
00590 01100 04370 05140 05200 05222 |
| TC1200000225.mm.2 |
Cmpk2 |
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
12 |
26469214 |
NM_020557, BC027329, BC057565 NM_020557, BC027329, BC057565 NM_020557, BC027329, BC057565 |
22169 |
17 |
nucleotide binding cytidylate kinase activity cytidylate kinase activity nucleoside diphosphate kinase activity nucleoside diphosphate kinase activity thymidylate kinase activity thymidylate kinase activity ATP binding nucleoplasm cytoplasm mitochondrion mitochondrion nucleoside diphosphate phosphorylation pyrimidine nucleotide biosynthetic process dUDP biosynthetic process dUDP biosynthetic process dTDP biosynthetic process dTDP biosynthetic process dTTP biosynthetic process uridylate kinase activity uridylate kinase activity nucleoside triphosphate biosynthetic process kinase activity phosphorylation transferase activity UMP kinase activity nucleoside monophosphate kinase activity cellular response to lipopolysaccharide |
00240 01100 |
| TC1700001902.mm.2 |
Psmb9 |
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) |
17 |
-34182098 |
NM_013585, BC116364 NM_013585, BC116364 |
16912 |
91 |
proteasome complex immune system process endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol cytosol proteasome core complex proteasome core complex proteolysis peptidase activity response to bacterium proteasomal ubiquitin-independent protein catabolic process hydrolase activity antigen processing and presentation antigen processing and presentation proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process proteasome binding spermatoproteasome complex regulation of cysteine-type endopeptidase activity |
03050 |
| TC0500000283.mm.2 |
Il6 |
interleukin 6 |
5 |
30013113 |
NM_031168, BC132458, BC138766 NM_031168, BC132458, BC138766 NM_031168, BC132458, BC138766 |
16193 |
2037 |
neutrophil apoptotic process neutrophil apoptotic process neutrophil apoptotic process myeloid cell homeostasis germinal center B cell differentiation immunoglobulin production hepatic immune response positive regulation of immunoglobulin production positive regulation of acute inflammatory response signaling receptor binding cytokine activity cytokine activity interleukin-6 receptor binding interleukin-6 receptor binding protein binding extracellular region extracellular space extracellular space cytoplasm interleukin-6 receptor complex interleukin-6 receptor complex negative regulation of protein kinase activity acute-phase response inflammatory response immune response growth factor activity positive regulation of cell population proliferation negative regulation of cell population proliferation regulation of cell shape response to wounding external side of plasma membrane gene expression vascular endothelial growth factor production regulation of vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of neuron projection development positive regulation of gliogenesis response to activity cytokine-mediated signaling pathway endocrine pancreas development neuron projection development interleukin-21 production negative regulation of chemokine production negative regulation of chemokine production positive regulation of chemokine production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production negative regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation cellular response to hepatocyte growth factor stimulus positive regulation of T cell proliferation T cell activation regulation of cell population proliferation positive regulation of protein import into nucleus positive regulation of tyrosine phosphorylation of STAT protein glucose homeostasis glucose homeostasis glucose homeostasis defense response to protozoan regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of nitric oxide biosynthetic process cell redox homeostasis positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of gluconeogenesis positive regulation of translation positive regulation of DNA replication negative regulation of bone resorption negative regulation of bone resorption negative regulation of membrane potential positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of receptor signaling pathway via JAK-STAT muscle cell cellular homeostasis negative regulation of hormone secretion negative regulation of muscle organ development positive regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of insulin secretion regulation of insulin secretion positive regulation of B cell activation positive regulation of DNA-binding transcription factor activity response to glucocorticoid defense response to virus positive regulation of protein kinase B signaling positive regulation of transmission of nerve impulse positive regulation of glial cell proliferation branching involved in salivary gland morphogenesis branching involved in salivary gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis T follicular helper cell differentiation glucagon secretion regulation of glucagon secretion regulation of glucagon secretion interleukin-6-mediated signaling pathway interleukin-6-mediated signaling pathway interleukin-6-mediated signaling pathway cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of cell proliferation in bone marrow T-helper 17 cell lineage commitment T-helper 17 cell lineage commitment hepatocyte proliferation positive regulation of extracellular matrix disassembly liver regeneration cellular response to virus positive regulation of cytokine production involved in inflammatory response negative regulation of neuron death positive regulation of apoptotic DNA fragmentation positive regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of T-helper 2 cell cytokine production negative regulation of primary miRNA processing negative regulation of interleukin-1-mediated signaling pathway |
04060 04620 04621 04623 04630 04640 04672 05020 05142 05143 05144 05146 05200 05323 05332 05410 |
| TC1900000439.mm.2 |
Jak2 |
Janus kinase 2 |
19 |
29251802 |
NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 |
16452 |
481 |
nucleotide binding activation of MAPKK activity euchromatin microglial cell activation adaptive immune response immune system process protein kinase activity protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signaling receptor binding growth hormone receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytosol cytosol cytoskeleton plasma membrane caveola focal adhesion chromatin organization protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process response to oxidative stress signal transduction enzyme linked receptor protein signaling pathway G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein protein C-terminus binding positive regulation of cell population proliferation negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to oxidative stress hormone-mediated signaling pathway negative regulation of cardiac muscle cell apoptotic process positive regulation of cell-substrate adhesion positive regulation of phosphatidylinositol 3-kinase signaling membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein kinase binding heme binding negative regulation of cell-cell adhesion myeloid cell differentiation cell differentiation erythrocyte differentiation erythrocyte differentiation positive regulation of cell migration axon regeneration type 1 angiotensin receptor binding mineralocorticoid receptor signaling pathway positive regulation of insulin secretion response to lipopolysaccharide positive regulation of phosphoprotein phosphatase activity positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production acetylcholine receptor binding response to hydroperoxide tumor necrosis factor-mediated signaling pathway programmed cell death induced by symbiont response to tumor necrosis factor post-embryonic hemopoiesis histone kinase activity (H3-Y41 specific) histone kinase activity (H3-Y41 specific) histone H3-Y41 phosphorylation histone H3-Y41 phosphorylation intracellular signal transduction interleukin-12-mediated signaling pathway cellular response to interleukin-3 SH2 domain binding positive regulation of protein import into nucleus histone binding positive regulation of tyrosine phosphorylation of STAT protein identical protein binding activation of Janus kinase activity regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of DNA binding negative regulation of DNA binding negative regulation of neuron apoptotic process phosphatidylinositol 3-kinase binding insulin receptor substrate binding innate immune response membrane raft positive regulation of MHC class II biosynthetic process regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation negative regulation of heart contraction positive regulation of transcription by RNA polymerase II response to antibiotic protein autophosphorylation protein autophosphorylation metal ion binding platelet-derived growth factor receptor signaling pathway regulation of inflammatory response positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation modulation of chemical synaptic transmission positive regulation of cell activation positive regulation of DNA-binding transcription factor activity peptide hormone receptor binding positive regulation of nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process interferon-gamma-mediated signaling pathway positive regulation of SMAD protein signal transduction growth hormone receptor signaling pathway growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT positive regulation of growth hormone receptor signaling pathway negative regulation of cell death mammary gland epithelium development response to interleukin-12 cellular response to lipopolysaccharide cellular response to dexamethasone stimulus response to granulocyte macrophage colony-stimulating factor extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway postsynapse glutamatergic synapse postsynapse to nucleus signaling pathway positive regulation of cold-induced thermogenesis positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of epithelial cell apoptotic process positive regulation of vascular associated smooth muscle cell proliferation positive regulation of signaling receptor activity positive regulation of apoptotic signaling pathway |
04062 04630 04920 05140 05145 |
| TC1700002224.mm.2 |
A530064D06Rik |
RIKEN cDNA A530064D06 gene |
17 |
-48151895 |
NM_001113556, NM_178796, BC139185, BC139186, BC145572 NM_001113556, NM_178796, BC139185, BC139186, BC145572 NM_001113556, NM_178796, BC139185, BC139186, BC145572 NM_001113556, NM_178796, BC139185, BC139186, BC145572 NM_001113556, NM_178796, BC139185, BC139186, BC145572 |
328830 |
11 |
protein binding cell surface signaling receptor activity |
|
| TC0700001116.mm.2 |
Isg20 |
interferon-stimulated protein |
7 |
78913423, 78913764, 78914234 |
NM_001113527, NM_020583, BC022751 NM_001113527, NM_020583, BC022751 NM_001113527, NM_020583, BC022751 |
57444 |
17 |
3'-5'-exoribonuclease activity DNA catabolic process, exonucleolytic DNA catabolic process, exonucleolytic immune system process nucleic acid binding RNA binding nuclease activity exonuclease activity exonuclease activity nucleus nucleus nucleolus cytoplasm rRNA processing RNA catabolic process RNA catabolic process single-stranded DNA 3'-5' exodeoxyribonuclease activity exoribonuclease II activity response to virus Cajal body PML body hydrolase activity U1 snRNA binding U2 snRNA binding U3 snoRNA binding negative regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus defense response to virus |
|
| TC0300002051.mm.2 |
|
|
|
|
NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 |
|
|
G protein-coupled receptor activity plasma membrane immune response signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane G protein-coupled purinergic nucleotide receptor activity hematopoietic stem cell homeostasis |
|
| TC0800000115.mm.2 |
F10 |
coagulation factor X |
8 |
13037307 |
NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 |
14058 |
49 |
serine-type endopeptidase activity calcium ion binding phospholipid binding extracellular region extracellular space endoplasmic reticulum proteolysis blood coagulation blood coagulation hemostasis peptidase activity serine-type peptidase activity membrane hydrolase activity intracellular membrane-bounded organelle positive regulation of protein kinase B signaling |
04610 |
| TC0700000693.mm.2 |
1600014C10Rik |
RIKEN cDNA 1600014C10 gene |
7 |
38183786, 38183216 |
NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 |
72244 |
15 |
molecular_function cytoplasm mitochondrion endoplasmic reticulum cytosol autophagy apoptotic process response to oxidative stress membrane integral component of membrane mitochondrial membrane mitochondrial calcium ion homeostasis |
|
| TC1100002641.mm.2 |
Irgm1 |
immunity-related GTPase family M member 1 |
11 |
-48865244 |
NM_008326, BC145957 NM_008326, BC145957 |
15944 |
77 |
autophagosome assembly nucleotide binding immune system process GTPase activity GTP binding lysosome endosome late endosome autophagosome endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus plasma membrane autophagy defense response defense response response to bacterium membrane hydrolase activity cytoplasmic vesicle cellular response to interferon-beta cell projection autolysosome innate immune response phagocytic vesicle positive regulation of interferon-gamma-mediated signaling pathway cellular response to interferon-gamma positive regulation by symbiont of host autophagy positive regulation of autophagosome maturation |
|
| TC1600001556.mm.2 |
Parp14 |
poly (ADP-ribose) polymerase family, member 14 |
16 |
-35832877 |
NM_001039530, BC138874 NM_001039530, BC138874 |
547253 |
32 |
immune system process transcription corepressor activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity protein binding nucleus cytoplasm cytoplasm cytoplasm cytosol plasma membrane protein ADP-ribosylation negative regulation of gene expression negative regulation of gene expression transferase activity transferase activity, transferring glycosyl groups enzyme binding positive regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein innate immune response negative regulation of interferon-gamma-mediated signaling pathway negative regulation of interferon-gamma-mediated signaling pathway protein poly-ADP-ribosylation protein poly-ADP-ribosylation NAD+ binding protein mono-ADP-ribosylation protein mono-ADP-ribosylation positive regulation of interleukin-4-mediated signaling pathway positive regulation of interleukin-4-mediated signaling pathway protein ADP-ribosylase activity protein ADP-ribosylase activity |
|
| TC0300002659.mm.2 |
Mov10 |
Mov10 RISC complex RNA helicase |
3 |
-104794833, -104794833 |
NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 |
17454 |
39 |
nucleotide binding P-body RNA binding RNA binding helicase activity protein binding ATP binding nucleus cytoplasm cytosol cytosol cytosol negative regulation of transposition, RNA-mediated negative regulation of transposition, RNA-mediated hydrolase activity gene silencing by RNA 5'-3' RNA helicase activity post-transcriptional gene silencing by RNA gene silencing by miRNA mRNA cleavage involved in gene silencing by miRNA cytoplasmic ribonucleoprotein granule P granule defense response to virus positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization regulation of neuron projection arborization |
|
| TC0200001849.mm.2 |
Slc28a2 |
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 |
2 |
122426434 |
NM_172980, BC055376 NM_172980, BC055376 |
269346 |
20 |
retina homeostasis retina homeostasis neurotransmitter transmembrane transporter activity nucleoside transmembrane transporter activity nucleoside transmembrane transporter activity purine nucleobase transmembrane transporter activity nucleoside:sodium symporter activity nucleoside:sodium symporter activity plasma membrane integral component of plasma membrane integral component of plasma membrane neurotransmitter transport vesicle membrane purine nucleoside transmembrane transporter activity purine nucleoside transmembrane transporter activity purine nucleoside transmembrane transporter activity uridine transmembrane transporter activity symporter activity pyrimidine- and adenine-specific:sodium symporter activity purine nucleoside transmembrane transport purine nucleoside transmembrane transport uridine transport membrane integral component of membrane coated vesicle brush border membrane adenosine transport protein localization to cell surface inosine transport pyrimidine-containing compound transmembrane transport nucleoside transmembrane transport nucleoside transmembrane transport purine nucleobase transmembrane transport |
|
| TC1300000624.mm.2 |
Hrh2 |
histamine receptor H2 |
13 |
54192128, 54192132 |
NM_001010973, NM_008286, BC165958 NM_001010973, NM_008286, BC165958 NM_001010973, NM_008286, BC165958 |
15466 |
62 |
gastric acid secretion histamine-induced gastric acid secretion gastrin-induced gastric acid secretion epithelial cell morphogenesis G protein-coupled receptor activity histamine receptor activity G protein-coupled serotonin receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission memory visual learning membrane integral component of membrane dendrite neurotransmitter receptor activity positive regulation of vasoconstriction regulation of synaptic plasticity digestive tract development gland development negative regulation of arachidonic acid secretion heterocyclic compound binding toxin transport |
04020 04080 04971 |
| TC1200001552.mm.2 |
Rsad2 |
radical S-adenosyl methionine domain containing 2 |
12 |
-26442742 |
NM_021384, BC057868 NM_021384, BC057868 |
58185 |
39 |
ossification fibrillar center immune system process catalytic activity protein binding mitochondrion mitochondrion mitochondrial outer membrane mitochondrial inner membrane endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane lipid droplet response to virus response to virus membrane regulation of ossification positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 9 signaling pathway CD4-positive, alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation protein self-association negative regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding negative regulation of protein secretion positive regulation of immune response iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding defense response to virus defense response to virus defense response to virus positive regulation of T-helper 2 cell cytokine production |
|
| TC0600003503.mm.2 |
Herc6 |
hect domain and RLD 6 |
6 |
57580991 |
NM_025992 |
67138 |
17 |
hematopoietic progenitor cell differentiation immune system process ubiquitin-protein transferase activity nucleoplasm cytoplasm cytosol response to bacterium protein ubiquitination transferase activity protein phosphopantetheinylation cyclin binding innate immune response ubiquitin protein ligase activity |
|
| TC0800002330.mm.2 |
Tma16 |
translation machinery associated 16 |
8 |
-66476342 |
NM_025465, BC016246, BC034844 NM_025465, BC016246, BC034844 NM_025465, BC016246, BC034844 |
66282 |
15 |
molecular_function nucleus nucleoplasm nucleolus biological_process |
|
| TC0100001604.mm.2 |
Slamf6 |
SLAM family member 6 |
1 |
171917461, 171917461 |
NM_030710, BC030031 NM_030710, BC030031 |
30925 |
44 |
natural killer cell differentiation natural killer cell proliferation adaptive immune response immune system process plasma membrane integral component of plasma membrane membrane integral component of membrane positive regulation of interferon-gamma production positive regulation of interleukin-17 production innate immune response positive regulation of natural killer cell mediated cytotoxicity T-helper 17 cell lineage commitment |
|
| TC1700001178.mm.2 |
Crim1 |
cysteine rich transmembrane BMP regulator 1 (chordin like) |
17 |
78200247 |
NM_015800, BC100348 NM_015800, BC100348 |
50766 |
50 |
enzyme inhibitor activity serine-type endopeptidase inhibitor activity insulin-like growth factor binding extracellular region membrane integral component of membrane PDZ domain binding negative regulation of BMP signaling pathway negative regulation of osteoblast differentiation |
|
| TC1700000214.mm.2 |
|
|
|
|
NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 |
|
|
amyloid-beta binding amyloid-beta binding microglial cell activation positive regulation of protein phosphorylation complement receptor mediated signaling pathway immune response-regulating cell surface receptor signaling pathway complement receptor activity G protein-coupled receptor activity N-formyl peptide receptor activity N-formyl peptide receptor activity scavenger receptor binding cytoplasm plasma membrane plasma membrane receptor-mediated endocytosis chemotaxis chemotaxis inflammatory response signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane calcium-mediated signaling positive regulation of superoxide anion generation signaling receptor activity signaling receptor activity cargo receptor activity defense response to bacterium negative regulation of neuron apoptotic process positive regulation of innate immune response positive regulation of G protein-coupled receptor signaling pathway astrocyte activation negative regulation of inflammatory response positive regulation of phagocytosis RAGE receptor binding positive chemotaxis positive regulation of protein kinase B signaling positive regulation of 1-phosphatidylinositol-3-kinase activity positive regulation of ERK1 and ERK2 cascade positive regulation of monocyte chemotaxis cellular response to amyloid-beta cellular response to amyloid-beta |
|
| TC0100000765.mm.2 |
Sp140 |
Sp140 nuclear body protein |
1 |
85600702 |
NM_001013817, BC069971 NM_001013817, BC069971 |
434484 |
5 |
fibrillar center mitochondrion |
|
| TC1700000864.mm.2 |
Nfkbie |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon |
17 |
45555699 |
NM_008690, BC030923 NM_008690, BC030923 |
18037 |
38 |
fibrillar center protein binding nucleoplasm cytoplasm Golgi apparatus cytosol D-serine transport negative regulation of transcription, DNA-templated perinuclear region of cytoplasm |
04660 04662 04722 04920 |
| TC0200004109.mm.2 |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
2 |
-91184060, -91184060 |
NM_001177730, NM_013839, BC012646 NM_001177730, NM_013839, BC012646 NM_001177730, NM_013839, BC012646 |
22259 |
438 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II chromatin transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity nuclear receptor activity nuclear receptor activity protein binding nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol regulation of transcription, DNA-templated fatty acid biosynthetic process zinc ion binding positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux positive regulation of cholesterol efflux negative regulation of cholesterol storage negative regulation of cholesterol storage cell differentiation positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport response to progesterone sterol response element binding positive regulation of toll-like receptor 4 signaling pathway phosphatidylcholine acyl-chain remodeling cholesterol homeostasis cholesterol homeostasis cholesterol homeostasis negative regulation of macrophage activation receptor complex apoptotic cell clearance sequence-specific DNA binding cellular lipid metabolic process protein-containing complex binding positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding retinoid X receptor binding negative regulation of pinocytosis negative regulation of inflammatory response negative regulation of inflammatory response positive regulation of lipoprotein lipase activity lipid homeostasis lipid homeostasis sterol homeostasis triglyceride homeostasis triglyceride homeostasis cellular response to lipopolysaccharide cellular response to lipopolysaccharide negative regulation of pancreatic juice secretion negative regulation of secretion of lysosomal enzymes RNA polymerase II transcription regulator complex RNA polymerase II transcription regulator complex negative regulation of cold-induced thermogenesis negative regulation of response to endoplasmic reticulum stress |
03320 05160 |
| TC0300001937.mm.2 |
Slc7a11 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 |
3 |
-50364935 |
NM_011990, BC141402, BC141408 NM_011990, BC141402, BC141408 NM_011990, BC141402, BC141408 |
26570 |
91 |
amino acid transmembrane transport rough endoplasmic reticulum cytoskeleton plasma membrane plasma membrane glutathione metabolic process amino acid transport brain development visual learning response to toxic substance cell surface response to organic cyclic compound L-amino acid transmembrane transporter activity membrane integral component of membrane ventricular system development striatum development transmembrane transporter activity adult behavior brush border membrane regulation of neutrophil apoptotic process cellular response to stress cellular response to oxidative stress glutathione transmembrane transport regulation of cell population proliferation intracellular membrane-bounded organelle apical part of cell regulation of melanin biosynthetic process lung alveolus development modulation of chemical synaptic transmission regulation of synapse organization regulation of protein transport response to redox state transmembrane transport limb development platelet aggregation organic substance transport glutamate homeostasis glutamate homeostasis astrocyte projection L-glutamate import across plasma membrane dipeptide import across plasma membrane regulation of cellular response to oxidative stress regulation of cysteine metabolic process negative regulation of oxidative stress-induced neuron death negative regulation of oxidative stress-induced neuron death regulation of glutathione biosynthetic process regulation of AMPA glutamate receptor clustering regulation of glutamate metabolic process |
|
| TC0400003679.mm.2 |
Xkr8 |
X-linked Kx blood group related 8 |
4 |
-132724903 |
NM_201368, BC057035 NM_201368, BC057035 |
381560 |
18 |
tolerance induction to self antigen molecular_function plasma membrane plasma membrane apoptotic process membrane integral component of membrane engulfment of apoptotic cell engulfment of apoptotic cell establishment of localization in cell phosphatidylserine exposure on apoptotic cell surface phosphatidylserine exposure on apoptotic cell surface phosphatidylserine exposure on apoptotic cell surface apoptotic process involved in development |
|
| TC1200000837.mm.2 |
Jdp2 |
Jun dimerization protein 2 |
12 |
85599415, 85600017, 85599104 |
NM_001205052, NM_001205053, NM_030887, BC019780 NM_001205052, NM_001205053, NM_030887, BC019780 NM_001205052, NM_001205053, NM_030887, BC019780 NM_001205052, NM_001205053, NM_030887, BC019780 |
81703 |
43 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding chromatin binding double-stranded DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of histone deacetylation positive regulation of histone deacetylation protein-containing complex binding negative regulation of fat cell differentiation sequence-specific double-stranded DNA binding |
|
| TC0600001193.mm.2 |
Itpr1 |
inositol 1,4,5-trisphosphate receptor 1 |
6 |
108213095 |
NM_010585, BC172648 NM_010585, BC172648 |
16438 |
282 |
response to hypoxia response to hypoxia ion channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium channel activity calcium ion binding protein binding nuclear envelope nuclear envelope nuclear inner membrane nucleolus cytoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane plasma membrane plasma membrane calcineurin complex ion transport calcium ion transport apoptotic process positive regulation of cytosolic calcium ion concentration protein C-terminus binding post-embryonic development positive regulation of neuron projection development postsynaptic density postsynaptic density calcium-release channel activity membrane integral component of membrane sarcoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum calcium channel inhibitor activity protein phosphatase binding integral component of endoplasmic reticulum membrane dendrite cytoplasmic vesicle membrane secretory granule membrane secretory granule membrane smooth endoplasmic reticulum membrane platelet dense granule membrane platelet dense tubular network cytoplasmic vesicle endoplasmic reticulum calcium ion homeostasis protein-containing complex protein-containing complex phosphatidylinositol binding phosphatidylinositol binding epithelial fluid transport identical protein binding neuronal cell body positive regulation of apoptotic process intracellular membrane-bounded organelle ion channel binding protein-containing complex binding membrane raft perinuclear region of cytoplasm negative regulation of calcium-mediated signaling voluntary musculoskeletal movement release of sequestered calcium ion into cytosol release of sequestered calcium ion into cytosol release of sequestered calcium ion into cytosol positive regulation of calcium ion transport transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress calcium ion transmembrane transport inositol 1,4,5 trisphosphate binding cellular response to cAMP synaptic membrane liver regeneration Schaffer collateral - CA1 synapse Schaffer collateral - CA1 synapse inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels presynapse postsynapse GABA-ergic synapse negative regulation of neuron death positive regulation of hepatocyte proliferation |
04020 04070 04114 04270 04540 04720 04730 04912 04970 04971 04972 05010 05016 |
| TC0900000032.mm.2 |
Casp4 |
caspase 4, apoptosis-related cysteine peptidase |
9 |
5308848, 5308859 |
NM_007609, BC061255 NM_007609, BC061255 |
12363 |
223 |
immune system process cysteine-type endopeptidase activity cysteine-type endopeptidase activity protein binding extracellular region cytoplasm mitochondrion endoplasmic reticulum cytosol plasma membrane proteolysis inflammatory response actin filament organization peptidase activity cysteine-type peptidase activity programmed cell death membrane protein autoprocessing protein autoprocessing hydrolase activity positive regulation of interleukin-1 beta production protein-containing complex ectopic germ cell programmed cell death ectopic germ cell programmed cell death regulation of apoptotic process neuron projection neuronal cell body innate immune response CARD domain binding regulation of inflammatory response regulation of inflammatory response regulation of inflammatory response inflammasome complex intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress pyroptosis pyroptosis pyroptosis IPAF inflammasome complex NLRP3 inflammasome complex scaffold protein binding AIM2 inflammasome complex intrinsic apoptotic signaling pathway cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of tumor necrosis factor-mediated signaling pathway cellular response to amyloid-beta |
|
| TC0100002707.mm.2 |
|
|
|
|
NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 |
|
|
DNA-binding transcription factor activity, RNA polymerase II-specific nucleus regulation of transcription by RNA polymerase II |
|
| TC0700002499.mm.2 |
Nectin2 |
nectin cell adhesion molecule 2 |
7 |
-19724160, -19716643 |
NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 |
19294 |
73 |
acrosome assembly acrosome assembly positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of immunoglobulin mediated immune response positive regulation of immunoglobulin mediated immune response protein binding plasma membrane plasma membrane cell-cell junction cell-cell junction zonula adherens cytoskeleton organization cytoskeleton organization cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules spermatid development spermatid nucleus differentiation fertilization cell surface membrane integral component of membrane integral component of membrane virion attachment to host cell fusion of virus membrane with host plasma membrane fusion of virus membrane with host plasma membrane sperm mitochondrion organization cell part morphogenesis positive regulation of mast cell activation positive regulation of mast cell activation susceptibility to natural killer cell mediated cytotoxicity susceptibility to natural killer cell mediated cytotoxicity identical protein binding identical protein binding protein homodimerization activity protein homodimerization activity apical junction complex apical junction complex cell-cell contact zone adhesion of symbiont to host cilium organization positive regulation of natural killer cell mediated cytotoxicity regulation of viral entry into host cell regulation of viral entry into host cell coreceptor-mediated virion attachment to host cell coreceptor-mediated virion attachment to host cell cell adhesion molecule binding cell adhesion molecule binding cell adhesion molecule binding positive regulation of T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway establishment of mitochondrion localization establishment of mitochondrion localization susceptibility to T cell mediated cytotoxicity susceptibility to T cell mediated cytotoxicity |
04514 04520 |
| TC0500001349.mm.2 |
Oas1b |
2'-5' oligoadenylate synthetase 1B |
5 |
120812634, 120812637 |
NM_001083925, NR_003507, BC012877 NM_001083925, NR_003507, BC012877 NM_001083925, NR_003507, BC012877 |
23961 |
46 |
2'-5'-oligoadenylate synthetase activity double-stranded RNA binding nucleoplasm cytosol membrane negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity |
05160 |
| TC0300002506.mm.2 |
Fcgr1 |
Fc receptor, IgG, high affinity I |
3 |
-96282908 |
NM_010186, BC160240 NM_010186, BC160240 |
14129 |
186 |
antibody-dependent cellular cytotoxicity positive regulation of type IIa hypersensitivity positive regulation of type III hypersensitivity immune system process transmembrane signaling receptor activity plasma membrane integral component of plasma membrane receptor-mediated endocytosis phagocytosis, recognition phagocytosis, engulfment cell surface receptor signaling pathway cell surface receptor signaling pathway response to bacterium external side of plasma membrane membrane integral component of membrane IgG receptor activity IgG binding IgG binding antigen processing and presentation of exogenous antigen leukotriene receptor binding antigen processing and presentation of exogenous peptide antigen via MHC class I defense response to bacterium innate immune response membrane raft positive regulation of phagocytosis regulation of immune response regulation of immune response positive regulation of phagocytosis, engulfment positive regulation of protein tyrosine kinase activity |
04145 04380 04640 04666 05140 05150 05322 |
| TC1900000105.mm.2 |
Majin |
membrane anchored junction protein |
19 |
6184344 |
NM_001165919, BC138005, BC145092 NM_001165919, BC138005, BC145092 NM_001165919, BC138005, BC145092 |
622554 |
13 |
chromosome, telomeric region molecular_function DNA binding nucleus integral component of nuclear inner membrane integral component of nuclear inner membrane chromosome homologous chromosome pairing at meiosis homologous chromosome pairing at meiosis membrane integral component of membrane meiotic telomere clustering meiotic cell cycle meiotic attachment of telomere to nuclear envelope meiotic attachment of telomere to nuclear envelope |
|
| TC0500003730.mm.2 |
Gbp9 |
guanylate-binding protein 9 |
5 |
-105076465 |
NM_172777, BC057170 NM_172777, BC057170 |
236573 |
13 |
GTPase activity GTP binding symbiont-containing vacuole membrane cytoplasmic vesicle cytoplasmic vesicle defense response to protozoan defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium defense response to Gram-positive bacterium cellular response to interferon-gamma cellular response to interferon-gamma |
|
| TC1900001253.mm.2 |
Gda |
guanine deaminase |
19 |
-21391306 |
NM_010266, BC076583 NM_010266, BC076583 |
14544 |
33 |
protein binding cytosol cytosol guanine catabolic process zinc ion binding guanine deaminase activity guanine deaminase activity guanine deaminase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds deaminase activity positive regulation of microtubule polymerization GMP catabolic process dGMP catabolic process guanine metabolic process metal ion binding |
00230 01100 |
| TC0200003630.mm.2 |
Ifih1 |
interferon induced with helicase C domain 1 |
2 |
-62595792 |
NM_001164477, NM_027835, BC080200 NM_001164477, NM_027835, BC080200 NM_001164477, NM_027835, BC080200 |
71586 |
136 |
nucleotide binding immune system process DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding single-stranded RNA binding single-stranded RNA binding helicase activity protein binding ATP binding nucleus cytoplasm zinc ion binding zinc ion binding response to virus response to virus hydrolase activity protein sumoylation positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production MDA-5 signaling pathway identical protein binding ribonucleoprotein complex binding innate immune response innate immune response metal ion binding defense response to virus positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA |
04622 |
| TC1900000500.mm.2 |
Ifit2 |
interferon-induced protein with tetratricopeptide repeats 2 |
19 |
34551087, 34550693 |
NM_008332, BC050835 NM_008332, BC050835 |
15958 |
39 |
immune system process RNA binding cytoplasm endoplasmic reticulum cytosol apoptotic process response to virus response to virus negative regulation of protein binding cellular response to interferon-alpha positive regulation of apoptotic process innate immune response defense response to virus |
|
| TC0400000458.mm.2 |
Glipr2 |
GLI pathogenesis-related 2 |
4 |
43957701 |
NM_027450, BC031750 NM_027450, BC031750 |
384009 |
25 |
Golgi membrane extracellular region extracellular space Golgi apparatus positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition membrane protein homodimerization activity positive regulation of ERK1 and ERK2 cascade |
|
| TC0800000770.mm.2 |
Il12rb1 |
interleukin 12 receptor, beta 1 |
8 |
70808448 |
NM_008353, BC057212 NM_008353, BC057212 |
16161 |
77 |
positive regulation of defense response to virus by host positive regulation of T-helper 1 type immune response cytokine receptor activity interleukin-12 receptor binding interleukin-12 receptor binding protein binding plasma membrane external side of plasma membrane external side of plasma membrane membrane integral component of membrane interleukin-12 receptor activity peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cytokine binding positive regulation of interferon-gamma production interleukin-23 binding interleukin-23 binding interleukin-23 receptor activity interleukin-12 receptor complex interleukin-12 receptor complex positive regulation of activated T cell proliferation positive regulation of activated T cell proliferation receptor complex cellular response to interferon-gamma interleukin-23 receptor complex interleukin-23 receptor complex interleukin-23 receptor complex |
04060 04630 |
| TC0Y00000551.mm.2 |
|
|
|
|
|
|
|
|
|
| TC0Y00000552.mm.2 |
|
|
|
|
|
|
|
|
|
| TC1700001953.mm.2 |
Lst1 |
leukocyte specific transcript 1 |
17 |
-35185094 |
NM_010734, BC086881 NM_010734, BC086881 |
16988 |
21 |
cell morphogenesis immune system process immune response regulation of cell shape membrane integral component of membrane dendrite development dendrite development |
|
| TC0100003320.mm.2 |
Tor3a |
torsin family 3, member A |
1 |
-156653616 |
NM_023141, BC071216 NM_023141, BC071216 |
30935 |
24 |
nucleotide binding protein binding ATP binding nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum lumen endoplasmic reticulum lumen ATPase activity ATPase activity |
|
| TC0500003175.mm.2 |
Oas2 |
2'-5' oligoadenylate synthetase 2 |
5 |
-120730332 |
NM_145227 |
246728 |
27 |
nucleotide binding 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity 2'-5'-oligoadenylate synthetase activity immune system process RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleoplasm cytoplasm cytosol RNA catabolic process immune response response to virus response to bacterium membrane transferase activity nucleotidyltransferase activity negative regulation of viral genome replication innate immune response metal ion binding perinuclear region of cytoplasm defense response to virus defense response to virus type I interferon signaling pathway regulation of ribonuclease activity regulation of lactation |
05160 |
| TC1600001580.mm.2 |
Cd86 |
CD86 antigen |
16 |
-36603868 |
NM_019388, BC013807, CD86 NM_019388, BC013807, CD86 NM_019388, BC013807, CD86 |
12524 |
335 |
toll-like receptor signaling pathway adaptive immune response immune system process immunoglobulin production negative regulation of T cell anergy signaling receptor binding protein binding plasma membrane immune response cell surface receptor signaling pathway activation of phospholipase C activity external side of plasma membrane external side of plasma membrane cell surface membrane integral component of membrane CD40 signaling pathway T cell costimulation toll-like receptor 3 signaling pathway centriolar satellite positive regulation of T cell proliferation positive regulation of T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation B cell activation negative regulation of T cell proliferation intracellular membrane-bounded organelle defense response to virus extracellular exosome cellular response to lipopolysaccharide cellular response to lipopolysaccharide positive regulation of NIK/NF-kappaB signaling activation of protein kinase C activity |
04514 04620 04672 04940 05320 05322 05323 05330 05332 05416 |
| TC0400001510.mm.2 |
Rnf19b |
ring finger protein 19B |
4 |
129058143 |
NM_029219 |
75234 |
19 |
ubiquitin ligase complex protein polyubiquitination adaptive immune response immune system process ubiquitin-protein transferase activity cytoplasm endoplasmic reticulum cytosol ubiquitin-dependent protein catabolic process membrane integral component of membrane protein ubiquitination transferase activity ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process interferon-gamma production natural killer cell mediated cytotoxicity ubiquitin binding cytolytic granule cytolytic granule metal ion binding protein autoubiquitination ubiquitin protein ligase activity ubiquitin protein ligase activity |
|
| TC0900003335.mm.2 |
Uba7 |
ubiquitin-like modifier activating enzyme 7 |
9 |
107975566 |
NM_023738, BC138843 NM_023738, BC138843 |
74153 |
30 |
ubiquitin-protein transferase activity nucleus cytoplasm cellular protein modification process cellular response to DNA damage stimulus ISG15 activating enzyme activity ISG15 activating enzyme activity ISG15 activating enzyme activity modification-dependent protein catabolic process ISG15-protein conjugation ISG15-protein conjugation ISG15-protein conjugation ISG15-protein conjugation protein modification by small protein conjugation |
04120 05012 |
| TC0400004173.mm.2 |
Plekhn1 |
pleckstrin homology domain containing, family N member 1 |
4 |
-156221455, -156221455 |
NM_001008233 |
231002 |
11 |
response to hypoxia response to hypoxia phosphatidylserine binding phosphatidylserine binding protein binding mitochondrion mitochondrion cytoskeleton cytoskeleton mitochondrial membrane mitochondrial membrane positive regulation of apoptotic process positive regulation of apoptotic process 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA destabilization phosphatidic acid binding phosphatidic acid binding cardiolipin binding cardiolipin binding phosphatidylinositol phosphate binding phosphatidylinositol phosphate binding |
|
| TC1800001334.mm.2 |
Lox |
lysyl oxidase |
18 |
-52516059, -52516059, -52516059 |
NM_001286181, NM_001286182, NM_010728, BC018439 NM_001286181, NM_001286182, NM_010728, BC018439 NM_001286181, NM_001286182, NM_010728, BC018439 NM_001286181, NM_001286182, NM_010728, BC018439 |
16948 |
142 |
blood vessel development osteoblast differentiation regulation of protein phosphorylation protein-lysine 6-oxidase activity protein-lysine 6-oxidase activity protein-lysine 6-oxidase activity copper ion binding protein binding collagen binding extracellular region collagen trimer extracellular space extracellular space extracellular space nucleus heart development response to hormone regulation of gene expression regulation of striated muscle tissue development oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor regulation of transforming growth factor beta receptor signaling pathway peptidyl-lysine oxidation peptidyl-lysine oxidation protein oxidation collagen fibril organization collagen fibril organization collagen fibril organization bone mineralization lung development extracellular matrix extracellular matrix platelet-derived growth factor receptor-beta signaling pathway platelet-derived growth factor receptor-beta signaling pathway aorta development ascending aorta development descending aorta development wound healing regulation of apoptotic process protein kinase B signaling protein kinase B signaling regulation of megakaryocyte differentiation muscle cell cellular homeostasis metal ion binding elastic fiber assembly elastic fiber assembly blood vessel morphogenesis response to steroid hormone muscle fiber development cell chemotaxis cell chemotaxis connective tissue development collagen-containing extracellular matrix cellular response to organic substance DNA biosynthetic process regulation of receptor binding regulation of receptor binding regulation of bone development cellular response to chemokine regulation of platelet-derived growth factor receptor-beta signaling pathway |
|
| TC1100001236.mm.2 |
Slfn5 |
schlafen 5 |
11 |
82952101 |
NM_183201, BC117909, BC117910 NM_183201, BC117909, BC117910 NM_183201, BC117909, BC117910 |
327978 |
19 |
nucleotide binding ATP binding nucleus cell differentiation |
|
| TC0700001841.mm.2 |
Itgal |
integrin alpha L |
7 |
127296259 |
NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 |
16408 |
202 |
immunological synapse T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell plasma membrane cell-cell junction phagocytosis cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion cell surface receptor signaling pathway integrin-mediated signaling pathway integrin complex external side of plasma membrane cell surface membrane integral component of membrane regulation of cell-cell adhesion positive regulation of cell-cell adhesion ICAM-3 receptor activity integrin alphaL-beta2 complex memory T cell extravasation positive regulation of T cell proliferation receptor clustering protein-containing complex binding metal ion binding activated T cell proliferation cell adhesion molecule binding positive regulation of calcium-mediated signaling cell-cell adhesion cell-cell adhesion |
04514 04650 04670 04810 05144 05150 05323 05416 |
| TC0100000375.mm.2 |
Stat1 |
signal transducer and activator of transcription 1 |
1 |
52119437, 52119621 |
NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 |
20846 |
857 |
chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific negative regulation of endothelial cell proliferation positive regulation of defense response to virus by host DNA binding double-stranded DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity tumor necrosis factor receptor binding protein binding nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytosol cytosol transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II activation of cysteine-type endopeptidase activity involved in apoptotic process defense response signal transduction receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT response to nutrient blood circulation positive regulation of cell population proliferation response to mechanical stimulus response to bacterium macrophage derived foam cell differentiation negative regulation of angiogenesis cytokine-mediated signaling pathway cytokine-mediated signaling pathway enzyme binding axon dendrite lipopolysaccharide-mediated signaling pathway CCR5 chemokine receptor binding response to lipopolysaccharide positive regulation of interferon-alpha production cellular response to insulin stimulus protein-containing complex tumor necrosis factor-mediated signaling pathway response to cytokine negative regulation of macrophage fusion response to type I interferon histone acetyltransferase binding nuclear hormone receptor binding response to interferon-beta cellular response to interferon-beta regulation of cell population proliferation histone binding response to drug identical protein binding protein homodimerization activity negative regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA response to peptide hormone response to peptide hormone sequence-specific DNA binding ubiquitin-like protein ligase binding positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation by virus of viral protein levels in host cell perinuclear region of cytoplasm positive regulation of smooth muscle cell proliferation response to cAMP defense response to virus protein phosphatase 2A binding positive regulation of nitric-oxide synthase biosynthetic process interferon-gamma-mediated signaling pathway interferon-gamma-mediated signaling pathway type I interferon signaling pathway type I interferon signaling pathway type I interferon signaling pathway renal tubule development repressing transcription factor binding cellular response to lipopolysaccharide cellular response to cytokine stimulus cellular response to interferon-gamma cellular response to organic cyclic compound promoter-specific chromatin binding |
04062 04380 04620 04630 05140 05145 05160 05200 05212 |
| TC1700001905.mm.2 |
H2-Aa |
histocompatibility 2, class II antigen A, alpha |
17 |
-34282743 |
NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 |
14960 |
115 |
adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II protein binding lysosome plasma membrane immune response external side of plasma membrane membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II response to interferon-gamma negative regulation of T cell proliferation peptide antigen binding MHC class II protein complex protein-containing complex binding positive regulation of T cell differentiation antigen processing and presentation of peptide antigen |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1300002725.mm.2 |
Parp8 |
poly (ADP-ribose) polymerase family, member 8 |
13 |
-116850843 |
NM_001081009, BC021315, BC021881 NM_001081009, BC021315, BC021881 NM_001081009, BC021315, BC021881 |
52552 |
20 |
NAD+ ADP-ribosyltransferase activity intracellular anatomical structure protein ADP-ribosylation transferase activity transferase activity, transferring glycosyl groups protein auto-ADP-ribosylation protein mono-ADP-ribosylation protein ADP-ribosylase activity |
|
| TC0700003850.mm.2 |
Il18bp |
interleukin 18 binding protein |
7 |
-102015073 |
NM_010531, BC018332 NM_010531, BC018332 |
16068 |
30 |
extracellular region extracellular space extracellular space interleukin-18 binding interleukin-18 binding T-helper 1 type immune response T-helper 1 type immune response |
|
| TC1100003779.mm.2 |
Dhx58 |
DEXH (Asp-Glu-X-His) box polypeptide 58 |
11 |
-100694883 |
NM_030150, BC029209 NM_030150, BC029209 |
80861 |
36 |
nucleotide binding immune system process DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding single-stranded RNA binding single-stranded RNA binding helicase activity ATP binding cytoplasm cytoplasm zinc ion binding zinc ion binding response to virus response to virus response to bacterium hydrolase activity negative regulation of type I interferon production negative regulation of type I interferon production positive regulation of type I interferon production positive regulation of interferon-beta production negative regulation of MDA-5 signaling pathway negative regulation of RIG-I signaling pathway negative regulation of RIG-I signaling pathway innate immune response regulation of innate immune response negative regulation of innate immune response negative regulation of innate immune response metal ion binding defense response to virus positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway |
04622 |
| TC0300000521.mm.2 |
Kcnab1 |
potassium voltage-gated channel, shaker-related subfamily, beta member 1 |
3 |
65109013, 65188102, 64949211 |
NM_001289450, NM_010597, BC014701 NM_001289450, NM_010597, BC014701 NM_001289450, NM_010597, BC014701 |
16497 |
33 |
aldo-keto reductase (NADP) activity aldo-keto reductase (NADP) activity voltage-gated ion channel activity voltage-gated potassium channel activity protein binding cytoplasm cytosol plasma membrane ion transport potassium ion transport learning or memory voltage-gated potassium channel complex voltage-gated potassium channel complex voltage-gated potassium channel complex potassium channel regulator activity potassium channel regulator activity membrane integral component of membrane oxidoreductase activity protein domain specific binding axon extrinsic component of cytoplasmic side of plasma membrane extrinsic component of cytoplasmic side of plasma membrane dendrite cytoplasm potassium channel complex regulation of ion transmembrane transport neuronal cell body perikaryon juxtaparanode region of axon juxtaparanode region of axon ion channel binding ion channel binding transmembrane transport NADPH binding regulation of potassium ion transmembrane transporter activity regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport regulation of delayed rectifier potassium channel activity negative regulation of delayed rectifier potassium channel activity negative regulation of delayed rectifier potassium channel activity negative regulation of voltage-gated potassium channel activity proximal dendrite |
|
| TC1500000565.mm.2 |
Gsdmd |
gasdermin D |
15 |
75862338 |
NM_026960, BC029813 NM_026960, BC029813 |
69146 |
94 |
phosphatidylserine binding phosphatidylserine binding immune system process phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-4,5-bisphosphate binding extracellular region extracellular space nucleoplasm cytoplasm cytosol plasma membrane inflammatory response lipid binding programmed cell death membrane integral component of membrane wide pore channel activity wide pore channel activity cellular response to extracellular stimulus positive regulation of interleukin-1 beta production pore formation in membrane of other organism defense response to bacterium innate immune response pore complex assembly defense response to Gram-negative bacterium defense response to Gram-positive bacterium protein homooligomerization inflammasome complex pyroptosis pyroptosis pyroptosis phosphatidylinositol-4-phosphate binding phosphatidylinositol-4-phosphate binding phosphatidic acid binding NLRP3 inflammasome complex NLRP3 inflammasome complex cardiolipin binding |
|
| TC0300000161.mm.2 |
Tnfsf10 |
tumor necrosis factor (ligand) superfamily, member 10 |
3 |
27317076 |
NM_009425, BC138807, BC138808 NM_009425, BC138807, BC138808 NM_009425, BC138807, BC138808 |
22035 |
189 |
cytokine activity tumor necrosis factor receptor binding extracellular region extracellular space plasma membrane apoptotic process immune response zinc ion binding membrane integral component of membrane tumor necrosis factor receptor superfamily binding identical protein binding positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process TRAIL binding metal ion binding positive regulation of release of cytochrome c from mitochondria positive regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway |
04060 04210 04650 |
| TC0700003943.mm.2 |
Trim30a |
tripartite motif-containing 30A |
7 |
-104409025, -104409025 |
NM_009099, BC005447 NM_009099, BC005447 |
20128 |
34 |
protein polyubiquitination DNA binding ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm cytoplasm cytosol autophagy zinc ion binding response to bacterium regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production regulation of protein localization negative regulation of toll-like receptor signaling pathway protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of protein catabolic process regulation of viral entry into host cell positive regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity defense response to virus protein autoubiquitination ubiquitin protein ligase activity negative regulation of NLRP3 inflammasome complex assembly negative regulation of reactive oxygen species metabolic process |
|
| TC1100004266.mm.2 |
Irgm2 |
immunity-related GTPase family M member 2 |
11 |
58214976 |
NM_019440 |
54396 |
22 |
autophagosome assembly Golgi membrane positive regulation of protein phosphorylation GTPase activity GTPase activity mitochondrion endoplasmic reticulum membrane Golgi apparatus Golgi apparatus cytosol defense response response to bacterium positive regulation of autophagy positive regulation of peptidyl-threonine phosphorylation protein kinase binding symbiont-containing vacuole protein destabilization positive regulation of peptidyl-serine phosphorylation response to interferon-gamma response to interferon-gamma cellular response to interferon-beta defense response to bacterium defense response to bacterium defense response to protozoan regulation of protein-containing complex assembly protein serine/threonine kinase activator activity innate immune response CARD domain binding protein stabilization defense response to Gram-negative bacterium BH3 domain binding positive regulation of interferon-gamma-mediated signaling pathway regulation of protein complex stability protein lipidation involved in autophagosome assembly CAMKK-AMPK signaling cascade nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide positive regulation of protein serine/threonine kinase activity positive regulation by symbiont of host autophagy cellular response to virus positive regulation of autophagosome maturation |
|
| TC0600003169.mm.2 |
Ccnd2 |
cyclin D2 |
6 |
-127125708 |
NM_009829, BC049086 NM_009829, BC049086 |
12444 |
357 |
regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex cyclin-dependent protein kinase holoenzyme complex chromatin positive regulation of protein phosphorylation protein binding nucleus nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytosol cell cycle long-term memory positive regulation of cell population proliferation adult locomotory behavior membrane cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding nuclear membrane negative regulation of apoptotic process mitotic cell cycle phase transition positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of epithelial cell proliferation cell division regulation of cell cycle cellular response to X-ray cyclin D2-CDK4 complex positive regulation of G1/S transition of mitotic cell cycle positive regulation of G1/S transition of mitotic cell cycle |
04110 04115 04310 04510 04630 |
| TC0900001858.mm.2 |
Tyk2 |
tyrosine kinase 2 |
9 |
-21104067 |
NM_001205312, NM_018793, BC094240 NM_001205312, NM_018793, BC094240 NM_001205312, NM_018793, BC094240 |
54721 |
96 |
nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity growth hormone receptor binding ATP binding nucleus cytoplasm cytosol cytoskeleton protein phosphorylation membrane kinase activity phosphorylation transferase activity type 1 angiotensin receptor binding intracellular signal transduction |
04380 04630 05145 05160 |
| TC0500003297.mm.2 |
Stx2 |
syntaxin 2 |
5 |
-128984557, -128984557 |
NM_001286033, NM_001286034, NM_007941, BC046279 NM_001286033, NM_001286034, NM_007941, BC046279 NM_001286033, NM_001286034, NM_007941, BC046279 NM_001286033, NM_001286034, NM_007941, BC046279 |
13852 |
51 |
SNARE binding SNARE binding mitotic cytokinesis structural molecule activity SNAP receptor activity protein binding extracellular space plasma membrane plasma membrane cell-cell junction intracellular protein transport exocytosis vesicle fusion acrosome reaction embryo implantation synaptic vesicle cell surface endomembrane system membrane integral component of membrane vesicle-mediated transport basolateral plasma membrane lamellipodium microvillus assembly transport vesicle cell differentiation midbody epithelial cell differentiation SNARE complex cytoplasmic vesicle synaptic vesicle fusion to presynaptic active zone membrane protein-containing complex cellular response to oxidative stress identical protein binding membrane raft synapse vesicle docking calcium-dependent protein binding digestive tract morphogenesis presynaptic active zone membrane midbody abscission cornified envelope assembly |
04130 |
| TC0600002114.mm.2 |
Parp12 |
poly (ADP-ribose) polymerase family, member 12 |
6 |
-39086411 |
NM_172893, BC120733, BC137645 NM_172893, BC120733, BC137645 NM_172893, BC120733, BC137645 |
243771 |
25 |
NAD+ ADP-ribosyltransferase activity cellular_component nucleus protein ADP-ribosylation transferase activity protein phosphopantetheinylation metal ion binding protein auto-ADP-ribosylation protein mono-ADP-ribosylation protein ADP-ribosylase activity |
|
| TC1700000685.mm.2 |
H2-Q5 |
histocompatibility 2, Q region locus 5 |
17 |
35394098 |
NR_051981, BC160245, XM_003688944 NR_051981, BC160245, XM_003688944 NR_051981, BC160245, XM_003688944 |
15016 |
29 |
|
|
| TC0200003278.mm.2 |
Ptges |
prostaglandin E synthase |
2 |
-30889470 |
NM_022415, BC024960 NM_022415, BC024960 |
64292 |
186 |
prostaglandin biosynthetic process prostaglandin biosynthetic process prostaglandin biosynthetic process glutathione transferase activity glutathione peroxidase activity prostaglandin-D synthase activity prostaglandin-D synthase activity prostaglandin-D synthase activity nuclear envelope lumen cytoplasm lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process negative regulation of cell population proliferation membrane integral component of membrane integral component of membrane oxidoreductase activity transferase activity isomerase activity sensory perception of pain regulation of fever generation positive regulation of prostaglandin secretion intracellular membrane-bounded organelle glutathione binding perinuclear region of cytoplasm prostaglandin-E synthase activity prostaglandin-E synthase activity regulation of inflammatory response |
00590 01100 |
| TC0800000538.mm.2 |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
8 |
46490965, 46471036 |
NM_007981, BC056644 NM_007981, BC056644 |
14081 |
64 |
very long-chain fatty acid metabolic process very long-chain fatty acid metabolic process nucleotide binding long-chain fatty acid metabolic process catalytic activity long-chain fatty acid-CoA ligase activity long-chain fatty acid-CoA ligase activity ATP binding mitochondrion mitochondrion mitochondrial outer membrane peroxisome peroxisomal membrane endoplasmic reticulum endoplasmic reticulum plasma membrane lipid metabolic process fatty acid metabolic process lipid biosynthetic process lipid biosynthetic process response to organic substance positive regulation of long-chain fatty acid import across plasma membrane fatty acid transport membrane integral component of membrane ligase activity triglyceride biosynthetic process adiponectin-activated signaling pathway long-chain fatty-acyl-CoA biosynthetic process long-chain fatty-acyl-CoA biosynthetic process xenobiotic catabolic process intracellular membrane-bounded organelle acetate-CoA ligase (ADP-forming) activity long-chain fatty acid import into cell arachidonate-CoA ligase activity arachidonate-CoA ligase activity phytanate-CoA ligase activity positive regulation of protein serine/threonine kinase activity oleoyl-CoA ligase activity decanoate-CoA ligase activity positive regulation of cold-induced thermogenesis |
00071 01100 03320 04146 04920 |
| TC0600001481.mm.2 |
Parp11 |
poly (ADP-ribose) polymerase family, member 11 |
6 |
127453626, 127446839 |
NM_181402, BC040269 NM_181402, BC040269 |
101187 |
18 |
NAD+ ADP-ribosyltransferase activity nucleus nuclear envelope nuclear pore nucleoplasm cytosol protein ADP-ribosylation nuclear envelope organization spermatogenesis protein transport nuclear body transferase activity transferase activity, transferring glycosyl groups protein phosphopantetheinylation cell differentiation mRNA transport protein auto-ADP-ribosylation protein mono-ADP-ribosylation protein ADP-ribosylase activity |
|
| TC1700001993.mm.2 |
H2-T24 |
histocompatibility 2, T region locus 24 |
17 |
-36005694 |
NM_008207, BC156693 NM_008207, BC156693 |
15042 |
11 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| TC1400000071.mm.2 |
Flnb |
filamin, beta |
14 |
7817956 |
NM_134080 |
286940 |
65 |
stress fiber keratinocyte development epithelial cell morphogenesis actin binding protein binding nucleus cytoplasm cytosol cytoskeleton plasma membrane brush border focal adhesion skeletal muscle tissue development actin cytoskeleton organization cell differentiation identical protein binding neuron projection neuronal cell body phagocytic vesicle cellular response to interferon-gamma |
04010 04510 |
| TC1700000622.mm.2 |
Psmb8 |
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) |
17 |
34198194 |
NM_010724, BC013785, BC051450 NM_010724, BC013785, BC051450 NM_010724, BC013785, BC051450 |
16913 |
114 |
proteasome complex immune system process endopeptidase activity threonine-type endopeptidase activity protein binding nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteasome core complex proteolysis peptidase activity proteasomal ubiquitin-independent protein catabolic process hydrolase activity antigen processing and presentation cell differentiation proteasome-mediated ubiquitin-dependent protein catabolic process fat cell differentiation fat cell differentiation proteolysis involved in cellular protein catabolic process regulation of endopeptidase activity spermatoproteasome complex |
03050 |
| TC0400003681.mm.2 |
Themis2 |
thymocyte selection associated family member 2 |
4 |
-132782356 |
NM_001033308, BC151122, BC151126 NM_001033308, BC151122, BC151126 NM_001033308, BC151122, BC151126 |
230787 |
18 |
immune system process protein binding nucleus nucleus cytoplasm cytoplasm inflammatory response T cell receptor signaling pathway T cell receptor signaling pathway |
|
| TC1100002642.mm.2 |
Gm5431 |
predicted gene 5431 |
11 |
-48887421 |
NM_001024230 |
432555 |
9 |
GTPase activity endoplasmic reticulum membrane defense response cellular response to interferon-beta |
|
| TC0100000919.mm.2 |
Dusp28 |
dual specificity phosphatase 28 |
1 |
92906988 |
NM_175118, BC119127 NM_175118, BC119127 |
67446 |
10 |
phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein dephosphorylation protein tyrosine/serine/threonine phosphatase activity dephosphorylation hydrolase activity phosphatase activity |
|
| TC0500002989.mm.2 |
Fbrsl1 |
fibrosin-like 1 |
5 |
-110429874, -110361751, -110361751 |
NM_001142642, NM_028596, BC151196 NM_001142642, NM_028596, BC151196 NM_001142642, NM_028596, BC151196 |
381668 |
19 |
cellular_component biological_process |
|
| TC1600001198.mm.2 |
Socs1 |
suppressor of cytokine signaling 1 |
16 |
-10783808 |
NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 |
12703 |
310 |
regulation of cytokine production regulation of protein phosphorylation insulin-like growth factor receptor binding protein binding nucleus nucleoplasm cytoplasm cytosol phosphatidylinositol 3-kinase complex receptor signaling pathway via JAK-STAT negative regulation of signal transduction regulation of activation of Janus kinase activity kinase inhibitor activity cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein kinase binding cytoplasmic vesicle intracellular signal transduction cytoplasmic ribonucleoprotein granule regulation of growth regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein negative regulation of tyrosine phosphorylation of STAT protein positive regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of CD8-positive, alpha-beta T cell differentiation fat cell differentiation positive regulation of regulatory T cell differentiation regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via JAK-STAT negative regulation of insulin receptor signaling pathway phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity regulation of interferon-gamma-mediated signaling pathway cellular response to amino acid stimulus cellular response to cytokine stimulus cellular response to organic cyclic compound |
04120 04380 04630 04910 04930 05145 |
| TC1700002819.mm.2 |
H2-T23 |
histocompatibility 2, T region locus 23 |
17 |
-36029976 |
NM_010398, BC099472 NM_010398, BC099472 |
15040 |
74 |
positive regulation of antibody-dependent cellular cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity adaptive immune response immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent natural killer cell tolerance induction positive regulation of immunoglobulin production regulation of natural killer cell mediated immunity positive regulation of natural killer cell mediated immunity positive regulation of natural killer cell cytokine production signaling receptor binding signaling receptor binding extracellular space plasma membrane immune response external side of plasma membrane cell surface membrane integral component of membrane antibacterial humoral response phagocytic vesicle membrane beta-2-microglobulin binding MHC class Ib protein complex positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of TRAIL production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation CD8-positive, alpha-beta T cell activation protection from natural killer cell mediated cytotoxicity MHC class I protein binding peptide antigen binding peptide antigen binding T cell receptor binding MHC class I protein complex negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity natural killer cell lectin-like receptor binding inner ear development defense response to Gram-positive bacterium integral component of lumenal side of endoplasmic reticulum membrane positive regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell activation |
04144 04145 04514 04612 04650 04940 05320 05330 05332 05416 |
| TC1400002833.mm.2 |
Rnf31 |
ring finger protein 31 |
14 |
55591741 |
NM_194346, BC057595 NM_194346, BC057595 |
268749 |
49 |
protein polyubiquitination ubiquitin-protein transferase activity protein binding cytoplasm cytosol cytoplasmic side of plasma membrane protein ubiquitination transferase activity CD40 signaling pathway ubiquitin protein ligase binding CD40 receptor complex identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding metal ion binding T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity negative regulation of necroptotic process LUBAC complex protein linear polyubiquitination |
|
| TC1_GL456212_random00000013.mm.2 |
Sp110 |
Sp110 nuclear body protein |
1 |
-85576898, -85576898 |
BC039938 |
109032 |
29 |
DNA-binding transcription factor activity, RNA polymerase II-specific immune system process DNA binding nucleus nucleoplasm regulation of transcription by RNA polymerase II apoptotic process response to bacterium response to bacterium positive regulation of apoptotic process innate immune response |
|
| TC0500003186.mm.2 |
Trafd1 |
TRAF type zinc finger domain containing 1 |
5 |
-121371724, -121371724 |
NM_001163470, NM_172275, BC038396 NM_001163470, NM_172275, BC038396 NM_001163470, NM_172275, BC038396 |
231712 |
19 |
protein binding zinc ion binding negative regulation of innate immune response metal ion binding |
|
| TC0400001924.mm.2 |
Mthfr |
methylenetetrahydrofolate reductase |
4 |
148039076, 148041188 |
NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 |
17769 |
98 |
neural tube closure catalytic activity methylenetetrahydrofolate reductase (NAD(P)H) activity methylenetetrahydrofolate reductase (NAD(P)H) activity methylenetetrahydrofolate reductase (NAD(P)H) activity cytosol cytosol methionine metabolic process metabolic process methionine biosynthetic process methionine biosynthetic process oxidoreductase activity regulation of histone methylation tetrahydrofolate interconversion tetrahydrofolate interconversion protein-containing complex binding synapse tetrahydrofolate metabolic process flavin adenine dinucleotide binding NADP binding homocysteine metabolic process heterochromatin maintenance FAD binding modified amino acid binding |
00670 01100 |
| TC0100002725.mm.2 |
Sp110 |
Sp110 nuclear body protein |
1 |
-85576898, -85576898 |
NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 |
109032 |
29 |
DNA-binding transcription factor activity, RNA polymerase II-specific immune system process DNA binding nucleus nucleoplasm regulation of transcription by RNA polymerase II apoptotic process response to bacterium response to bacterium positive regulation of apoptotic process innate immune response |
|
| TC0700003862.mm.2 |
Trim21 |
tripartite motif-containing 21 |
7 |
-102557919 |
NM_001082552, NM_009277, BC010580 NM_001082552, NM_009277, BC010580 NM_001082552, NM_009277, BC010580 |
20821 |
59 |
protein polyubiquitination protein polyubiquitination DNA binding transcription coactivator activity RNA binding ubiquitin-protein transferase activity protein binding nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytoplasm cytosol protein monoubiquitination cell cycle zinc ion binding regulation of gene expression positive regulation of autophagy positive regulation of autophagy protein ubiquitination protein ubiquitination transferase activity SCF ubiquitin ligase complex protein kinase binding cytoplasmic vesicle protein destabilization negative regulation of NF-kappaB transcription factor activity positive regulation of protein binding regulation of protein localization negative regulation of viral transcription response to interferon-gamma identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response innate immune response positive regulation of cell cycle negative regulation of innate immune response regulation of viral entry into host cell positive regulation of viral entry into host cell metal ion binding positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein autoubiquitination ubiquitin protein ligase activity ubiquitin protein ligase activity protein K63-linked ubiquitination negative regulation of protein deubiquitination negative regulation of viral release from host cell |
05322 |
| TC1700002782.mm.2 |
H2-Eb1 |
histocompatibility 2, class II antigen E beta |
17 |
34305866 |
NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 |
14969 |
80 |
adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II protein binding lysosomal membrane immune response membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II late endosome membrane response to interferon-gamma MHC class II protein complex |
04145 04514 04612 04640 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC0700004538.mm.2 |
Slc25a22 |
solute carrier family 25 (mitochondrial carrier, glutamate), member 22 |
7 |
-141429748, -141429748, -141429748 |
NM_001177576, NM_026646, BC037949 NM_001177576, NM_026646, BC037949 NM_001177576, NM_026646, BC037949 |
68267 |
35 |
L-glutamate transmembrane transporter activity L-glutamate transmembrane transporter activity mitochondrion mitochondrial inner membrane transport L-aspartate transmembrane transporter activity symporter activity aspartate transmembrane transport L-glutamate transmembrane transport L-glutamate transmembrane transport membrane integral component of membrane transmembrane transporter activity malate-aspartate shuttle transmembrane transport |
|
| TC1000001149.mm.2 |
Tmcc3 |
transmembrane and coiled coil domains 3 |
10 |
94575256, 94576262, 94550919, 94311948, 94550871, 94514856 |
NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 |
319880 |
20 |
endoplasmic reticulum biological_process endomembrane system membrane integral component of membrane identical protein binding 14-3-3 protein binding |
|
| TC1300000607.mm.2 |
Gadd45g |
growth arrest and DNA-damage-inducible 45 gamma |
13 |
51846674 |
NM_011817, BC001989 NM_011817, BC001989 |
23882 |
68 |
activation of MAPKKK activity activation of MAPKKK activity activation of MAPKK activity protein binding nucleus nucleus nucleus cytoplasm cytoplasm negative regulation of protein kinase activity apoptotic process multicellular organism development cell differentiation interferon-gamma production identical protein binding positive regulation of apoptotic process T-helper 1 cell differentiation positive regulation of JNK cascade regulation of cell cycle regulation of cell cycle positive regulation of cold-induced thermogenesis positive regulation of p38MAPK cascade |
04010 04110 04115 |
| TC1100003382.mm.2 |
Slfn8 |
schlafen 8 |
11 |
-83002157, -83002157 |
NM_001167743, NM_181545 NM_001167743, NM_181545 |
276950 |
15 |
tRNA binding nucleotide binding immune system process nuclease activity endonuclease activity endoribonuclease activity endoribonuclease activity ATP binding cytoplasm zinc ion binding rRNA catabolic process tRNA catabolic process hydrolase activity metal ion binding defense response to virus |
|
| TC1100002003.mm.2 |
|
|
|
|
XM_001477846 |
|
|
|
|
| TC0700003946.mm.2 |
Trim30d |
tripartite motif-containing 30D |
7 |
-104470013 |
NM_001167828, NM_199146, BC056631 NM_001167828, NM_199146, BC056631 NM_001167828, NM_199146, BC056631 |
209387 |
13 |
protein polyubiquitination nucleoplasm cytoplasm cytosol regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell positive regulation of NF-kappaB transcription factor activity ubiquitin protein ligase activity |
|
| TC1900000217.mm.2 |
Ms4a4c |
membrane-spanning 4-domains, subfamily A, member 4C |
19 |
11407660 |
NM_029499, BC027496 NM_029499, BC027496 |
64380 |
12 |
molecular_function cellular_component biological_process |
|
| TC0600000340.mm.2 |
Tmem140 |
transmembrane protein 140 |
6 |
34863145 |
NM_197986, BC020080, BC023802 NM_197986, BC020080, BC023802 NM_197986, BC020080, BC023802 |
68487 |
10 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC1100002567.mm.2 |
Pttg1 |
pituitary tumor-transforming gene 1 |
11 |
-43420243, -43420243 |
NM_001131054, NM_013917, BC023324 NM_001131054, NM_013917, BC023324 NM_001131054, NM_013917, BC023324 |
30939 |
83 |
regulation of cell growth cysteine-type endopeptidase inhibitor activity nucleus nucleus nucleus cytoplasm cytosol DNA repair cellular response to DNA damage stimulus cell cycle chromosome segregation mitotic sister chromatid cohesion negative regulation of cell population proliferation cellular process SH3 domain binding heat shock protein binding ribosome binding homologous chromosome segregation homologous chromosome segregation chromosome organization cell division negative regulation of mitotic sister chromatid separation |
04110 04114 |
| TC0100002204.mm.2 |
Mgat4a |
mannoside acetylglucosaminyltransferase 4, isoenzyme A |
1 |
-37439339, -37439339 |
NM_173870, BC165942 NM_173870, BC165942 |
269181 |
19 |
extracellular region endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus Golgi stack protein N-linked glycosylation protein N-linked glycosylation acetylglucosaminyltransferase activity acetylglucosaminyltransferase activity alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups metal ion binding |
00510 01100 |
| TC0800002146.mm.2 |
Tlr3 |
toll-like receptor 3 |
8 |
-45395664, -45395664 |
NM_126166, BC099937 NM_126166, BC099937 |
142980 |
523 |
microglial cell activation positive regulation of cytokine production toll-like receptor signaling pathway toll-like receptor signaling pathway immune system process regulation of dendritic cell cytokine production MyD88-independent toll-like receptor signaling pathway RNA binding double-stranded RNA binding transmembrane signaling receptor activity protein binding cytoplasm endosome endoplasmic reticulum integral component of plasma membrane defense response inflammatory response signal transduction I-kappaB phosphorylation response to virus cell surface positive regulation of gene expression membrane integral component of membrane positive regulation of type I interferon production positive regulation of chemokine production positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor signaling pathway toll-like receptor 3 signaling pathway positive regulation of type III interferon production signaling receptor activity identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA response to exogenous dsRNA response to dsRNA innate immune response positive regulation of angiogenesis positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity defense response to virus defense response to virus cellular response to exogenous dsRNA extrinsic apoptotic signaling pathway necroptotic signaling pathway positive regulation of NIK/NF-kappaB signaling |
04620 05160 |
| TC0400003680.mm.2 |
Smpdl3b |
sphingomyelin phosphodiesterase, acid-like 3B |
4 |
-132732965 |
NM_133888, BC009087 NM_133888, BC009087 |
100340 |
25 |
immune system process sphingomyelin phosphodiesterase activity protein binding extracellular region extracellular space plasma membrane lipid metabolic process sphingomyelin catabolic process inflammatory response phosphoric diester hydrolase activity phosphoric diester hydrolase activity phosphoric diester hydrolase activity phosphoric diester hydrolase activity metabolic process zinc ion binding membrane lipid catabolic process hydrolase activity hydrolase activity, acting on glycosyl bonds anchored component of membrane negative regulation of toll-like receptor signaling pathway innate immune response negative regulation of innate immune response membrane lipid catabolic process metal ion binding negative regulation of inflammatory response |
|
| TC1700000935.mm.2 |
Treml2 |
triggering receptor expressed on myeloid cells-like 2 |
17 |
48300037 |
NM_001033405, BC160362 NM_001033405, BC160362 |
328833 |
17 |
plasma membrane cell surface cell surface membrane integral component of membrane signaling receptor activity signaling receptor activity T cell activation T cell activation |
|
| TC0300002188.mm.2 |
Rapgef2 |
Rap guanine nucleotide exchange factor (GEF) 2 |
3 |
-79062510, -79062510 |
NM_001099624 |
76089 |
38 |
blood vessel development neuron migration guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity GTPase activator activity intracellular anatomical structure cytoplasm endosome late endosome cytosol plasma membrane bicellular tight junction signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway neuropeptide signaling pathway neuropeptide signaling pathway small GTPase mediated signal transduction multicellular organism development nervous system development negative regulation of cell population proliferation negative regulation of cell population proliferation positive regulation of neuron projection development membrane apical plasma membrane protein kinase binding cAMP-mediated signaling cAMP-mediated signaling ventricular system development forebrain neuron development microvillus assembly cell junction endocytic vesicle cell differentiation PDZ domain binding neuron projection development neuron projection development brain-derived neurotrophic factor receptor signaling pathway beta-1 adrenergic receptor binding positive regulation of protein binding Rap protein signal transduction protein-containing complex nerve growth factor signaling pathway regulation of cell population proliferation neuron projection neuronal cell body positive regulation of GTPase activity positive regulation of GTPase activity positive regulation of GTPase activity positive regulation of cAMP-mediated signaling synapse positive regulation of protein kinase activity positive regulation of protein kinase activity negative regulation of melanin biosynthetic process regulation of synaptic plasticity perinuclear region of cytoplasm WW domain binding negative regulation of dendrite morphogenesis negative regulation of dendrite morphogenesis establishment of endothelial barrier phosphatidic acid binding positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to cAMP cellular response to cAMP cellular response to cAMP cellular response to cGMP adenylate cyclase-activating adrenergic receptor signaling pathway protein localization to plasma membrane establishment of endothelial intestinal barrier regulation of cell junction assembly cellular response to nerve growth factor stimulus positive regulation of cAMP-dependent protein kinase activity positive regulation of cAMP-dependent protein kinase activity positive regulation of dendritic cell apoptotic process positive regulation of dendritic cell apoptotic process positive regulation of vasculogenesis positive regulation of neuron migration |
04010 |
| TC1900001118.mm.2 |
Ccdc86 |
coiled-coil domain containing 86 |
19 |
-10941480 |
NM_023731, BC043326 NM_023731, BC043326 |
108673 |
21 |
nucleus nucleoplasm chromosome nucleolus nucleolus |
|
| TC1700002135.mm.2 |
Enpp4 |
ectonucleotide pyrophosphatase/phosphodiesterase 4 |
17 |
-44096309, -44096309 |
NM_199016, BC027749 NM_199016, BC027749 |
224794 |
17 |
catalytic activity plasma membrane blood coagulation hemostasis membrane integral component of membrane hydrolase activity positive regulation of blood coagulation purine ribonucleoside catabolic process metal ion binding bis(5'-adenosyl)-triphosphatase activity |
|
| TC0300000096.mm.2 |
Car2 |
carbonic anhydrase 2 |
3 |
14886268, 14886287 |
NM_009801, BC055291 NM_009801, BC055291 |
12349 |
152 |
morphogenesis of an epithelium arylesterase activity carbonate dehydratase activity carbonate dehydratase activity carbonate dehydratase activity carbonate dehydratase activity extracellular space cytoplasm cytoplasm cytosol plasma membrane plasma membrane microvillus one-carbon metabolic process regulation of pH zinc ion binding carbon dioxide transport carbon dioxide transport carbon dioxide transport membrane basolateral plasma membrane lyase activity hydro-lyase activity axon positive regulation of synaptic transmission, GABAergic positive regulation of cellular pH reduction positive regulation of cellular pH reduction angiotensin-activated signaling pathway myelin sheath myelin sheath regulation of anion transport apical part of cell apical part of cell positive regulation of osteoclast differentiation positive regulation of bone resorption metal ion binding secretion regulation of intracellular pH regulation of intracellular pH positive regulation of dipeptide transmembrane transport regulation of chloride transport |
00910 04966 04971 04972 04976 |
| TC0200001851.mm.2 |
Slc28a2b |
solute carrier family 28 member 2b |
2 |
122484940 |
NM_001085518 |
381417 |
8 |
retina homeostasis nucleoside transmembrane transporter activity nucleoside:sodium symporter activity integral component of plasma membrane purine nucleoside transmembrane transporter activity symporter activity nucleoside transmembrane transport |
|
| TC1000002642.mm.2 |
Dram1 |
DNA-damage regulated autophagy modulator 1 |
10 |
-88322803 |
NM_027878, BC021433 NM_027878, BC021433 |
71712 |
16 |
molecular_function cytoplasm lysosome lysosome autophagy apoptotic process regulation of autophagy regulation of autophagy membrane integral component of membrane |
|
| TC0200000868.mm.2 |
Gpd2 |
glycerol phosphate dehydrogenase 2, mitochondrial |
2 |
57237677, 57238381 |
NM_001145820, NM_010274, BC021359 NM_001145820, NM_010274, BC021359 NM_001145820, NM_010274, BC021359 |
14571 |
55 |
glycerol-3-phosphate dehydrogenase [NAD+] activity glycerol-3-phosphate dehydrogenase (quinone) activity calcium ion binding mitochondrion mitochondrion mitochondrion mitochondrial inner membrane glycerol-3-phosphate metabolic process glycerol-3-phosphate metabolic process gluconeogenesis NADH metabolic process glycerol-3-phosphate dehydrogenase complex membrane oxidoreductase activity multicellular organism growth camera-type eye development metal ion binding sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity |
00564 |
| TC0400003917.mm.2 |
Pdpn |
podoplanin |
4 |
-143267408 |
NM_010329, BC026551 NM_010329, BC026551 |
14726 |
331 |
cell morphogenesis cell morphogenesis ruffle lymphangiogenesis signaling receptor binding signaling receptor binding protein binding mitochondrion cytosol plasma membrane plasma membrane prostaglandin metabolic process movement of cell or subcellular component cell adhesion signal transduction Rho protein signal transduction Rho protein signal transduction multicellular organism development cell population proliferation negative regulation of cell population proliferation regulation of cell shape external side of plasma membrane positive regulation of platelet activation positive regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition membrane integral component of membrane basolateral plasma membrane basolateral plasma membrane apical plasma membrane apical plasma membrane chemokine binding chemokine binding lamellipodium lamellipodium cell junction regulation of cell adhesion filopodium filopodium lung development lung development positive regulation of cell migration positive regulation of cell migration lamellipodium membrane cytoplasmic vesicle filopodium membrane microvillus membrane ruffle membrane tube morphogenesis tube morphogenesis cell projection negative regulation of apoptotic process wound healing, spreading of cells membrane raft lung alveolus development lymph node development chaperone binding chaperone binding positive regulation of cellular component movement response to hyperoxia lymphatic endothelial cell fate commitment visceral serous pericardium development leading edge of lamellipodium actin-mediated cell contraction actin-mediated cell contraction positive regulation of extracellular matrix disassembly positive regulation of extracellular matrix disassembly tetraspanin-enriched microdomain cell-cell adhesion cell-cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of substrate adhesion-dependent cell spreading positive regulation of platelet aggregation positive regulation of platelet aggregation positive regulation of platelet aggregation positive regulation of platelet aggregation regulation of myofibroblast contraction regulation of myofibroblast contraction regulation of G1/S transition of mitotic cell cycle regulation of lamellipodium morphogenesis regulation of lamellipodium morphogenesis |
|
| TC1100000614.mm.2 |
Irf1 |
interferon regulatory factor 1 |
11 |
53770013, 53770013, 53770472 |
NM_001159393, NM_001159396, NM_008390, BC003821 NM_001159393, NM_001159396, NM_008390, BC003821 NM_001159393, NM_001159396, NM_008390, BC003821 NM_001159393, NM_001159396, NM_008390, BC003821 |
16362 |
297 |
chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific immune system process regulation of adaptive immune response DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleus nucleus cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II apoptotic process cell cycle arrest I-kappaB kinase/NF-kappaB signaling negative regulation of cell population proliferation regulation of gene expression positive regulation of cell death positive regulation of type I interferon production positive regulation of interferon-beta production positive regulation of interleukin-12 production positive regulation of interleukin-12 production positive regulation of natural killer cell differentiation regulation of MyD88-dependent toll-like receptor signaling pathway cellular response to interferon-beta negative regulation of tyrosine phosphorylation of STAT protein CD8-positive, alpha-beta T cell differentiation sequence-specific DNA binding sequence-specific DNA binding innate immune response regulation of innate immune response negative regulation of regulatory T cell differentiation positive regulation of T-helper 1 cell differentiation negative regulation of T-helper 2 cell differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of immune response defense response to virus defense response to virus interferon-gamma-mediated signaling pathway response to growth hormone cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to peptide hormone stimulus regulation of CD8-positive, alpha-beta T cell proliferation |
05160 |
| TC0100003889.mm.2 |
Ifi211 |
interferon activated gene 211 |
1 |
-173896340 |
NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 |
381308 |
19 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus nucleolus cytosol transcription factor binding response to bacterium nuclear speck positive regulation of interleukin-1 beta production nuclear periphery cellular response to interferon-beta identical protein binding |
|
| TC1100004291.mm.2 |
Psme2b |
protease (prosome, macropain) activator subunit 2B |
11 |
-48945351 |
NM_001281472 |
621823 |
13 |
molecular_function cellular_component biological_process |
|
| TC1500001812.mm.2 |
Apol7c |
apolipoprotein L 7c |
15 |
-77524866 |
NM_175391, BC139148, BC139149 NM_175391, BC139148, BC139149 NM_175391, BC139148, BC139149 |
108956 |
9 |
cellular_component lipid binding |
|
| TC1000000171.mm.2 |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
10 |
21993889, 21992222, 21882183, 21978671, 21986103, 21994665 |
NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 |
20393 |
198 |
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding nucleus nucleus cytoplasm cytoplasm mitochondrion endoplasmic reticulum cytosol cytosol plasma membrane protein phosphorylation cellular sodium ion homeostasis apoptotic process cellular response to DNA damage stimulus microtubule depolymerization long-term memory visual learning positive regulation of sodium ion transport potassium channel regulator activity membrane kinase activity phosphorylation nuclear speck transferase activity peptidyl-serine phosphorylation peptidyl-serine phosphorylation positive regulation of cell growth negative regulation of microtubule polymerization cellular response to insulin stimulus regulation of protein localization intracellular signal transduction neuron projection negative regulation of apoptotic process glucocorticoid mediated signaling pathway 3-phosphoinositide-dependent protein kinase binding tau protein binding perinuclear region of cytoplasm neuron projection morphogenesis neuron projection morphogenesis positive regulation of dendrite morphogenesis regulation of cell cycle cellular response to aldosterone |
04960 |
| TC1100003097.mm.2 |
Cxcl16 |
chemokine (C-X-C motif) ligand 16 |
11 |
-70455188, -70454388 |
NM_023158, BC019961 NM_023158, BC019961 |
66102 |
81 |
low-density lipoprotein particle receptor activity low-density lipoprotein particle receptor activity scavenger receptor activity scavenger receptor activity cytokine activity extracellular space extracellular space extracellular space extracellular space receptor-mediated endocytosis chemotaxis chemokine activity chemokine activity chemokine activity T cell chemotaxis T cell chemotaxis membrane integral component of membrane positive regulation of cell growth positive regulation of cell migration positive regulation of cell migration response to cytokine response to interferon-gamma response to tumor necrosis factor chemokine receptor binding lymphocyte chemotaxis cellular response to lipopolysaccharide |
04060 04062 |
| TC0100003890.mm.2 |
Mndal |
myeloid nuclear differentiation antigen like |
1 |
-173857219, -173857221 |
NM_001170853 |
100040462 |
12 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleus nucleoplasm nucleolus nucleolus cytosol transcription factor binding response to bacterium negative regulation of cell growth positive regulation of interleukin-1 beta production cellular response to interferon-beta regulation of growth identical protein binding |
|
| TC0200001448.mm.2 |
Trp53i11 |
transformation related protein 53 inducible protein 11 |
2 |
93187547, 93187547 |
NM_001025246, BC048398, BC098206 NM_001025246, BC048398, BC098206 NM_001025246, BC048398, BC098206 |
277414 |
18 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC0200000740.mm.2 |
Kynu |
kynureninase |
2 |
43555324, 43555324, 43555324 |
NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 |
70789 |
13 |
catalytic activity nucleoplasm cytoplasm mitochondrion mitochondrion cytosol tryptophan catabolic process NAD biosynthetic process hydrolase activity pyridine nucleotide biosynthetic process tryptophan catabolic process to kynurenine tryptophan catabolic process to acetyl-CoA quinolinate biosynthetic process pyridoxal phosphate binding kynureninase activity kynureninase activity response to interferon-gamma response to vitamin B6 protein homodimerization activity anthranilate metabolic process anthranilate metabolic process 3-hydroxykynureninase activity |
00380 01100 |
| TC1100000496.mm.2 |
|
|
|
|
NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 |
|
|
GTPase activity G protein-coupled receptor activity olfactory receptor activity endoplasmic reticulum endoplasmic reticulum membrane plasma membrane defense response defense response signal transduction G protein-coupled receptor signaling pathway sensory perception of smell membrane integral component of membrane cellular response to interferon-beta response to stimulus |
|
| TC1900001340.mm.2 |
Insl6 |
insulin-like 6 |
19 |
-29321353 |
NM_013754, BC028752 NM_013754, BC028752 |
27356 |
19 |
hormone activity extracellular region spermatogenesis spermatid development male gonad development fertilization flagellated sperm motility negative regulation of apoptotic process |
|
| TC0200000484.mm.2 |
Gbgt1 |
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 |
2 |
28496890 |
NM_139197, BC106831 NM_139197, BC106831 |
227671 |
6 |
Golgi apparatus carbohydrate metabolic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups lipid glycosylation lipid glycosylation vesicle metal ion binding globoside alpha-N-acetylgalactosaminyltransferase activity globoside alpha-N-acetylgalactosaminyltransferase activity |
00603 01100 |
| TC0500000468.mm.2 |
Cd38 |
CD38 antigen |
5 |
43868808 |
NM_007646, BC046312, CD38 NM_007646, BC046312, CD38 NM_007646, BC046312, CD38 |
12494 |
193 |
response to hypoxia NAD+ nucleosidase activity NAD+ nucleosidase activity nucleus plasma membrane plasma membrane positive regulation of cytosolic calcium ion concentration positive regulation of cell population proliferation response to hormone cell surface negative regulation of neuron projection development artery smooth muscle contraction membrane integral component of membrane basolateral plasma membrane transferase activity hydrolase activity hydrolase activity, acting on glycosyl bonds phosphorus-oxygen lyase activity phosphorus-oxygen lyase activity positive regulation of cell growth secretory granule membrane positive regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of B cell proliferation positive regulation of insulin secretion response to hydroperoxide response to drug identical protein binding negative regulation of apoptotic process intracellular membrane-bounded organelle negative regulation of bone resorption negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of vasoconstriction NAD(P)+ nucleosidase activity B cell receptor signaling pathway long-term synaptic depression NAD+ nucleotidase, cyclic ADP-ribose generating |
00760 01100 04020 04640 04970 04972 |
| TC1600001557.mm.2 |
Dtx3l |
deltex 3-like, E3 ubiquitin ligase |
16 |
-35926514 |
NM_001013371, BC085093, BC137694 NM_001013371, BC085093, BC137694 NM_001013371, BC085093, BC137694 |
209200 |
18 |
positive regulation of defense response to virus by host immune system process ubiquitin-protein transferase activity enzyme inhibitor activity nucleus nucleoplasm nucleoplasm cytoplasm lysosome endosome early endosome cytosol DNA repair double-strand break repair chromatin organization ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus Notch signaling pathway enzyme activator activity endosome to lysosome transport histone monoubiquitination protein transport membrane protein ubiquitination transferase activity enzyme binding positive regulation of protein binding protein-containing complex histone H2A ubiquitination histone H2B ubiquitination positive regulation of chromatin binding histone binding ubiquitin-like protein ligase binding innate immune response positive regulation of transcription, DNA-templated metal ion binding negative regulation of ubiquitin-protein transferase activity defense response to virus protein autoubiquitination ubiquitin protein ligase activity protein K48-linked ubiquitination STAT family protein binding positive regulation of protein localization to nucleus positive regulation of NAD+ ADP-ribosyltransferase activity positive regulation of protein localization to early endosome positive regulation of receptor catabolic process positive regulation of double-strand break repair via nonhomologous end joining |
04330 |
| TC0800002113.mm.2 |
Mtus1 |
mitochondrial tumor suppressor 1 |
8 |
-40990911, -40990911, -40990911, -40990911 |
NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 |
102103 |
30 |
nucleus nucleolus cytoplasm mitochondrion Golgi apparatus plasma membrane cell cycle microtubule binding regulation of macrophage chemotaxis regulation of macrophage chemotaxis microtubule cytoskeleton membrane |
|
| TC0800000659.mm.2 |
Ddx60 |
DExD/H box helicase 60 |
8 |
61928086 |
NM_001081215 |
234311 |
16 |
double-stranded DNA binding RNA binding double-stranded RNA binding single-stranded RNA binding protein binding cytoplasm cytoplasm cytosol response to virus intermediate filament cytoskeleton defense response to virus positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway |
|
| TC0600002323.mm.2 |
Nod1 |
nucleotide-binding oligomerization domain containing 1 |
6 |
-54923941, -54923941 |
NM_001171007, NM_172729, BC042670 NM_001171007, NM_172729, BC042670 NM_001171007, NM_172729, BC042670 |
107607 |
170 |
nucleotide binding pattern recognition receptor signaling pathway immune system process positive regulation of dendritic cell antigen processing and presentation protein binding ATP binding cytoplasm cytosol plasma membrane apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process defense response positive regulation of cell death membrane detection of bacterium basolateral plasma membrane positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade intracellular signal transduction intracellular signal transduction pattern recognition receptor activity defense response to bacterium identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein-containing complex binding innate immune response phagocytic vesicle positive regulation of JNK cascade anchored component of plasma membrane CARD domain binding defense response to Gram-positive bacterium defense response to Gram-positive bacterium positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade cellular response to muramyl dipeptide positive regulation of NIK/NF-kappaB signaling positive regulation of xenophagy |
04621 |
| TC0100003888.mm.2 |
Ifi204 |
interferon activated gene 204 |
1 |
-173747293 |
NM_008329 |
15951 |
60 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding double-stranded DNA binding transcription coregulator activity protein binding nucleus nucleoplasm nucleolus nucleolus nucleolus cytoplasm cytosol regulation of transcription by RNA polymerase II multicellular organism development transcription factor binding response to bacterium response to bacterium nuclear speck positive regulation of interleukin-1 beta production cellular response to interferon-alpha cellular response to interferon-beta cellular response to interferon-beta nuclear inclusion body intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding positive regulation of osteoblast differentiation inner ear development |
|
| TC1500001730.mm.2 |
Ly6c2 |
lymphocyte antigen 6 complex, locus C2 |
15 |
-75108160, -75108160 |
NM_001099217, BC092082 NM_001099217, BC092082 |
100041546 |
8 |
plasma membrane cell surface membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway |
|
| TC1100001657.mm.2 |
Ifi35 |
interferon-induced protein 35 |
11 |
101448411 |
NM_027320, BC008158 NM_027320, BC008158 |
70110 |
21 |
macrophage activation involved in immune response extracellular space extracellular space nucleus nucleus cytoplasm cytosol negative regulation of cell population proliferation membrane positive regulation of toll-like receptor 4 signaling pathway identical protein binding positive regulation of innate immune response positive regulation of innate immune response positive regulation of inflammatory response positive regulation of inflammatory response negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling |
|
| TC0800001132.mm.2 |
Usb1 |
U6 snRNA biogenesis 1 |
8 |
95332283 |
NM_133954, BC016418, U6 NM_133954, BC016418, U6 NM_133954, BC016418, U6 |
101985 |
15 |
3'-5'-exoribonuclease activity 3'-5'-exoribonuclease activity nuclease activity nucleus nucleus nucleoplasm RNA splicing hydrolase activity U6 snRNA 3'-end processing U6 snRNA 3'-end processing intercellular bridge |
|
| TC1700000936.mm.2 |
B430306N03Rik |
RIKEN cDNA B430306N03 gene |
17 |
48316161 |
NM_177083, BC156662 NM_177083, BC156662 |
320148 |
11 |
cell surface signaling receptor activity |
|
| TC1700001221.mm.2 |
Tmem178 |
transmembrane protein 178 |
17 |
80944631 |
NM_026516, BC160326 NM_026516, BC160326 |
68027 |
18 |
protein binding endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane membrane integral component of membrane negative regulation of osteoclast differentiation negative regulation of osteoclast differentiation regulation of cytosolic calcium ion concentration regulation of cytosolic calcium ion concentration |
|
| TC1700001522.mm.2 |
Fpr1 |
formyl peptide receptor 1 |
17 |
-17876470 |
NM_013521, BC148696 NM_013521, BC148696 |
14293 |
76 |
G protein-coupled receptor binding complement receptor mediated signaling pathway complement receptor activity G protein-coupled receptor activity N-formyl peptide receptor activity N-formyl peptide receptor activity N-formyl peptide receptor activity scavenger receptor binding cytoplasm plasma membrane plasma membrane chemotaxis inflammatory response signal transduction G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration membrane integral component of membrane RAGE receptor binding |
04080 05150 |
| TC1500000688.mm.2 |
Apobec3 |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 |
15 |
79895022, 79892407 |
NM_001160415, NM_030255, BC003314 NM_001160415, NM_030255, BC003314 NM_001160415, NM_030255, BC003314 |
80287 |
101 |
P-body hematopoietic progenitor cell differentiation immune system process RNA binding catalytic activity cytidine deaminase activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm zinc ion binding negative regulation of transposition negative regulation of transposition negative regulation of transposition cytidine to uridine editing hydrolase activity negative regulation of viral genome replication innate immune response negative regulation of single stranded viral RNA replication via double stranded DNA intermediate metal ion binding deoxycytidine deaminase activity deoxycytidine deaminase activity regulation of defense response to virus defense response to virus defense response to virus DNA cytosine deamination DNA demethylation regulation of viral life cycle |
|
| TC0400000495.mm.2 |
Aldh1b1 |
aldehyde dehydrogenase 1 family, member B1 |
4 |
45799021 |
NM_028270, BC020001, BC086768 NM_028270, BC020001, BC086768 NM_028270, BC020001, BC086768 |
72535 |
32 |
aldehyde dehydrogenase (NAD+) activity nucleoplasm mitochondrion mitochondrion cytosol oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor intracellular membrane-bounded organelle |
00010 00040 00053 00071 00280 00310 00330 00340 00380 00410 00561 00620 00640 01100 |
| TC0700001794.mm.2 |
Il21r |
interleukin 21 receptor |
7 |
125603428 |
NM_021887, BC057861 NM_021887, BC057861 |
60504 |
141 |
transmembrane signaling receptor activity cytokine receptor activity cytokine receptor activity membrane integral component of membrane |
04060 04630 |
| TC1700000623.mm.2 |
Tap2 |
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
17 |
34204478 |
NM_011530, BC005578, BC051257 NM_011530, BC005578, BC051257 NM_011530, BC005578, BC051257 |
21355 |
52 |
nucleotide binding positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin adaptive immune response immune system process antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent positive regulation of antigen processing and presentation of peptide antigen via MHC class I protein binding ATP binding endoplasmic reticulum protein transport ABC-type peptide antigen transporter activity ABC-type peptide antigen transporter activity ABC-type peptide transporter activity peptide transport peptide transport membrane integral component of membrane integral component of membrane nuclear speck ATPase activity antigen processing and presentation of endogenous peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I MHC class Ib protein binding integral component of endoplasmic reticulum membrane protection from natural killer cell mediated cytotoxicity MHC protein binding MHC class I protein binding MHC class I protein binding peptide antigen binding ATPase-coupled transmembrane transporter activity identical protein binding protein homodimerization activity MHC class I peptide loading complex MHC class I peptide loading complex TAP complex intracellular membrane-bounded organelle ADP binding protein-containing complex binding cytosol to endoplasmic reticulum transport peptide antigen transport TAP1 binding TAP1 binding TAP1 binding TAP2 binding tapasin binding transmembrane transport protein-containing complex assembly peptide transmembrane transporter activity |
02010 04145 04612 05340 |
| TC1900000517.mm.2 |
Pcgf5 |
polycomb group ring finger 5 |
19 |
36409747, 36348328, 36379066 |
NM_029508, BC139258, BC139259, BC145590, BC145591 NM_029508, BC139258, BC139259, BC145590, BC145591 NM_029508, BC139258, BC139259, BC145590, BC145591 NM_029508, BC139258, BC139259, BC145590, BC145591 NM_029508, BC139258, BC139259, BC145590, BC145591 |
76073 |
27 |
X chromosome protein binding nucleus nucleoplasm Golgi apparatus centrosome regulation of transcription by RNA polymerase II PcG protein complex PcG protein complex PRC1 complex histone H2A-K119 monoubiquitination histone H2A-K119 monoubiquitination positive regulation of transcription by RNA polymerase II metal ion binding inactivation of X chromosome by genetic imprinting inactivation of X chromosome by genetic imprinting |
|
| TC0900003011.mm.2 |
Parp3 |
poly (ADP-ribose) polymerase family, member 3 |
9 |
-106470321 |
NM_145619, BC014870, BC058754 NM_145619, BC014870, BC058754 NM_145619, BC014870, BC058754 |
235587 |
19 |
telomere maintenance NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity nucleus nucleoplasm nucleolus cytoplasm DNA repair double-strand break repair double-strand break repair double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus nuclear body transferase activity transferase activity, transferring glycosyl groups DNA ADP-ribosylation site of double-strand break site of double-strand break site of double-strand break intercellular bridge negative regulation of isotype switching positive regulation of DNA ligation regulation of mitotic spindle organization protein poly-ADP-ribosylation protein auto-ADP-ribosylation protein mono-ADP-ribosylation NAD DNA ADP-ribosyltransferase activity negative regulation of telomerase RNA reverse transcriptase activity protein localization to site of double-strand break protein ADP-ribosylase activity protein ADP-ribosylase activity positive regulation of double-strand break repair via nonhomologous end joining |
03410 |
| TC1500001809.mm.2 |
Apol9a |
apolipoprotein L 9a |
15 |
-77403788, -77403788 |
NM_001162883, NM_173786, BC020489, BC057684 NM_001162883, NM_173786, BC020489, BC057684 NM_001162883, NM_173786, BC020489, BC057684 NM_001162883, NM_173786, BC020489, BC057684 |
223672 |
5 |
cellular_component biological_process lipid binding |
|
| TC0900000184.mm.2 |
Icam1 |
intercellular adhesion molecule 1 |
9 |
21015939 |
NM_010493, BC008626 NM_010493, BC008626 |
15894 |
567 |
immunological synapse T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell acute inflammatory response to antigenic stimulus T cell antigen processing and presentation positive regulation of cellular extravasation integrin binding integrin binding extracellular space plasma membrane integral component of plasma membrane cell adhesion cell adhesion cell adhesion leukocyte cell-cell adhesion leukocyte cell-cell adhesion sensory perception of sound regulation of cell shape external side of plasma membrane cell surface membrane integral component of membrane positive regulation of actin filament polymerization cell adhesion mediated by integrin positive regulation of GTPase activity adhesion of symbiont to host protein-containing complex binding membrane raft positive regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction receptor-mediated virion attachment to host cell positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity negative regulation of calcium ion transport establishment of endothelial barrier extracellular exosome positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus T cell extravasation establishment of endothelial intestinal barrier establishment of Sertoli cell barrier cell-cell adhesion regulation of ruffle assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cellular response to amyloid-beta positive regulation of leukocyte adhesion to vascular endothelial cell cellular response to leukemia inhibitory factor negative regulation of endothelial cell apoptotic process |
04514 04650 04670 05143 05144 05150 05323 05416 |
| TC0700002967.mm.2 |
Spib |
Spi-B transcription factor (Spi-1/PU.1 related) |
7 |
-44525994 |
NM_019866, BC141118 NM_019866, BC141118 |
272382 |
55 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus transcription regulator complex regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cell differentiation macrophage differentiation sequence-specific DNA binding positive regulation of transcription by RNA polymerase II sequence-specific double-stranded DNA binding |
|
| TC1900001388.mm.2 |
Asah2 |
N-acylsphingosine amidohydrolase 2 |
19 |
-31984650 |
NM_018830, BC137898, BC145016 NM_018830, BC137898, BC145016 NM_018830, BC137898, BC145016 |
54447 |
35 |
calcium ion binding protein binding extracellular region extracellular space extracellular space mitochondrion mitochondrion mitochondrion Golgi apparatus plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane caveola lipid metabolic process sphingolipid metabolic process sphingosine metabolic process ceramide metabolic process apoptotic process regulation of mitotic cell cycle zinc ion binding response to organic substance membrane integral component of membrane hydrolase activity N-acylsphingosine amidohydrolase activity N-acylsphingosine amidohydrolase activity N-acylsphingosine amidohydrolase activity N-acylsphingosine amidohydrolase activity long-chain fatty acid biosynthetic process lipid digestion membrane raft sphingosine biosynthetic process sphingosine biosynthetic process sphingosine biosynthetic process sphingosine biosynthetic process ceramide biosynthetic process ceramide biosynthetic process ceramide catabolic process ceramide catabolic process ceramide catabolic process ceramide catabolic process metal ion binding extracellular exosome phytoceramidase activity cellular response to cytokine stimulus dihydroceramidase activity negative regulation of apoptotic signaling pathway |
00600 01100 |
| TC1900001019.mm.2 |
Prdx5 |
peroxiredoxin 5 |
19 |
-6906696 |
NM_012021, BC008174 NM_012021, BC008174 |
54683 |
60 |
RNA polymerase III transcription regulatory region sequence-specific DNA binding peroxidase activity signaling receptor binding signaling receptor binding protein binding nucleus cytoplasm cytoplasm cytoplasm mitochondrion mitochondrion mitochondrion peroxisome peroxisome peroxisomal matrix peroxisomal matrix cytosol response to oxidative stress response to oxidative stress thioredoxin peroxidase activity thioredoxin peroxidase activity antioxidant activity antioxidant activity negative regulation of transcription by RNA polymerase III oxidoreductase activity cytoplasmic vesicle positive regulation of collagen biosynthetic process cellular response to oxidative stress cellular response to reactive oxygen species hydrogen peroxide catabolic process hydrogen peroxide catabolic process hydrogen peroxide catabolic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle cell redox homeostasis perinuclear region of cytoplasm negative regulation of oxidoreductase activity peroxiredoxin activity regulation of apoptosis involved in tissue homeostasis NADPH oxidation peroxynitrite reductase activity reactive nitrogen species metabolic process |
04146 |
| TC0700004003.mm.2 |
|
|
|
|
NR_040453, NR_040456 NR_040453, NR_040456 |
|
|
|
|
| MG-1-pos-10338280_st |
|
|
|
|
|
|
|
|
|
| TC0700004002.mm.2 |
|
|
|
|
NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 |
|
|
molecular_function cellular_component biological_process |
|
| TC1400002091.mm.2 |
Psme2 |
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) |
14 |
-55587439, -55587439 |
NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 |
19188 |
43 |
protein binding nucleoplasm cytoplasm positive regulation of endopeptidase activity antigen processing and presentation of exogenous antigen identical protein binding endopeptidase activator activity regulation of proteasomal protein catabolic process regulation of G1/S transition of mitotic cell cycle |
03050 04612 |
| TC1100000205.mm.2 |
Peli1 |
pellino 1 |
11 |
21091323 |
NM_023324, BC016515 NM_023324, BC016515 |
67245 |
62 |
protein polyubiquitination protein polyubiquitination condensed nuclear chromosome kinetochore positive regulation of cytokine production ubiquitin-protein transferase activity protein binding nucleus Toll signaling pathway regulation of Toll signaling pathway transferase activity positive regulation of B cell proliferation positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to lipopolysaccharide response to lipopolysaccharide positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway negative regulation of T cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process response to dsRNA negative regulation of T cell activation positive regulation of B cell activation negative regulation of necroptotic process negative regulation of necroptotic process ubiquitin protein ligase activity ubiquitin protein ligase activity ubiquitin protein ligase activity protein K63-linked ubiquitination protein K48-linked ubiquitination protein K48-linked ubiquitination protein K48-linked ubiquitination |
|
| TC0800002947.mm.2 |
Mlkl |
mixed lineage kinase domain-like |
8 |
-111311797 |
NM_029005, BC023755 NM_029005, BC023755 |
74568 |
139 |
nucleotide binding JUN kinase kinase kinase activity protein binding ATP binding ATP binding nucleus cytoplasm cytoplasm cytosol plasma membrane plasma membrane cell surface receptor signaling pathway activation of JUN kinase activity programmed cell death membrane protein kinase binding cell junction identical protein binding protein-containing complex binding defense response to virus defense response to virus protein homotrimerization necroptotic process necroptotic process necroptotic signaling pathway necroptotic signaling pathway execution phase of necroptosis execution phase of necroptosis |
|
| TC1400000575.mm.2 |
Pnp2 |
purine-nucleoside phosphorylase 2 |
14 |
50956140 |
NM_001123371 |
667034 |
10 |
nucleoside binding purine nucleobase binding purine-nucleoside phosphorylase activity purine-nucleoside phosphorylase activity extracellular region nucleus cytoplasm cytoplasm cytosol phosphate ion binding identical protein binding |
00230 00240 00760 01100 |
| TC0200003528.mm.2 |
Nmi |
N-myc (and STAT) interactor |
2 |
-51948498 |
NM_001141948, NM_001141949, NM_019401, BC002019 NM_001141948, NM_001141949, NM_019401, BC002019 NM_001141948, NM_001141949, NM_019401, BC002019 NM_001141948, NM_001141949, NM_019401, BC002019 |
64685 |
23 |
macrophage activation involved in immune response transcription coregulator activity protein binding extracellular space extracellular space nucleus nucleoplasm cytoplasm cytoplasm cytosol transcription by RNA polymerase II negative regulation of cell population proliferation response to virus membrane negative regulation of type I interferon production negative regulation of interferon-alpha production negative regulation of interferon-beta production toll-like receptor 4 signaling pathway identical protein binding positive regulation of innate immune response negative regulation of innate immune response negative regulation of innate immune response positive regulation of inflammatory response interferon-gamma-mediated signaling pathway negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of protein K48-linked ubiquitination |
|
| TC1200002359.mm.2 |
Wars |
tryptophanyl-tRNA synthetase |
12 |
-108860029, -108860029, -108860029 |
NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 |
22375 |
35 |
nucleotide binding angiogenesis negative regulation of protein phosphorylation aminoacyl-tRNA ligase activity tryptophan-tRNA ligase activity tryptophan-tRNA ligase activity tryptophan-tRNA ligase activity tryptophan-tRNA ligase activity ATP binding nucleus cytoplasm cytosol translation tRNA aminoacylation for protein translation tryptophanyl-tRNA aminoacylation tryptophanyl-tRNA aminoacylation negative regulation of protein kinase activity positive regulation of gene expression regulation of protein ADP-ribosylation ligase activity kinase inhibitor activity protein kinase binding protein domain specific binding positive regulation of protein-containing complex assembly protein-containing complex protein homodimerization activity regulation of angiogenesis |
00380 00970 |
| TC0100002711.mm.2 |
|
|
|
|
XR_140448 |
|
|
|
|
| TC1300002506.mm.2 |
Tmem171 |
transmembrane protein 171 |
13 |
-98686237, -98686237 |
NM_001025606, BC099490 NM_001025606, BC099490 |
380863 |
4 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC1700000618.mm.2 |
H2-DMa |
histocompatibility 2, class II, locus DMa |
17 |
34122831, 34125517 |
NM_010386, BC001996, BC049992 NM_010386, BC001996, BC049992 NM_010386, BC001996, BC049992 |
14998 |
91 |
adaptive immune response immune system process peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of germinal center formation positive regulation of humoral immune response protein binding intracellular anatomical structure lysosome lysosomal membrane lysosomal membrane endosome late endosome multivesicular body immune response cell surface endosome membrane protein transport membrane integral component of membrane immunoglobulin mediated immune response antigen processing and presentation antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding late endosome membrane MHC class II protein complex intracellular membrane-bounded organelle positive thymic T cell selection positive regulation of T cell differentiation inner ear development positive regulation of immune response chaperone cofactor-dependent protein refolding chaperone cofactor-dependent protein refolding protein-containing complex assembly |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1000002374.mm.2 |
Gucd1 |
guanylyl cyclase domain containing 1 |
10 |
-75506813, -75506813 |
NM_175133, BC024851, BC043463, BC118613, BC119795 NM_175133, BC024851, BC043463, BC118613, BC119795 NM_175133, BC024851, BC043463, BC118613, BC119795 NM_175133, BC024851, BC043463, BC118613, BC119795 NM_175133, BC024851, BC043463, BC118613, BC119795 |
68778 |
15 |
molecular_function cellular_component biological_process |
|
| TC0200004636.mm.2 |
Slc4a11 |
solute carrier family 4, sodium bicarbonate transporter-like, member 11 |
2 |
-130684107 |
NM_001081162, BC111884 NM_001081162, BC111884 |
269356 |
26 |
sodium channel activity inorganic anion exchanger activity plasma membrane plasma membrane ion transport sodium ion transport anion transport vesicle membrane bicarbonate transmembrane transporter activity proton channel activity symporter activity anion:anion antiporter activity bicarbonate transport membrane integral component of membrane basolateral plasma membrane basolateral plasma membrane apical plasma membrane transmembrane transporter activity cellular cation homeostasis fluid transport borate transport active borate transmembrane transporter activity protein dimerization activity ion homeostasis ion homeostasis transmembrane transport proton transmembrane transport |
|
| TC1300000586.mm.2 |
Fbxw17 |
F-box and WD-40 domain protein 17 |
13 |
50417863 |
NM_175401, BC040428 NM_175401, BC040428 |
109082 |
14 |
molecular_function cellular_component |
|
| TC1600001177.mm.2 |
Carhsp1 |
calcium regulated heat stable protein 1 |
16 |
-8658586 |
NM_025821, BC011225, BC086754 NM_025821, BC011225, BC086754 NM_025821, BC011225, BC086754 |
52502 |
33 |
cytoplasmic exosome (RNase complex) nucleic acid binding RNA binding mRNA 3'-UTR binding mRNA 3'-UTR binding protein binding cytoplasm cytoplasm cytosol P granule regulation of mRNA stability regulation of mRNA stability |
|
| TC0800002842.mm.2 |
Psmb10 |
proteasome (prosome, macropain) subunit, beta type 10 |
8 |
-105935727 |
NM_013640, BC004730 NM_013640, BC004730 |
19171 |
66 |
proteasome complex cell morphogenesis immune system process endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol proteasome core complex proteasome core complex proteolysis peptidase activity proteasomal ubiquitin-independent protein catabolic process hydrolase activity T cell proliferation proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process spermatoproteasome complex |
03050 |
| MG-1-pos-10342553_st |
|
|
|
|
|
|
|
|
|
| TC0800001037.mm.2 |
Nod2 |
nucleotide-binding oligomerization domain containing 2 |
8 |
88647346 |
NM_145857, BC168407 NM_145857, BC168407 |
257632 |
337 |
nucleotide binding pattern recognition receptor signaling pathway innate immune response in mucosa activation of immune response cytokine production involved in immune response immune system process immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of dendritic cell antigen processing and presentation negative regulation of T cell mediated immunity positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response negative regulation of inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin actin binding protein binding ATP binding cytoplasm cytoplasm Golgi apparatus cytosol cytosol cytosol cytoskeleton plasma membrane defense response inflammatory response positive regulation of antibacterial peptide biosynthetic process positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria signal transduction positive regulation of cell population proliferation detection of biotic stimulus cell surface membrane detection of bacterium basolateral plasma membrane endodeoxyribonuclease activity, producing 5'-phosphomonoesters enzyme binding protein kinase binding maintenance of gastrointestinal epithelium Hsp70 protein binding positive regulation of protein ubiquitination vesicle negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to peptidoglycan response to muramyl dipeptide response to muramyl dipeptide response to muramyl dipeptide response to muramyl dipeptide response to lipopolysaccharide detection of muramyl dipeptide muramyl dipeptide binding muramyl dipeptide binding negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-12 production negative regulation of interleukin-18 production negative regulation of interleukin-2 production negative regulation of tumor necrosis factor production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade positive regulation of stress-activated MAPK cascade protein-containing complex negative regulation of toll-like receptor 2 signaling pathway intracellular signal transduction intracellular signal transduction pattern recognition receptor activity defense response to bacterium defense response to bacterium peptidoglycan binding peptidoglycan binding regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity protein-containing complex binding innate immune response positive regulation of innate immune response positive regulation of innate immune response phagocytic vesicle positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade positive regulation of JNK cascade anchored component of plasma membrane positive regulation of epithelial cell proliferation CARD domain binding regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis defense response to Gram-positive bacterium defense response to Gram-positive bacterium positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase biosynthetic process Hsp90 protein binding positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 2 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide cellular response to peptidoglycan cellular response to muramyl dipeptide macrophage inflammatory protein-1 alpha production positive regulation of monocyte chemotactic protein-1 production regulation of neutrophil chemotaxis positive regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked ubiquitination positive regulation of xenophagy negative regulation of macrophage apoptotic process positive regulation of prostaglandin-E synthase activity |
04621 |
| TC1500001729.mm.2 |
Ly6c1 |
lymphocyte antigen 6 complex, locus C1 |
15 |
-75045472, -75045014, -75045472, -75044017 |
NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 |
17067 |
61 |
plasma membrane external side of plasma membrane cell surface membrane acetylcholine receptor inhibitor activity anchored component of membrane acetylcholine receptor binding acetylcholine receptor signaling pathway |
|
| TC1500002042.mm.2 |
Dennd6b |
DENN/MADD domain containing 6B |
15 |
-89182212 |
NM_027081, BC139003 NM_027081, BC139003 |
69440 |
13 |
guanyl-nucleotide exchange factor activity cytoplasm endosome recycling endosome |
|
| TC1900000527.mm.2 |
Marchf5 |
membrane associated ring-CH-type finger 5 |
19 |
37207544, 37207544, 37207544, 37207539 |
NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 |
69104 |
29 |
protein polyubiquitination mitochondrion mitochondrial outer membrane endoplasmic reticulum endoplasmic reticulum membrane zinc ion binding membrane integral component of membrane transferase activity metal ion binding GTPase binding protein autoubiquitination ubiquitin protein ligase activity protein localization to mitochondrion regulation of mitochondrial fission positive regulation of mitochondrial fission negative regulation of cell aging |
|
| TC1100000078.mm.2 |
Dbnl |
drebrin-like |
11 |
5788482 |
NM_001146308, NM_001146309, NM_013810, BC046430 NM_001146308, NM_001146309, NM_013810, BC046430 NM_001146308, NM_001146309, NM_013810, BC046430 NM_001146308, NM_001146309, NM_013810, BC046430 |
13169 |
48 |
ruffle podosome adaptive immune response immune system process actin binding protein binding intracellular anatomical structure cytoplasm cytoplasm endosome Golgi apparatus cytoskeleton actin filament plasma membrane cell cortex endocytosis receptor-mediated endocytosis synapse assembly protein C-terminus binding postsynaptic density postsynaptic density membrane Rac protein signal transduction protein domain specific binding lamellipodium lamellipodium cell junction dendrite dendrite site of polarized growth regulation of actin filament polymerization cortical actin cytoskeleton cytoplasmic vesicle cell projection synapse postsynaptic membrane positive regulation of axon extension neuron projection morphogenesis neuron projection morphogenesis actin filament binding actin filament binding positive regulation of dendritic spine morphogenesis podosome assembly ruffle assembly postsynaptic actin cytoskeleton organization |
|
| TC1700000881.mm.2 |
Gtpbp2 |
GTP binding protein 2 |
17 |
46161031, 46162063 |
NM_001145979, NM_019581, BC049089, BC051958 NM_001145979, NM_019581, BC049089, BC051958 NM_001145979, NM_019581, BC049089, BC051958 NM_001145979, NM_019581, BC049089, BC051958 |
56055 |
23 |
nucleotide binding translation elongation factor activity GTPase activity protein binding GTP binding translational elongation identical protein binding nuclear-transcribed mRNA catabolic process, no-go decay rescue of stalled ribosome |
|
| TC1100001628.mm.2 |
Cnp |
2',3'-cyclic nucleotide 3' phosphodiesterase |
11 |
100574938, 100575890 |
NM_001146318, NM_009923, BC005544, BC021904 NM_001146318, NM_009923, BC005544, BC021904 NM_001146318, NM_009923, BC005544, BC021904 NM_001146318, NM_009923, BC005544, BC021904 |
12799 |
281 |
microtubule cytoskeleton organization RNA binding 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity extracellular space cytoplasm cytoplasm cytoplasm mitochondrial outer membrane mitochondrial inner membrane microtubule plasma membrane microvillus axonogenesis adult locomotory behavior cyclic nucleotide catabolic process response to toxic substance membrane hydrolase activity cyclic nucleotide binding pseudopodium myelin sheath abaxonal region myelin sheath adaxonal region cell projection myelin sheath myelin sheath myelin sheath regulation of mitochondrial membrane permeability perinuclear region of cytoplasm oligodendrocyte differentiation |
|
| TC1700000362.mm.2 |
Clcn7 |
chloride channel, voltage-sensitive 7 |
17 |
25136630, 25133390 |
NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 |
26373 |
53 |
nucleotide binding voltage-gated chloride channel activity protein binding ATP binding nucleoplasm lysosome ion transport chloride transport response to pH chloride transmembrane transporter activity antiporter activity membrane integral component of membrane cytoplasmic vesicle intracellular membrane-bounded organelle transmembrane transport |
|
| TC0900001768.mm.2 |
Endod1 |
endonuclease domain containing 1 |
9 |
-14353989 |
NM_028013, BC019813, BC096490 NM_028013, BC019813, BC096490 NM_028013, BC019813, BC096490 |
71946 |
19 |
nucleic acid binding nuclease activity endonuclease activity extracellular region biological_process hydrolase activity metal ion binding |
04210 |
| TC1800001415.mm.2 |
Slc26a2 |
solute carrier family 26 (sulfate transporter), member 2 |
18 |
-61196853 |
NM_007885, BC028345 NM_007885, BC028345 |
13521 |
34 |
ossification plasma membrane integral component of plasma membrane integral component of plasma membrane ion transport secondary active sulfate transmembrane transporter activity sulfate transport bicarbonate transmembrane transporter activity chloride transmembrane transporter activity sulfate transmembrane transporter activity sulfate transmembrane transporter activity anion:anion antiporter activity membrane integral component of membrane apical plasma membrane oxalate transmembrane transporter activity microvillus membrane transmembrane transport sulfate transmembrane transport |
|
| MG-1-pos-10339750_st |
|
|
|
|
|
|
|
|
|
| TC1100003600.mm.2 |
Abi3 |
ABI family member 3 |
11 |
-95830071, -95830071 |
NM_001163464, NM_025659, BC058260 NM_001163464, NM_025659, BC058260 NM_001163464, NM_025659, BC058260 |
66610 |
22 |
intracellular anatomical structure intracellular anatomical structure cytoplasm SH3 domain binding lamellipodium lamellipodium regulation of cell migration regulation of cell migration identical protein binding |
|
| MG-1-pos-10339765_st |
|
|
|
|
|
|
|
|
|
| TC0800000482.mm.2 |
Slc7a2 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
8 |
40862366 |
NM_001044740, NM_007514, BC127082 NM_001044740, NM_007514, BC127082 NM_001044740, NM_007514, BC127082 |
11988 |
62 |
L-ornithine transmembrane transporter activity L-ornithine transmembrane transporter activity nitric oxide production involved in inflammatory response high-affinity arginine transmembrane transporter activity high-affinity lysine transmembrane transporter activity plasma membrane plasma membrane nitric oxide biosynthetic process amino acid transport amino acid transmembrane transporter activity amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity arginine transmembrane transporter activity arginine transmembrane transporter activity arginine transmembrane transporter activity L-lysine transmembrane transporter activity L-lysine transmembrane transporter activity L-amino acid transport arginine transport membrane integral component of membrane transmembrane transporter activity cell junction macrophage activation regulation of macrophage activation regulation of inflammatory response transmembrane transport L-arginine transmembrane transporter activity L-arginine transmembrane transporter activity amino acid import across plasma membrane low-affinity L-arginine transmembrane transporter activity high-affinity L-ornithine transmembrane transporter activity L-arginine import across plasma membrane L-arginine import across plasma membrane L-arginine import across plasma membrane L-lysine import across plasma membrane L-ornithine import across plasma membrane L-arginine transport L-alpha-amino acid transmembrane transport L-ornithine transmembrane transport L-ornithine transmembrane transport |
|
| TC0700002632.mm.2 |
Lipe |
lipase, hormone sensitive |
7 |
-25379526, -25379526 |
NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 |
16890 |
153 |
sterol esterase activity sterol esterase activity triglyceride lipase activity triglyceride lipase activity triglyceride lipase activity protein binding extracellular space nucleus cytoplasm cytoplasm mitochondrion lipid droplet cytosol cytosol plasma membrane caveola transcription initiation from RNA polymerase I promoter termination of RNA polymerase I transcription lipid metabolic process steroid metabolic process cholesterol metabolic process membrane lipid catabolic process lipase activity hydrolase activity hydrolase activity, acting on ester bonds serine hydrolase activity triglyceride catabolic process triglyceride catabolic process triglyceride catabolic process protein kinase binding hormone-sensitive lipase activity rRNA primary transcript binding long-chain fatty acid catabolic process diacylglycerol catabolic process diacylglycerol catabolic process ether lipid metabolic process acylglycerol lipase activity acylglycerol lipase activity retinyl-palmitate esterase activity retinyl-palmitate esterase activity 1,3-diacylglycerol acylhydrolase activity 1,2-diacylglycerol acylhydrolase activity |
04910 |
| TC0800002542.mm.2 |
Il15 |
interleukin 15 |
8 |
-82331623 |
NM_001254747, NM_008357, BC023698 NM_001254747, NM_008357, BC023698 NM_001254747, NM_008357, BC023698 |
16168 |
475 |
positive regulation of cytokine production NK T cell proliferation cytokine activity cytokine activity cytokine activity cytokine receptor binding extracellular region extracellular region extracellular space extracellular space nucleoplasm cytoplasm cytosol immune response tyrosine phosphorylation of STAT protein positive regulation of cell population proliferation cell surface nuclear speck hyaluronan metabolic process macrophage differentiation positive regulation of interleukin-17 production positive regulation of natural killer cell proliferation positive regulation of natural killer cell differentiation positive regulation of natural killer cell differentiation positive regulation of natural killer cell differentiation interleukin-15-mediated signaling pathway positive regulation of T cell proliferation positive regulation of T cell proliferation neutrophil activation neutrophil activation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein extrathymic T cell selection regulation of T cell differentiation cell maturation lymph node development negative regulation of smooth muscle cell proliferation regulation of defense response to virus by host positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis positive regulation of immune response positive regulation of immune response negative regulation of cold-induced thermogenesis positive regulation of protein O-linked glycosylation |
04060 04630 04672 05323 |
| TC1700000148.mm.2 |
Sod2 |
superoxide dismutase 2, mitochondrial |
17 |
13007838 |
NM_013671, BC010548 NM_013671, BC010548 |
20656 |
394 |
response to reactive oxygen species response to superoxide response to superoxide age-dependent response to oxidative stress age-dependent response to reactive oxygen species release of cytochrome c from mitochondria liver development detection of oxygen acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure DNA binding superoxide dismutase activity superoxide dismutase activity superoxide dismutase activity superoxide dismutase activity protein binding cytoplasm mitochondrion mitochondrion mitochondrion mitochondrion mitochondrial inner membrane mitochondrial matrix regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II glutathione metabolic process superoxide metabolic process superoxide metabolic process response to oxidative stress response to oxidative stress mitochondrion organization heart development locomotory behavior regulation of blood pressure negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic mitochondrial changes post-embryonic development response to gamma radiation positive regulation of hydrogen peroxide biosynthetic process response to activity oxidoreductase activity removal of superoxide radicals removal of superoxide radicals oxygen binding enzyme binding respiratory electron transport chain hemopoiesis manganese ion binding manganese ion binding positive regulation of cell migration response to nutrient levels oxygen homeostasis vasodilation response to drug response to hydrogen peroxide superoxide anion generation mitochondrial nucleoid hydrogen peroxide metabolic process identical protein binding negative regulation of apoptotic process myelin sheath negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation metal ion binding negative regulation of fibroblast proliferation neuron development response to axon injury erythrophore differentiation hydrogen peroxide biosynthetic process regulation of catalytic activity protein homotetramerization regulation of mitochondrial membrane potential iron ion homeostasis response to hyperoxia negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of membrane hyperpolarization negative regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching |
04146 05016 |
| TC1100001565.mm.2 |
Stard3 |
START domain containing 3 |
11 |
98358367 |
NM_021547, BC003313 NM_021547, BC003313 |
59045 |
30 |
nucleoplasm cytoplasm mitochondrion endosome endosome late endosome endoplasmic reticulum membrane progesterone biosynthetic process lipid transport lipid binding cholesterol binding membrane integral component of membrane cholesterol transport late endosome membrane protein homodimerization activity intracellular membrane-bounded organelle organelle membrane contact site vesicle tethering to endoplasmic reticulum cholesterol transfer activity endoplasmic reticulum-endosome membrane contact site |
|
| TC0300002312.mm.2 |
|
|
|
|
NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 |
|
|
angiogenesis neural crest cell migration adaptive immune response T cell differentiation involved in immune response immune system process extracellular space plasma membrane integral component of plasma membrane multicellular organism development nervous system development axonogenesis axon guidance regulation of cell shape regulation of endothelial cell migration membrane integral component of membrane negative regulation of angiogenesis cell differentiation semaphorin receptor binding positive regulation of cell migration T-helper 1 cell differentiation chemorepellent activity negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway positive regulation of excitatory synapse assembly positive regulation of inhibitory synapse assembly |
|
| TC0500003243.mm.2 |
Hcar2 |
hydroxycarboxylic acid receptor 2 |
5 |
-123863569 |
NM_030701, BC120715, BC125296 NM_030701, BC120715, BC125296 NM_030701, BC120715, BC125296 |
80885 |
66 |
purinergic nucleotide receptor activity neutrophil apoptotic process G protein-coupled receptor activity GTP binding plasma membrane apoptotic process signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway membrane integral component of membrane cell junction positive regulation of neutrophil apoptotic process negative regulation of lipid catabolic process positive regulation of adiponectin secretion nicotinic acid receptor activity |
|
| TC0700000946.mm.2 |
Atp10a |
ATPase, class V, type 10A |
7 |
58658201 |
NM_009728, BC138356, BC138357 NM_009728, BC138356, BC138357 NM_009728, BC138356, BC138357 |
11982 |
30 |
nucleotide binding magnesium ion binding ATP binding endoplasmic reticulum plasma membrane integral component of plasma membrane lipid transport phospholipid transport membrane integral component of membrane phospholipid translocation metal ion binding ATPase-coupled intramembrane lipid transporter activity phosphatidylcholine flippase activity glycosylceramide flippase activity positive regulation of membrane tubulation phospholipid-translocating ATPase complex |
|
| TC1200000069.mm.2 |
Sdc1 |
syndecan 1 |
12 |
8771395 |
NM_011519, BC010560 NM_011519, BC010560 |
20969 |
238 |
protein binding extracellular region extracellular region Golgi lumen inflammatory response protein C-terminus binding external side of plasma membrane cell surface cell surface cell surface membrane integral component of membrane cell migration protein-containing complex wound healing identical protein binding myoblast development canonical Wnt signaling pathway positive regulation of exosomal secretion positive regulation of extracellular exosome assembly |
04512 04514 05144 |
| TC1100003395.mm.2 |
Heatr9 |
HEAT repeat containing 9 |
11 |
-83511678 |
NM_001045543 |
629303 |
3 |
hematopoietic progenitor cell differentiation cellular_component |
|
| TC1700002788.mm.2 |
|
|
|
|
NM_023124, NM_207648, BC156754 NM_023124, NM_207648, BC156754 NM_023124, NM_207648, BC156754 |
|
|
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface phagocytic vesicle membrane beta-2-microglobulin binding peptide binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding TAP complex binding endoplasmic reticulum exit site integral component of lumenal side of endoplasmic reticulum membrane |
|
| TC0400002434.mm.2 |
Ddx58 |
DEAD/H box helicase 58 |
4 |
-40203776 |
NM_172689, BC167209 NM_172689, BC167209 |
230073 |
157 |
nucleotide binding positive regulation of defense response to virus by host immune system process positive regulation of myeloid dendritic cell cytokine production DNA binding double-stranded DNA binding RNA binding double-stranded RNA binding double-stranded RNA binding double-stranded RNA binding single-stranded RNA binding single-stranded RNA binding single-stranded RNA binding helicase activity protein binding ATP binding cytoplasm cytoplasm cytosol cytosol cytoskeleton plasma membrane bicellular tight junction zinc ion binding zinc ion binding detection of virus response to virus response to virus positive regulation of gene expression actin cytoskeleton membrane hydrolase activity cell junction regulation of cell migration ubiquitin protein ligase binding ruffle membrane positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production RIG-I signaling pathway identical protein binding cell projection response to exogenous dsRNA innate immune response innate immune response innate immune response positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of DNA-binding transcription factor activity defense response to virus positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA antiviral innate immune response ribonucleoprotein complex |
04622 04623 05160 |
| MG-1-pos-10339726_st |
|
|
|
|
|
|
|
|
|
| TC1000001761.mm.2 |
Stx11 |
syntaxin 11 |
10 |
-12939982 |
NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 |
74732 |
21 |
SNARE binding T cell mediated cytotoxicity SNAP receptor activity Golgi apparatus plasma membrane intracellular protein transport exocytosis vesicle fusion synaptic vesicle endomembrane system protein transport membrane integral component of membrane vesicle-mediated transport SNARE complex synaptic vesicle fusion to presynaptic active zone membrane natural killer cell mediated cytotoxicity neutrophil degranulation cytotoxic T cell degranulation natural killer cell degranulation phagocytic vesicle vesicle docking presynaptic active zone membrane cellular response to interferon-gamma |
04130 |
| TC0900003250.mm.2 |
Csrnp1 |
cysteine-serine-rich nuclear protein 1 |
9 |
-119971162, -119971162, -119971162, -119971162 |
NM_153287, BC050066 NM_153287, BC050066 |
215418 |
24 |
DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II apoptotic process post-embryonic development sequence-specific DNA binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II platelet-derived growth factor receptor signaling pathway skeletal system morphogenesis roof of mouth development face morphogenesis |
|
| TC0700000153.mm.2 |
Zfp324 |
zinc finger protein 324 |
7 |
12965837 |
NM_178732, BC053093 NM_178732, BC053093 |
243834 |
19 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific nucleus regulation of transcription by RNA polymerase II |
|
| TC0900000031.mm.2 |
Casp1 |
caspase 1 |
9 |
5298516 |
NM_009807, BC008152 NM_009807, BC008152 |
12362 |
835 |
response to hypoxia response to hypoxia microglial cell activation positive regulation of cytokine production positive regulation of cytokine production endopeptidase activity cysteine-type endopeptidase activity cysteine-type endopeptidase activity protein binding extracellular region nucleus cytoplasm cytoplasm cytoplasm cytosol plasma membrane proteolysis myoblast fusion memory peptidase activity cysteine-type peptidase activity response to bacterium regulation of autophagy response to organic cyclic compound membrane protein processing protein processing protein autoprocessing hydrolase activity kinase binding response to lipopolysaccharide response to lipopolysaccharide interleukin-1 beta production interleukin-1 beta production positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production protein-containing complex response to ATP response to drug identical protein binding regulation of apoptotic process neuron projection positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of circadian sleep/wake cycle, non-REM sleep CARD domain binding regulation of inflammatory response regulation of inflammatory response regulation of inflammatory response mitochondrial depolarization membrane hyperpolarization pyroptosis pyroptosis cellular response to lipopolysaccharide cellular response to organic substance cellular response to interferon-gamma IPAF inflammasome complex IPAF inflammasome complex NLRP1 inflammasome complex NLRP3 inflammasome complex NLRP3 inflammasome complex scaffold protein binding AIM2 inflammasome complex AIM2 inflammasome complex protease inhibitor complex cysteine-type endopeptidase activity involved in apoptotic signaling pathway programmed necrotic cell death signaling receptor ligand precursor processing toxin transport positive regulation of tumor necrosis factor-mediated signaling pathway |
04621 04623 05014 |
| TC0600001258.mm.2 |
Irak2 |
interleukin-1 receptor-associated kinase 2 |
6 |
113638466 |
NM_001113553, NM_172161, BC085324 NM_001113553, NM_172161, BC085324 NM_001113553, NM_172161, BC085324 |
108960 |
42 |
nucleotide binding regulation of cytokine-mediated signaling pathway MyD88-dependent toll-like receptor signaling pathway protein kinase activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus cytoplasm plasma membrane protein phosphorylation inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity intracellular signal transduction protein homodimerization activity regulation of apoptotic process negative regulation of DNA-binding transcription factor activity protein heterodimerization activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1 |
04210 04722 |
| TC0700001519.mm.2 |
Trim6 |
tripartite motif-containing 6 |
7 |
104218794 |
NM_001013616, BC138965 NM_001013616, BC138965 |
94088 |
25 |
protein polyubiquitination protein polyubiquitination positive regulation of defense response to virus by host positive regulation of cytokine production involved in immune response protein binding nucleus nucleoplasm cytoplasm cytoplasm cytoplasm cytosol cytosol transcription factor binding zinc ion binding regulation of gene expression positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation free ubiquitin chain polymerization protein ubiquitination transferase activity protein kinase binding protein kinase binding protein kinase binding protein-macromolecule adaptor activity response to lipopolysaccharide regulation of protein localization positive regulation of peptidyl-serine phosphorylation cellular response to interferon-beta identical protein binding protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of viral genome replication negative regulation of viral genome replication innate immune response negative regulation of transcription, DNA-templated regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity positive regulation of type I interferon-mediated signaling pathway positive regulation of type I interferon-mediated signaling pathway ubiquitin protein ligase activity ubiquitin protein ligase activity cellular response to virus protein tyrosine kinase binding positive regulation of transcription regulatory region DNA binding negative regulation of stem cell differentiation |
|
| TC1400001432.mm.2 |
Dnase1l3 |
deoxyribonuclease 1-like 3 |
14 |
-7965189 |
NM_007870, BC012671 NM_007870, BC012671 |
13421 |
25 |
DNA catabolic process, endonucleolytic DNA catabolic process, endonucleolytic neutrophil activation involved in immune response regulation of acute inflammatory response DNA binding DNA binding nuclease activity endonuclease activity endodeoxyribonuclease activity deoxyribonuclease I activity deoxyribonuclease activity extracellular region nucleus nucleus nucleus endoplasmic reticulum DNA catabolic process apoptotic DNA fragmentation apoptotic DNA fragmentation apoptotic DNA fragmentation apoptotic process programmed cell death involved in cell development programmed cell death involved in cell development programmed cell death hydrolase activity regulation of neutrophil mediated cytotoxicity |
|
| TC0X00000316.mm.2 |
Il13ra1 |
interleukin 13 receptor, alpha 1 |
X |
36112107 |
NM_133990, BC052425, BC059939 NM_133990, BC052425, BC059939 NM_133990, BC052425, BC059939 |
16164 |
62 |
cytokine receptor activity leukemia inhibitory factor receptor activity oncostatin-M receptor activity ciliary neurotrophic factor receptor binding positive regulation of cell population proliferation external side of plasma membrane membrane integral component of membrane interleukin-13 receptor activity cytokine-mediated signaling pathway cytokine binding receptor complex |
04060 04630 |
| TC0200004647.mm.2 |
Siglec1 |
sialic acid binding Ig-like lectin 1, sialoadhesin |
2 |
-131069219 |
NM_011426, BC141335, BC141336 NM_011426, BC141335, BC141336 NM_011426, BC141335, BC141336 |
20612 |
103 |
protein binding extracellular region early endosome late endosome plasma membrane endocytosis cell adhesion membrane integral component of membrane carbohydrate binding virion binding positive regulation of T cell apoptotic process clathrin-dependent endocytosis of virus by host cell positive regulation of extrinsic apoptotic signaling pathway |
04514 |
| TC0500003487.mm.2 |
Adap1 |
ArfGAP with dual PH domains 1 |
5 |
-139271875 |
NM_172723 |
231821 |
19 |
GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding nucleus cytoplasm cytosol plasma membrane plasma membrane regulation of GTPase activity intracellular membrane-bounded organelle |
|
| TC1000000011.mm.2 |
Plekhg1 |
pleckstrin homology domain containing, family G (with RhoGef domain) member 1 |
10 |
3872666, 3740376 |
NM_001033253, NM_001159942, BC117965, BC117966 NM_001033253, NM_001159942, BC117965, BC117966 NM_001033253, NM_001159942, BC117965, BC117966 NM_001033253, NM_001159942, BC117965, BC117966 |
213783 |
22 |
nucleoplasm |
|
| TC0700001520.mm.2 |
|
|
|
|
NM_001243916, NM_030684, BC165966 NM_001243916, NM_030684, BC165966 NM_001243916, NM_030684, BC165966 |
|
|
protein polyubiquitination nucleoplasm cytoplasm cytosol zinc ion binding regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity defense response to virus ubiquitin protein ligase activity |
|
| TC0300000769.mm.2 |
Adar |
adenosine deaminase, RNA-specific |
3 |
89715021, 89730717, 89715237 |
NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 |
56417 |
115 |
osteoblast differentiation in utero embryonic development hematopoietic progenitor cell differentiation immune system process somatic diversification of immune receptors via somatic mutation DNA binding left-handed Z-DNA binding RNA binding double-stranded RNA binding double-stranded RNA adenosine deaminase activity double-stranded RNA adenosine deaminase activity double-stranded RNA adenosine deaminase activity adenosine deaminase activity protein binding nucleus nucleus nucleoplasm nucleolus nucleolus nucleolus cytoplasm cytoplasm cytoplasm adenosine to inosine editing adenosine to inosine editing adenosine to inosine editing adenosine to inosine editing RNA processing mRNA processing protein import into nucleus protein export from nucleus tRNA-specific adenosine deaminase activity response to virus base conversion or substitution editing nuclear speck hydrolase activity erythrocyte differentiation gene silencing by RNA pre-miRNA processing production of miRNAs involved in gene silencing by miRNA miRNA loading onto RISC involved in gene silencing by miRNA response to interferon-alpha negative regulation of apoptotic process negative regulation of protein kinase activity by regulation of protein phosphorylation negative regulation of protein kinase activity by regulation of protein phosphorylation supraspliceosomal complex positive regulation of viral genome replication positive regulation of viral genome replication negative regulation of viral genome replication innate immune response metal ion binding defense response to virus definitive hemopoiesis negative regulation of type I interferon-mediated signaling pathway hematopoietic stem cell homeostasis cellular response to virus negative regulation of RNA interference |
04623 |
| TC1_GL456211_random00000010.mm.2 |
|
|
|
|
|
|
|
|
|
| TC0400001135.mm.2 |
Lrp8 |
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
4 |
107802258, 107802884, 107802288, 107823160, 107830952 |
NM_001080926, NR_033496 NM_001080926, NR_033496 |
16975 |
161 |
amyloid-beta binding low-density lipoprotein particle receptor activity calcium ion binding protein binding extracellular region extracellular space microtubule associated complex plasma membrane caveola endocytosis chemical synaptic transmission high-density lipoprotein particle binding cell surface postsynaptic density membrane integral component of membrane kinesin binding ventral spinal cord development ammon gyrus development hippocampus development layer formation in cerebral cortex very-low-density lipoprotein particle receptor activity axon dendrite positive regulation of CREB transcription factor activity apolipoprotein binding reelin receptor activity reelin-mediated signaling pathway regulation of apoptotic process neuronal cell body receptor complex regulation of innate immune response positive regulation of protein kinase activity protein N-terminus binding calcium-dependent protein binding dendrite morphogenesis positive regulation of peptidyl-tyrosine phosphorylation modulation of chemical synaptic transmission positive regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity positive regulation of dendrite development |
|
| TC0300002680.mm.2 |
I830077J02Rik |
RIKEN cDNA I830077J02 gene |
3 |
-105925890 |
NM_001033780, BC147821, BC147828 NM_001033780, BC147821, BC147828 NM_001033780, BC147821, BC147828 |
433638 |
10 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC0200002410.mm.2 |
Src |
Rous sarcoma oncogene |
2 |
157424292 |
NM_001025395, NM_009271, BC039953 NM_001025395, NM_009271, BC039953 NM_001025395, NM_009271, BC039953 |
20779 |
555 |
nucleotide binding primary ovarian follicle growth positive regulation of cytokine production podosome immune system process protein kinase activity protein kinase activity protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding signaling receptor binding signaling receptor binding insulin receptor binding integrin binding protein binding ATP binding nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm mitochondrion mitochondrion mitochondrial inner membrane mitochondrial inner membrane lysosome late endosome cytosol cytosol cytoskeleton actin filament plasma membrane plasma membrane plasma membrane caveola caveola focal adhesion protein phosphorylation cell cycle cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway protein C-terminus binding cell population proliferation positive regulation of gene expression regulation of epithelial cell migration positive regulation of epithelial cell migration positive regulation of glucose metabolic process positive regulation of protein processing postsynaptic density positive regulation of smooth muscle cell migration membrane membrane kinase activity phosphorylation cell migration transferase activity peptidyl-serine phosphorylation peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation enzyme binding kinase binding protein kinase binding protein domain specific binding heme binding regulation of cell-cell adhesion cell junction cell differentiation estrogen receptor binding forebrain development extrinsic component of cytoplasmic side of plasma membrane negative regulation of protein-containing complex assembly ubiquitin protein ligase binding protein destabilization positive regulation of protein autophosphorylation activation of protein kinase B activity negative regulation of telomere maintenance via telomerase ruffle membrane regulation of intracellular estrogen receptor signaling pathway substrate adhesion-dependent cell spreading cellular response to reactive oxygen species positive regulation of dephosphorylation intracellular signal transduction intracellular signal transduction osteoclast development osteoclast development cellular response to platelet-derived growth factor stimulus peptidyl-tyrosine autophosphorylation SH2 domain binding odontogenesis neuron projection positive regulation of apoptotic process negative regulation of apoptotic process stress fiber assembly negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of protein binding positive regulation of MAP kinase activity positive regulation of phosphatidylinositol 3-kinase activity ion channel binding protein-containing complex binding transcytosis innate immune response bone resorption bone resorption positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of Notch signaling pathway positive regulation of Notch signaling pathway positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of insulin receptor signaling pathway protein autophosphorylation ephrin receptor binding ephrin receptor binding neurotrophin TRK receptor signaling pathway focal adhesion assembly perinuclear region of cytoplasm perinuclear region of cytoplasm oogenesis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding progesterone receptor signaling pathway progesterone receptor signaling pathway positive regulation of small GTPase mediated signal transduction phosphoprotein binding positive regulation of protein transport negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization negative regulation of telomerase activity uterus development branching involved in mammary gland duct morphogenesis regulation of cell projection assembly intestinal epithelial cell development intestinal epithelial cell development interleukin-6-mediated signaling pathway interleukin-6-mediated signaling pathway cellular response to hydrogen peroxide positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade response to interleukin-1 BMP receptor binding growth factor receptor binding growth factor receptor binding connexin binding cellular response to peptide hormone stimulus cellular response to progesterone stimulus cellular response to fluid shear stress cellular response to transforming growth factor beta stimulus positive regulation of podosome assembly positive regulation of podosome assembly positive regulation of protein serine/threonine kinase activity angiotensin-activated signaling pathway involved in heart process positive regulation of canonical Wnt signaling pathway scaffold protein binding scaffold protein binding regulation of postsynaptic neurotransmitter receptor activity glutamatergic synapse postsynaptic specialization, intracellular component positive regulation of protein localization to nucleus positive regulation of intracellular signal transduction positive regulation of ovarian follicle development positive regulation of lamellipodium morphogenesis positive regulation of DNA biosynthetic process positive regulation of platelet-derived growth factor receptor-beta signaling pathway regulation of early endosome to late endosome transport negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway regulation of caveolin-mediated endocytosis |
04012 04144 04370 04510 04520 04530 04540 04912 05100 |
| TC0100001859.mm.2 |
Slc30a1 |
solute carrier family 30 (zinc transporter), member 1 |
1 |
191906780 |
NM_009579, BC052166 NM_009579, BC052166 |
22782 |
33 |
in utero embryonic development zinc ion transmembrane transporter activity zinc ion transmembrane transporter activity cytoplasm endoplasmic reticulum endoplasmic reticulum Golgi apparatus Golgi apparatus plasma membrane ion transport cation transport zinc ion transport zinc ion transport cellular calcium ion homeostasis cellular zinc ion homeostasis cellular zinc ion homeostasis cellular zinc ion homeostasis cation transmembrane transporter activity detoxification of zinc ion membrane integral component of membrane integral component of membrane calcium channel inhibitor activity calcium channel inhibitor activity calcium channel inhibitor activity T-tubule nuclear membrane negative regulation of neurotransmitter secretion transmembrane transport calcium ion import cadmium ion transmembrane transport zinc ion transmembrane transport negative regulation of zinc ion transmembrane import detoxification of cadmium ion negative regulation of calcium ion import Schaffer collateral - CA1 synapse integral component of postsynaptic density membrane |
|
| TC0500001597.mm.2 |
|
|
|
|
NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 |
|
|
GTPase activator activity phospholipid binding cytoplasm cytosol plasma membrane signal transduction membrane negative regulation of GTPase activity intracellular signal transduction regulation of GTPase activity negative regulation of Ras protein signal transduction metal ion binding cellular response to calcium ion |
|
| TC1000000050.mm.2 |
Katna1 |
katanin p60 (ATPase-containing) subunit A1 |
10 |
7725999 |
NM_011835, BC009136 NM_011835, BC009136 |
23924 |
33 |
nucleotide binding spindle pole microtubule bundle formation neuron migration protein binding ATP binding nucleus nucleus cytoplasm lipid droplet centrosome spindle cytoskeleton microtubule plasma membrane cell cycle microtubule binding protein localization microtubule-severing ATPase activity microtubule-severing ATPase activity negative regulation of neuron projection development microtubule cytoskeleton isomerase activity ATPase activity ATPase activity axon axon growth cone midbody cytoplasmic microtubule organization cytoplasmic microtubule organization neuronal cell body protein heterodimerization activity microtubule severing microtubule severing microtubule severing cell division dynein complex binding mitotic spindle pole |
|
| TC1000001813.mm.2 |
Tnfaip3 |
tumor necrosis factor, alpha-induced protein 3 |
10 |
-19000909, -19000909 |
NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 |
21929 |
188 |
B-1 B cell homeostasis protease binding response to molecule of bacterial origin response to molecule of bacterial origin marginal zone B cell differentiation negative regulation of granuloma formation regulation of germinal center formation regulation of immunoglobulin production negative regulation of chronic inflammatory response DNA binding catalytic activity ubiquitin-protein transferase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity protein binding nucleus nucleus cytoplasm cytoplasm lysosome proteolysis apoptotic process inflammatory response cytoskeleton organization protein C-terminus binding metabolic process peptidase activity cysteine-type peptidase activity zinc ion binding response to wounding negative regulation of autophagy cell migration protein ubiquitination protein deubiquitination transferase activity hydrolase activity kinase binding positive regulation of Wnt signaling pathway negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to muramyl dipeptide negative regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of heterotypic cell-cell adhesion negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 5 signaling pathway protein K29-linked deubiquitination protein K11-linked deubiquitination identical protein binding negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling ubiquitin binding protein self-association regulation of innate immune response positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of innate immune response metal ion binding negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response negative regulation of inflammatory response negative regulation of B cell activation negative regulation of cell death Lys63-specific deubiquitinase activity cellular response to hydrogen peroxide negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway K63-linked polyubiquitin modification-dependent protein binding protein K63-linked deubiquitination protein K63-linked deubiquitination protein K48-linked ubiquitination protein K48-linked deubiquitination cellular response to lipopolysaccharide protein deubiquitination involved in ubiquitin-dependent protein catabolic process tolerance induction to lipopolysaccharide establishment of protein localization to vacuole negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of cellular protein catabolic process protein K33-linked deubiquitination positive regulation of hepatocyte proliferation negative regulation of CD40 signaling pathway negative regulation of endothelial cell apoptotic process |
04621 |
| TC0700002414.mm.2 |
Selenow |
selenoprotein W |
7 |
-15917207 |
NM_009156, BC052719 NM_009156, BC052719 |
20364 |
32 |
cytoplasm cytosol plasma membrane response to selenium ion antioxidant activity oxidoreductase activity |
|
| TC0300000697.mm.2 |
Etv3 |
ets variant 3 |
3 |
87525577 |
NM_001083318, NM_001286844, NM_012051, BC078636 NM_001083318, NM_001286844, NM_012051, BC078636 NM_001083318, NM_001286844, NM_012051, BC078636 NM_001083318, NM_001286844, NM_012051, BC078636 |
27049 |
36 |
negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of cell population proliferation transcription repressor complex DEAD/H-box RNA helicase binding cell differentiation intracellular membrane-bounded organelle sequence-specific DNA binding RNA polymerase II transcription repressor complex cellular response to granulocyte macrophage colony-stimulating factor stimulus sequence-specific double-stranded DNA binding |
|
| TC1800000590.mm.2 |
Isoc1 |
isochorismatase domain containing 1 |
18 |
58659481 |
NM_025478, BC016576 NM_025478, BC016576 |
66307 |
21 |
molecular_function catalytic activity cytoplasm peroxisome peroxisome biological_process |
|
| TC1600000116.mm.2 |
Ciita |
class II transactivator |
16 |
10480071, 10489780, 10488177 |
NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 |
12265 |
178 |
negative regulation of transcription by RNA polymerase II nucleotide binding transcription regulatory region sequence-specific DNA binding ATP binding GTP binding nucleus nucleoplasm cytosol regulation of transcription, DNA-templated inflammatory response protein C-terminus binding cell surface kinase activity phosphorylation PML body transferase activity transferase activity, transferring acyl groups activating transcription factor binding activating transcription factor binding response to interferon-gamma response to interferon-gamma protein-containing complex binding positive regulation of MHC class I biosynthetic process positive regulation of MHC class I biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of viral entry into host cell response to antibiotic |
04612 05145 05340 |
| TC1100003379.mm.2 |
Slfn9 |
schlafen 9 |
11 |
-82980302 |
NM_172796 |
237886 |
12 |
tRNA binding nucleotide binding nuclease activity endonuclease activity endoribonuclease activity ATP binding nucleus cytoplasm zinc ion binding hydrolase activity metal ion binding defense response to virus |
|
| MG-1-pos-10343468_st |
|
|
|
|
|
|
|
|
|
| TC1100002871.mm.2 |
Tom1l2 |
target of myb1-like 2 (chicken) |
11 |
-60226713, -60240569 |
NM_001039092, NM_001039093, NM_153080, BC062947, BC127266 NM_001039092, NM_001039093, NM_153080, BC062947, BC127266 NM_001039092, NM_001039093, NM_153080, BC062947, BC127266 NM_001039092, NM_001039093, NM_153080, BC062947, BC127266 NM_001039092, NM_001039093, NM_153080, BC062947, BC127266 |
216810 |
27 |
intracellular anatomical structure endosome intracellular protein transport signal transduction signal transduction protein transport membrane protein kinase binding clathrin binding clathrin binding negative regulation of mitotic nuclear division |
|
| TC0700003839.mm.2 |
Art2a |
ADP-ribosyltransferase 2a |
7 |
-101552775, -101552452 |
NM_007490, NR_033804, BC120753 NM_007490, NR_033804, BC120753 NM_007490, NR_033804, BC120753 |
11871 |
40 |
NAD+ ADP-ribosyltransferase activity peptidyl-arginine ADP-ribosylation |
|
| TC1800001181.mm.2 |
Sting1 |
stimulator of interferon response cGAMP interactor 1 |
18 |
-35733677 |
NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 |
72512 |
348 |
autophagosome assembly autophagosome assembly autophagosome assembly nucleotide binding activation of innate immune response activation of innate immune response activation of innate immune response positive regulation of defense response to virus by host immune system process protein binding nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane endosome autophagosome autophagosome autophagosome peroxisome endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Golgi apparatus cytosol plasma membrane autophagy transcription factor binding regulation of gene expression membrane integral component of membrane positive regulation of macroautophagy positive regulation of macroautophagy positive regulation of macroautophagy protein kinase binding integral component of endoplasmic reticulum membrane regulation of cellular metabolic process cytoplasmic vesicle ubiquitin protein ligase binding positive regulation of protein binding positive regulation of type I interferon production positive regulation of type I interferon production positive regulation of type I interferon production interferon-beta production interferon-beta production cyclic-di-GMP binding cyclic-di-GMP binding cyclic-di-GMP binding cellular response to interferon-beta identical protein binding protein homodimerization activity innate immune response innate immune response innate immune response positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II perinuclear region of cytoplasm regulation of inflammatory response positive regulation of DNA-binding transcription factor activity protein complex oligomerization defense response to virus defense response to virus defense response to virus cyclic-GMP-AMP binding cyclic-GMP-AMP binding cyclic-GMP-AMP binding reticulophagy reticulophagy cellular response to exogenous dsRNA cellular response to organic cyclic compound cellular response to organic cyclic compound integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane |
04622 04623 |
| TC0100001018.mm.2 |
Phlpp1 |
PH domain and leucine rich repeat protein phosphatase 1 |
1 |
106171868 |
NM_133821, BC059254 NM_133821, BC059254 |
98432 |
54 |
regulation of protein phosphorylation regulation of T cell anergy catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein serine/threonine phosphatase activity nucleus nucleoplasm cytoplasm cytoplasm plasma membrane protein dephosphorylation apoptotic process signal transduction entrainment of circadian clock membrane hydrolase activity nuclear membrane regulation of apoptotic process intracellular membrane-bounded organelle regulation of MAPK cascade regulation of JNK cascade metal ion binding positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade positive regulation of protein kinase C signaling negative regulation of protein kinase C signaling regulation of p38MAPK cascade |
|
| TC1700002780.mm.2 |
H2-DMb1 |
histocompatibility 2, class II, locus Mb1 |
17 |
34153190 |
NM_010387, BC002237, BC003718 NM_010387, BC002237, BC003718 NM_010387, BC002237, BC003718 |
14999 |
23 |
adaptive immune response immune system process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II lysosome lysosomal membrane endosome immune response membrane integral component of membrane antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding late endosome membrane MHC class II protein complex intracellular membrane-bounded organelle chaperone cofactor-dependent protein refolding |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC1300002392.mm.2 |
Vcan |
versican |
13 |
-89655309, -89709947 |
NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 |
13003 |
200 |
skeletal system development ureteric bud development calcium ion binding hyaluronic acid binding extracellular region cell adhesion central nervous system development heart development glial cell migration cell surface protein phosphatase binding extracellular matrix structural constituent conferring compression resistance carbohydrate binding extracellular matrix extracellular matrix cell projection regulation of phosphoprotein phosphatase activity synapse collagen-containing extracellular matrix collagen-containing extracellular matrix perineuronal net |
04514 |
| TC1700001898.mm.2 |
Brd2 |
bromodomain containing 2 |
17 |
-34112018, -34112018, -34112018 |
NM_001204973, NM_010238, NR_037970, BC138655, BC138656 NM_001204973, NM_010238, NR_037970, BC138655, BC138656 NM_001204973, NM_010238, NR_037970, BC138655, BC138656 NM_001204973, NM_010238, NR_037970, BC138655, BC138656 NM_001204973, NM_010238, NR_037970, BC138655, BC138656 |
14312 |
68 |
neural tube closure chromatin binding protein serine/threonine kinase activity nucleus nucleus nucleoplasm cytoplasm chromatin organization nucleosome assembly regulation of transcription by RNA polymerase II protein phosphorylation regulation of gene expression nuclear speck lysine-acetylated histone binding |
|
| TC0500001615.mm.2 |
|
|
|
|
NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 |
|
|
in utero embryonic development endothelial cell morphogenesis catalytic activity iron ion binding extracellular region extracellular space endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum Golgi apparatus trans-Golgi network protein O-linked glycosylation protein localization metabolic process procollagen-lysine 5-dioxygenase activity procollagen-lysine 5-dioxygenase activity procollagen-lysine 5-dioxygenase activity negative regulation of gene expression membrane oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen transferase activity transferase activity, transferring glycosyl groups peptidyl-lysine hydroxylation peptidyl-lysine hydroxylation peptidyl-lysine hydroxylation peptidyl-lysine hydroxylation neural tube development collagen fibril organization L-ascorbic acid binding collagen metabolic process procollagen glucosyltransferase activity procollagen glucosyltransferase activity procollagen glucosyltransferase activity vasodilation metal ion binding hydroxylysine biosynthetic process epidermis morphogenesis procollagen galactosyltransferase activity dioxygenase activity lung morphogenesis collagen-containing extracellular matrix collagen-containing extracellular matrix basement membrane assembly positive regulation of stem cell proliferation |
|
| TC0700003842.mm.2 |
Art2b |
ADP-ribosyltransferase 2b |
7 |
-101575728 |
NM_019915, BC148693 NM_019915, BC148693 |
11872 |
37 |
NAD+ ADP-ribosyltransferase activity NAD(P)+-protein-arginine ADP-ribosyltransferase activity NAD(P)+-protein-arginine ADP-ribosyltransferase activity plasma membrane protein ADP-ribosylation membrane transferase activity transferase activity, transferring glycosyl groups hydrolase activity hydrolase activity, acting on glycosyl bonds peptidyl-arginine ADP-ribosylation peptidyl-arginine ADP-ribosylation NAD catabolic process extrinsic component of plasma membrane anchored component of membrane anchored component of external side of plasma membrane anchored component of plasma membrane NAD glycohydrolase activity |
|
| TC0500001043.mm.2 |
Lrrc8c |
leucine rich repeat containing 8 family, member C |
5 |
105519470 |
NM_133897, BC025473, BC026572 NM_133897, BC025473, BC026572 NM_133897, BC025473, BC026572 |
100604 |
21 |
volume-sensitive anion channel activity volume-sensitive anion channel activity cytoplasm endoplasmic reticulum plasma membrane integral component of plasma membrane integral component of plasma membrane ion transport taurine transport aspartate transmembrane transport membrane integral component of membrane protein hexamerization ion channel complex ion channel complex fat cell differentiation fat cell differentiation cellular response to osmotic stress anion transmembrane transport anion transmembrane transport |
|
| TC0200001729.mm.2 |
Thbs1 |
thrombospondin 1 |
2 |
118111875 |
NM_011580, BC042422, BC050917 NM_011580, BC042422, BC050917 NM_011580, BC042422, BC050917 |
21825 |
301 |
activation of MAPK activity phosphatidylserine binding negative regulation of endothelial cell proliferation negative regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion fibronectin binding sprouting angiogenesis negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and presentation outflow tract morphogenesis endocardial cushion development growth plate cartilage development growth plate cartilage development integrin binding extracellular matrix structural constituent calcium ion binding protein binding extracellular region fibrinogen complex extracellular space extracellular space extracellular space cytoplasm endoplasmic reticulum inflammatory response inflammatory response response to unfolded protein cell cycle arrest cell adhesion heparin binding positive regulation of cell population proliferation response to mechanical stimulus response to glucose external side of plasma membrane cell surface positive regulation of endothelial cell migration negative regulation of endothelial cell migration negative regulation of long-chain fatty acid import across plasma membrane negative regulation of nitric oxide mediated signal transduction negative regulation of cGMP-mediated signaling negative regulation of plasminogen activation positive regulation of macrophage chemotaxis positive regulation of fibroblast migration positive regulation of cell-substrate adhesion cell migration negative regulation of angiogenesis negative regulation of angiogenesis negative regulation of angiogenesis negative regulation of angiogenesis sarcoplasmic reticulum fibroblast growth factor binding peptide cross-linking secretory granule low-density lipoprotein particle binding positive regulation of blood coagulation positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway extracellular matrix platelet alpha granule response to magnesium ion negative regulation of interleukin-12 production positive regulation of tumor necrosis factor production response to endoplasmic reticulum stress negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of phosphorylation positive regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process laminin binding positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration engulfment of apoptotic cell positive regulation of translation positive regulation of angiogenesis behavioral response to pain blood vessel morphogenesis positive regulation of smooth muscle cell proliferation transforming growth factor beta binding extracellular matrix binding positive regulation of chemotaxis response to calcium ion positive regulation of protein kinase B signaling negative regulation of fibrinolysis collagen-containing extracellular matrix collagen-containing extracellular matrix fibrinogen binding collagen V binding monocyte aggregation positive regulation of transforming growth factor beta production cellular response to nitric oxide negative regulation of cell migration involved in sprouting angiogenesis positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of sprouting angiogenesis positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process negative regulation of endothelial cell chemotaxis |
04115 04145 04350 04510 04512 05144 05219 |
| TC0200005013.mm.2 |
Samhd1 |
SAM domain and HD domain, 1 |
2 |
-157119560, -157097533 |
NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 |
56045 |
46 |
nucleotide binding double-strand break repair via homologous recombination immune system process nucleic acid binding single-stranded DNA binding RNA binding catalytic activity GTP binding nucleus nucleus nucleoplasm chromosome plasma membrane dGTP catabolic process dGTP catabolic process DNA replication DNA repair cellular response to DNA damage stimulus metabolic process zinc ion binding dGTPase activity dGTPase activity dGTPase activity deoxyribonucleotide catabolic process somatic hypermutation of immunoglobulin genes hydrolase activity triphosphoric monoester hydrolase activity triphosphoric monoester hydrolase activity dGTP binding site of double-strand break identical protein binding innate immune response regulation of innate immune response regulation of innate immune response dATP catabolic process dATP catabolic process metal ion binding protein homotetramerization protein homotetramerization defense response to virus defense response to virus negative regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway tetraspanin-enriched microdomain DNA strand resection involved in replication fork processing |
|
| TC0100000743.mm.2 |
Gm7609 |
predicted pseudogene 7609 |
1 |
85199610 |
NM_001081746 |
665378 |
10 |
|
|
| TC1300000157.mm.2 |
Aoah |
acyloxyacyl hydrolase |
13 |
20794112, 20794112 |
NM_001281854, NM_012054, BC150767 NM_001281854, NM_012054, BC150767 NM_001281854, NM_012054, BC150767 |
27052 |
35 |
calcium ion binding calcium ion binding calcium ion binding extracellular region lipid metabolic process fatty acid metabolic process lipopolysaccharide metabolic process lipopolysaccharide catabolic process lipopolysaccharide catabolic process hydrolase activity hydrolase activity, acting on ester bonds cytoplasmic vesicle intracellular membrane-bounded organelle metal ion binding acyloxyacyl hydrolase activity acyloxyacyl hydrolase activity acyloxyacyl hydrolase activity negative regulation of inflammatory response negative regulation of inflammatory response |
|
| TC0500002840.mm.2 |
Plac8 |
placenta-specific 8 |
5 |
-100553725, -100553725 |
NM_139198, BC010789 NM_139198, BC010789 |
231507 |
35 |
chromatin binding protein binding nucleus positive regulation of cell population proliferation response to cold negative regulation of multicellular organism growth defense response to bacterium negative regulation of apoptotic process negative regulation of apoptotic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II brown fat cell differentiation positive regulation of cold-induced thermogenesis |
|
| TSUnmapped00000016.mm.2 |
Ddit3 |
DNA-damage inducible transcript 3 |
10 |
127290792 |
NM_001290183 |
13198 |
353 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific blood vessel maturation DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus cytoplasm cytoplasm cytoplasm late endosome regulation of transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II apoptotic process ER overload response ER overload response ER overload response response to unfolded protein cell cycle cell cycle arrest sensory perception of sound transcription factor binding transcription factor binding transcription factor binding cAMP response element binding protein binding cAMP response element binding protein binding anterior/posterior axis specification regulation of autophagy Wnt signaling pathway endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response negative regulation of NF-kappaB transcription factor activity negative regulation of interferon-gamma production negative regulation of interleukin-17 production negative regulation of interleukin-4 production positive regulation of interleukin-8 production negative regulation of CREB transcription factor activity negative regulation of CREB transcription factor activity protein-DNA complex positive regulation of autophagy in response to ER overload response to endoplasmic reticulum stress response to endoplasmic reticulum stress CHOP-C/EBP complex CHOP-C/EBP complex CHOP-C/EBP complex response to starvation positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of DNA binding negative regulation of DNA-binding transcription factor activity leucine zipper domain binding positive regulation of neuron apoptotic process positive regulation of neuron apoptotic process sequence-specific DNA binding cell redox homeostasis negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein heterodimerization activity protein heterodimerization activity protein heterodimerization activity protein heterodimerization activity positive regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity release of sequestered calcium ion into cytosol negative regulation of protein kinase B signaling intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress establishment of protein localization to mitochondrion negative regulation of canonical Wnt signaling pathway RNA polymerase II transcription regulator complex negative regulation of cold-induced thermogenesis transcription regulator inhibitor activity positive regulation of neuron death negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to nitrosative stress CHOP-ATF4 complex CHOP-ATF4 complex CHOP-ATF3 complex CHOP-ATF3 complex negative regulation of determination of dorsal identity negative regulation of determination of dorsal identity positive regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway |
04010 04141 |
| TC0600000570.mm.2 |
Tmem176a |
transmembrane protein 176A |
6 |
48841655, 48841482 |
NM_001098271, NM_025326, BC010831 NM_001098271, NM_025326, BC010831 NM_001098271, NM_025326, BC010831 |
66058 |
18 |
protein binding membrane integral component of membrane negative regulation of dendritic cell differentiation negative regulation of dendritic cell differentiation |
|
| TC1900000219.mm.2 |
Ms4a4b |
membrane-spanning 4-domains, subfamily A, member 4B |
19 |
11443557 |
NM_021718, BC028433 NM_021718, BC028433 |
60361 |
19 |
integral component of plasma membrane |
|
| TC0400002220.mm.2 |
Tmem67 |
transmembrane protein 67 |
4 |
-12039355, -12039358 |
NM_177861 |
329795 |
28 |
kidney development cytoplasm endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane centrosome cytoskeleton plasma membrane cilium axoneme determination of left/right symmetry heart development negative regulation of centrosome duplication negative regulation of centrosome duplication membrane integral component of membrane cell projection organization ubiquitin-dependent ERAD pathway cytoplasmic vesicle membrane cytoplasmic vesicle membrane filamin binding photoreceptor cell outer segment organization ciliary transition zone ciliary transition zone MKS complex cell projection branching morphogenesis of an epithelial tube unfolded protein binding misfolded protein binding ciliary membrane cilium assembly cilium assembly cilium assembly head development positive regulation of non-motile cilium assembly positive regulation of ERAD pathway |
|
| TC1700000528.mm.2 |
Abcg1 |
ATP binding cassette subfamily G member 1 |
17 |
31057693 |
NM_009593, BC119471 NM_009593, BC119471 |
11307 |
166 |
nucleotide binding ATP binding mitochondrion endosome endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane lipid transport cholesterol metabolic process external side of plasma membrane external side of plasma membrane negative regulation of macrophage derived foam cell differentiation regulation of cholesterol esterification positive regulation of cholesterol efflux negative regulation of lipid storage membrane integral component of membrane ATPase activity toxin transmembrane transporter activity cholesterol transport intracellular cholesterol transport cholesterol efflux cholesterol efflux cholesterol efflux phospholipid efflux response to lipid ABC-type sterol transporter activity ABC-type sterol transporter activity low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling glycoprotein transport cholesterol homeostasis cholesterol homeostasis protein homodimerization activity amyloid precursor protein catabolic process ADP binding reverse cholesterol transport positive regulation of cholesterol biosynthetic process protein heterodimerization activity positive regulation of protein secretion recycling endosome transmembrane transport phospholipid homeostasis cellular response to high density lipoprotein particle stimulus phosphatidylcholine floppase activity cholesterol transfer activity floppase activity positive regulation of amyloid-beta formation |
02010 |
| TC0300002053.mm.2 |
P2ry13 |
purinergic receptor P2Y, G-protein coupled 13 |
3 |
-59207893 |
NM_028808, BC119043 NM_028808, BC119043 |
74191 |
40 |
G protein-coupled receptor activity endoplasmic reticulum plasma membrane signal transduction G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase activity membrane integral component of membrane G protein-coupled purinergic nucleotide receptor activity G protein-coupled purinergic nucleotide receptor activity cellular response to organic cyclic compound |
04080 |
| TC0800002431.mm.2 |
Bst2 |
bone marrow stromal cell antigen 2 |
8 |
-71534255 |
NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 |
69550 |
43 |
immune system process cytoplasm endosome Golgi apparatus plasma membrane metalloendopeptidase inhibitor activity response to virus cell surface cell surface cell surface membrane integral component of membrane apical plasma membrane anchored component of membrane regulation of actin cytoskeleton organization response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response innate immune response defense response to virus negative regulation of intracellular transport of viral material negative regulation of intracellular transport of viral material |
|
| TC1900001085.mm.2 |
Stxbp3-ps |
syntaxin-binding protein 3, pseudogene |
19 |
-9557605 |
NR_073559 |
619371 |
3 |
|
|
| TC0700003996.mm.2 |
|
|
|
|
NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 |
|
|
molecular_function cellular_component biological_process |
|
| TC1700002778.mm.2 |
Tapbp |
TAP binding protein |
17 |
33919477 |
NM_001025313, NM_009318, BC015074 NM_001025313, NM_009318, BC015074 NM_001025313, NM_009318, BC015074 |
21356 |
69 |
Golgi membrane MHC class Ib protein complex assembly antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent protein binding endoplasmic reticulum endoplasmic reticulum membrane integral component of plasma membrane defense response regulation of gene expression membrane integral component of membrane antigen processing and presentation of endogenous peptide antigen via MHC class I phagocytic vesicle membrane MHC class I peptide loading complex TAP1 binding TAP2 binding peptide antigen stabilization regulation of protein complex stability TAP complex binding protein-containing complex assembly |
04612 |
| TC0600000637.mm.2 |
Creb5 |
cAMP responsive element binding protein 5 |
6 |
53573373, 53287302 |
NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 |
231991 |
23 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cAMP response element binding identical protein binding fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II adipose tissue development sequence-specific double-stranded DNA binding |
04962 05016 05215 |
| TC0900002764.mm.2 |
Hmgn3 |
high mobility group nucleosomal binding domain 3 |
9 |
-83109941 |
NM_026122, NM_175074, BC005693 NM_026122, NM_175074, BC005693 NM_026122, NM_175074, BC005693 |
94353 |
32 |
chromatin DNA binding chromatin binding chromatin binding chromatin binding nucleus nucleus nucleus chromatin organization regulation of transcription by RNA polymerase II nucleosomal DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity regulation of insulin secretion involved in cellular response to glucose stimulus |
|
| TC0200005175.mm.2 |
Prex1 |
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 |
2 |
-166566344 |
NM_177782, BC151074, BC157940 NM_177782, BC151074, BC157940 NM_177782, BC151074, BC157940 |
277360 |
42 |
guanyl-nucleotide exchange factor activity phospholipid binding cytoplasm cytosol plasma membrane plasma membrane G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway membrane T cell differentiation positive regulation of cell migration growth cone neutrophil chemotaxis regulation of actin filament polymerization regulation of Rho protein signal transduction intracellular signal transduction dendritic shaft positive regulation of GTPase activity positive regulation of cell adhesion perinuclear region of cytoplasm regulation of dendrite development reactive oxygen species metabolic process positive regulation of substrate adhesion-dependent cell spreading |
04062 |
| TC1700000954.mm.2 |
Plcl2 |
phospholipase C-like 2 |
17 |
50509546 |
NM_013880, BC027746 NM_013880, BC027746 |
224860 |
35 |
B cell proliferation involved in immune response B-1a B cell differentiation phosphatidylinositol phospholipase C activity cytoplasm lipid metabolic process signal transduction gamma-aminobutyric acid signaling pathway phosphoric diester hydrolase activity regulation of synaptic transmission, GABAergic regulation of peptidyl-serine phosphorylation intracellular signal transduction phosphatidylinositol-mediated signaling GABA receptor binding negative regulation of B cell receptor signaling pathway inositol 1,4,5 trisphosphate binding negative regulation of cold-induced thermogenesis positive regulation of receptor binding |
|
| TC0200002961.mm.2 |
Pfkfb3 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
2 |
-11471430, -11471430 |
NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 |
170768 |
55 |
6-phosphofructo-2-kinase activity fructose-2,6-bisphosphate 2-phosphatase activity nucleoplasm cytosol fructose 2,6-bisphosphate metabolic process fructose 2,6-bisphosphate metabolic process |
00051 |
| TC1100002310.mm.2 |
Aftph |
aftiphilin |
11 |
-20685084 |
NM_001252503, NM_181411, BC052036 NM_001252503, NM_181411, BC052036 NM_001252503, NM_181411, BC052036 |
216549 |
21 |
nucleoplasm cytoplasm Golgi apparatus cytosol protein transport AP-1 adaptor complex AP-1 adaptor complex clathrin binding clathrin binding trans-Golgi network membrane intracellular membrane-bounded organelle intracellular transport |
|
| TC0600003084.mm.2 |
Clec4e |
C-type lectin domain family 4, member e |
6 |
-123281788 |
NM_019948, BC003218 NM_019948, BC003218 |
56619 |
84 |
positive regulation of cytokine production pattern recognition receptor signaling pathway T cell differentiation involved in immune response immune system process calcium ion binding protein binding immune response membrane integral component of membrane carbohydrate binding signaling receptor activity Fc-gamma receptor signaling pathway pattern recognition receptor activity defense response to bacterium innate immune response metal ion binding |
|
| TC1000000778.mm.2 |
Icosl |
icos ligand |
10 |
78069367 |
NM_015790, BC029227 NM_015790, BC029227 |
50723 |
107 |
regulation of cytokine production adaptive immune response immune system process signaling receptor binding signaling receptor binding protein binding plasma membrane integral component of plasma membrane signal transduction external side of plasma membrane external side of plasma membrane membrane integral component of membrane positive regulation of interleukin-4 production cytoplasmic ribonucleoprotein granule positive regulation of activated T cell proliferation T cell activation B cell activation identical protein binding isotype switching T cell receptor signaling pathway |
04514 04672 |
| TC1100003069.mm.2 |
Nlgn2 |
neuroligin 2 |
11 |
-69823122, -69823122 |
NM_198862, BC156963 NM_198862, BC156963 |
216856 |
99 |
thigmotaxis regulation of respiratory gaseous exchange by nervous system process protein binding cytoplasm plasma membrane integral component of plasma membrane cell adhesion neuron cell-cell adhesion neuron cell-cell adhesion chemical synaptic transmission synapse assembly jump response positive regulation of cell population proliferation cell surface cell surface membrane integral component of membrane sensory perception of pain cell junction positive regulation of insulin secretion positive regulation of synaptic transmission, GABAergic social behavior protein localization to synapse locomotory exploration behavior signaling receptor activity neurexin family protein binding neurexin family protein binding identical protein binding cell projection dendritic shaft synapse synapse postsynaptic membrane synaptic vesicle endocytosis modulation of chemical synaptic transmission modulation of chemical synaptic transmission synapse organization cell adhesion molecule binding neuromuscular process controlling balance positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic excitatory synapse excitatory synapse inhibitory synapse inhibitory synapse positive regulation of dendritic spine development terminal button organization postsynaptic membrane assembly postsynaptic membrane assembly presynaptic membrane assembly presynaptic membrane assembly presynaptic membrane assembly presynaptic membrane assembly gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering positive regulation of inhibitory postsynaptic potential positive regulation of inhibitory postsynaptic potential ribbon synapse glycinergic synapse glycinergic synapse glycinergic synapse dopaminergic synapse postsynaptic specialization assembly postsynaptic specialization assembly postsynaptic specialization assembly GABA-ergic synapse GABA-ergic synapse GABA-ergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of postsynaptic specialization membrane integral component of postsynaptic specialization membrane insulin metabolic process positive regulation of protein localization to synapse positive regulation of t-SNARE clustering inhibitory synapse assembly regulation of presynapse assembly regulation of AMPA receptor activity positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering |
04514 |
| MG-1-pos-10338116_st |
|
|
|
|
|
|
|
|
|
| TC1500000776.mm.2 |
Tspo |
translocator protein |
15 |
83563572 |
NM_009775, BC002055 NM_009775, BC002055 |
12257 |
111 |
androgen binding mitochondrion mitochondrion mitochondrion mitochondrial outer membrane endoplasmic reticulum cytosol steroid biosynthetic process ion transport chloride transport lipid transport glial cell migration benzodiazepine receptor activity negative regulation of mitochondrion organization positive regulation of necrotic cell death cholesterol binding membrane integral component of membrane negative regulation of protein ubiquitination negative regulation of tumor necrosis factor production positive regulation of apoptotic process intracellular membrane-bounded organelle ion channel binding negative regulation of nitric oxide biosynthetic process behavioral response to pain regulation of steroid biosynthetic process positive regulation of mitochondrial depolarization positive regulation of calcium ion transport contact inhibition positive regulation of glial cell proliferation negative regulation of glial cell proliferation establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion negative regulation of autophagy of mitochondrion negative regulation of ATP metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process |
04080 |
| TC0400003794.mm.2 |
C1qa |
complement component 1, q subcomponent, alpha polypeptide |
4 |
-136895915 |
NM_007572, BC002086 NM_007572, BC002086 |
12259 |
212 |
microglial cell activation immune system process protein binding extracellular region collagen trimer extracellular space complement activation, classical pathway aging aging neuron remodeling innate immune response synapse synapse synapse astrocyte activation synapse organization postsynapse synapse pruning complement-mediated synapse pruning vertebrate eye-specific patterning positive regulation of neuron death |
04610 05020 05142 05150 05322 |
| TC0500000816.mm.2 |
Dck |
deoxycytidine kinase |
5 |
88765012 |
NM_007832, BC052004, BC060062 NM_007832, BC052004, BC060062 NM_007832, BC052004, BC060062 |
13178 |
28 |
nucleotide binding magnesium ion binding deoxyadenosine kinase activity deoxycytidine kinase activity deoxycytidine kinase activity deoxyguanosine kinase activity ATP binding nucleus nucleoplasm cytoplasm mitochondrion cytosol nucleobase-containing compound metabolic process pyrimidine nucleotide metabolic process drug binding kinase activity transferase activity deoxynucleoside kinase activity nucleoside kinase activity pyrimidine deoxyribonucleoside binding protein homodimerization activity deoxycytidine metabolic process nucleotide phosphorylation |
00230 00240 01100 |
| TC0500000627.mm.2 |
Rhoh |
ras homolog family member H |
5 |
65861219, 65863583 |
NM_001081105, BC094937 NM_001081105, BC094937 |
74734 |
32 |
nucleotide binding immunological synapse GTPase activity protein binding GTP binding GTP binding intracellular anatomical structure cytoplasm cytoplasm cytoskeleton plasma membrane plasma membrane cell cortex actin filament organization establishment or maintenance of cell polarity small GTPase mediated signal transduction motor neuron axon guidance regulation of cell shape membrane Rac protein signal transduction kinase inhibitor activity protein kinase binding cell projection assembly T cell differentiation cortical cytoskeleton organization cytoplasmic vesicle regulation of actin cytoskeleton organization cell projection negative regulation of I-kappaB kinase/NF-kappaB signaling intracellular membrane-bounded organelle engulfment of apoptotic cell mast cell activation positive regulation of T cell differentiation regulation of neutrophil migration |
04670 |
| MG-1-pos-10340809_st |
|
|
|
|
|
|
|
|
|
| TC0200002588.mm.2 |
Rnf114 |
ring finger protein 114 |
2 |
167503442, 167492644 |
NM_030743, BC054416, BC085146 NM_030743, BC054416, BC085146 NM_030743, BC054416, BC085146 |
81018 |
28 |
protein polyubiquitination nucleic acid binding nucleus cytoplasm cytosol plasma membrane ubiquitin-dependent protein catabolic process multicellular organism development spermatogenesis transferase activity cell differentiation metal ion binding ubiquitin protein ligase activity |
|
| TC0900003331.mm.2 |
|
|
|
|
NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 |
|
|
B cell homeostasis negative regulation of B cell apoptotic process protein binding cytoplasm mitochondrial outer membrane apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein-containing complex binding protein heterodimerization activity BH domain binding extrinsic apoptotic signaling pathway in absence of ligand |
|
| TC0900002346.mm.2 |
Tspan3 |
tetraspanin 3 |
9 |
-56135883 |
NM_019793, BC043072 NM_019793, BC043072 |
56434 |
23 |
integral component of plasma membrane membrane integral component of membrane |
|
| TC0500000466.mm.2 |
Bst1 |
bone marrow stromal cell antigen 1 |
5 |
43818892 |
NM_009763 |
12182 |
37 |
uropod regulation of cell-matrix adhesion NAD+ nucleosidase activity plasma membrane positive regulation of cell population proliferation membrane transferase activity hydrolase activity phosphorus-oxygen lyase activity extrinsic component of membrane positive regulation of B cell proliferation anchored component of membrane regulation of actin cytoskeleton organization NAD(P)+ nucleosidase activity regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling NAD+ nucleotidase, cyclic ADP-ribose generating ADP-ribosyl cyclase activity cyclic ADP-ribose hydrolase regulation of neutrophil chemotaxis |
00760 01100 04020 04970 04972 |
| TC0600002250.mm.2 |
Osbpl3 |
oxysterol binding protein-like 3 |
6 |
-50293326, -50293326, -50293326 |
NM_001163645, NM_027881, BC044866, BC086485 NM_001163645, NM_027881, BC044866, BC086485 NM_001163645, NM_027881, BC044866, BC086485 NM_001163645, NM_027881, BC044866, BC086485 |
71720 |
25 |
nucleus cytoplasm endoplasmic reticulum cytosol cytosol plasma membrane plasma membrane lipid transport lipid binding sterol transporter activity cholesterol binding cholesterol binding membrane nuclear membrane sterol binding cell projection intracellular membrane-bounded organelle perinuclear endoplasmic reticulum perinuclear endoplasmic reticulum |
|
| TC0800002597.mm.2 |
Junb |
jun B proto-oncogene |
8 |
-84976908 |
NM_008416, BC003790, BC092302 NM_008416, BC003790, BC092302 NM_008416, BC003790, BC092302 |
16477 |
179 |
RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific vasculogenesis osteoblast differentiation in utero embryonic development trophectodermal cell differentiation trophectodermal cell differentiation DNA binding DNA binding double-stranded DNA binding DNA-binding transcription factor activity protein binding nucleus nucleoplasm transcription regulator complex regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription factor binding cellular process osteoclast differentiation osteoblast proliferation transcription factor AP-1 complex regulation of cell population proliferation sequence-specific DNA binding positive regulation of cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II decidualization regulation of cell cycle regulation of cell cycle embryonic process involved in female pregnancy labyrinthine layer blood vessel development cellular response to calcium ion sequence-specific double-stranded DNA binding |
04380 |
| TC0400003957.mm.2 |
Tnfrsf1b |
tumor necrosis factor receptor superfamily, member 1b |
4 |
-145212367 |
NM_011610, BC141405 NM_011610, BC141405 |
21938 |
631 |
regulation of cytokine production involved in immune response regulation of T cell cytokine production regulation of T cell cytokine production aortic valve development pulmonary valve development negative regulation of extracellular matrix constituent secretion tumor necrosis factor-activated receptor activity tumor necrosis factor-activated receptor activity tumor necrosis factor-activated receptor activity protein binding nucleus inflammatory response immune response cell surface receptor signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of cardiac muscle hypertrophy membrane membrane integral component of membrane axon ubiquitin protein ligase binding regulation of myelination positive regulation of myelination positive regulation of myelination regulation of T cell proliferation regulation of T cell proliferation neuronal cell body tumor necrosis factor binding tumor necrosis factor binding varicosity membrane raft membrane raft perinuclear region of cytoplasm positive regulation of oligodendrocyte differentiation positive regulation of oligodendrocyte differentiation negative regulation of inflammatory response RNA destabilization positive regulation of membrane protein ectodomain proteolysis positive regulation of membrane protein ectodomain proteolysis negative regulation of cell death cellular response to lipopolysaccharide extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway regulation of neuroinflammatory response negative regulation of neuroinflammatory response negative regulation of neuroinflammatory response glial cell-neuron signaling negative regulation of neuron death negative regulation of neuron death positive regulation of apoptotic process involved in morphogenesis regulation of RNA biosynthetic process |
04060 04920 05014 |
| TC0900001511.mm.2 |
Bcl2a1c |
B cell leukemia/lymphoma 2 related protein A1c |
9 |
114330134 |
NM_007535, BC120720 NM_007535, BC120720 |
12046 |
4 |
mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity protein heterodimerization activity extrinsic apoptotic signaling pathway in absence of ligand |
|
| MG-1-pos-10342761_st |
|
|
|
|
|
|
|
|
|
| TC1600000760.mm.2 |
Dcbld2 |
discoidin, CUB and LCCL domain containing 2 |
16 |
58408534 |
NM_028523, BC066097 NM_028523, BC066097 |
73379 |
21 |
integral component of plasma membrane cell surface membrane integral component of membrane negative regulation of cell growth wound healing |
|
| TC1100004159.mm.2 |
Lgals3bp |
lectin, galactoside-binding, soluble, 3 binding protein |
11 |
-118392746 |
NM_011150, BC090658 NM_011150, BC090658 |
19039 |
38 |
scavenger receptor activity scavenger receptor activity protein binding extracellular region extracellular space extracellular space extracellular space cell adhesion membrane |
|
| TC0700004011.mm.2 |
Gvin3 |
GTPase, very large interferon inducible, family member 3 |
7 |
-106595548 |
NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 |
434223 |
8 |
molecular_function cellular_component biological_process |
|
| TC1700000505.mm.2 |
Pim1 |
proviral integration site 1 |
17 |
29493084, 29490784 |
NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 |
18712 |
186 |
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding ATP binding nucleus nucleolus cytoplasm cytoplasm cytosol plasma membrane protein phosphorylation protein phosphorylation apoptotic process cell cycle transcription factor binding membrane kinase activity phosphorylation transferase activity regulation of transmembrane transporter activity manganese ion binding manganese ion binding ribosomal small subunit binding negative regulation of apoptotic process negative regulation of DNA-binding transcription factor activity protein serine/threonine kinase activator activity positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated protein autophosphorylation protein autophosphorylation metal ion binding protein stabilization positive regulation of cardiac muscle cell proliferation vitamin D receptor signaling pathway positive regulation of protein serine/threonine kinase activity positive regulation of brown fat cell differentiation regulation of hematopoietic stem cell proliferation positive regulation of cardioblast proliferation cellular detoxification |
04630 05221 |
| TC0700004637.mm.2 |
Dnaaf3 |
dynein, axonemal assembly factor 3 |
7 |
-4522932 |
NM_001033548, BC150983 NM_001033548, BC150983 |
436022 |
14 |
molecular_function cellular_component cytoplasm determination of left/right symmetry heart development cell projection organization motile cilium assembly axonemal dynein complex assembly |
|
| TC1700000721.mm.2 |
Gm6034 |
predicted gene 6034 |
17 |
36042960 |
BC147141, BC147142 BC147141, BC147142 |
547347 |
11 |
molecular_function cellular_component biological_process |
|
| TC0200003526.mm.2 |
Rbm43 |
RNA binding motif protein 43 |
2 |
-51924448, -51924448, -51924448 |
NM_001141981, NM_001141982, NM_030243, BC003333 NM_001141981, NM_001141982, NM_030243, BC003333 NM_001141981, NM_001141982, NM_030243, BC003333 NM_001141981, NM_001141982, NM_030243, BC003333 |
71684 |
14 |
molecular_function nucleic acid binding RNA binding cellular_component biological_process |
|
| TC0400000696.mm.2 |
Slc31a2 |
solute carrier family 31, member 2 |
4 |
62291546, 62286428 |
NM_025286, BC029183, BC099447 NM_025286, BC029183, BC099447 NM_025286, BC029183, BC099447 |
20530 |
24 |
protein binding late endosome plasma membrane ion transport cellular copper ion homeostasis cellular copper ion homeostasis cellular copper ion homeostasis membrane integral component of membrane recycling endosome regulation of copper ion transmembrane transport |
|
| TC0700004404.mm.2 |
Chst15 |
carbohydrate sulfotransferase 15 |
7 |
-132235779, -132235779 |
NM_029935, BC031443 NM_029935, BC031443 |
77590 |
30 |
Golgi apparatus membrane integral component of membrane transferase activity hexose biosynthetic process hexose biosynthetic process 3'-phosphoadenosine 5'-phosphosulfate binding N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity |
00532 |
| TC0200001222.mm.2 |
Ube2l6 |
ubiquitin-conjugating enzyme E2L 6 |
2 |
84798827 |
NM_019949, BC008238 NM_019949, BC008238 |
56791 |
22 |
ubiquitin ligase complex nucleotide binding protein polyubiquitination protein binding ATP binding nucleus ubiquitin-dependent protein catabolic process transferase activity ubiquitin-like protein transferase activity modification-dependent protein catabolic process ubiquitin protein ligase binding ISG15-protein conjugation ISG15-protein conjugation ISG15 transferase activity ISG15 transferase activity ubiquitin binding ubiquitin conjugating enzyme activity |
04120 05012 |
| TC0700001448.mm.2 |
Pgap2 |
post-GPI attachment to proteins 2 |
7 |
102223027, 102210334, 102210510, 102223070, 102210172 |
NM_145583, BC004794 NM_145583, BC004794 |
233575 |
23 |
Golgi membrane endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane Golgi apparatus GPI anchor biosynthetic process GPI anchor biosynthetic process membrane integral component of membrane protein localization to plasma membrane |
|
| TC0700001258.mm.2 |
Ctsc |
cathepsin C |
7 |
88278084, 88278084 |
NM_009982, BC067063 NM_009982, BC067063 |
13032 |
77 |
T cell mediated cytotoxicity cysteine-type endopeptidase activity serine-type endopeptidase activity extracellular space nucleoplasm cytoplasm lysosome lysosome endoplasmic reticulum Golgi apparatus centrosome proteolysis proteolysis peptidase activity cysteine-type peptidase activity cysteine-type peptidase activity response to organic substance peptidase activator activity involved in apoptotic process hydrolase activity phosphatase binding chloride ion binding negative regulation of myelination negative regulation of myelination identical protein binding intracellular membrane-bounded organelle protein self-association chaperone binding proteolysis involved in cellular protein catabolic process collagen-containing extracellular matrix positive regulation of proteolysis involved in cellular protein catabolic process positive regulation of microglial cell activation positive regulation of apoptotic signaling pathway |
04142 |
| TC1800001595.mm.2 |
Lipg |
lipase, endothelial |
18 |
-74939321 |
NM_010720, BC020991 NM_010720, BC020991 |
16891 |
57 |
lipoprotein lipase activity phospholipase activity phospholipase activity phospholipase activity triglyceride lipase activity extracellular region extracellular space extracellular space early endosome Golgi apparatus lipid metabolic process fatty acid biosynthetic process heparin binding cell population proliferation phospholipase A1 activity cell surface positive regulation of high-density lipoprotein particle clearance lipid catabolic process lipase activity hydrolase activity triglyceride catabolic process positive regulation of cholesterol transport high-density lipoprotein particle remodeling cholesterol homeostasis reverse cholesterol transport regulation of lipoprotein metabolic process carboxylic ester hydrolase activity phosphatidylserine 1-acylhydrolase activity 1-acyl-2-lysophosphatidylserine acylhydrolase activity phospholipid homeostasis |
00561 01100 |
| TC0900001722.mm.2 |
Birc3 |
baculoviral IAP repeat-containing 3 |
9 |
-7848700 |
NM_007464, BC011338 NM_007464, BC011338 |
11796 |
101 |
ubiquitin-protein transferase activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol apoptotic process transferase activity positive regulation of protein ubiquitination positive regulation of protein ubiquitination protein-containing complex negative regulation of phosphorylation regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process protein-containing complex binding membrane raft metal ion binding regulation of cell cycle regulation of necroptotic process negative regulation of necroptotic process negative regulation of necroptotic process ubiquitin protein ligase activity necroptotic process cellular response to tumor necrosis factor regulation of NIK/NF-kappaB signaling positive regulation of protein polyubiquitination negative regulation of reactive oxygen species metabolic process |
04120 04210 04510 04621 05145 05200 05222 |
| TC0100000736.mm.2 |
|
|
|
|
|
|
|
|
|
| TC1600000130.mm.2 |
Snn |
stannin |
16 |
11066297 |
NM_009223, BC006961, BC017685, BC038475, BC063027, BC087932 NM_009223, BC006961, BC017685, BC038475, BC063027, BC087932 NM_009223, BC006961, BC017685, BC038475, BC063027, BC087932 NM_009223, BC006961, BC017685, BC038475, BC063027, BC087932 NM_009223, BC006961, BC017685, BC038475, BC063027, BC087932 NM_009223, BC006961, BC017685, BC038475, BC063027, BC087932 |
20621 |
16 |
cytoplasm mitochondrion mitochondrial outer membrane biological_process membrane integral component of membrane integral component of membrane metal ion binding |
|
| TC1700000934.mm.2 |
Treml4 |
triggering receptor expressed on myeloid cells-like 4 |
17 |
48264294 |
NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 NM_001033922, NM_001163795, NM_001163796, NM_172623, BC117091, BC137666 |
224840 |
15 |
positive regulation of defense response to virus by host immune system process T cell antigen processing and presentation protein binding lysosomal membrane endoplasmic reticulum plasma membrane phagocytosis, engulfment protein localization cell surface endosome membrane membrane integral component of membrane positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 13 signaling pathway signaling receptor activity innate immune response defense response to virus |
|
| TC0300000137.mm.2 |
Cp |
ceruloplasmin |
3 |
19957053, 19957053, 19957053, 19957248 |
NM_001276248, NM_001276250, NM_007752, BC062957, NM_001042611 NM_001276248, NM_001276250, NM_007752, BC062957, NM_001042611 NM_001276248, NM_001276250, NM_007752, BC062957, NM_001042611 NM_001276248, NM_001276250, NM_007752, BC062957, NM_001042611 NM_001276248, NM_001276250, NM_007752, BC062957, NM_001042611 |
12870 |
94 |
ferroxidase activity ferroxidase activity copper ion binding copper ion binding extracellular region extracellular space extracellular space extracellular space plasma membrane ion transport copper ion transport iron ion transport cellular iron ion homeostasis oxidoreductase activity anchored component of plasma membrane response to copper ion metal ion binding chaperone binding iron ion homeostasis |
00860 |
| TC0100001252.mm.2 |
Csrp1 |
cysteine and glycine-rich protein 1 |
1 |
135729166, 135720062 |
NM_007791, BC006912 NM_007791, BC006912 |
13007 |
46 |
protein binding nucleus nucleus nucleoplasm cytoplasm structural constituent of muscle actin cytoskeleton Z disc actin cytoskeleton organization actin cytoskeleton organization actinin binding sarcomere organization metal ion binding muscle tissue development |
|
| TC1200000279.mm.2 |
Nampt |
nicotinamide phosphoribosyltransferase |
12 |
32820334 |
NM_021524, BC004059, BC018358 NM_021524, BC004059, BC018358 NM_021524, BC004059, BC018358 |
59027 |
155 |
nucleotide binding microglial cell activation catalytic activity nicotinate-nucleotide diphosphorylase (carboxylating) activity cytokine activity extracellular region extracellular space nucleus cytoplasm cytoplasm cytosol plasma membrane circadian rhythm NAD biosynthetic process negative regulation of autophagy regulation of lung blood pressure nuclear speck transferase activity transferase activity, transferring glycosyl groups pyridine nucleotide biosynthetic process cell junction circadian regulation of gene expression identical protein binding identical protein binding positive regulation of transcription by RNA polymerase II nicotinamide phosphoribosyltransferase activity nicotinamide phosphoribosyltransferase activity rhythmic process positive regulation of smooth muscle cell proliferation positive regulation of nitric-oxide synthase biosynthetic process negative regulation of cellular senescence |
00760 |
| TC0200002796.mm.2 |
Ogfr |
opioid growth factor receptor |
2 |
180589406 |
NM_031373, BC003875, BC049965 NM_031373, BC003875, BC049965 NM_031373, BC003875, BC049965 |
72075 |
19 |
opioid receptor activity nucleus cytoplasm membrane signaling receptor activity regulation of growth |
|
| TC1700002789.mm.2 |
|
|
|
|
NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 |
|
|
positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response embryo implantation external side of plasma membrane external side of plasma membrane cell surface cell surface membrane integral component of membrane phagocytic vesicle membrane beta-2-microglobulin binding MHC class Ib protein complex positive regulation of interferon-gamma production peptide binding peptide antigen binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding defense response to virus TAP complex binding endoplasmic reticulum exit site cellular response to interferon-gamma integral component of lumenal side of endoplasmic reticulum membrane |
|
| TC0200003601.mm.2 |
Ly75 |
lymphocyte antigen 75 |
2 |
-60292102 |
NM_013825, BC150734 NM_013825, BC150734 |
17076 |
67 |
endocytosis external side of plasma membrane external side of plasma membrane membrane integral component of membrane carbohydrate binding signaling receptor activity |
|
| TC0100001190.mm.2 |
Nuak2 |
NUAK family, SNF1-like kinase, 2 |
1 |
132316124 |
NM_001195025, NM_028778, BC033302, BC046833 NM_001195025, NM_028778, BC033302, BC046833 NM_001195025, NM_028778, BC033302, BC046833 NM_001195025, NM_028778, BC033302, BC046833 |
74137 |
30 |
nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity ATP binding nucleus cytoplasm protein phosphorylation protein phosphorylation apoptotic process kinase activity phosphorylation transferase activity actin cytoskeleton organization intracellular signal transduction cellular response to glucose starvation cellular response to glucose starvation negative regulation of apoptotic process metal ion binding |
|
| TC0400003383.mm.2 |
St3gal3 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
4 |
-117932152 |
NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 |
20441 |
29 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Golgi apparatus protein glycosylation protein glycosylation N-acetyllactosaminide alpha-2,3-sialyltransferase activity sialyltransferase activity ganglioside biosynthetic process via lactosylceramide membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups |
00514 00533 00601 01100 |
| TC1000000877.mm.2 |
Gadd45b |
growth arrest and DNA-damage-inducible 45 beta |
10 |
80930090 |
NM_008655, BC023815 NM_008655, BC023815 |
17873 |
88 |
activation of MAPKKK activity activation of MAPKKK activity activation of MAPKK activity protein binding nucleus nucleus nucleus cytoplasm cytoplasm negative regulation of protein kinase activity apoptotic process multicellular organism development cell differentiation positive regulation of apoptotic process positive regulation of JNK cascade regulation of cell cycle regulation of cell cycle positive regulation of p38MAPK cascade |
04010 04110 04115 |
| TC1700001596.mm.2 |
Mmp25 |
matrix metallopeptidase 25 |
17 |
-23629175 |
NM_001033339, BC112379 NM_001033339, BC112379 |
240047 |
20 |
metalloendopeptidase activity plasma membrane plasma membrane proteolysis inflammatory response peptidase activity metallopeptidase activity zinc ion binding cell surface membrane integral component of membrane peptidase activator activity hydrolase activity extracellular matrix organization collagen catabolic process extracellular matrix anchored component of membrane metal ion binding hard palate development |
|
| TC0700002491.mm.2 |
Relb |
avian reticuloendotheliosis viral (v-rel) oncogene related B |
7 |
-19606222, -19606221 |
NM_009046, BC019765, BC034523, BC117793 NM_009046, BC019765, BC034523, BC117793 NM_009046, BC019765, BC034523, BC117793 NM_009046, BC019765, BC034523, BC117793 |
19698 |
204 |
chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm cytoplasm centrosome cytosol cytosol cytoskeleton regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II inflammatory response I-kappaB kinase/NF-kappaB signaling positive regulation of gene expression transcription repressor complex antigen processing and presentation protein kinase binding lymphocyte differentiation negative regulation of interferon-beta production circadian regulation of gene expression protein-containing complex cellular response to stress response to cytokine NIK/NF-kappaB signaling NIK/NF-kappaB signaling T-helper 1 type immune response identical protein binding myeloid dendritic cell differentiation T-helper 1 cell differentiation innate immune response negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II rhythmic process cellular response to osmotic stress |
04010 04380 |
| TC1900000497.mm.2 |
Fas |
Fas (TNF receptor superfamily member 6) |
19 |
34290658, 34290658 |
NM_001146708, NM_007987, BC061160 NM_001146708, NM_007987, BC061160 NM_001146708, NM_007987, BC061160 |
14102 |
1558 |
positive regulation of protein phosphorylation protease binding immunoglobulin production transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity tumor necrosis factor-activated receptor activity protein binding calmodulin binding extracellular region extracellular space cytoplasm cytosol plasma membrane apoptotic process apoptotic process activation-induced cell death of T cells activation-induced cell death of T cells activation-induced cell death of T cells inflammatory cell apoptotic process inflammatory cell apoptotic process immune response signal transduction circadian rhythm extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors response to toxic substance external side of plasma membrane external side of plasma membrane cell surface cell surface gene expression regulation of gene expression negative regulation of Schwann cell proliferation positive regulation of cell death membrane integral component of membrane apical plasma membrane nuclear body B cell mediated immunity kinase binding secretory granule dendrite regeneration death-inducing signaling complex CD95 death-inducing signaling complex CD95 death-inducing signaling complex CD95 death-inducing signaling complex positive regulation of protein-containing complex assembly regulation of stress-activated MAPK cascade regulation of stress-activated MAPK cascade cellular response to amino acid starvation Fas signaling pathway regulation of cell population proliferation sarcolemma identical protein binding identical protein binding regulation of apoptotic process neuron projection neuronal cell body T cell homeostasis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of neuron apoptotic process protein-containing complex binding negative thymic T cell selection membrane raft membrane raft regulation of lymphocyte differentiation regulation of myeloid cell differentiation perinuclear region of cytoplasm spleen development negative regulation of B cell activation response to glucocorticoid neuron apoptotic process lymphocyte apoptotic process cellular response to lithium ion cellular response to hyperoxia positive regulation of release of cytochrome c from mitochondria motor neuron apoptotic process motor neuron apoptotic process apoptotic signaling pathway apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process apical dendrite necroptotic signaling pathway necroptotic signaling pathway necroptotic signaling pathway negative regulation of Schwann cell migration positive regulation of apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
04010 04060 04115 04210 04650 04940 05010 05142 05143 05200 05320 05330 05332 |
| TC1500000580.mm.2 |
Grina |
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) |
15 |
76246806 |
NM_023168, BC010802, BC037667 NM_023168, BC010802, BC037667 NM_023168, BC010802, BC037667 |
66168 |
20 |
endoplasmic reticulum Golgi apparatus membrane integral component of membrane endoplasmic reticulum calcium ion homeostasis ion channel binding negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
|
| MG-1-pos-10341395_st |
|
|
|
|
|
|
|
|
|
| TC0800001952.mm.2 |
Rab11fip1 |
RAB11 family interacting protein 1 (class I) |
8 |
-27138772 |
NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 |
75767 |
17 |
endosome cytosol protein transport membrane small GTPase binding cytoplasmic vesicle intracellular membrane-bounded organelle intracellular membrane-bounded organelle regulated exocytosis negative regulation of adiponectin secretion |
04144 |
| TC0300003243.mm.2 |
Bcl9 |
B cell CLL/lymphoma 9 |
3 |
-97203661 |
NM_029933, BC137850 NM_029933, BC137850 |
77578 |
39 |
transcription coactivator activity nucleus cytoplasm Golgi apparatus Golgi apparatus cis-Golgi network cis-Golgi network beta-catenin binding beta-catenin binding myotube differentiation involved in skeletal muscle regeneration Wnt signaling pathway somatic stem cell population maintenance skeletal muscle cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II canonical Wnt signaling pathway canonical Wnt signaling pathway beta-catenin-TCF complex beta-catenin-TCF complex |
|
| TC0400004170.mm.2 |
Agrn |
agrin |
4 |
-156165289, -156190167, -156165291 |
NM_021604, BC150703 NM_021604, BC150703 |
11603 |
172 |
regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of protein phosphorylation dystroglycan binding extracellular matrix structural constituent calcium ion binding protein binding extracellular region basement membrane basement membrane extracellular space extracellular space extracellular space Golgi lumen plasma membrane plasma membrane organization chemical synaptic transmission chemical synaptic transmission multicellular organism development synapse assembly neuromuscular junction development neuromuscular junction development regulation of synaptic growth at neuromuscular junction animal organ morphogenesis tissue development cell surface membrane integral component of membrane cell junction cell differentiation acetylcholine receptor regulator activity positive regulation of protein binding chondroitin sulfate binding BMP binding ATPase inhibitor activity sarcolemma synaptic cleft regulation of GTPase activity receptor clustering receptor clustering receptor clustering receptor clustering receptor clustering heparan sulfate proteoglycan binding positive regulation of neuron apoptotic process positive regulation of GTPase activity axonal growth cone ion channel binding synapse synapse synapse neurotransmitter receptor metabolic process positive regulation of synaptic growth at neuromuscular junction positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II transforming growth factor beta binding positive regulation of peptidyl-tyrosine phosphorylation regulation of synapse organization positive regulation of filopodium assembly regulation of cardiac muscle contraction positive regulation of protein tyrosine kinase activity collagen-containing extracellular matrix collagen-containing extracellular matrix regulation of microtubule cytoskeleton organization skeletal muscle acetylcholine-gated channel clustering regulation of cardiac muscle cell membrane potential glutamatergic synapse regulation of axon guidance negative regulation of sodium ion export across plasma membrane negative regulation of sodium:potassium-exchanging ATPase activity positive regulation of protein geranylgeranylation |
04512 |
| TC1800000457.mm.2 |
Dcp2 |
decapping mRNA 2 |
18 |
44380499 |
NM_027490 |
70640 |
26 |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay deadenylation-dependent decapping of nuclear-transcribed mRNA P-body P-body RNA binding 5'-3' exoribonuclease activity nucleus nucleoplasm cytoplasm mRNA catabolic process mRNA catabolic process RISC complex hydrolase activity cell junction manganese ion binding negative regulation of telomere maintenance via telomerase cytoplasmic ribonucleoprotein granule regulation of mRNA stability metal ion binding m7G(5')pppN diphosphatase activity m7G(5')pppN diphosphatase activity histone mRNA catabolic process regulation of telomerase RNA localization to Cajal body |
03018 |
| MG-1-pos-10343623_st |
|
|
|
|
|
|
|
|
|
| TC1700001463.mm.2 |
Gpr31b |
G protein-coupled receptor 31, D17Leh66b region |
17 |
-13051320 |
NM_001013832, BC160363 NM_001013832, BC160363 |
436440 |
11 |
response to molecule of bacterial origin response to ischemia G protein-coupled receptor activity plasma membrane signal transduction G protein-coupled receptor signaling pathway response to acidic pH membrane integral component of membrane bioactive lipid receptor activity arachidonic acid binding negative regulation of inflammatory response positive regulation of immune response |
|
| TC0500003464.mm.2 |
Pilrb1 |
paired immunoglobin-like type 2 receptor beta 1 |
5 |
-137852146 |
NM_133209, BC145880, BC145906, BC172053 NM_133209, BC145880, BC145906, BC172053 NM_133209, BC145880, BC145906, BC172053 NM_133209, BC145880, BC145906, BC172053 |
170741 |
12 |
myeloid dendritic cell activation protein binding plasma membrane membrane integral component of membrane MHC class I protein binding MHC class I protein binding negative regulation of osteoclast differentiation |
|
| TC1600000424.mm.2 |
Pigz |
phosphatidylinositol glycan anchor biosynthesis, class Z |
16 |
31933850 |
NM_172822, BC117748 NM_172822, BC117748 |
239827 |
15 |
alpha-1,2-mannosyltransferase activity alpha-1,2-mannosyltransferase activity mannosyltransferase activity mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane GPI anchor biosynthetic process GPI anchor biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups |
00563 |
| TC0700000272.mm.2 |
Mill2 |
MHC I like leukocyte 2 |
7 |
18839965 |
NM_153760, NM_153761, BC137748, BC144886 NM_153760, NM_153761, BC137748, BC144886 NM_153760, NM_153761, BC137748, BC144886 NM_153760, NM_153761, BC137748, BC144886 |
243864 |
18 |
immune response-activating cell surface receptor signaling pathway protein binding extracellular space immune response response to oxidative stress response to heat external side of plasma membrane anchored component of external side of plasma membrane response to retinoic acid gamma-delta T cell activation natural killer cell lectin-like receptor binding negative regulation of defense response to virus by host |
|
| TC1200001912.mm.2 |
Six1 |
sine oculis-related homeobox 1 |
12 |
-73041826 |
NM_009189, BC023304 NM_009189, BC023304 |
20471 |
180 |
negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding DNA-binding transcription activator activity, RNA polymerase II-specific ureteric bud development ureteric bud development branching involved in ureteric bud morphogenesis organ induction kidney development outflow tract morphogenesis DNA binding chromatin binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm transcription regulator complex transcription regulator complex transcription regulator complex nucleolus cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II apoptotic process multicellular organism development pattern specification process pattern specification process skeletal muscle tissue development skeletal muscle tissue development sensory perception of sound cell population proliferation regulation of synaptic growth at neuromuscular junction regulation of gene expression regulation of skeletal muscle satellite cell proliferation regulation of skeletal muscle cell proliferation facial nerve morphogenesis neurogenesis epithelial cell differentiation thyroid gland development olfactory placode formation regulation of protein localization protein localization to nucleus aorta morphogenesis inner ear morphogenesis middle ear morphogenesis negative regulation of apoptotic process negative regulation of neuron apoptotic process sequence-specific DNA binding sequence-specific DNA binding tongue development regulation of neuron differentiation regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II animal organ development thymus development thymus development neuron fate specification generation of neurons embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis skeletal system morphogenesis skeletal muscle fiber development inner ear development anatomical structure development regulation of epithelial cell proliferation myoblast migration pharyngeal system development pharyngeal system development myotome development fungiform papilla morphogenesis trigeminal ganglion development otic vesicle development otic vesicle development metanephric mesenchyme development regulation of branch elongation involved in ureteric bud branching positive regulation of ureteric bud formation mesonephric tubule formation ureter smooth muscle cell differentiation positive regulation of secondary heart field cardioblast proliferation cochlea morphogenesis positive regulation of branching involved in ureteric bud morphogenesis positive regulation of branching involved in ureteric bud morphogenesis positive regulation of brown fat cell differentiation cellular response to 3,3',5-triiodo-L-thyronine sequence-specific double-stranded DNA binding positive regulation of mesenchymal cell proliferation involved in ureter development regulation of skeletal muscle cell differentiation |
|
| TC0300001081.mm.2 |
Rhoc |
ras homolog family member C |
3 |
104789033 |
NM_007484, BC004627 NM_007484, BC004627 |
11853 |
43 |
nucleotide binding mitotic cytokinesis GTPase activity protein binding GTP binding intracellular anatomical structure nucleus cytosol cytoskeleton plasma membrane plasma membrane plasma membrane cell cortex actin filament organization establishment or maintenance of cell polarity small GTPase mediated signal transduction regulation of cell shape membrane cell migration protein kinase binding positive regulation of cell migration cortical cytoskeleton organization positive regulation of protein-containing complex assembly cytoplasmic vesicle cleavage furrow stereocilium regulation of actin cytoskeleton organization cell projection neuron projection intracellular membrane-bounded organelle apical junction assembly apical junction assembly positive regulation of stress fiber assembly positive regulation of lipase activity |
|
| TC0600002490.mm.2 |
Vamp8 |
vesicle-associated membrane protein 8 |
6 |
-72385220 |
NM_016794, BC012668 NM_016794, BC012668 |
22320 |
67 |
SNAP receptor activity SNAP receptor activity protein binding cytoplasm mitochondrion lysosome lysosomal membrane endosome early endosome cytosol cytosol plasma membrane plasma membrane vesicle fusion vesicle fusion vesicle fusion autophagy cell surface protein transport membrane integral component of membrane vesicle-mediated transport autophagosome membrane docking basolateral plasma membrane chloride channel inhibitor activity syntaxin binding syntaxin binding regulation of endocytosis secretory granule midbody secretory granule membrane SNARE complex SNARE complex SNARE complex late endosome membrane vesicle SNARE complex assembly SNARE complex assembly azurophil granule membrane zymogen granule phagocytic vesicle viral entry into host cell perinuclear region of cytoplasm defense response to virus recycling endosome membrane fusion protein-containing complex assembly mucus secretion mucus secretion mucus secretion zymogen granule exocytosis cellular response to interferon-gamma autophagosome maturation mucin granule mucin granule positive regulation of pancreatic amylase secretion regulation of protein localization to plasma membrane negative regulation of secretion by cell positive regulation of histamine secretion by mast cell |
04130 |
| TC1700002308.mm.2 |
Stap2 |
signal transducing adaptor family member 2 |
17 |
-55997075, -55997078 |
NM_145934, NR_102313, BC026642 NM_145934, NR_102313, BC026642 NM_145934, NR_102313, BC026642 |
106766 |
30 |
protein binding cytoplasm plasma membrane membrane signaling adaptor activity |
|
| TC0100003662.mm.2 |
Coq8a |
coenzyme Q8A |
1 |
-180165237, -180165237, -180166613 |
NM_001163290, NM_023341, BC030937 NM_001163290, NM_023341, BC030937 NM_001163290, NM_023341, BC030937 |
67426 |
22 |
nucleotide binding ATP binding mitochondrion mitochondrion ubiquinone biosynthetic process ubiquinone biosynthetic process membrane integral component of membrane kinase activity kinase activity phosphorylation transferase activity extrinsic component of mitochondrial inner membrane ADP binding |
|
| TC0200002580.mm.2 |
|
|
|
|
NM_001081005, NR_028540 NM_001081005, NR_028540 |
|
|
molecular_function cellular_component biological_process negative regulation of mammary gland epithelial cell proliferation mammary gland epithelial cell differentiation |
|
| TC1100001071.mm.2 |
Scarf1 |
scavenger receptor class F, member 1 |
11 |
75513540 |
NM_001004157, BC080288 NM_001004157, BC080288 |
380713 |
20 |
scavenger receptor activity protein binding plasma membrane receptor-mediated endocytosis cell adhesion positive regulation of neuron projection development positive regulation of neuron projection development membrane integral component of membrane neuron remodeling dendrite development low-density lipoprotein particle binding low-density lipoprotein particle binding positive regulation of axon regeneration |
|
| TC0900002389.mm.2 |
Pml |
promyelocytic leukemia |
9 |
-58217179 |
NM_008884, NM_178087, BC020990 NM_008884, NM_178087, BC020990 NM_008884, NM_178087, BC020990 |
18854 |
204 |
chromosome, telomeric region chromatin heterochromatin response to hypoxia response to hypoxia regulation of protein phosphorylation positive regulation of defense response to virus by host immune system process DNA binding transcription coactivator activity transcription coactivator activity ubiquitin-protein transferase activity protein binding nucleus nucleus nucleoplasm nucleoplasm nucleolus cytoplasm endosome endoplasmic reticulum cytosol regulation of transcription, DNA-templated regulation of transcription, DNA-templated protein targeting protein import into nucleus apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cell cycle arrest cell cycle arrest cell cycle arrest transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation cell aging zinc ion binding negative regulation of cell population proliferation negative regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress response to UV response to gamma radiation regulation of calcium ion transport into cytosol fibroblast migration membrane viral process nuclear matrix nuclear matrix negative regulation of angiogenesis negative regulation of angiogenesis PML body PML body PML body PML body myeloid cell differentiation regulation of cell adhesion negative regulation of cell growth PML body organization PML body organization PML body organization positive regulation of histone deacetylation ubiquitin protein ligase binding nuclear membrane SUMO binding positive regulation of telomere maintenance negative regulation of telomere maintenance via telomerase endoplasmic reticulum calcium ion homeostasis negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production circadian regulation of gene expression negative regulation of translation in response to oxidative stress response to cytokine extrinsic component of endoplasmic reticulum membrane regulation of circadian rhythm intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator identical protein binding protein homodimerization activity entrainment of circadian clock by photoperiod proteasome-mediated ubiquitin-dependent protein catabolic process innate immune response innate immune response cell fate commitment regulation of MHC class I biosynthetic process positive regulation of MHC class I biosynthetic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription by RNA polymerase II SMAD binding metal ion binding protein heterodimerization activity positive regulation of fibroblast proliferation retinoic acid receptor signaling pathway rhythmic process protein stabilization cobalt ion binding maintenance of protein location in nucleus defense response to virus negative regulation of telomerase activity positive regulation of apoptotic process involved in mammary gland involution branching involved in mammary gland duct morphogenesis protein-containing complex assembly intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to interleukin-4 intrinsic apoptotic signaling pathway by p53 class mediator cellular senescence extrinsic apoptotic signaling pathway sumo-dependent protein binding negative regulation of viral release from host cell negative regulation of viral release from host cell positive regulation of protein localization to chromosome, telomeric region cellular response to leukemia inhibitory factor negative regulation of ubiquitin-dependent protein catabolic process regulation of double-strand break repair positive regulation of apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway |
04120 04144 05200 05221 |
| TC1700002790.mm.2 |
|
|
|
|
NM_001267808, NM_010380, BC132088, BC132655 NM_001267808, NM_010380, BC132088, BC132655 NM_001267808, NM_010380, BC132088, BC132655 NM_001267808, NM_010380, BC132088, BC132655 |
|
|
positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding protein binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane plasma membrane defense response immune response external side of plasma membrane external side of plasma membrane cell surface negative regulation of neuron projection development negative regulation of neuron projection development negative regulation of neuron projection development membrane integral component of membrane antigen processing and presentation phagocytic vesicle membrane beta-2-microglobulin binding peptide binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding membrane raft TAP binding TAP complex binding endoplasmic reticulum exit site integral component of lumenal side of endoplasmic reticulum membrane |
|
| TC0100003550.mm.2 |
Slamf7 |
SLAM family member 7 |
1 |
-171632404, -171632402 |
NM_144539, BC011154 NM_144539, BC011154 |
75345 |
25 |
adaptive immune response immune system process protein binding plasma membrane external side of plasma membrane membrane integral component of membrane regulation of natural killer cell activation identical protein binding innate immune response |
|
| TC0200001371.mm.2 |
Acp2 |
acid phosphatase 2, lysosomal |
2 |
91202911 |
NM_007387, BC023343 NM_007387, BC023343 |
11432 |
37 |
skeletal system development phosphotyrosine residue binding acid phosphatase activity acid phosphatase activity acid phosphatase activity acid phosphatase activity phosphoprotein phosphatase activity lysosome lysosome lysosome lysosome lysosome organization lysosome organization response to organic substance membrane integral component of membrane dephosphorylation hydrolase activity phosphatase activity cytoplasmic vesicle neuron projection autophagic cell death |
00740 04142 |
| TC0100001574.mm.2 |
Fcgr4 |
Fc receptor, IgG, low affinity IV |
1 |
171018925 |
NM_144559, BC027310 NM_144559, BC027310 |
246256 |
54 |
transmembrane signaling receptor activity plasma membrane integral component of plasma membrane cell surface receptor signaling pathway external side of plasma membrane cell surface cell surface membrane integral component of membrane IgE receptor activity IgG receptor activity IgE binding IgG binding neutrophil activation positive regulation of bone resorption regulation of immune response regulation of sensory perception of pain cellular response to lipopolysaccharide |
04145 04380 04650 05140 05150 05322 |
| TC0500001403.mm.2 |
Rnf34 |
ring finger protein 34 |
5 |
122850187 |
NM_030564, BC004042 NM_030564, BC004042 |
80751 |
23 |
p53 binding ubiquitin-protein transferase activity nucleus nucleoplasm cytoplasm cytoplasm plasma membrane plasma membrane ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process apoptotic process membrane protein ubiquitination nuclear body transferase activity ubiquitin protein ligase binding nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase activity cellular response to cold protein K48-linked ubiquitination protein K48-linked ubiquitination negative regulation of signal transduction by p53 class mediator phosphatidylinositol phosphate binding negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of oxygen metabolic process negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
|
| TC1500000982.mm.2 |
Cacnb3 |
calcium channel, voltage-dependent, beta 3 subunit |
15 |
98632327, 98634766 |
NM_001044741, NM_001286226, NM_007581, BC160243 NM_001044741, NM_001286226, NM_007581, BC160243 NM_001044741, NM_001286226, NM_007581, BC160243 NM_001044741, NM_001286226, NM_007581, BC160243 |
12297 |
62 |
voltage-gated ion channel activity voltage-gated calcium channel activity calcium channel regulator activity calcium channel activity protein binding cytoplasm plasma membrane voltage-gated calcium channel complex voltage-gated calcium channel complex voltage-gated calcium channel complex ion transport calcium ion transport chemical synaptic transmission neuromuscular junction development high voltage-gated calcium channel activity high voltage-gated calcium channel activity high voltage-gated calcium channel activity membrane apical plasma membrane protein kinase binding regulation of ion transmembrane transport T cell receptor signaling pathway detection of mechanical stimulus involved in sensory perception of pain calcium ion transport into cytosol calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport protein localization to plasma membrane positive regulation of protein targeting to membrane regulation of membrane repolarization during action potential regulation of voltage-gated calcium channel activity negative regulation of voltage-gated calcium channel activity positive regulation of voltage-gated calcium channel activity positive regulation of high voltage-gated calcium channel activity regulation of membrane hyperpolarization negative regulation of detection of mechanical stimulus involved in sensory perception of touch L-type voltage-gated calcium channel complex positive regulation of excitatory postsynaptic potential |
04010 04260 05410 05412 05414 |
| TC0100001589.mm.2 |
Nectin4 |
nectin cell adhesion molecule 4 |
1 |
171370172 |
NM_001122680, NM_027893, BC024948 NM_001122680, NM_027893, BC024948 NM_001122680, NM_027893, BC024948 |
71740 |
25 |
plasma membrane adherens junction adherens junction cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules membrane integral component of membrane cell junction identical protein binding viral entry into host cell cell-cell adhesion |
04520 |
| TC1300000009.mm.2 |
Asb13 |
ankyrin repeat and SOCS box-containing 13 |
13 |
3634031 |
NM_001267724, NM_178283, BC018240, NM_080857 NM_001267724, NM_178283, BC018240, NM_080857 NM_001267724, NM_178283, BC018240, NM_080857 NM_001267724, NM_178283, BC018240, NM_080857 |
142688 |
14 |
molecular_function cellular_component biological_process intracellular signal transduction |
|
| TC0500001355.mm.2 |
Hectd4 |
HECT domain E3 ubiquitin protein ligase 4 |
5 |
121220218 |
NM_181421 |
269700 |
18 |
glucose metabolic process glucose homeostasis |
|
| TC0800001078.mm.2 |
Lpcat2 |
lysophosphatidylcholine acyltransferase 2 |
8 |
92855332 |
NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 |
270084 |
21 |
1-acylglycerol-3-phosphate O-acyltransferase activity calcium ion binding endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus Golgi stack lipid droplet plasma membrane lipid metabolic process platelet activating factor biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity transferase activity, transferring acyl groups phosphatidylcholine acyl-chain remodeling metal ion binding 1-acylglycerophosphocholine O-acyltransferase activity 1-acylglycerophosphocholine O-acyltransferase activity 1-alkylglycerophosphocholine O-acetyltransferase activity plasmalogen synthase activity membrane organization |
00564 00565 01100 |
| TC0500001610.mm.2 |
Ift22 |
intraflagellar transport 22 |
5 |
136908149 |
NM_026073, BC009150 NM_026073, BC009150 |
67286 |
17 |
nucleotide binding GTPase activity GTP binding centrosome cilium cilium intracellular protein transport endomembrane system intraciliary transport particle B intraciliary transport cell projection |
|
| TC1900000225.mm.2 |
Ms4a6b |
membrane-spanning 4-domains, subfamily A, member 6B |
19 |
11518558 |
NM_027209, BC027425 NM_027209, BC027425 |
69774 |
14 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC1100001238.mm.2 |
Slfn2 |
schlafen 2 |
11 |
83065111 |
NM_011408, BC138749, BC138750 NM_011408, BC138749, BC138750 NM_011408, BC138749, BC138750 |
20556 |
19 |
negative regulation of cell population proliferation response to bacterium |
|
| TC1300002303.mm.2 |
Slc6a19 |
solute carrier family 6 (neurotransmitter transporter), member 19 |
13 |
-73679744, -73679744 |
NM_028878, BC107411, BC107412 NM_028878, BC107411, BC107412 NM_028878, BC107411, BC107412 |
74338 |
34 |
neurotransmitter:sodium symporter activity protein binding plasma membrane integral component of plasma membrane amino acid transport neutral amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity symporter activity neutral amino acid transport neutral amino acid transport membrane integral component of membrane apical plasma membrane apical plasma membrane brush border membrane brush border membrane sodium ion transmembrane transport |
04974 |
| TC0500003024.mm.2 |
Grk3 |
G protein-coupled receptor kinase 3 |
5 |
-112910477 |
NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 |
320129 |
40 |
nucleotide binding positive regulation of protein phosphorylation desensitization of G protein-coupled receptor signaling pathway protein kinase activity protein serine/threonine kinase activity G protein-coupled receptor kinase activity G protein-coupled receptor kinase activity ATP binding nucleus cytosol cilium protein phosphorylation intracellular protein transport signal transduction membrane kinase activity phosphorylation transferase activity Z disc axon receptor internalization D1 dopamine receptor binding dendritic spine dendritic shaft inositol phosphate metabolic process dendrite terminus membrane raft synapse rhodopsin metabolic process beta-adrenergic receptor kinase activity perinuclear region of cytoplasm sperm midpiece |
04740 |
| TC1400001906.mm.2 |
|
|
|
|
NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 NM_001039106, NM_001042719, NM_001284399, NM_176845, NR_039593, BC043475 |
|
|
phospholipase activity cytoplasm lipid metabolic process lipid catabolic process hydrolase activity sperm mitochondrion organization metal ion binding positive regulation of mitochondrial fission |
|
| TC0200004602.mm.2 |
Il1b |
interleukin 1 beta |
2 |
-129364577 |
NM_008361, BC011437 NM_008361, BC011437 |
16176 |
1139 |
negative regulation of transcription by RNA polymerase II MAPK cascade activation of MAPK activity fever generation positive regulation of protein phosphorylation cytokine activity cytokine activity interleukin-1 receptor binding integrin binding extracellular region extracellular space extracellular space extracellular space cytoplasm lysosome inflammatory response inflammatory response immune response positive regulation of cytosolic calcium ion concentration memory positive regulation of cell population proliferation negative regulation of cell population proliferation response to carbohydrate vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of glucose transmembrane transport positive regulation of cell death negative regulation of glutamate secretion cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein domain specific binding secretory granule hyaluronan biosynthetic process positive regulation of cell migration neutrophil chemotaxis sequestering of triglyceride positive regulation of prostaglandin biosynthetic process cytoplasmic vesicle positive regulation of fever generation lipopolysaccharide-mediated signaling pathway vesicle positive regulation of prostaglandin secretion response to lipopolysaccharide response to lipopolysaccharide response to lipopolysaccharide interleukin-1 beta production interleukin-6 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of stress-activated MAPK cascade positive regulation of immature T cell proliferation in thymus positive regulation of immature T cell proliferation in thymus response to ATP response to ATP positive regulation of heterotypic cell-cell adhesion social behavior ectopic germ cell programmed cell death positive regulation of myosin light chain kinase activity cellular response to drug positive regulation of T cell proliferation positive regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity protein kinase B signaling positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process negative regulation of neuron differentiation positive regulation of glial cell differentiation positive regulation of angiogenesis positive regulation of angiogenesis negative regulation of lipid metabolic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of complement activation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of JNK cascade positive regulation of JNK cascade positive regulation of JNK cascade negative regulation of insulin receptor signaling pathway astrocyte activation positive regulation of astrocyte differentiation regulation of defense response to virus by host positive regulation of inflammatory response positive regulation of phagocytosis regulation of neurogenesis negative regulation of neurogenesis regulation of insulin secretion negative regulation of synaptic transmission leukocyte migration negative regulation of lipid catabolic process positive regulation of lipid catabolic process regulation of nitric-oxide synthase activity regulation of nitric-oxide synthase activity regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of cell division positive regulation of glial cell proliferation positive regulation of calcidiol 1-monooxygenase activity negative regulation of adiponectin secretion regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade monocyte aggregation interleukin-1-mediated signaling pathway response to interleukin-1 cellular response to lipopolysaccharide cellular response to organic substance cellular response to organic cyclic compound positive regulation of monocyte chemotactic protein-1 production positive regulation of neutrophil chemotaxis extrinsic apoptotic signaling pathway in absence of ligand positive regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling positive regulation of RNA biosynthetic process regulation of establishment of endothelial barrier negative regulation of gap junction assembly negative regulation of branching morphogenesis of a nerve negative regulation of neural precursor cell proliferation positive regulation of T-helper 1 cell cytokine production negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
04010 04060 04210 04380 04620 04621 04623 04640 04940 05010 05020 05140 05142 05143 05144 05146 05323 05332 |
| TC0200005181.mm.2 |
Znfx1 |
zinc finger, NFX1-type containing 1 |
2 |
-167035795, -167035796 |
NM_001033196 |
98999 |
24 |
DNA-binding transcription factor activity RNA binding nucleus regulation of transcription, DNA-templated zinc ion binding heterochromatin assembly by small RNA nuclear RNA-directed RNA polymerase complex metal ion binding |
|
| TC0900002806.mm.2 |
Bcl2a1d |
B cell leukemia/lymphoma 2 related protein A1d |
9 |
-88723287 |
NM_007536, BC027536, BC116240 NM_007536, BC027536, BC116240 NM_007536, BC027536, BC116240 |
12047 |
20 |
mitochondrial outer membrane intrinsic apoptotic signaling pathway in response to DNA damage T cell differentiation protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein-containing complex binding protein heterodimerization activity T cell receptor signaling pathway BH domain binding extrinsic apoptotic signaling pathway in absence of ligand |
|
| TC1000001557.mm.2 |
Ddit3 |
DNA-damage inducible transcript 3 |
10 |
127290792 |
NM_007837, BC013718 NM_007837, BC013718 |
13198 |
353 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific blood vessel maturation DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus cytoplasm cytoplasm cytoplasm late endosome regulation of transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II apoptotic process ER overload response ER overload response ER overload response response to unfolded protein cell cycle cell cycle arrest sensory perception of sound transcription factor binding transcription factor binding transcription factor binding cAMP response element binding protein binding cAMP response element binding protein binding anterior/posterior axis specification regulation of autophagy Wnt signaling pathway endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response negative regulation of NF-kappaB transcription factor activity negative regulation of interferon-gamma production negative regulation of interleukin-17 production negative regulation of interleukin-4 production positive regulation of interleukin-8 production negative regulation of CREB transcription factor activity negative regulation of CREB transcription factor activity protein-DNA complex positive regulation of autophagy in response to ER overload response to endoplasmic reticulum stress response to endoplasmic reticulum stress CHOP-C/EBP complex CHOP-C/EBP complex CHOP-C/EBP complex response to starvation positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of DNA binding negative regulation of DNA-binding transcription factor activity leucine zipper domain binding positive regulation of neuron apoptotic process positive regulation of neuron apoptotic process sequence-specific DNA binding cell redox homeostasis negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein heterodimerization activity protein heterodimerization activity protein heterodimerization activity protein heterodimerization activity positive regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity release of sequestered calcium ion into cytosol negative regulation of protein kinase B signaling intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress establishment of protein localization to mitochondrion negative regulation of canonical Wnt signaling pathway RNA polymerase II transcription regulator complex negative regulation of cold-induced thermogenesis transcription regulator inhibitor activity positive regulation of neuron death negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to nitrosative stress CHOP-ATF4 complex CHOP-ATF4 complex CHOP-ATF3 complex CHOP-ATF3 complex negative regulation of determination of dorsal identity negative regulation of determination of dorsal identity positive regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway |
04010 04141 |
| TC0100002721.mm.2 |
|
|
|
|
BC071209, XM_001474231 BC071209, XM_001474231 |
|
|
|
|
| TC0300000210.mm.2 |
Skil |
SKI-like |
3 |
31095057 |
NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 |
20482 |
57 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific acrosomal vesicle blastocyst formation lymphocyte homeostasis chromatin binding protein binding nucleus nucleus nucleus transcription regulator complex cytoplasm cell cycle arrest transforming growth factor beta receptor signaling pathway skeletal muscle tissue development PML body protein domain specific binding negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway protein-containing complex identical protein binding protein-containing complex binding negative regulation of cell differentiation SMAD binding SMAD binding positive regulation of axonogenesis lens fiber cell differentiation response to growth factor positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
|
| TC0800000916.mm.2 |
Tbc1d9 |
TBC1 domain family, member 9 |
8 |
83165351 |
NM_001111304, NM_027758, BC057027 NM_001111304, NM_027758, BC057027 NM_001111304, NM_027758, BC057027 |
71310 |
17 |
GTPase activator activity calcium ion binding intracellular protein transport activation of GTPase activity |
|
| TC0400000092.mm.2 |
Gem |
GTP binding protein (gene overexpressed in skeletal muscle) |
4 |
11704446 |
NM_010276, BC029668 NM_010276, BC029668 |
14579 |
35 |
nucleotide binding mitotic cell cycle magnesium ion binding GTPase activity calcium channel regulator activity protein binding GTP binding GTP binding nucleus plasma membrane signal transduction cytoplasmic side of plasma membrane membrane GDP binding midbody spindle midzone chromosome organization metaphase plate congression mitotic spindle negative regulation of high voltage-gated calcium channel activity |
|
| TC1200000280.mm.2 |
Gdap10 |
ganglioside-induced differentiation-associated-protein 10 |
12 |
32824115 |
NR_045032, BC052902 NR_045032, BC052902 |
100504486 |
5 |
molecular_function cellular_component response to bacterium |
|
| TC0800001698.mm.2 |
Rab20 |
RAB20, member RAS oncogene family |
8 |
-11453389 |
NM_011227, BC089570 NM_011227, BC089570 |
19332 |
33 |
nucleotide binding GTPase activity GTP binding Golgi apparatus intracellular protein transport endomembrane system protein transport membrane cytoplasmic vesicle intracellular membrane-bounded organelle phagocytic vesicle phagocytic vesicle cellular response to interferon-gamma phagosome acidification phagosome-lysosome fusion |
|
| TC0600000841.mm.2 |
St3gal5 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
6 |
72097607 |
NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 |
20454 |
59 |
Golgi apparatus protein glycosylation sialyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups lactosylceramide alpha-2,3-sialyltransferase activity lactosylceramide alpha-2,3-sialyltransferase activity |
00604 01100 |
| TC0900000199.mm.2 |
AB124611 |
cDNA sequence AB124611 |
9 |
21526176 |
NM_001198794, NM_206536 NM_001198794, NM_206536 |
382062 |
12 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC0800002905.mm.2 |
Hp |
haptoglobin |
8 |
-109575127 |
NM_017370, BC138872 NM_017370, BC138872 |
15439 |
96 |
liver development immune system process acute inflammatory response serine-type endopeptidase activity extracellular region extracellular space extracellular space extracellular space endoplasmic reticulum Golgi apparatus acute-phase response Notch signaling pathway response to bacterium positive regulation of cell death positive regulation of cell death antioxidant activity hemoglobin binding zymogen activation haptoglobin-hemoglobin complex response to hydrogen peroxide defense response to bacterium identical protein binding negative regulation of oxidoreductase activity blood microparticle blood microparticle negative regulation of hydrogen peroxide catabolic process |
|
| TC1400002744.mm.2 |
Gpr18 |
G protein-coupled receptor 18 |
14 |
-121911433 |
NM_182806, BC034872 NM_182806, BC034872 |
110168 |
23 |
CD8-positive, alpha-beta intraepithelial T cell differentiation CD8-positive, alpha-beta intraepithelial T cell differentiation CD8-positive, gamma-delta intraepithelial T cell differentiation CD8-positive, gamma-delta intraepithelial T cell differentiation negative regulation of leukocyte chemotaxis G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway membrane integral component of membrane cytoplasmic vesicle negative regulation of tumor necrosis factor production positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
|
| TC0400001047.mm.2 |
Pde4b |
phosphodiesterase 4B, cAMP specific |
4 |
102589842, 102254938, 102254741, 102570059, 102587557, 102421554 |
NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 |
18578 |
65 |
gamma-tubulin complex neutrophil homeostasis 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding nucleus nucleus cytoplasm centrosome cytosol cytosol cytosol voltage-gated calcium channel complex signal transduction synaptic vesicle response to heat postsynaptic density membrane Z disc cAMP binding neutrophil chemotaxis positive regulation of interferon-gamma production positive regulation of interleukin-2 production cellular response to drug gamma-tubulin binding dendritic spine ion channel binding ion channel binding perinuclear region of cytoplasm perinuclear region of cytoplasm T cell receptor signaling pathway leukocyte migration excitatory synapse cellular response to lipopolysaccharide cellular response to epinephrine stimulus cell periphery regulation of cardiac muscle cell contraction negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process regulation of high voltage-gated calcium channel activity negative regulation of relaxation of cardiac muscle |
00230 |
| TC1500001870.mm.2 |
Tmem184b |
transmembrane protein 184b |
15 |
-79360683, -79360683, -79360683, -79360683, -79360683 |
NM_001253817, NM_001253819, NM_001253820, NM_172608, BC046959 NM_001253817, NM_001253819, NM_001253820, NM_172608, BC046959 NM_001253817, NM_001253819, NM_001253820, NM_172608, BC046959 NM_001253817, NM_001253819, NM_001253820, NM_172608, BC046959 NM_001253817, NM_001253819, NM_001253820, NM_172608, BC046959 |
223693 |
19 |
transporter activity transport membrane integral component of membrane |
|
| TC1600000346.mm.2 |
Rtp4 |
receptor transporter protein 4 |
16 |
23609918 |
NM_023386, BC024872 NM_023386, BC024872 |
67775 |
15 |
detection of chemical stimulus involved in sensory perception of bitter taste detection of chemical stimulus involved in sensory perception of bitter taste protein binding cytoplasm cytoplasm protein targeting to membrane protein targeting to membrane membrane integral component of membrane olfactory receptor binding protein insertion into membrane defense response to virus |
|
| TC0X00002637.mm.2 |
Pdk3 |
pyruvate dehydrogenase kinase, isoenzyme 3 |
X |
-93764615 |
NM_145630, BC008126 NM_145630, BC008126 |
236900 |
29 |
nucleotide binding protein kinase activity protein serine/threonine kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity pyruvate dehydrogenase (acetyl-transferring) kinase activity ATP binding nucleolus mitochondrion mitochondrion mitochondrion carbohydrate metabolic process glucose metabolic process protein phosphorylation regulation of acetyl-CoA biosynthetic process from pyruvate regulation of glucose metabolic process regulation of glucose metabolic process kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peroxisome proliferator activated receptor signaling pathway cellular response to glucose stimulus cellular response to fatty acid hypoxia-inducible factor-1alpha signaling pathway regulation of reactive oxygen species metabolic process |
|
| TC0200000485.mm.2 |
|
|
|
|
|
|
|
|
|
| TC0300000092.mm.2 |
Car13 |
carbonic anhydrase 13 |
3 |
14641726 |
NM_024495, BC064050 NM_024495, BC064050 |
71934 |
21 |
carbonate dehydratase activity carbonate dehydratase activity cytoplasm cytosol cytosol one-carbon metabolic process zinc ion binding lyase activity hydro-lyase activity myelin sheath intracellular membrane-bounded organelle metal ion binding |
00910 |
| TC0600001964.mm.2 |
Zfp800 |
zinc finger protein 800 |
6 |
-28239930, -28239930 |
NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 |
627049 |
12 |
nucleic acid binding DNA binding nucleus biological_process metal ion binding |
|
| TC0700000242.mm.2 |
Ptgir |
prostaglandin I receptor (IP) |
7 |
16906489 |
NM_008967, BC094386 NM_008967, BC094386 |
19222 |
84 |
G protein-coupled receptor activity cytosol plasma membrane plasma membrane inflammatory response signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration negative regulation of platelet-derived growth factor receptor signaling pathway membrane integral component of membrane prostacyclin receptor activity response to lipopolysaccharide negative regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation |
04080 04270 |
| TC0100003590.mm.2 |
Ifi214 |
interferon activated gene 214 |
1 |
-173521310 |
NM_001024721, BC094916 NM_001024721, BC094916 |
545384 |
12 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta identical protein binding |
|
| TC0100001409.mm.2 |
Tor1aip2 |
torsin A interacting protein 2 |
1 |
156036035, 156040860, 156035726, 156040839, 156035663 |
NM_001160180, NM_001160181, NM_001160182, NM_022329, NM_172843, BC064017, BC066790, BC092059 NM_001160180, NM_001160181, NM_001160182, NM_022329, NM_172843, BC064017, BC066790, BC092059 NM_001160180, NM_001160181, NM_001160182, NM_022329, NM_172843, BC064017, BC066790, BC092059 NM_001160180, NM_001160181, NM_001160182, NM_022329, NM_172843, BC064017, BC066790, BC092059 NM_001160180, NM_001160181, NM_001160182, NM_022329, NM_172843, BC064017, BC066790, BC092059 NM_001160180, NM_001160181, NM_001160182, NM_022329, NM_172843, BC064017, BC066790, BC092059 NM_001160180, NM_001160181, NM_001160182, NM_022329, NM_172843, BC064017, BC066790, BC092059 NM_001160180, NM_001160181, NM_001160182, NM_022329, NM_172843, BC064017, BC066790, BC092059 |
240832 |
31 |
ATPase activator activity protein binding nucleus endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum organization endoplasmic reticulum organization membrane membrane integral component of membrane positive regulation of ATPase activity ATPase binding membrane organization protein localization to nuclear envelope |
|
| TC1000001743.mm.2 |
Adgb |
androglobin |
10 |
-10335702 |
NM_001127353, BC153036 NM_001127353, BC153036 |
215772 |
11 |
calcium-dependent cysteine-type endopeptidase activity intracellular anatomical structure proteolysis oxygen binding heme binding |
|
| TC1500002183.mm.2 |
Rnd1 |
Rho family GTPase 1 |
15 |
-98669204 |
NM_172612, BC048531 NM_172612, BC048531 |
223881 |
18 |
nucleotide binding GTPase activity signaling receptor binding GTP binding intracellular anatomical structure cytoplasm cytosol cytoskeleton plasma membrane plasma membrane adherens junction cell cortex actin filament organization actin filament organization negative regulation of cell adhesion establishment or maintenance of cell polarity small GTPase mediated signal transduction regulation of cell shape actin cytoskeleton membrane neuron remodeling cell migration protein kinase binding cortical cytoskeleton organization cytoplasmic vesicle regulation of actin cytoskeleton organization cell projection intracellular membrane-bounded organelle intracellular membrane-bounded organelle |
04360 |
| TC1600001742.mm.2 |
Nfkbiz |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta |
16 |
-55811376, -55811376 |
NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 |
80859 |
64 |
protein binding nucleus nucleus inflammatory response regulation of gene expression nuclear speck cytoplasmic ribonucleoprotein granule positive regulation of inflammatory response T cell receptor signaling pathway positive regulation of T-helper 17 cell differentiation |
|
| TC1100004288.mm.2 |
Urgcp |
upregulator of cell proliferation |
11 |
-5713416, -5713416 |
NM_001077661, NM_178623, BC066994 NM_001077661, NM_178623, BC066994 NM_001077661, NM_178623, BC066994 |
72046 |
16 |
nucleotide binding molecular_function GTP binding nucleus cytoplasm cytosol cell cycle biological_process |
|
| TC0300002688.mm.2 |
Cept1 |
choline/ethanolaminephosphotransferase 1 |
3 |
-106502259, -106502259, -106502259 |
NM_133869, BC021753, BC023783 NM_133869, BC021753, BC023783 NM_133869, BC021753, BC023783 |
99712 |
22 |
diacylglycerol cholinephosphotransferase activity ethanolaminephosphotransferase activity nucleus endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane Golgi apparatus lipid metabolic process phosphatidylethanolamine biosynthetic process phosphatidylcholine biosynthetic process phospholipid biosynthetic process membrane integral component of membrane transferase activity phosphotransferase activity, for other substituted phosphate groups metal ion binding |
00564 00565 01100 |
| TC1100001197.mm.2 |
Rnf135 |
ring finger protein 135 |
11 |
80183868 |
NM_028019, BC096385, BC132307, BC138303 NM_028019, BC096385, BC132307, BC138303 NM_028019, BC096385, BC132307, BC138303 NM_028019, BC096385, BC132307, BC138303 |
71956 |
25 |
protein polyubiquitination protein polyubiquitination immune system process ubiquitin-protein transferase activity ubiquitin-protein transferase activity protein binding cytoplasm cytoplasm cytoplasm cytoplasmic stress granule free ubiquitin chain polymerization protein ubiquitination transferase activity positive regulation of interferon-beta production RIG-I signaling pathway RIG-I signaling pathway RIG-I signaling pathway RIG-I binding identical protein binding ribonucleoprotein complex binding ribonucleoprotein complex binding innate immune response regulation of innate immune response regulation of innate immune response metal ion binding protein homooligomerization ubiquitin protein ligase activity protein K63-linked ubiquitination antiviral innate immune response antiviral innate immune response ribonucleoprotein complex |
|
| TC0500003178.mm.2 |
Oas1c |
2'-5' oligoadenylate synthetase 1C |
5 |
-120800198 |
NM_033541, BC108955, BC126877 NM_033541, BC108955, BC126877 NM_033541, BC108955, BC126877 |
114643 |
18 |
RNA binding double-stranded RNA binding double-stranded RNA binding ATP binding nucleoplasm cytosol immune response membrane transferase activity negative regulation of viral genome replication defense response to virus regulation of ribonuclease activity |
|
| TC0600001696.mm.2 |
Etnk1 |
ethanolamine kinase 1 |
6 |
143167229 |
NM_029250 |
75320 |
33 |
nucleotide binding ethanolamine kinase activity ATP binding cytoplasm lipid metabolic process phosphatidylethanolamine biosynthetic process phospholipid biosynthetic process kinase activity phosphorylation transferase activity |
00564 01100 |
| TC1100001386.mm.2 |
Trim25 |
tripartite motif-containing 25 |
11 |
88999402 |
NM_009546, BC006908, BC034276 NM_009546, BC006908, BC034276 NM_009546, BC006908, BC034276 |
217069 |
44 |
immune system process transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm cytosol ubiquitin-dependent protein catabolic process protein monoubiquitination cytoplasmic stress granule nuclear body transferase activity ligase activity ubiquitin-dependent ERAD pathway regulation of protein localization RIG-I binding positive regulation of I-kappaB kinase/NF-kappaB signaling response to estrogen innate immune response innate immune response regulation of viral entry into host cell negative regulation of viral entry into host cell metal ion binding positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity defense response to virus ubiquitin protein ligase activity regulation of viral release from host cell negative regulation of viral release from host cell cellular response to leukemia inhibitory factor |
04622 |
| TC0700004303.mm.2 |
Tmem219 |
transmembrane protein 219 |
7 |
-126886218, -126886219 |
NM_026827, NM_028389, BC023442, BC046763 NM_026827, NM_028389, BC023442, BC046763 NM_026827, NM_028389, BC023442, BC046763 NM_026827, NM_028389, BC023442, BC046763 |
68742 |
15 |
molecular_function cellular_component plasma membrane apoptotic process biological_process membrane integral component of membrane |
|
| TC0200000037.mm.2 |
Phyh |
phytanoyl-CoA hydroxylase |
2 |
4918995 |
NM_010726, BC002018 NM_010726, BC002018 |
16922 |
28 |
fatty acid alpha-oxidation fatty acid alpha-oxidation fatty acid alpha-oxidation catalytic activity protein binding mitochondrion mitochondrion peroxisome peroxisome peroxisomal matrix 2-oxoglutarate metabolic process isoprenoid metabolic process ferrous iron binding oxidoreductase activity 2-oxobutyrate catabolic process carboxylic acid binding L-ascorbic acid binding metal ion binding phytanoyl-CoA dioxygenase activity phytanoyl-CoA dioxygenase activity dioxygenase activity methyl-branched fatty acid metabolic process 9+0 non-motile cilium |
04146 |
| TC1100000713.mm.2 |
|
|
|
|
NM_031172, NM_178218, BC055112, BC058119, BC063781 NM_031172, NM_178218, BC055112, BC058119, BC063781 NM_031172, NM_178218, BC055112, BC058119, BC063781 NM_031172, NM_178218, BC055112, BC058119, BC063781 NM_031172, NM_178218, BC055112, BC058119, BC063781 |
|
|
nucleosome DNA binding DNA binding ubiquitin-protein transferase activity nucleus chromosome cytoplasm nucleosome disassembly chromatin silencing autophagy zinc ion binding regulation of gene expression protein ubiquitination transferase activity protein-macromolecule adaptor activity regulation of protein localization innate immune response metal ion binding protein heterodimerization activity protein autoubiquitination ubiquitin protein ligase activity UV-damage excision repair |
|
| TC1700001954.mm.2 |
Tnf |
tumor necrosis factor |
17 |
-35199366 |
NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 |
21926 |
2923 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II MAPK cascade activation of MAPKKK activity activation of MAPK activity transcription regulatory region sequence-specific DNA binding microglial cell activation microglial cell activation cell activation positive regulation of cytokine production phagocytic cup regulation of protein phosphorylation positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation protease binding protease binding negative regulation of L-glutamate import across plasma membrane leukocyte activation involved in inflammatory response chronic inflammatory response to antigenic stimulus regulation of immunoglobulin production negative regulation of cytokine production involved in immune response positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of systemic arterial blood pressure cytokine activity cytokine activity cytokine activity tumor necrosis factor receptor binding tumor necrosis factor receptor binding tumor necrosis factor receptor binding tumor necrosis factor receptor binding tumor necrosis factor receptor binding protein binding extracellular region extracellular space extracellular space extracellular space intracellular anatomical structure cytoplasm plasma membrane integral component of plasma membrane integral component of plasma membrane glucose metabolic process regulation of transcription by RNA polymerase II apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process defense response inflammatory response inflammatory response inflammatory response immune response humoral immune response signal transduction JNK cascade multicellular organism development positive regulation of cell population proliferation negative regulation of cell population proliferation extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage response to virus animal organ morphogenesis external side of plasma membrane external side of plasma membrane cell surface cell surface response to organic substance negative regulation of heart rate vascular endothelial growth factor production positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of gene expression negative regulation of alkaline phosphatase activity positive regulation of phosphatidylinositol 3-kinase signaling membrane integral component of membrane calcium-mediated signaling secretory granule extracellular matrix organization osteoclast differentiation sequestering of triglyceride cortical actin cytoskeleton organization positive regulation of protein-containing complex assembly positive regulation of fever generation negative regulation of myelination lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide negative regulation of interleukin-6 production positive regulation of chemokine production positive regulation of fractalkine production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of peptidyl-serine phosphorylation tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway positive regulation of heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion toll-like receptor 3 signaling pathway negative regulation of myosin-light-chain-phosphatase activity regulation of cell population proliferation regulation of cell population proliferation vasodilation positive regulation of tyrosine phosphorylation of STAT protein defense response to bacterium identical protein binding neuronal cell body positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of protein-containing complex disassembly positive regulation of protein-containing complex disassembly positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAP kinase activity protein kinase B signaling positive regulation of JUN kinase activity positive regulation of neuron apoptotic process positive regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration negative regulation of viral genome replication membrane raft membrane raft cellular extravasation positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of osteoclast differentiation positive regulation of protein catabolic process positive regulation of action potential positive regulation of cell adhesion positive regulation of mitotic nuclear division positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of translational initiation by iron negative regulation of glucose import negative regulation of glucose import positive regulation of JNK cascade positive regulation of JNK cascade positive regulation of receptor signaling pathway via JAK-STAT positive regulation of smooth muscle cell proliferation regulation of protein secretion regulation of inflammatory response positive regulation of inflammatory response positive regulation of phagocytosis regulation of insulin secretion positive regulation of synaptic transmission positive regulation of synaptic transmission regulation of synapse organization defense response to Gram-positive bacterium leukocyte migration leukocyte tethering or rolling detection of mechanical stimulus involved in sensory perception of pain negative regulation of lipid catabolic process positive regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of nitrogen compound metabolic process positive regulation of protein transport response to glucocorticoid positive regulation of hair follicle development positive regulation of protein kinase B signaling positive regulation of protein kinase B signaling recycling endosome positive regulation of glial cell proliferation positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity epithelial cell proliferation involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis negative regulation of vascular wound healing negative regulation of branching involved in lung morphogenesis positive regulation of calcineurin-NFAT signaling cascade cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to nicotine cellular response to organic cyclic compound positive regulation of podosome assembly endothelial cell apoptotic process protein localization to plasma membrane negative regulation of oxidative phosphorylation apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway necroptotic signaling pathway necroptotic signaling pathway negative regulation of bile acid secretion positive regulation of interleukin-33 production positive regulation of cytokine production involved in inflammatory response negative regulation of amyloid-beta clearance positive regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of synoviocyte proliferation positive regulation of superoxide dismutase activity positive regulation of amyloid-beta formation positive regulation of neutrophil activation positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of protein localization to plasma membrane positive regulation of protein localization to plasma membrane regulation of establishment of endothelial barrier positive regulation of oxidative stress-induced neuron death negative regulation of bicellular tight junction assembly positive regulation of I-kappaB phosphorylation negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of vascular associated smooth muscle cell proliferation positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of leukocyte adhesion to arterial endothelial cell positive regulation of protein localization to cell surface negative regulation of signaling receptor activity positive regulation of blood microparticle formation positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of hepatocyte proliferation regulation of endothelial cell apoptotic process regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process negative regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
04010 04060 04210 04350 04380 04612 04620 04621 04622 04640 04650 04660 04664 04920 04930 04940 05010 05014 05140 05142 05143 05144 05145 05146 05160 05310 05322 05323 05330 05332 05410 05414 |
| TC1700002820.mm.2 |
H2-T-ps |
histocompatibility 2, T region locus, pseudogene |
17 |
-36109029 |
NM_001271005, XM_003688945 NM_001271005, XM_003688945 |
667803 |
13 |
|
|
| TC0900003121.mm.2 |
Tdgf1 |
teratocarcinoma-derived growth factor 1 |
9 |
-110939607 |
NM_011562, BC052646 NM_011562, BC052646 |
21667 |
158 |
activation of MAPK activity blood vessel development vasculogenesis in utero embryonic development morphogenesis of a branching structure positive regulation of cell-matrix adhesion cell migration involved in sprouting angiogenesis signaling receptor binding signaling receptor binding protein binding extracellular region extracellular region extracellular space extracellular space nucleus cytoplasm Golgi apparatus plasma membrane plasma membrane determination of left/right symmetry gastrulation heart development heart development heart development growth factor activity positive regulation of cell population proliferation anterior/posterior axis specification, embryo anterior/posterior axis specification anterior/posterior pattern specification regulation of signal transduction regulation of signal transduction cell surface cell surface cell surface positive regulation of endothelial cell migration coreceptor activity membrane apical plasma membrane Wnt-protein binding peptidyl-serine phosphorylation extrinsic component of plasma membrane cell differentiation regulation of cell migration positive regulation of cell migration positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway anchored component of membrane cellular response to hepatocyte growth factor stimulus nodal signaling pathway nodal signaling pathway nodal signaling pathway nodal binding nodal binding negative regulation of apoptotic process cellular response to fibroblast growth factor stimulus membrane raft positive regulation of transcription by RNA polymerase II positive regulation of fibroblast proliferation perinuclear region of cytoplasm anatomical structure development positive regulation of peptidyl-tyrosine phosphorylation cardiac muscle cell differentiation activin receptor binding type I activin receptor binding cellular response to interferon-gamma cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus |
|
| TC0100002327.mm.2 |
Inpp1 |
inositol polyphosphate-1-phosphatase |
1 |
-52789419 |
NM_008384, BC025072 NM_008384, BC025072 |
16329 |
25 |
inositol-1,4-bisphosphate 1-phosphatase activity hydrolase activity phosphatidylinositol phosphorylation inositol phosphate dephosphorylation metal ion binding |
00562 01100 04070 |
| TC1500001279.mm.2 |
Basp1 |
brain abundant, membrane attached signal protein 1 |
15 |
-25363276 |
NM_027395, BC160328 NM_027395, BC160328 |
70350 |
37 |
chromatin transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding transcription corepressor activity transcription corepressor activity transcription corepressor activity protein binding nucleus nucleus nucleus cytoplasm cytoplasm cytoplasm plasma membrane COP9 signalosome membrane nuclear matrix PML body nuclear speck protein domain specific binding cell junction cell projection negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated glomerular visceral epithelial cell differentiation |
|
| TC1100001196.mm.2 |
Adap2 |
ArfGAP with dual PH domains 2 |
11 |
80154161 |
NM_172133, BC027165 NM_172133, BC027165 |
216991 |
17 |
GTPase activator activity 1-phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding cytoplasm mitochondrial envelope plasma membrane plasma membrane heart development membrane intracellular membrane-bounded organelle phosphatidylinositol-3,4-bisphosphate binding inositol 1,3,4,5 tetrakisphosphate binding positive regulation of GTPase activity metal ion binding inositol lipid-mediated signaling phosphatidylinositol bisphosphate binding |
|
| TC0100003891.mm.2 |
Ifi203 |
interferon activated gene 203 |
1 |
-173920400, -173920400 |
BC008167, NM_001045481, NM_008328 BC008167, NM_001045481, NM_008328 BC008167, NM_001045481, NM_008328 |
15950 |
26 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific activation of innate immune response double-stranded DNA binding double-stranded DNA binding nucleus nucleoplasm nucleolus cytosol transcription factor binding cellular response to interferon-beta cellular response to interferon-beta identical protein binding |
|
| TC0600002878.mm.2 |
Crbn |
cereblon |
6 |
-106778244 |
NM_021449, NM_175357, BC086488 NM_021449, NM_175357, BC086488 NM_021449, NM_175357, BC086488 |
58799 |
49 |
nucleus cytoplasm membrane protein ubiquitination protein ubiquitination negative regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly Cul4A-RING E3 ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex negative regulation of ion transmembrane transport locomotory exploration behavior proteasome-mediated ubiquitin-dependent protein catabolic process ion channel binding metal ion binding perinuclear region of cytoplasm negative regulation of large conductance calcium-activated potassium channel activity |
|
| TC0400000718.mm.2 |
Orm1 |
orosomucoid 1 |
4 |
63344555 |
NM_008768, BC012725 NM_008768, BC012725 |
18405 |
58 |
regulation of immune system process extracellular region extracellular space acute-phase response |
|
| TC1500002318.mm.2 |
Itga5 |
integrin alpha 5 (fibronectin receptor alpha) |
15 |
-103344285 |
NM_010577, BC050943, BC059829 NM_010577, BC050943, BC059829 NM_010577, BC050943, BC059829 |
16402 |
224 |
epidermal growth factor receptor binding integrin binding integrin binding protein binding cytoplasm endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane cell-cell junction focal adhesion cell-substrate junction assembly cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion integrin-mediated signaling pathway memory integrin complex external side of plasma membrane cell surface cell surface positive regulation of cell-substrate adhesion membrane integral component of membrane CD40 signaling pathway cell junction positive regulation of cell migration cytoplasmic vesicle cell-substrate adhesion ruffle membrane cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion integrin alpha5-beta1 complex endodermal cell differentiation synapse regulation of angiogenesis metal ion binding positive regulation of peptidyl-tyrosine phosphorylation cell adhesion molecule binding positive regulation of sprouting angiogenesis negative regulation of anoikis |
04145 04510 04512 04640 04810 05100 05410 05412 05414 |
| TC0200000525.mm.2 |
Tbc1d13 |
TBC1 domain family, member 13 |
2 |
30133745 |
NM_146252, BC025586 NM_146252, BC025586 |
70296 |
21 |
GTPase activator activity GTPase activator activity protein binding cytoplasm cytosol intracellular protein transport intracellular protein transport membrane small GTPase binding activation of GTPase activity |
|
| TC1900000443.mm.2 |
Ric1 |
RAB6A GEF complex partner 1 |
19 |
29522281 |
NM_001081319 |
226089 |
17 |
Golgi membrane regulation of extracellular matrix constituent secretion guanyl-nucleotide exchange factor activity cytoplasm cytosol cytosol intracellular protein transport membrane small GTPase binding protein-containing complex Ric1-Rgp1 guanyl-nucleotide exchange factor complex Ric1-Rgp1 guanyl-nucleotide exchange factor complex retrograde transport, endosome to Golgi retrograde transport, endosome to Golgi positive regulation of GTPase activity negative regulation of cellular protein catabolic process cranial skeletal system development |
|
| TC1300001776.mm.2 |
Serpinb6c |
serine (or cysteine) peptidase inhibitor, clade B, member 6c |
13 |
-33879815, -33879815 |
NM_148942, BC062169 NM_148942, BC062169 |
97848 |
11 |
serine-type endopeptidase inhibitor activity extracellular space cytoplasm negative regulation of endopeptidase activity |
05146 |
| TC1700002354.mm.2 |
Gpr108 |
G protein-coupled receptor 108 |
17 |
-57234914, -57234914 |
NM_030084, BC016104 NM_030084, BC016104 |
78308 |
21 |
molecular_function Golgi apparatus transport membrane integral component of membrane |
|
| TC0200003560.mm.2 |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
2 |
-57107225, -57107225 |
NM_001139509, NM_013613, BC137715 NM_001139509, NM_013613, BC137715 NM_001139509, NM_013613, BC137715 |
18227 |
310 |
negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific response to hypoxia neuron migration response to amphetamine DNA binding DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity protein binding nucleus nucleus nucleus nucleoplasm transcription regulator complex cytoplasm transcription, DNA-templated transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II nervous system development zinc ion binding adult locomotory behavior post-embryonic development response to inorganic substance gene expression regulation of gene expression nuclear speck response to insecticide central nervous system projection neuron axonogenesis central nervous system neuron differentiation central nervous system neuron differentiation habenula development neuron differentiation cellular response to extracellular stimulus cellular response to extracellular stimulus cellular response to oxidative stress glucocorticoid receptor binding glucocorticoid receptor binding regulation of dopamine metabolic process dopamine biosynthetic process dopamine metabolic process neuron maturation positive regulation of catalytic activity negative regulation of neuron apoptotic process sequence-specific DNA binding sequence-specific DNA binding regulation of respiratory gaseous exchange fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding protein heterodimerization activity general adaptation syndrome cellular response to corticotropin-releasing hormone stimulus cellular response to corticotropin-releasing hormone stimulus dopaminergic neuron differentiation dopaminergic neuron differentiation dopaminergic neuron differentiation sequence-specific double-stranded DNA binding negative regulation of apoptotic signaling pathway |
|
| TC1000000045.mm.2 |
Lrp11 |
low density lipoprotein receptor-related protein 11 |
10 |
7589816 |
NM_172784 |
237253 |
21 |
cellular_component endocytosis response to heat response to cold response to water deprivation response to mechanical stimulus membrane integral component of membrane multicellular organismal response to stress response to immobilization stress response to starvation phosphoprotein binding |
|
| TC1900000797.mm.2 |
Casp7 |
caspase 7 |
19 |
56397128 |
NM_007611, BC005428 NM_007611, BC005428 |
12369 |
111 |
aspartic-type endopeptidase activity cysteine-type endopeptidase activity cysteine-type endopeptidase activity protein binding nucleus cytoplasm cytosol proteolysis proteolysis apoptotic process apoptotic process apoptotic process heart development peptidase activity peptidase activity cysteine-type peptidase activity response to UV protein processing hydrolase activity intracellular membrane-bounded organelle neuron apoptotic process cellular response to staurosporine cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process execution phase of apoptosis execution phase of apoptosis cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in execution phase of apoptosis |
04210 05010 |
| TC0400001608.mm.2 |
|
|
|
|
NM_016981, NR_039582, BC051431, BC052708 NM_016981, NR_039582, BC051431, BC052708 NM_016981, NR_039582, BC051431, BC052708 NM_016981, NR_039582, BC051431, BC052708 |
|
|
regulation of the force of heart contraction calmodulin binding nucleoplasm cytoplasm mitochondrion endoplasmic reticulum plasma membrane plasma membrane integral component of plasma membrane ion transport cation transport sodium ion transport cellular sodium ion homeostasis regulation of pH regulation of pH regulation of pH embryo development cell surface response to acidic pH response to acidic pH positive regulation of cardiac muscle hypertrophy regulation of cardiac muscle contraction by calcium ion signaling response to organic cyclic compound intercalated disc antiporter activity solute:proton antiporter activity sodium:proton antiporter activity sodium:proton antiporter activity sodium:proton antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity membrane integral component of membrane basolateral plasma membrane basolateral plasma membrane apical plasma membrane positive regulation of cell growth T-tubule protein phosphatase 2B binding cellular response to insulin stimulus positive regulation of mitochondrial membrane permeability response to muscle stretch sarcolemma positive regulation of apoptotic process negative regulation of apoptotic process membrane raft positive regulation of action potential positive regulation of transcription by RNA polymerase II calcium-dependent protein binding perinuclear region of cytoplasm regulation of intracellular pH regulation of intracellular pH regulation of sensory perception of pain cardiac muscle cell differentiation transmembrane transport positive regulation of calcineurin-NFAT signaling cascade neuron death cellular response to hypoxia cellular response to acidic pH potassium ion transmembrane transport cellular response to epinephrine stimulus regulation of the force of heart contraction by cardiac conduction cation-transporting ATPase complex sodium ion import across plasma membrane sodium ion import across plasma membrane positive regulation of the force of heart contraction positive regulation of intracellular signal transduction proton transmembrane transport positive regulation of calcium:sodium antiporter activity |
|
| TC1500002316.mm.2 |
Gpr84 |
G protein-coupled receptor 84 |
15 |
-103308234 |
NM_030720, BC023249 NM_030720, BC023249 |
80910 |
22 |
urotensin II receptor activity G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway neuropeptide signaling pathway G protein-coupled peptide receptor activity membrane integral component of membrane receptor complex |
|
| TC0200004545.mm.2 |
Sppl2a |
signal peptide peptidase like 2A |
2 |
-126890394 |
NM_023220, BC026578 NM_023220, BC026578 |
66552 |
31 |
aspartic-type endopeptidase activity lysosome lysosomal membrane lysosomal membrane endosome late endosome plasma membrane proteolysis membrane protein ectodomain proteolysis peptidase activity membrane integral component of membrane hydrolase activity Golgi-associated vesicle membrane Golgi-associated vesicle membrane membrane protein intracellular domain proteolysis late endosome membrane membrane protein proteolysis membrane protein proteolysis aspartic endopeptidase activity, intramembrane cleaving aspartic endopeptidase activity, intramembrane cleaving protein homodimerization activity intracellular membrane-bounded organelle regulation of immune response integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of cytoplasmic side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane integral component of lumenal side of endoplasmic reticulum membrane |
|
| TC0400002251.mm.2 |
Ripk2 |
receptor (TNFRSF)-interacting serine-threonine kinase 2 |
4 |
-16122740 |
NM_138952, BC069878 NM_138952, BC069878 |
192656 |
141 |
nucleotide binding positive regulation of cytokine-mediated signaling pathway adaptive immune response adaptive immune response immune system process positive regulation of T-helper 1 type immune response protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity non-membrane spanning protein tyrosine kinase activity signaling receptor binding ATP binding cytoplasm cytosol cytosol cytoskeleton apoptotic process I-kappaB kinase/NF-kappaB signaling activation of JUN kinase activity positive regulation of peptidyl-threonine phosphorylation positive regulation of cell death kinase activity phosphorylation transferase activity LIM domain binding positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway vesicle positive regulation of protein binding positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade protein-containing complex positive regulation of immature T cell proliferation positive regulation of peptidyl-serine phosphorylation toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway T cell proliferation identical protein binding protein homodimerization activity regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA innate immune response innate immune response innate immune response positive regulation of T-helper 1 cell differentiation positive regulation of JNK cascade positive regulation of alpha-beta T cell proliferation CARD domain binding positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-positive bacterium T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway response to interleukin-1 response to interleukin-12 response to interleukin-18 cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to peptidoglycan cellular response to muramyl dipeptide caspase binding activation of cysteine-type endopeptidase activity positive regulation of xenophagy |
04621 04722 |
| TC1300001366.mm.2 |
BC147527 |
cDNA sequence BC147527 |
13 |
120300391 |
NM_001037925, BC147527, BC147545 NM_001037925, BC147527, BC147545 NM_001037925, BC147527, BC147545 |
625360 |
8 |
|
|
| TC0200003603.mm.2 |
Pla2r1 |
phospholipase A2 receptor 1 |
2 |
-60417542 |
NM_008867, BC141355, BC141356 NM_008867, BC141355, BC141356 NM_008867, BC141355, BC141356 |
18779 |
35 |
cytokine production extracellular region plasma membrane plasma membrane endocytosis receptor-mediated endocytosis receptor-mediated endocytosis cell surface membrane integral component of membrane carbohydrate binding signaling receptor activity signaling receptor activity signaling receptor activity receptor complex receptor complex phospholipase binding phospholipase binding positive regulation of DNA damage response, signal transduction by p53 class mediator reactive oxygen species metabolic process positive regulation of arachidonic acid secretion replicative senescence oxidative stress-induced premature senescence negative regulation of phospholipase A2 activity negative regulation of arachidonic acid secretion positive regulation of glomerular visceral epithelial cell apoptotic process |
04145 |
| TC0200005030.mm.2 |
Tgm2 |
transglutaminase 2, C polypeptide |
2 |
-158116404 |
NM_009373, BC016492 NM_009373, BC016492 |
21817 |
250 |
blood vessel remodeling protein-glutamine gamma-glutamyltransferase activity protein-glutamine gamma-glutamyltransferase activity protein-glutamine gamma-glutamyltransferase activity calcium ion binding GTP binding GTP binding cytoplasm mitochondrion mitochondrion cytosol cytosol plasma membrane G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway transaminase activity membrane transferase activity transferase activity, transferring acyl groups peptide cross-linking peptide cross-linking peptide cross-linking isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine protein domain specific binding extracellular matrix intrinsic component of plasma membrane negative regulation of endoplasmic reticulum calcium ion concentration negative regulation of endoplasmic reticulum calcium ion concentration identical protein binding positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling apoptotic cell clearance positive regulation of cell adhesion metal ion binding positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of mitochondrial calcium ion concentration positive regulation of mitochondrial calcium ion concentration branching involved in salivary gland morphogenesis salivary gland cavitation collagen-containing extracellular matrix |
05016 |
| TC0900000550.mm.2 |
Sik3 |
SIK family kinase 3 |
9 |
46012819 |
NM_027498, BC063268, BC080688 NM_027498, BC063268, BC080688 NM_027498, BC063268, BC080688 |
70661 |
46 |
nucleotide binding microtubule cytoskeleton organization magnesium ion binding endochondral ossification protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding cytoplasm cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity limb morphogenesis multicellular organism growth intracellular signal transduction metal ion binding skeletal system morphogenesis tau-protein kinase activity cartilage development involved in endochondral bone morphogenesis positive regulation of TORC1 signaling positive regulation of TORC2 signaling |
|
| TC1500000615.mm.2 |
1110038F14Rik |
RIKEN cDNA 1110038F14 gene |
15 |
76948260 |
NM_054099, BC038324, BC091734 NM_054099, BC038324, BC091734 NM_054099, BC038324, BC091734 |
117171 |
12 |
molecular_function cellular_component biological_process |
|
| TC1400000163.mm.2 |
Nudt13 |
nudix (nucleoside diphosphate linked moiety X)-type motif 13 |
14 |
20294689 |
NM_026341, BC049948 NM_026341, BC049948 |
67725 |
16 |
NAD+ diphosphatase activity mitochondrion mitochondrion NADH metabolic process NADP catabolic process hydrolase activity NADH pyrophosphatase activity metal ion binding |
|
| TC1700002821.mm.2 |
Gm7030 |
predicted gene 7030 |
17 |
-36127608 |
NM_001177467 |
630294 |
4 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding |
|
| TC1000000711.mm.2 |
Adora2a |
adenosine A2a receptor |
10 |
75316876, 75324857, 75317599 |
NM_009630, BC110692 NM_009630, BC110692 |
11540 |
432 |
G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor activity synaptic transmission, dopaminergic G protein-coupled adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway response to amphetamine G protein-coupled receptor activity protein binding intermediate filament plasma membrane plasma membrane integral component of plasma membrane regulation of transcription, DNA-templated negative regulation of protein kinase activity signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway protein kinase C-activating G protein-coupled receptor signaling pathway synaptic transmission, cholinergic locomotory behavior locomotory behavior negative regulation of cell population proliferation endomembrane system positive regulation of glutamate secretion positive regulation of acetylcholine secretion, neurotransmission regulation of norepinephrine secretion postsynaptic density membrane membrane integral component of membrane enzyme binding axon dendrite axolemma response to caffeine type 5 metabotropic glutamate receptor binding positive regulation of synaptic transmission, GABAergic positive regulation of synaptic transmission, GABAergic asymmetric synapse synaptic transmission, glutamatergic positive regulation of urine volume positive regulation of renal sodium excretion negative regulation of locomotion vasodilation presynaptic membrane eating behavior eating behavior identical protein binding neuronal cell body negative regulation of vascular permeability negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to alkaloid negative regulation of neuron apoptotic process protein-containing complex binding postsynaptic membrane positive regulation of circadian sleep/wake cycle, sleep negative regulation of alpha-beta T cell activation astrocyte activation presynaptic active zone neuron projection morphogenesis positive regulation of protein secretion negative regulation of inflammatory response alpha-actinin binding regulation of mitochondrial membrane potential membrane depolarization regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential inhibitory postsynaptic potential prepulse inhibition glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane positive regulation of long-term synaptic potentiation regulation of synaptic vesicle exocytosis positive regulation of apoptotic signaling pathway |
04020 04080 04270 |
| TC0900001155.mm.2 |
Ctsh |
cathepsin H |
9 |
90054266 |
NM_007801, BC006878 NM_007801, BC006878 |
13036 |
45 |
outer dense fiber acrosomal vesicle T cell mediated cytotoxicity immune response-regulating signaling pathway endopeptidase activity endopeptidase activity aminopeptidase activity cysteine-type endopeptidase activity cysteine-type endopeptidase activity cysteine-type endopeptidase activity serine-type endopeptidase activity extracellular space extracellular space lysosome lysosome cytosol axoneme proteolysis proteolysis peptidase activity cysteine-type peptidase activity positive regulation of cell population proliferation cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase activator activity involved in apoptotic process positive regulation of gene expression positive regulation of epithelial cell migration neuropeptide catabolic process bradykinin catabolic process positive regulation of peptidase activity positive regulation of peptidase activity peptidase activator activity involved in apoptotic process hydrolase activity HLA-A specific activating MHC class I receptor activity positive regulation of cell migration kininogen binding zymogen activation zymogen activation protein destabilization protein destabilization response to retinoic acid membrane protein proteolysis membrane protein proteolysis cytoplasmic ribonucleoprotein granule negative regulation of apoptotic process surfactant homeostasis intracellular membrane-bounded organelle protein self-association protein-containing complex binding positive regulation of angiogenesis proteolysis involved in cellular protein catabolic process dichotomous subdivision of terminal units involved in lung branching thyroid hormone binding ERK1 and ERK2 cascade alveolar lamellar body positive regulation of apoptotic signaling pathway |
04142 |
| TC1600001400.mm.2 |
Bcl6 |
B cell leukemia/lymphoma 6 |
16 |
-23965049, -23965049 |
NM_009744, BC052315 NM_009744, BC052315 |
12053 |
285 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II cell morphogenesis cell morphogenesis RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific regulation of cytokine production negative regulation of cell-matrix adhesion immune system process germinal center formation regulation of immune system process negative regulation of type 2 immune response nucleic acid binding DNA binding chromatin binding chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm replication fork nucleolus Golgi apparatus regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II inflammatory response cellular response to DNA damage stimulus Rho protein signal transduction spermatogenesis protein localization negative regulation of cell population proliferation actin cytoskeleton organization B cell differentiation negative regulation of cell growth positive regulation of B cell proliferation positive regulation of histone deacetylation chromatin DNA binding negative regulation of mast cell cytokine production negative regulation of Rho protein signal transduction type 2 immune response type 2 immune response regulation of cell population proliferation regulation of cell population proliferation identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process regulation of GTPase activity regulation of memory T cell differentiation sequence-specific DNA binding sequence-specific DNA binding positive regulation of regulatory T cell differentiation regulation of cell differentiation negative regulation of cell differentiation negative regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated metal ion binding negative regulation of isotype switching to IgE isotypes negative regulation of isotype switching to IgE isotypes erythrocyte development regulation of inflammatory response regulation of inflammatory response positive regulation of cellular component movement sequence-specific double-stranded DNA binding negative regulation of cellular senescence |
|
| TC1900001018.mm.2 |
Ccdc88b |
coiled-coil domain containing 88B |
19 |
-6844622 |
NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 |
78317 |
12 |
positive regulation of cytokine production cytoplasm endoplasmic reticulum Golgi apparatus centrosome cytoskeleton microtubule binding membrane cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization positive regulation of T cell proliferation defense response to protozoan positive regulation of T cell activation dynein light intermediate chain binding |
|
| TC1300002534.mm.2 |
Naip1 |
NLR family, apoptosis inhibitory protein 1 |
13 |
-100407769 |
NM_008670, BC132413 NM_008670, BC132413 |
17940 |
46 |
nucleotide binding cysteine-type endopeptidase inhibitor activity ATP binding cytoplasm cytoplasm apoptotic process inflammatory response negative regulation of peptidase activity detection of bacterium basolateral plasma membrane peptidase inhibitor activity defense response to bacterium neuron projection neuronal cell body cysteine-type endopeptidase inhibitor activity involved in apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process perikaryon metal ion binding pyroptosis cellular response to estrogen stimulus IPAF inflammasome complex |
04621 |
| TC0500003465.mm.2 |
Pilrb2 |
paired immunoglobin-like type 2 receptor beta 2 |
5 |
-137865828, -137865820 |
NM_001024932, BC147405, BC147406 NM_001024932, BC147405, BC147406 NM_001024932, BC147405, BC147406 |
545812 |
10 |
membrane integral component of membrane MHC class I protein binding |
|
| TC0400001327.mm.2 |
Svbp |
small vasohibin binding protein |
4 |
119195309, 119195524 |
NM_001038998, NM_024462, BC002274 NM_001038998, NM_024462, BC002274 NM_001038998, NM_024462, BC002274 |
69216 |
16 |
protein binding extracellular region cytoplasm cytoskeleton proteolysis proteolysis microtubule binding protein secretion protein secretion negative regulation of endothelial cell migration negative regulation of protein ubiquitination negative regulation of protein ubiquitination apical part of cell apical part of cell axon development axon development regulation of metallopeptidase activity |
|
| TC1400002378.mm.2 |
Cysltr2 |
cysteinyl leukotriene receptor 2 |
14 |
-73029127 |
NM_001162412, NM_133720, BC132414, BC132418 NM_001162412, NM_133720, BC132414, BC132418 NM_001162412, NM_133720, BC132414, BC132418 NM_001162412, NM_133720, BC132414, BC132418 |
70086 |
41 |
cysteinyl leukotriene receptor activity cysteinyl leukotriene receptor activity G protein-coupled receptor activity leukotriene receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway neuropeptide signaling pathway G protein-coupled peptide receptor activity positive regulation of cell death membrane membrane integral component of membrane positive regulation of angiogenesis positive regulation of ERK1 and ERK2 cascade |
04020 04080 |
| TC1400001930.mm.2 |
Gch1 |
GTP cyclohydrolase 1 |
14 |
-47153894 |
NM_008102, BC005643, BC069921 NM_008102, BC005643, BC069921 NM_008102, BC005643, BC069921 |
14528 |
72 |
nucleotide binding catalytic activity GTPase activity GTP cyclohydrolase I activity GTP cyclohydrolase I activity GTP cyclohydrolase I activity calcium ion binding GTP binding GTP binding nucleus nucleoplasm cytoplasm cytoplasm cytosol tetrahydrobiopterin biosynthetic process tetrahydrobiopterin biosynthetic process tetrahydrobiopterin biosynthetic process metabolic process regulation of blood pressure regulation of blood pressure zinc ion binding zinc ion binding positive regulation of heart rate regulation of lung blood pressure hydrolase activity GTP-dependent protein binding translation initiation factor binding cytoplasmic vesicle nuclear membrane protein-containing complex response to interferon-gamma response to tumor necrosis factor vasodilation dopamine biosynthetic process pteridine-containing compound biosynthetic process identical protein binding protein homodimerization activity protein-containing complex binding negative regulation of blood pressure tetrahydrofolate biosynthetic process metal ion binding response to pain neuromuscular process controlling posture positive regulation of nitric-oxide synthase activity mitogen-activated protein kinase binding dihydrobiopterin metabolic process protein-containing complex assembly cellular response to lipopolysaccharide regulation of serotonin biosynthetic process regulation of removal of superoxide radicals |
00790 01100 |
| TC1100002397.mm.2 |
Vrk2 |
vaccinia related kinase 2 |
11 |
-26471401 |
NM_001252447, NM_027260, BC013520 NM_001252447, NM_027260, BC013520 NM_001252447, NM_027260, BC013520 |
69922 |
27 |
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity ATP binding nucleus nucleus nuclear envelope cytoplasm cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane protein phosphorylation membrane integral component of membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation protein kinase binding protein domain specific binding mitochondrial membrane protein-containing complex cellular response to oxidative stress regulation of MAPK cascade protein autophosphorylation protein autophosphorylation regulation of interleukin-1-mediated signaling pathway |
|
| TC1300000362.mm.2 |
Serpinb6b |
serine (or cysteine) peptidase inhibitor, clade B, member 6b |
13 |
32965260 |
NM_011454, BC061050 NM_011454, BC061050 |
20708 |
18 |
serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity extracellular space nucleus cytoplasm cytoplasm gonad development negative regulation of endopeptidase activity negative regulation of endopeptidase activity |
05146 |
| TC1700001717.mm.2 |
Ip6k3 |
inositol hexaphosphate kinase 3 |
17 |
-27143970 |
NM_173027, BC141263 NM_173027, BC141263 |
271424 |
16 |
nucleotide binding inositol hexakisphosphate kinase activity inositol hexakisphosphate kinase activity inositol hexakisphosphate 6-kinase activity inositol hexakisphosphate 5-kinase activity ATP binding nucleus nucleus cytoplasm cytoplasm protein phosphorylation kinase activity phosphorylation transferase activity inositol phosphate biosynthetic process inositol phosphate biosynthetic process locomotion phosphatidylinositol metabolic process phosphatidylinositol phosphorylation inositol hexakisphosphate 1-kinase activity inositol hexakisphosphate 3-kinase activity |
|
| TC1200001974.mm.2 |
Tmem229b |
transmembrane protein 229B |
12 |
-78961794, -78961794, -78961794 |
NM_001170401, NM_178745, BC066067, BC079613 NM_001170401, NM_178745, BC066067, BC079613 NM_001170401, NM_178745, BC066067, BC079613 NM_001170401, NM_178745, BC066067, BC079613 |
268567 |
18 |
molecular_function cellular_component response to bacterium membrane integral component of membrane |
|
| TC1300002530.mm.2 |
Naip2 |
NLR family, apoptosis inhibitory protein 2 |
13 |
-100144062 |
NM_001126182, NM_010872, BC116626 NM_001126182, NM_010872, BC116626 NM_001126182, NM_010872, BC116626 |
17948 |
25 |
nucleotide binding immune system process protein binding ATP binding ATP binding apoptotic process inflammatory response inflammatory response detection of bacterium detection of bacterium defense response to bacterium defense response to bacterium cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process innate immune response metal ion binding pyroptosis pyroptosis cellular response to estrogen stimulus IPAF inflammasome complex IPAF inflammasome complex |
04621 |
| TC1100001744.mm.2 |
Tlk2 |
tousled-like kinase 2 (Arabidopsis) |
11 |
105178806, 105181526, 105181526 |
NM_001112705, NM_011903 NM_001112705, NM_011903 |
24086 |
25 |
nucleotide binding regulation of chromatin assembly or disassembly regulation of chromatin assembly or disassembly protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleus nucleus cytoplasm cytoskeleton intermediate filament intermediate filament chromatin organization protein phosphorylation cellular response to DNA damage stimulus cell cycle chromosome segregation chromosome segregation multicellular organism development spermatogenesis kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation peptidyl-serine phosphorylation cell differentiation negative regulation of proteasomal ubiquitin-dependent protein catabolic process intracellular signal transduction intracellular signal transduction identical protein binding perinuclear region of cytoplasm perinuclear region of cytoplasm cellular response to gamma radiation |
|
| TC0700003464.mm.2 |
Arrdc4 |
arrestin domain containing 4 |
7 |
-68741592, -68736993 |
NM_001042592, NM_025549, BC017528 NM_001042592, NM_025549, BC017528 NM_001042592, NM_025549, BC017528 |
66412 |
19 |
cytoplasm endosome plasma membrane plasma membrane plasma membrane protein transport protein transport membrane protein ubiquitination cytoplasmic vesicle intracellular membrane-bounded organelle positive regulation of ubiquitin-protein transferase activity extracellular vesicle biogenesis extracellular vesicle ubiquitin ligase-substrate adaptor activity ubiquitin ligase-substrate adaptor activity |
|
| TC0900002197.mm.2 |
Il10ra |
interleukin 10 receptor, alpha |
9 |
-45253836 |
NM_008348, BC146496 NM_008348, BC146496 |
16154 |
73 |
cytokine receptor activity interleukin-10 receptor activity cytoplasm cytosol plasma membrane plasma membrane negative regulation of autophagy membrane integral component of membrane cytokine-mediated signaling pathway interleukin-10 binding positive regulation of receptor signaling pathway via JAK-STAT regulation of synapse organization ubiquitin-dependent endocytosis |
04060 04630 05145 |
| TC1300000365.mm.2 |
Serpinb9b |
serine (or cysteine) peptidase inhibitor, clade B, member 9b |
13 |
33027413 |
NM_011452, BC064768 NM_011452, BC064768 |
20706 |
19 |
T cell mediated cytotoxicity serine-type endopeptidase inhibitor activity protein binding extracellular space cytoplasm negative regulation of endopeptidase activity |
05146 |
| TC1600000500.mm.2 |
Parp9 |
poly (ADP-ribose) polymerase family, member 9 |
16 |
35938469 |
NM_030253, BC003281, BC070466 NM_030253, BC003281, BC070466 NM_030253, BC003281, BC070466 |
80285 |
21 |
negative regulation of transcription by RNA polymerase II positive regulation of defense response to virus by host immune system process transcription corepressor activity transcription corepressor activity NAD+ ADP-ribosyltransferase activity enzyme inhibitor activity nucleus nucleus nucleoplasm cytoplasm cytoplasm mitochondrion cytosol DNA repair double-strand break repair protein ADP-ribosylation cellular response to DNA damage stimulus posttranscriptional regulation of gene expression negative regulation of gene expression negative regulation of gene expression transferase activity enzyme binding protein-containing complex positive regulation of chromatin binding histone binding positive regulation of tyrosine phosphorylation of STAT protein negative regulation of catalytic activity ubiquitin-like protein ligase binding ubiquitin-like protein ligase binding innate immune response positive regulation of transcription, DNA-templated defense response to virus regulation of response to interferon-gamma positive regulation of interferon-gamma-mediated signaling pathway positive regulation of interferon-gamma-mediated signaling pathway positive regulation of interferon-gamma-mediated signaling pathway protein poly-ADP-ribosylation ADP-D-ribose binding site of DNA damage STAT family protein binding protein mono-ADP-ribosylation positive regulation of protein localization to nucleus protein ADP-ribosylase activity positive regulation of double-strand break repair via nonhomologous end joining |
|
| TC1200002127.mm.2 |
Snw1 |
SNW domain containing 1 |
12 |
-87449909 |
NM_025507 |
66354 |
28 |
negative regulation of transcription by RNA polymerase II mRNA splicing, via spliceosome chromatin transcription coactivator activity transcription corepressor activity Notch binding protein binding nucleus nucleoplasm nucleoplasm spliceosomal complex cytoplasm mRNA processing cyclin/CDK positive transcription elongation factor complex RNA splicing nuclear matrix nuclear body nuclear speck enzyme binding positive regulation of transforming growth factor beta receptor signaling pathway nuclear hormone receptor binding skeletal muscle cell differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator vitamin D receptor binding retinoic acid receptor binding positive regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II SMAD binding positive regulation of mRNA splicing, via spliceosome retinoic acid receptor signaling pathway regulation of retinoic acid receptor signaling pathway androgen receptor binding positive regulation of neurogenesis positive regulation of histone H3-K4 methylation regulation of vitamin D receptor signaling pathway positive regulation of vitamin D receptor signaling pathway U2-type catalytic step 2 spliceosome catalytic step 2 spliceosome SMAD protein complex cellular response to retinoic acid cellular response to retinoic acid |
03040 04330 |
| TC0800000724.mm.2 |
Atp13a1 |
ATPase type 13A1 |
8 |
69791162 |
NM_133224, BC138721, BC138722 NM_133224, BC138721, BC138722 NM_133224, BC138721, BC138722 |
170759 |
19 |
nucleotide binding ATP binding endoplasmic reticulum cation transport cellular calcium ion homeostasis membrane integral component of membrane ATPase activity metal ion binding |
|
| TC0100003823.mm.2 |
Traf5 |
TNF receptor-associated factor 5 |
1 |
-191997202 |
NM_011633, BC012702 NM_011633, BC012702 |
22033 |
61 |
ubiquitin-protein transferase activity tumor necrosis factor receptor binding protein binding cytoplasm centrosome cytosol apoptotic process signal transduction zinc ion binding positive regulation of cell population proliferation cytoplasmic side of plasma membrane cytoplasmic side of plasma membrane ubiquitin protein ligase binding ubiquitin protein ligase binding thioesterase binding thioesterase binding tumor necrosis factor-mediated signaling pathway CD40 receptor complex identical protein binding regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade metal ion binding positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity protein K63-linked ubiquitination plasma membrane signaling receptor complex |
05200 05222 |
| TC1700002526.mm.2 |
Xdh |
xanthine dehydrogenase |
17 |
-73883894 |
NM_011723, BC141183 NM_011723, BC141183 |
22436 |
89 |
negative regulation of protein phosphorylation negative regulation of endothelial cell proliferation xanthine dehydrogenase activity xanthine dehydrogenase activity xanthine dehydrogenase activity xanthine dehydrogenase activity xanthine oxidase activity xanthine oxidase activity xanthine oxidase activity iron ion binding protein binding extracellular region extracellular space extracellular space cytoplasm peroxisome cytosol cytosol inosine catabolic process inosine catabolic process inosine catabolic process adenosine catabolic process adenosine catabolic process adenosine catabolic process AMP catabolic process AMP catabolic process IMP catabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process lactation electron transfer activity hypoxanthine catabolic process xanthine catabolic process xanthine catabolic process xanthine catabolic process response to aluminum ion negative regulation of gene expression iron-sulfur cluster assembly oxidoreductase activity oxidoreductase activity sarcoplasmic reticulum molybdenum ion binding regulation of epithelial cell differentiation identical protein binding protein homodimerization activity molybdopterin cofactor binding negative regulation of endothelial cell differentiation GMP catabolic process dGMP catabolic process metal ion binding nitrite reductase (NO-forming) activity flavin adenine dinucleotide binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding negative regulation of protein kinase B signaling hypoxanthine dehydrogenase activity hypoxanthine dehydrogenase activity hypoxanthine oxidase activity hypoxanthine oxidase activity FAD binding positive regulation of p38MAPK cascade negative regulation of vascular endothelial growth factor signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of vasculogenesis |
00230 00232 00983 01100 04146 |
| TC0200005472.mm.2 |
Eng |
endoglin |
2 |
32646594 |
NM_001146348, NM_001146350, NM_007932, BC029080 NM_001146348, NM_001146350, NM_007932, BC029080 NM_001146348, NM_001146350, NM_007932, BC029080 NM_001146348, NM_001146350, NM_007932, BC029080 |
13805 |
211 |
negative regulation of transcription by RNA polymerase II angiogenesis angiogenesis branching involved in blood vessel morphogenesis vasculogenesis vasculogenesis vasculogenesis response to hypoxia epithelial to mesenchymal transition positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation heart looping positive regulation of systemic arterial blood pressure outflow tract septum morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation transforming growth factor beta-activated receptor activity type II transforming growth factor beta receptor binding type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding glycosaminoglycan binding extracellular space extracellular space plasma membrane regulation of transcription, DNA-templated cell adhesion transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway heart development external side of plasma membrane cell surface cell surface positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation coreceptor activity membrane integral component of membrane cell migration cell migration nuclear body regulation of transforming growth factor beta receptor signaling pathway regulation of transforming growth factor beta receptor signaling pathway regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis extracellular matrix disassembly negative regulation of cell migration positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation positive regulation of collagen biosynthetic process type I transforming growth factor beta receptor binding dorsal aorta morphogenesis BMP binding wound healing identical protein binding protein homodimerization activity protein homodimerization activity receptor complex positive regulation of angiogenesis positive regulation of angiogenesis positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis cell motility transforming growth factor beta binding transforming growth factor beta binding transforming growth factor beta binding negative regulation of nitric-oxide synthase activity positive regulation of protein kinase B signaling atrial cardiac muscle tissue morphogenesis cell chemotaxis negative regulation of pathway-restricted SMAD protein phosphorylation extracellular matrix constituent secretion detection of hypoxia endothelial microparticle vascular associated smooth muscle cell development positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of vascular associated smooth muscle cell differentiation atrioventricular canal morphogenesis |
|
| TC0400001449.mm.2 |
Csf3r |
colony stimulating factor 3 receptor (granulocyte) |
4 |
126024658 |
NM_001252651, NM_007782, NR_045561, BC115865, BC116635 NM_001252651, NM_007782, NR_045561, BC115865, BC116635 NM_001252651, NM_007782, NR_045561, BC115865, BC116635 NM_001252651, NM_007782, NR_045561, BC115865, BC116635 NM_001252651, NM_007782, NR_045561, BC115865, BC116635 |
12986 |
122 |
cytokine receptor activity protein binding cell adhesion external side of plasma membrane membrane integral component of membrane cytokine-mediated signaling pathway cytokine binding neutrophil chemotaxis receptor complex regulation of myeloid cell differentiation granulocyte colony-stimulating factor binding granulocyte colony-stimulating factor binding |
04060 04630 04640 05200 |
| TC0600003231.mm.2 |
Klrk1 |
killer cell lectin-like receptor subfamily K, member 1 |
6 |
-129610322, -129610322 |
NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 |
27007 |
199 |
stimulatory C-type lectin receptor signaling pathway adaptive immune response immune system process positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target protein binding plasma membrane plasma membrane external side of plasma membrane external side of plasma membrane cell surface cell surface membrane integral component of membrane kinase binding natural killer cell activation natural killer cell activation cell differentiation carbohydrate binding positive regulation of myeloid dendritic cell activation MHC class Ib receptor activity positive regulation of interferon-gamma production signaling receptor activity MHC class I protein binding identical protein binding positive regulation of apoptotic process innate immune response positive regulation of nitric oxide biosynthetic process positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity defense response to Gram-positive bacterium cellular response to lipopolysaccharide |
04650 |
| TC1600001343.mm.2 |
Abcc5 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
16 |
-20400760, -20331303 |
NM_013790, NM_176839, BC090629 NM_013790, NM_176839, BC090629 NM_013790, NM_176839, BC090629 |
27416 |
29 |
nucleotide binding ATP binding endosome Golgi apparatus plasma membrane organic anion transmembrane transporter activity purine nucleotide transmembrane transporter activity efflux transmembrane transporter activity organic anion transport purine nucleotide transport membrane membrane integral component of membrane basolateral plasma membrane apical plasma membrane ATPase activity glutathione transmembrane transporter activity glutathione transmembrane transport ATPase-coupled transmembrane transporter activity xenobiotic transport xenobiotic transmembrane transporter activity perinuclear region of cytoplasm transmembrane transport export across plasma membrane |
02010 |
| TC1600000666.mm.2 |
Cd200r3 |
CD200 receptor 3 |
16 |
44943677, 44943677 |
NM_001128132, NM_001128133, NM_027578, NM_029018, BC106838, CD200 NM_001128132, NM_001128133, NM_027578, NM_029018, BC106838, CD200 NM_001128132, NM_001128133, NM_027578, NM_029018, BC106838, CD200 NM_001128132, NM_001128133, NM_027578, NM_029018, BC106838, CD200 NM_001128132, NM_001128133, NM_027578, NM_029018, BC106838, CD200 NM_001128132, NM_001128133, NM_027578, NM_029018, BC106838, CD200 |
74603 |
19 |
protein binding external side of plasma membrane external side of plasma membrane membrane integral component of membrane signaling receptor activity signaling receptor activity regulation of neuroinflammatory response |
|
| TC1700000948.mm.2 |
Mocs1 |
molybdenum cofactor synthesis 1 |
17 |
49428363 |
NM_020042, NM_028464 NM_020042, NM_028464 |
56738 |
18 |
nucleotide binding catalytic activity GTP binding Mo-molybdopterin cofactor biosynthetic process lyase activity molybdopterin synthase complex molybdopterin cofactor biosynthetic process metal ion binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding GTP 3',8'-cyclase activity GTP 3',8'-cyclase activity cyclic pyranopterin monophosphate synthase activity cyclic pyranopterin monophosphate synthase activity |
04122 |
| TC1200002081.mm.2 |
Npc2 |
NPC intracellular cholesterol transporter 2 |
12 |
-84754558 |
NM_023409, BC003471, BC007190 NM_023409, BC003471, BC007190 NM_023409, BC003471, BC007190 |
67963 |
68 |
extracellular region extracellular space extracellular space lysosome lysosome lysosome endoplasmic reticulum lipid metabolic process lipid transport steroid metabolic process cholesterol metabolic process cholesterol binding cholesterol binding cholesterol binding cholesterol binding sterol transport enzyme binding cholesterol transport cholesterol transport cholesterol transport intracellular sterol transport intracellular sterol transport intracellular cholesterol transport intracellular cholesterol transport intracellular cholesterol transport sterol binding cholesterol efflux cholesterol efflux cholesterol efflux cholesterol homeostasis cholesterol homeostasis cholesterol transfer activity |
04142 |
| TC0400003708.mm.2 |
Zdhhc18 |
zinc finger, DHHC domain containing 18 |
4 |
-133606991 |
NM_001017968, BC167166 NM_001017968, BC167166 |
503610 |
17 |
endoplasmic reticulum Golgi apparatus Golgi apparatus protein targeting to membrane membrane integral component of membrane palmitoyltransferase activity palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups peptidyl-L-cysteine S-palmitoylation peptidyl-L-cysteine S-palmitoylation protein palmitoylation protein-cysteine S-palmitoyltransferase activity cellular protein localization |
|
| TC0200002347.mm.2 |
Chmp4b |
charged multivesicular body protein 4B |
2 |
154657025 |
NM_029362, BC011429, BC059279 NM_029362, BC011429, BC059279 NM_029362, BC011429, BC059279 |
75608 |
30 |
mitotic cytokinesis ESCRT III complex ESCRT III complex protein binding nucleus nucleus nuclear envelope cytoplasm endosome multivesicular body cytosol posttranslational protein targeting to endoplasmic reticulum membrane vesicle budding from membrane autophagy nucleus organization vacuolar transport mitotic metaphase plate congression cytoplasmic side of plasma membrane cytoplasmic side of plasma membrane exit from mitosis regulation of autophagy regulation of centrosome duplication postsynaptic density protein transport membrane membrane coat midbody nuclear envelope reassembly vesicle late endosome to vacuole transport via multivesicular body sorting pathway maintenance of lens transparency viral budding via host ESCRT complex identical protein binding protein homodimerization activity viral budding regulation of viral process protein polymerization negative regulation of cell death midbody abscission membrane fission ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway glutamatergic synapse regulation of postsynapse organization negative regulation of neuron death regulation of mitotic spindle assembly positive regulation of viral release from host cell negative regulation of autophagosome assembly |
04144 |
| TC0100000541.mm.2 |
Ccnyl1 |
cyclin Y-like 1 |
1 |
64691344 |
NM_001097644 |
227210 |
18 |
regulation of protein phosphorylation protein binding cytoplasm plasma membrane plasma membrane spermatogenesis membrane cyclin-dependent protein serine/threonine kinase regulator activity flagellated sperm motility positive regulation of cyclin-dependent protein serine/threonine kinase activity regulation of protein kinase activity |
|
| TC0100000766.mm.2 |
Sp100 |
nuclear antigen Sp100 |
1 |
85649987, 85649987, 85649987, 85650013 |
NM_013673, BC069183 NM_013673, BC069183 |
20684 |
27 |
DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding protein binding nucleus nucleus cytoplasm regulation of transcription by RNA polymerase II PML body |
|
| TC1700000614.mm.2 |
H2-Oa |
histocompatibility 2, O region alpha locus |
17 |
34092378 |
NM_008206, BC138996, BC138997 NM_008206, BC138996, BC138997 NM_008206, BC138996, BC138997 |
15001 |
30 |
negative regulation of antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding MHC class II protein complex regulation of T cell differentiation |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| MG-1-pos-10341016_st |
|
|
|
|
|
|
|
|
|
| TC0X00002999.mm.2 |
Armcx6 |
armadillo repeat containing, X-linked 6 |
X |
-134748454 |
NM_001007578, BC027264 NM_001007578, BC027264 |
278097 |
14 |
molecular_function mitochondrion mitochondrial outer membrane biological_process membrane integral component of membrane |
|
| TC0100000439.mm.2 |
Cflar |
CASP8 and FADD-like apoptosis regulator |
1 |
58713285, 58730551, 58711490, 58713285, 58711490, 58711490 |
NM_001289704, NM_009805, NM_207653, BC029223, NR_110361 NM_001289704, NM_009805, NM_207653, BC029223, NR_110361 NM_001289704, NM_009805, NM_207653, BC029223, NR_110361 NM_001289704, NM_009805, NM_207653, BC029223, NR_110361 NM_001289704, NM_009805, NM_207653, BC029223, NR_110361 |
12633 |
140 |
protease binding cysteine-type endopeptidase activity death receptor binding protein binding cytoplasm cytoplasm cytoplasm proteolysis apoptotic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process skeletal muscle tissue development enzyme activator activity cysteine-type peptidase activity response to bacterium negative regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development skeletal muscle atrophy regulation of skeletal muscle satellite cell proliferation skeletal myofibril assembly peptidase activator activity death-inducing signaling complex CD95 death-inducing signaling complex response to testosterone wound healing regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process skeletal muscle tissue regeneration protein-containing complex binding membrane raft positive regulation of NF-kappaB transcription factor activity regulation of necroptotic process negative regulation of necroptotic process positive regulation of ERK1 and ERK2 cascade cellular response to nitric oxide positive regulation of glomerular mesangial cell proliferation cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic signaling pathway cysteine-type endopeptidase activity involved in execution phase of apoptosis ripoptosome negative regulation of myoblast fusion negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extracellular matrix organization negative regulation of reactive oxygen species biosynthetic process negative regulation of cellular response to transforming growth factor beta stimulus negative regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process positive regulation of hepatocyte proliferation negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway |
04210 05142 |
| TC1300000425.mm.2 |
Ly86 |
lymphocyte antigen 86 |
13 |
37345344 |
NM_010745, BC096414 NM_010745, BC096414 |
17084 |
42 |
immune system process protein binding extracellular region inflammatory response immune response positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of lipopolysaccharide-mediated signaling pathway innate immune response |
|
| TC1000002725.mm.2 |
Socs2 |
suppressor of cytokine signaling 2 |
10 |
-95411489, -95411489, -95411489, -95411489 |
NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 NM_001168655, NM_001168656, NM_001168657, NM_007706, BC106153 |
216233 |
137 |
regulation of cell growth growth hormone receptor binding insulin-like growth factor receptor binding protein binding cytoplasm phosphatidylinositol 3-kinase complex lactation lactation JAK pathway signal transduction adaptor activity negative regulation of signal transduction response to estradiol cellular response to hormone stimulus intracellular signal transduction regulation of growth regulation of multicellular organism growth negative regulation of multicellular organism growth negative regulation of multicellular organism growth positive regulation of neuron differentiation negative regulation of receptor signaling pathway via JAK-STAT phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-kinase regulator activity growth hormone receptor signaling pathway mammary gland alveolus development mammary gland alveolus development |
04630 04910 04930 |
| TC0300003067.mm.2 |
Lmo4 |
LIM domain only 4 |
3 |
-144188529, -144188529, -144188529 |
NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 |
16911 |
153 |
neural tube closure ventricular septum development protein binding nucleus regulation of transcription by RNA polymerase II transcription factor binding ventral spinal cord interneuron differentiation spinal cord motor neuron differentiation spinal cord association neuron differentiation regulation of cell migration cell leading edge negative regulation of protein-containing complex assembly positive regulation of kinase activity regulation of cell fate specification positive regulation of transcription by RNA polymerase II metal ion binding thymus development regulation of cell activation RNA polymerase II transcription regulator complex |
|
| TC0100002210.mm.2 |
Mitd1 |
MIT, microtubule interacting and transport, domain containing 1 |
1 |
-37878887, -37874800 |
NM_026913, BC020137 NM_026913, BC020137 |
69028 |
14 |
mitotic cytokinesis endosome cell cycle membrane extrinsic component of membrane protein domain specific binding midbody negative regulation of protein binding phosphatidylinositol binding identical protein binding intracellular membrane-bounded organelle cell division midbody abscission |
|
| TC0700004516.mm.2 |
Ifitm6 |
interferon induced transmembrane protein 6 |
7 |
-141015811 |
NM_001033632, BC104338, BC104339 NM_001033632, BC104338, BC104339 NM_001033632, BC104338, BC104339 |
213002 |
19 |
molecular_function plasma membrane response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication negative regulation of viral entry into host cell defense response to virus type I interferon signaling pathway |
|
| TC0400002694.mm.2 |
Klf4 |
Kruppel-like factor 4 (gut) |
4 |
-55527136 |
NM_010637, BC010301 NM_010637, BC010301 |
16600 |
370 |
negative regulation of transcription by RNA polymerase II chromatin euchromatin transcription regulatory region sequence-specific DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity RNA polymerase II transcription factor binding RNA polymerase II transcription factor binding transcription coregulator binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific nucleic acid binding DNA binding double-stranded DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex transcription regulator complex cytoplasm transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II beta-catenin binding transcription factor binding negative regulation of cell population proliferation epidermal cell differentiation response to organic substance positive regulation of gene expression negative regulation of gene expression negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of muscle hyperplasia negative regulation of angiogenesis stem cell population maintenance cell differentiation negative regulation of cell migration post-embryonic camera-type eye development negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process response to retinoic acid negative regulation of interleukin-8 production negative regulation of heterotypic cell-cell adhesion phosphatidylinositol 3-kinase regulator activity post-embryonic hemopoiesis regulation of cell population proliferation histone deacetylase binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA-binding transcription factor activity sequence-specific DNA binding sequence-specific DNA binding positive regulation of nitric oxide biosynthetic process fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation regulation of axon regeneration regulation of axon regeneration epidermis morphogenesis positive regulation of protein metabolic process negative regulation of protein kinase B signaling positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of response to cytokine stimulus negative regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to laminar fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis regulation of blastocyst development positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of sprouting angiogenesis positive regulation of core promoter binding negative regulation of leukocyte adhesion to arterial endothelial cell cellular response to leukemia inhibitory factor sequence-specific double-stranded DNA binding promoter-specific chromatin binding negative regulation of G1/S transition of mitotic cell cycle negative regulation of chemokine (C-X-C motif) ligand 2 production |
|
| MG-1-neg-10344120_st |
|
|
|
|
|
|
|
|
|
| TC1400000784.mm.2 |
Psme1 |
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
14 |
55578493 |
NM_011189, BC088981 NM_011189, BC088981 |
19186 |
48 |
proteasome complex protein binding nucleoplasm cytoplasm proteasome activator complex positive regulation of endopeptidase activity antigen processing and presentation of exogenous antigen endopeptidase activator activity regulation of proteasomal protein catabolic process regulation of G1/S transition of mitotic cell cycle |
03050 04612 |
| TC0400002601.mm.2 |
Trim14 |
tripartite motif-containing 14 |
4 |
-46505071 |
NM_029077, BC116738, BC119130 NM_029077, BC116738, BC119130 NM_029077, BC116738, BC119130 |
74735 |
27 |
protein polyubiquitination immune system process transcription coactivator activity nucleoplasm cytoplasm cytoplasm mitochondrion mitochondrial outer membrane cytosol zinc ion binding regulation of gene expression positive regulation of autophagy membrane protein ubiquitination protein kinase binding cytoplasmic vesicle regulation of protein localization negative regulation of viral transcription protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response innate immune response regulation of viral entry into host cell metal ion binding positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity ubiquitin protein ligase activity |
|
| TC0200000697.mm.2 |
Lhx2 |
LIM homeobox protein 2 |
2 |
38339280, 38351307 |
NM_010710, BC055741 NM_010710, BC055741 |
16870 |
346 |
RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific neural tube closure hair follicle development DNA binding chromatin binding protein binding intracellular anatomical structure nucleus nucleus nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II nervous system development axon guidance brain development mesoderm development transcription factor binding dorsal/ventral pattern formation telencephalon development olfactory bulb development telencephalon regionalization telencephalon regionalization cerebral cortex development neurogenesis neuron differentiation neuron differentiation sequence-specific DNA binding maintenance of epithelial cell apical/basal polarity negative regulation of gene expression, epigenetic positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding anatomical structure formation involved in morphogenesis axon extension negative regulation of neurogenesis retina development in camera-type eye positive regulation of neural precursor cell proliferation negative regulation of transcription regulatory region DNA binding |
|
| TC1100004060.mm.2 |
Cd300lf |
CD300 molecule like family member F |
11 |
-115116213 |
NM_001169153, NM_145634, BC057864, CD300 NM_001169153, NM_145634, BC057864, CD300 NM_001169153, NM_145634, BC057864, CD300 NM_001169153, NM_145634, BC057864, CD300 |
246746 |
50 |
virus receptor activity phosphatidylserine binding immune system process transmembrane signaling receptor activity interleukin-4 receptor binding protein binding plasma membrane lipid binding membrane integral component of membrane osteoclast differentiation negative regulation of mast cell activation negative regulation of mast cell activation negative regulation of MyD88-dependent toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway interleukin-13-mediated signaling pathway ceramide binding ceramide binding positive regulation of interleukin-4-mediated signaling pathway negative regulation of apoptotic cell clearance positive regulation of apoptotic cell clearance positive regulation of apoptotic cell clearance |
|
| TC1400000892.mm.2 |
|
|
|
|
NM_001034910, NR_046019, BC146022, BC146024 NM_001034910, NR_046019, BC146022, BC146024 NM_001034910, NR_046019, BC146022, BC146024 NM_001034910, NR_046019, BC146022, BC146024 |
|
|
molecular_function cellular_component extracellular region defense response biological_process defense response to bacterium |
|
| TC0X00002476.mm.2 |
|
|
|
|
NM_001039373, NM_010839, BC138811, BC138812 NM_001039373, NM_010839, BC138811, BC138812 NM_001039373, NM_010839, BC138811, BC138812 NM_001039373, NM_010839, BC138811, BC138812 |
|
|
mitochondrion mitochondrion mitochondrion mitochondrial intermembrane space positive regulation of peptidyl-serine phosphorylation protein serine/threonine kinase activator activity |
|
| TC0200000382.mm.2 |
Il1rn |
interleukin 1 receptor antagonist |
2 |
24345370, 24345290, 24336859 |
NM_001039701, NM_001159562, NM_031167, BC042532 NM_001039701, NM_001159562, NM_031167, BC042532 NM_001039701, NM_001159562, NM_031167, BC042532 NM_001039701, NM_001159562, NM_031167, BC042532 |
16181 |
185 |
fever generation inflammatory response to antigenic stimulus cytokine activity interleukin-1 receptor binding interleukin-1, type I receptor binding interleukin-1, type II receptor binding interleukin-1 receptor antagonist activity interleukin-1 receptor antagonist activity extracellular region extracellular space extracellular space cytoplasm lipid metabolic process acute-phase response inflammatory response immune response memory negative regulation of glutamate secretion sensory perception of pain insulin secretion negative regulation of cell migration vesicle negative regulation of heterotypic cell-cell adhesion negative regulation of apoptotic process positive regulation of JUN kinase activity interleukin-1 type I receptor antagonist activity interleukin-1 type II receptor antagonist activity negative regulation of membrane potential response to glucocorticoid negative regulation of interleukin-1-mediated signaling pathway negative regulation of interleukin-1-mediated signaling pathway |
|
| TC0700003938.mm.2 |
Trim12a |
tripartite motif-containing 12A |
7 |
-104299896, -104303594 |
NM_023835, BC094899 NM_023835, BC094899 |
76681 |
20 |
protein polyubiquitination ubiquitin-protein transferase activity nucleoplasm cytoplasm cytoplasm cytosol autophagy zinc ion binding regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding regulation of protein localization protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell metal ion binding positive regulation of NF-kappaB transcription factor activity defense response to virus ubiquitin protein ligase activity |
|
| TC0800000817.mm.2 |
Hsh2d |
hematopoietic SH2 domain containing |
8 |
72189667 |
NM_197944, BC094291 NM_197944, BC094291 |
209488 |
18 |
negative regulation of B cell apoptotic process cytoplasm mitochondrion cytosol signal transduction protein-macromolecule adaptor activity T cell activation negative regulation of mitochondrial depolarization |
|
| TC0100001468.mm.2 |
Tnfsf4 |
tumor necrosis factor (ligand) superfamily, member 4 |
1 |
161395437 |
NM_009452, BC153120 NM_009452, BC153120 |
22164 |
112 |
blood vessel development negative regulation of cytokine production positive regulation of cytokine production defense response to nematode acute inflammatory response positive regulation of immunoglobulin production positive regulation of immune effector process positive regulation of T cell cytokine production regulation of adaptive immune response positive regulation of type 2 immune response positive regulation of type 2 immune response positive regulation of immunoglobulin mediated immune response cytokine activity tumor necrosis factor receptor binding protein binding extracellular space extracellular space inflammatory response inflammatory response immune response cholesterol metabolic process response to virus cell surface membrane integral component of membrane negative regulation of interferon-gamma production negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of interleukin-4 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor superfamily binding memory T cell activation T-helper 2 cell activation response to nitrogen dioxide cellular response to nitrogen dioxide CD4-positive, alpha-beta T cell costimulation T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of memory T cell differentiation negative regulation of DNA-binding transcription factor activity innate immune response negative regulation of regulatory T cell differentiation negative regulation of T-helper 1 cell differentiation positive regulation of T-helper 2 cell differentiation negative regulation of transcription, DNA-templated positive regulation of alpha-beta T cell proliferation regulation of inflammatory response positive regulation of inflammatory response positive regulation of B cell activation negative regulation of T cell apoptotic process negative regulation of activation-induced cell death of T cells cellular response to lipopolysaccharide cellular response to lipopolysaccharide cellular response to prostaglandin E stimulus chemokine (C-C motif) ligand 11 production positive regulation of CD4-positive, alpha-beta T cell costimulation positive regulation of T cell migration positive regulation of T cell costimulation positive regulation of memory T cell activation positive regulation of T-helper 2 cell activation positive regulation of interleukin-4-dependent isotype switching to IgE isotypes negative regulation of extrinsic apoptotic signaling pathway |
04060 |
| TC1800001130.mm.2 |
Gypc |
glycophorin C |
18 |
-32528319 |
NM_001048207, BC027408 NM_001048207, BC027408 |
71683 |
17 |
plasma membrane membrane membrane integral component of membrane cortical cytoskeleton cortical cytoskeleton cortical cytoskeleton |
05144 |
| TC0900001018.mm.2 |
Lysmd2 |
LysM, putative peptidoglycan-binding, domain containing 2 |
9 |
75625731 |
NM_027309, BC048545 NM_027309, BC048545 |
70082 |
15 |
molecular_function cellular_component biological_process |
|
| MG-1-pos-10341579_st |
|
|
|
|
|
|
|
|
|
| TC0600003264.mm.2 |
Klra2 |
killer cell lectin-like receptor, subfamily A, member 2 |
6 |
-131219234 |
NM_001170851, NM_008462, BC064711 NM_001170851, NM_008462, BC064711 NM_001170851, NM_008462, BC064711 |
16633 |
25 |
plasma membrane cell adhesion membrane integral component of membrane carbohydrate binding |
|
| TC0600002099.mm.2 |
Zc3hav1 |
zinc finger CCCH type, antiviral 1 |
6 |
-38305285, -38315671, -38310496 |
NM_028421, NM_028864, BC029090 NM_028421, NM_028864, BC029090 NM_028421, NM_028864, BC029090 |
78781 |
28 |
immune system process RNA binding NAD+ ADP-ribosyltransferase activity nucleus nucleus cytoplasm cytoplasm lysosome late endosome cytosol response to virus DEAD/H-box RNA helicase binding positive regulation of type I interferon production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of ATPase activity identical protein binding positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of viral genome replication innate immune response metal ion binding regulation of defense response to virus by host defense response to virus positive regulation of mRNA catabolic process cellular response to exogenous dsRNA cellular response to virus positive regulation of RIG-I signaling pathway positive regulation of RIG-I signaling pathway |
|
| TC0700000050.mm.2 |
Ssc5d |
scavenger receptor cysteine rich family, 5 domains |
7 |
4925820 |
NM_173008, BC141044 NM_173008, BC141044 |
269855 |
14 |
fibronectin binding immune system process scavenger receptor activity protein binding extracellular region extracellular region extracellular space extracellular space extracellular space cytoplasm defense response defense response multicellular organism development membrane extracellular matrix regulation of interleukin-8 production negative regulation of interleukin-8 production detection of bacterial lipoprotein detection of bacterial lipoprotein laminin binding innate immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium extracellular matrix binding extracellular matrix binding collagen-containing extracellular matrix |
|
| TC1900000111.mm.2 |
Ehd1 |
EH-domain containing 1 |
19 |
6276895 |
NM_010119, BC043332, BC054828 NM_010119, BC043332, BC054828 NM_010119, BC043332, BC054828 |
13660 |
48 |
nucleotide binding calcium ion binding protein binding ATP binding GTP binding cytoplasm endosome early endosome early endosome lipid droplet plasma membrane plasma membrane cilium intracellular protein transport endocytosis endocytosis endocytosis endosome membrane positive regulation of cholesterol storage positive regulation of neuron projection development protein transport membrane endosomal transport endosomal transport ciliary pocket membrane cell projection organization endocytic vesicle endocytic vesicle platelet dense tubular network membrane neuron projection development small GTPase binding cytoplasmic vesicle early endosome membrane endocytic recycling endocytic recycling low-density lipoprotein particle clearance cholesterol homeostasis identical protein binding cell projection myelin sheath intracellular membrane-bounded organelle metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm protein homooligomerization recycling endosome membrane recycling endosome membrane cilium assembly cilium assembly cilium assembly protein localization to cilium protein localization to plasma membrane positive regulation of myoblast fusion cellular response to nerve growth factor stimulus positive regulation of endocytic recycling |
04144 |
| TC0400001091.mm.2 |
Plpp3 |
phospholipid phosphatase 3 |
4 |
105157346 |
NM_080555, BC005558 NM_080555, BC005558 |
67916 |
46 |
blood vessel development gastrulation with mouth forming second negative regulation of protein phosphorylation negative regulation of protein phosphorylation integrin binding integrin binding endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus trans-Golgi network plasma membrane integral component of plasma membrane lipid metabolic process phospholipid metabolic process phospholipid metabolic process phospholipid metabolic process sphingosine metabolic process ceramide metabolic process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cell adhesion signal transduction integrin-mediated signaling pathway multicellular organism development phosphatidate phosphatase activity phosphatidate phosphatase activity membrane integral component of membrane basolateral plasma membrane hydrolase activity regulation of Wnt signaling pathway endoplasmic reticulum-Golgi intermediate compartment membrane cell-cell adhesion mediated by integrin homotypic cell-cell adhesion sphingosine-1-phosphate phosphatase activity sphingosine-1-phosphate phosphatase activity sphingosine-1-phosphate phosphatase activity lipid phosphatase activity lipid phosphatase activity canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion canonical Wnt signaling pathway involved in positive regulation of wound healing membrane raft phospholipid dephosphorylation phospholipid dephosphorylation positive regulation of peptidyl-tyrosine phosphorylation protein stabilization protein stabilization positive regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity Bergmann glial cell differentiation canonical Wnt signaling pathway canonical Wnt signaling pathway endoplasmic reticulum exit site cell-cell adhesion ceramide-1-phosphate phosphatase activity regulation of sphingolipid mediated signaling pathway |
00561 00564 00565 00600 01100 04666 04975 |
| TC0900001576.mm.2 |
Acaa1a |
acetyl-Coenzyme A acyltransferase 1A |
9 |
119341293 |
NM_130864, BC012400 NM_130864, BC012400 |
113868 |
30 |
very long-chain fatty acid metabolic process catalytic activity acetyl-CoA C-acetyltransferase activity acetyl-CoA C-acyltransferase activity acetyl-CoA C-acyltransferase activity mitochondrion peroxisome peroxisome peroxisome peroxisome peroxisomal matrix lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation fatty acid beta-oxidation bile acid metabolic process acetate CoA-transferase activity phenylacetate catabolic process palmitoyl-CoA oxidase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups acetyl-CoA C-myristoyltransferase activity |
00071 00280 01040 01100 03320 04146 |
| TC1100003663.mm.2 |
Arl5c |
ADP-ribosylation factor-like 5C |
11 |
-97989579 |
NM_207231, BC065791 NM_207231, BC065791 |
217151 |
11 |
nucleotide binding GTP binding cytoplasm trans-Golgi network intracellular protein transport vesicle-mediated transport protein localization to Golgi membrane |
|
| TC0800001875.mm.2 |
Ap3m2 |
adaptor-related protein complex 3, mu 2 subunit |
8 |
-22787353 |
NM_001122820, NM_029505, BC027301, BC030484 NM_001122820, NM_029505, BC027301, BC030484 NM_001122820, NM_029505, BC027301, BC030484 NM_001122820, NM_029505, BC027301, BC030484 |
64933 |
20 |
Golgi apparatus intracellular protein transport endocytosis anterograde axonal transport protein transport membrane vesicle-mediated transport clathrin adaptor complex cytoplasmic vesicle intracellular membrane-bounded organelle anterograde synaptic vesicle transport |
04142 |
| TC1900000221.mm.2 |
Ms4a6c |
membrane-spanning 4-domains, subfamily A, member 6C |
19 |
11469367, 11469367 |
NM_001166376, NM_028595, BC062247 NM_001166376, NM_028595, BC062247 NM_001166376, NM_028595, BC062247 |
73656 |
13 |
membrane integral component of membrane |
|
| TC0400001525.mm.2 |
Marcksl1 |
MARCKS-like 1 |
4 |
129513580 |
NM_010807, BC006757 NM_010807, BC006757 |
17357 |
47 |
actin binding calmodulin binding cytoplasm cytoskeleton plasma membrane plasma membrane actin filament organization central nervous system development synaptic vesicle positive regulation of cell population proliferation membrane actin filament binding anchored component of presynaptic membrane presynaptic cytosol voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels |
04666 05140 |
| MG-1-pos-10338706_st |
|
|
|
|
|
|
|
|
|
| TC1900001137.mm.2 |
Ms4a6d |
membrane-spanning 4-domains, subfamily A, member 6D |
19 |
-11586605 |
NM_026835, BC018331, BC029738 NM_026835, BC018331, BC029738 NM_026835, BC018331, BC029738 |
68774 |
17 |
molecular_function trans-Golgi network biological_process membrane integral component of membrane |
|
| TC0900002770.mm.2 |
Tent5a |
terminal nucleotidyltransferase 5A |
9 |
-85320438, -85320438 |
NM_001160378, NM_001160379 NM_001160378, NM_001160379 |
212943 |
17 |
cellular_component response to bacterium mRNA stabilization RNA adenylyltransferase activity |
|
| TC0200003599.mm.2 |
Cd302 |
CD302 antigen |
2 |
-60251992 |
NM_025422, BC005501, CD302 NM_025422, BC005501, CD302 NM_025422, BC005501, CD302 |
66205 |
16 |
cytoplasm cell cortex phagocytosis external side of plasma membrane membrane integral component of membrane filopodium carbohydrate binding signaling receptor activity cell projection |
|
| TC1100004242.mm.2 |
Sectm1a |
secreted and transmembrane 1A |
11 |
-121067402 |
NM_145373, BC010462 NM_145373, BC010462 |
209588 |
15 |
cytokine activity extracellular region plasma membrane immune response membrane integral component of membrane integral component of membrane |
|
| TC1900000224.mm.2 |
Gm8369 |
predicted gene 8369 |
19 |
11492037 |
NM_001164202 |
666926 |
8 |
molecular_function cellular_component biological_process |
|
| TC1100000850.mm.2 |
Sco1 |
SCO1 cytochrome c oxidase assembly protein |
11 |
67052669 |
NM_001040026, BC139008, BC139009 NM_001040026, BC139008, BC139009 NM_001040026, BC139008, BC139009 |
52892 |
19 |
molecular_function mitochondrion mitochondrion mitochondrial inner membrane cellular copper ion homeostasis membrane integral component of membrane myofibril integral component of mitochondrial inner membrane mitochondrial cytochrome c oxidase assembly mitochondrial cytochrome c oxidase assembly mitochondrial cytochrome c oxidase assembly cell redox homeostasis metal ion binding negative regulation of proteasomal protein catabolic process |
|
| TC0200004111.mm.2 |
Ddb2 |
damage specific DNA binding protein 2 |
2 |
-91211581, -91211580 |
NM_028119, BC099410 NM_028119, BC099410 |
107986 |
33 |
protein polyubiquitination DNA binding damaged DNA binding damaged DNA binding ubiquitin-protein transferase activity nucleus nucleoplasm DNA repair pyrimidine dimer repair cellular response to DNA damage stimulus response to UV response to UV cell junction Cul4B-RING E3 ubiquitin ligase complex protein-containing complex histone H2A monoubiquitination protein-containing complex binding protein autoubiquitination UV-damage excision repair Cul4-RING E3 ubiquitin ligase complex |
03420 04115 04120 |
| TC1900000580.mm.2 |
Ccnj |
cyclin J |
19 |
40831278 |
NM_172839, BC117559, BC120921, BC120922 NM_172839, BC117559, BC120921, BC120922 NM_172839, BC117559, BC120921, BC120922 NM_172839, BC117559, BC120921, BC120922 |
240665 |
11 |
regulation of cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm centrosome cyclin-dependent protein serine/threonine kinase regulator activity mitotic cell cycle phase transition |
|
| TC1200000278.mm.2 |
Ccdc71l |
coiled-coil domain containing 71 like |
12 |
32378788 |
NM_001162903 |
72123 |
9 |
molecular_function cellular_component biological_process |
|
| TC0500003258.mm.2 |
Rilpl1 |
Rab interacting lysosomal protein-like 1 |
5 |
-124493079 |
NM_021430, BC051945, BC051946, BC058384 NM_021430, BC051945, BC051946, BC058384 NM_021430, BC051945, BC051946, BC058384 NM_021430, BC051945, BC051946, BC058384 |
75695 |
22 |
epithelial cell morphogenesis nucleoplasm cytoplasm centrosome cytosol cytoskeleton plasma membrane cilium protein transport ciliary basal body cell projection protein dimerization activity cilium assembly regulation of neuron death regulation of neuron death protein transport from ciliary membrane to plasma membrane |
|
| TC0300001802.mm.2 |
Gnb4 |
guanine nucleotide binding protein (G protein), beta 4 |
3 |
-32578586, -32580331, -32580331 |
NM_013531, BC028753 NM_013531, BC028753 |
14696 |
37 |
GTPase activity cytoplasm heterotrimeric G-protein complex heterotrimeric G-protein complex signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway G-protein gamma-subunit binding myelin sheath cell body protein-containing complex binding |
04062 |
| TC0900001445.mm.2 |
Map4 |
microtubule-associated protein 4 |
9 |
109931773, 110052020, 109931773 |
NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 |
17758 |
53 |
microtubule cytoskeleton organization microtubule cytoskeleton organization protein binding cytoplasm cytosol cytoskeleton microtubule plasma membrane axoneme mitotic spindle organization mitotic spindle organization microtubule binding microtubule binding postsynaptic density microtubule cytoskeleton tubulin binding axon neuron projection development neuron projection microtubule sliding microtubule sliding establishment of spindle orientation establishment of spindle orientation cell division mitotic spindle negative regulation of non-motile cilium assembly |
|
| TC1300002047.mm.2 |
Hk3 |
hexokinase 3 |
13 |
-55005984, -55005984 |
NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 |
212032 |
20 |
nucleotide binding cellular glucose homeostasis catalytic activity glucokinase activity glucokinase activity hexokinase activity ATP binding glucose binding mitochondrion mitochondrion cytosol carbohydrate metabolic process fructose 6-phosphate metabolic process glycolytic process metabolic process fructokinase activity fructokinase activity kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor mannokinase activity enzyme binding protein-containing complex hormone binding glucose 6-phosphate metabolic process glucose 6-phosphate metabolic process negative regulation of hydrogen peroxide-mediated programmed cell death |
00010 00051 00052 00500 00520 00524 01100 04910 04930 04973 |
| TC0400002198.mm.2 |
Plekhf2 |
pleckstrin homology domain containing, family F (with FYVE domain) member 2 |
4 |
-10988661 |
NM_175175, BC016134, BC039276 NM_175175, BC016134, BC039276 NM_175175, BC016134, BC039276 |
71801 |
23 |
endosome endoplasmic reticulum protein transport membrane transport vesicle phosphatidylinositol binding metal ion binding |
|
| TC0700001174.mm.2 |
Whamm |
WAS protein homolog associated with actin, golgi membranes and microtubules |
7 |
81571291 |
NM_001004185, BC042749, BC050804 NM_001004185, BC042749, BC050804 NM_001004185, BC042749, BC050804 |
434204 |
14 |
Golgi membrane actin binding cytoplasm Golgi apparatus cytosol microtubule endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport actin filament organization cell cycle arrest microtubule binding membrane lamellipodium assembly small GTPase binding cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment membrane Arp2/3 complex-mediated actin nucleation focal adhesion assembly positive regulation of actin nucleation Arp2/3 complex binding Arp2/3 complex binding actin filament reorganization plasma membrane tubulation |
|
| TC1400000358.mm.2 |
Arhgap22 |
Rho GTPase activating protein 22 |
14 |
33216822 |
NM_153800, BC038272 NM_153800, BC038272 |
239027 |
16 |
angiogenesis GTPase activator activity nucleus cytoplasm signal transduction multicellular organism development cell differentiation activation of GTPase activity glutamatergic synapse regulation of postsynapse organization |
|
| TC1100001076.mm.2 |
Inpp5k |
inositol polyphosphate 5-phosphatase K |
11 |
75631019 |
NM_008916, BC014725, BC066112 NM_008916, BC014725, BC066112 NM_008916, BC014725, BC066112 |
19062 |
31 |
in utero embryonic development ruffle ruffle negative regulation of protein phosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity vasopressin receptor activity protein binding nucleus cytoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum trans-Golgi network cytosol plasma membrane plasma membrane regulation of glycogen biosynthetic process negative regulation of protein kinase activity G protein-coupled receptor signaling pathway negative regulation of peptidyl-threonine phosphorylation negative regulation of glucose transmembrane transport membrane dephosphorylation dephosphorylation inositol bisphosphate phosphatase activity inositol bisphosphate phosphatase activity inositol bisphosphate phosphatase activity hydrolase activity ruffle membrane response to insulin cellular response to insulin stimulus cellular response to hormone stimulus negative regulation of peptidyl-serine phosphorylation negative regulation of peptidyl-serine phosphorylation negative regulation of peptidyl-serine phosphorylation phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol trisphosphate phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity negative regulation of dephosphorylation positive regulation of urine volume glucose homeostasis neuron projection negative regulation of MAP kinase activity negative regulation by host of viral transcription negative regulation of glycogen biosynthetic process negative regulation of glycogen biosynthetic process negative regulation of glycogen biosynthetic process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated inositol trisphosphate phosphatase activity negative regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway inositol phosphate dephosphorylation inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation phosphatidylinositol dephosphorylation perinuclear region of cytoplasm negative regulation of stress fiber assembly negative regulation of protein kinase B signaling negative regulation of protein kinase B signaling negative regulation of protein kinase B signaling negative regulation of calcium ion transport inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity cellular response to cAMP cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus protein localization to plasma membrane negative regulation of protein targeting to membrane ruffle assembly negative regulation of glycogen (starch) synthase activity positive regulation of renal water transport |
00562 01100 04070 04910 |
| TC1900000689.mm.2 |
Nfkb2 |
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 |
19 |
46305694, 46304736, 46305929 |
NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 |
18034 |
204 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific follicular dendritic cell differentiation germinal center formation DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II signal transduction extracellular matrix organization Bcl3/NF-kappaB2 complex NIK/NF-kappaB signaling positive regulation of transcription by RNA polymerase II rhythmic process lymph node development spleen development sequence-specific double-stranded DNA binding |
04010 04380 05200 |
| TC1700002779.mm.2 |
H2-DMb2 |
histocompatibility 2, class II, locus Mb2 |
17 |
34145248, 34143228 |
NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 |
15000 |
23 |
protein binding lysosome lysosomal membrane lysosomal membrane late endosome multivesicular body endosome membrane integral component of membrane antigen processing and presentation antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II MHC class II protein complex binding late endosome membrane MHC class II protein complex intracellular membrane-bounded organelle chaperone cofactor-dependent protein refolding |
04145 04514 04612 04672 04940 05140 05145 05150 05310 05320 05322 05323 05330 05332 05416 |
| TC0600000609.mm.2 |
Snx10 |
sorting nexin 10 |
6 |
51524259, 51545292, 51524083, 51544522, 51523902 |
NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 |
71982 |
30 |
gastric acid secretion 1-phosphatidylinositol binding nucleus nucleus cytoplasm endosome endoplasmic reticulum endoplasmic reticulum centrosome cytoskeleton endocytosis endosome organization lipid binding protein transport membrane cell projection organization secretory granule osteoclast differentiation extrinsic component of endosome membrane phosphatidylinositol binding bone mineralization involved in bone maturation tooth eruption bone resorption bone remodeling ATPase binding calcium ion homeostasis cilium assembly protein localization to cilium protein localization to centrosome apical cytoplasm ruffle assembly cellular response to leukemia inhibitory factor |
|
| TC0100001496.mm.2 |
Sell |
selectin, lymphocyte |
1 |
164062075 |
NM_001164059, NM_011346, BC052681 NM_001164059, NM_011346, BC052681 NM_001164059, NM_011346, BC052681 |
20343 |
263 |
protease binding calcium ion binding protein binding plasma membrane integral component of plasma membrane cell adhesion external side of plasma membrane cell surface cell surface membrane integral component of membrane calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules carbohydrate binding response to ATP regulation of apoptotic process metal ion binding cell adhesion molecule binding leukocyte migration leukocyte tethering or rolling glycolipid binding oligosaccharide binding positive regulation of neutrophil chemotaxis |
04514 |
| TC1300002274.mm.2 |
Tent4a |
terminal nucleotidyltransferase 4A |
13 |
-69497958 |
NM_001169131, NM_198600, BC059846 NM_001169131, NM_198600, BC059846 NM_001169131, NM_198600, BC059846 |
210106 |
17 |
nucleotide binding polynucleotide adenylyltransferase activity ATP binding nucleus nucleoplasm nucleolus cytoplasm Golgi apparatus mRNA processing transferase activity nucleotidyltransferase activity RNA 3'-end processing TRAMP complex nuclear membrane response to drug RNA polyadenylation metal ion binding negative regulation of nuclear-transcribed mRNA poly(A) tail shortening guanylyltransferase activity RNA 3' uridylation positive regulation of 3'-UTR-mediated mRNA stabilization |
03018 |
| TC0300002236.mm.2 |
Tlr2 |
toll-like receptor 2 |
3 |
-83836271 |
NM_011905, BC014693 NM_011905, BC014693 |
24088 |
1802 |
lipopolysaccharide binding amyloid-beta binding amyloid-beta binding microglial cell activation cell activation regulation of cytokine production positive regulation of cytokine production toll-like receptor signaling pathway toll-like receptor signaling pathway response to molecule of bacterial origin response to molecule of fungal origin immune system process positive regulation of leukocyte migration regulation of dendritic cell cytokine production cell surface pattern recognition receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway protein binding cytoplasm Golgi apparatus plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane leukotriene metabolic process defense response inflammatory response inflammatory response signal transduction I-kappaB phosphorylation learning negative regulation of cell population proliferation response to bacterium external side of plasma membrane cell surface positive regulation of gene expression microglia development membrane integral component of membrane hydrolase activity positive regulation of Wnt signaling pathway negative regulation of actin filament polymerization intrinsic component of plasma membrane cytoplasmic vesicle central nervous system myelin formation response to bacterial lipoprotein response to peptidoglycan interleukin-10 production negative regulation of interleukin-12 production negative regulation of interleukin-17 production positive regulation of chemokine production positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor signaling pathway toll-like receptor 2 signaling pathway Toll-like receptor binding Toll-like receptor 1-Toll-like receptor 2 protein complex Toll-like receptor 2-Toll-like receptor 6 protein complex signaling receptor activity pattern recognition receptor activity detection of triacyl bacterial lipopeptide detection of diacyl bacterial lipopeptide triacyl lipopeptide binding triacyl lipopeptide binding triacyl lipopeptide binding diacyl lipopeptide binding identical protein binding peptidoglycan binding cell projection cell body protein-containing complex binding protein-containing complex binding innate immune response membrane raft positive regulation of nitric oxide biosynthetic process positive regulation of transcription by RNA polymerase II nitric oxide metabolic process positive regulation of oligodendrocyte differentiation NAD(P)+ nucleosidase activity positive regulation of inflammatory response positive regulation of inflammatory response negative regulation of phagocytosis negative regulation of phagocytosis defense response to Gram-positive bacterium defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity positive regulation of nitric-oxide synthase biosynthetic process negative regulation of synapse assembly positive regulation of macrophage cytokine production NAD+ nucleotidase, cyclic ADP-ribose generating positive regulation of ERK1 and ERK2 cascade response to fatty acid lipoteichoic acid binding cellular response to bacterial lipopeptide cellular response to bacterial lipopeptide cellular response to lipoteichoic acid cellular response to lipoteichoic acid cellular response to peptidoglycan cellular response to interferon-gamma lipopeptide binding cellular response to diacyl bacterial lipopeptide cellular response to triacyl bacterial lipopeptide positive regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of cellular response to macrophage colony-stimulating factor stimulus positive regulation of xenophagy positive regulation of matrix metallopeptidase secretion |
04145 04620 05140 05142 05144 05145 05146 05323 |
| MG-1-neg-10340905_st |
|
|
|
|
|
|
|
|
|
| TC0900002155.mm.2 |
Hinfp |
histone H4 transcription factor |
9 |
-44295672 |
NM_172162, BC029091 NM_172162, BC029091 |
102423 |
28 |
DNA damage checkpoint G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle negative regulation of transcription by RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific in utero embryonic development nucleic acid binding DNA binding chromatin binding DNA-binding transcription factor activity DNA-binding transcription factor activity nucleus nucleoplasm DNA repair transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of gene expression positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression Cajal body enzyme binding histone binding establishment of protein localization myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II metal ion binding anatomical structure development |
|
| TC0300001136.mm.2 |
Psma5 |
proteasome subunit alpha 5 |
3 |
108256925 |
NM_011967, BC010709, BC083342, BC108368 NM_011967, BC010709, BC083342, BC108368 NM_011967, BC010709, BC083342, BC108368 NM_011967, BC010709, BC083342, BC108368 |
26442 |
26 |
proteasome complex endopeptidase activity threonine-type endopeptidase activity nucleus nucleoplasm cytoplasm cytosol cytosol proteasome core complex proteasome core complex ubiquitin-dependent protein catabolic process proteasomal ubiquitin-independent protein catabolic process proteasome core complex, alpha-subunit complex proteasome core complex, alpha-subunit complex proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process |
03050 |
| TC0300001232.mm.2 |
Cnn3 |
calponin 3, acidic |
3 |
121426540 |
NM_028044, BC055711, BC085268 NM_028044, BC055711, BC085268 NM_028044, BC055711, BC085268 |
71994 |
43 |
actin binding protein binding calmodulin binding cytosol microtubule binding postsynaptic density actin cytoskeleton dendrite actomyosin structure organization negative regulation of ATPase activity neuronal cell body dendritic spine |
|
| TC0900000730.mm.2 |
Stoml1 |
stomatin-like 1 |
9 |
58253163 |
NM_026942, NR_028146, BC037074 NM_026942, NR_028146, BC037074 NM_026942, NR_028146, BC037074 |
69106 |
23 |
endosome plasma membrane plasma membrane lipid transport ion channel inhibitor activity membrane integral component of membrane cytoplasmic vesicle SMAD protein signal transduction negative regulation of acid-sensing ion channel activity cellular response to leukemia inhibitory factor |
|
| TC0400003249.mm.2 |
Prpf38a |
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A |
4 |
-108564866 |
NM_172697, BC139277, BC139305 NM_172697, BC139277, BC139305 NM_172697, BC139277, BC139305 |
230596 |
16 |
mRNA splicing, via spliceosome nucleus nucleoplasm spliceosomal complex mRNA processing RNA splicing U2-type precatalytic spliceosome precatalytic spliceosome precatalytic spliceosome |
03040 |
| TC0900000599.mm.2 |
Il18 |
interleukin 18 |
9 |
50554699 |
NM_008360, BC024384 NM_008360, BC024384 |
16173 |
586 |
MAPK cascade angiogenesis angiogenesis response to hypoxia cytokine activity cytokine activity cytokine activity extracellular region extracellular space extracellular space cytoplasm inflammatory response inflammatory response immune response cell population proliferation cell population proliferation extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration apical plasma membrane natural killer cell activation regulation of cell adhesion regulation of cell adhesion sleep sleep lipopolysaccharide-mediated signaling pathway activation of protein kinase B activity interferon-gamma production interleukin-13 production interleukin-6 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interferon-gamma production positive regulation of interferon-gamma production positive regulation of interleukin-17 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation positive regulation of superoxide anion generation positive regulation of collagen biosynthetic process negative regulation of neutrophil apoptotic process interleukin-18-mediated signaling pathway interleukin-18-mediated signaling pathway T-helper 1 cell cytokine production T-helper 1 cell cytokine production T-helper 1 type immune response T-helper 1 type immune response positive regulation of activated T cell proliferation positive regulation of activated T cell proliferation neutrophil activation natural killer cell mediated cytotoxicity positive regulation of tyrosine phosphorylation of STAT protein cholesterol homeostasis positive regulation of apoptotic process positive regulation of vascular permeability positive regulation of neuron apoptotic process interleukin-18 receptor binding positive regulation of T-helper 2 cell differentiation negative regulation of myoblast differentiation positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle cell proliferation negative regulation of peptidyl-tyrosine phosphorylation detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity positive regulation of NK T cell proliferation positive regulation of protein kinase B signaling triglyceride homeostasis cellular response to peptide hormone stimulus cellular response to organic cyclic compound positive regulation of cold-induced thermogenesis positive regulation of NIK/NF-kappaB signaling positive regulation of male germ cell proliferation positive regulation of hepatocyte proliferation positive regulation of blood vessel remodeling positive regulation of T-helper 1 cell cytokine production |
04060 04621 04623 05143 05144 05323 |
| TC1700000990.mm.2 |
Adgre4 |
adhesion G protein-coupled receptor E4 |
17 |
55749983 |
NM_139138, BC120538, BC120540 NM_139138, BC120538, BC120540 NM_139138, BC120538, BC120540 |
52614 |
19 |
transmembrane signaling receptor activity G protein-coupled receptor activity calcium ion binding plasma membrane integral component of plasma membrane integral component of plasma membrane signal transduction cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway cell surface membrane integral component of membrane |
|
| TC1900000467.mm.2 |
Papss2 |
3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
19 |
32620004, 32595714 |
NM_001201470, NM_011864, BC090997 NM_001201470, NM_011864, BC090997 NM_001201470, NM_011864, BC090997 |
23972 |
59 |
sulfate assimilation sulfate assimilation nucleotide binding catalytic activity adenylylsulfate kinase activity adenylylsulfate kinase activity sulfate adenylyltransferase (ATP) activity ATP binding blood coagulation metabolic process kinase activity transferase activity nucleotidyltransferase activity 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process bone development |
00230 00450 00920 01100 |
| TC1300002126.mm.2 |
Tut7 |
terminal uridylyl transferase 7 |
13 |
-59771878, -59771875 |
NM_153538, BC023880, BC043111 NM_153538, BC023880, BC043111 NM_153538, BC023880, BC043111 |
214290 |
28 |
oocyte maturation nucleic acid binding nucleoplasm cytoplasm cytosol zinc ion binding negative regulation of transposition, RNA-mediated miRNA metabolic process transferase activity nucleotidyltransferase activity pre-miRNA processing RNA 3'-end processing RNA 3'-end processing miRNA binding metal ion binding RNA uridylyltransferase activity RNA uridylyltransferase activity uridylyltransferase activity uridylyltransferase activity RNA 3' uridylation RNA 3' uridylation RNA 3' uridylation polyuridylation-dependent mRNA catabolic process |
|
| TC0500000221.mm.2 |
Nub1 |
negative regulator of ubiquitin-like proteins 1 |
5 |
24685814 |
NM_016736, BC037451 NM_016736, BC037451 |
53312 |
27 |
molecular_function nucleus nucleoplasm nucleolus cytosol ubiquitin-dependent protein catabolic process protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of ubiquitin-dependent protein catabolic process |
|
| TC1300001794.mm.2 |
Eci2 |
enoyl-Coenzyme A delta isomerase 2 |
13 |
-34977747 |
NM_001110331, NM_011868, NR_073427, BC001983, NM_001110332 NM_001110331, NM_011868, NR_073427, BC001983, NM_001110332 NM_001110331, NM_011868, NR_073427, BC001983, NM_001110332 NM_001110331, NM_011868, NR_073427, BC001983, NM_001110332 NM_001110331, NM_011868, NR_073427, BC001983, NM_001110332 |
23986 |
21 |
fatty-acyl-CoA binding catalytic activity dodecenoyl-CoA delta-isomerase activity dodecenoyl-CoA delta-isomerase activity dodecenoyl-CoA delta-isomerase activity mitochondrion mitochondrion mitochondrion peroxisome peroxisome peroxisomal matrix peroxisomal matrix fatty acid beta-oxidation fatty acid catabolic process fatty acid catabolic process isomerase activity intramolecular oxidoreductase activity, transposing C=C bonds intracellular membrane-bounded organelle |
00071 04146 |
| TC1500000632.mm.2 |
Apol9b |
apolipoprotein L 9b |
15 |
77729071, 77729120 |
NM_001168660, NM_173743 NM_001168660, NM_173743 |
71898 |
11 |
cellular_component biological_process lipid binding |
|
| TC0600002351.mm.2 |
Ppm1k |
protein phosphatase 1K (PP2C domain containing) |
6 |
-57506501 |
NM_175523, BC092238, BC138473, BC138474 NM_175523, BC092238, BC138473, BC138474 NM_175523, BC092238, BC138473, BC138474 NM_175523, BC092238, BC138473, BC138474 |
243382 |
30 |
catalytic activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity mitochondrion mitochondrion protein dephosphorylation hydrolase activity cation binding metal ion binding |
|
| TC0900001142.mm.2 |
Bcl2a1a |
B cell leukemia/lymphoma 2 related protein A1a |
9 |
88956919 |
NM_009742 |
12044 |
56 |
B cell homeostasis negative regulation of B cell apoptotic process protein binding cytoplasm mitochondrial outer membrane apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage protein homodimerization activity regulation of apoptotic process negative regulation of apoptotic process protein-containing complex binding protein heterodimerization activity BH domain binding extrinsic apoptotic signaling pathway in absence of ligand |
|
| TC0200003313.mm.2 |
Stxbp1 |
syntaxin binding protein 1 |
2 |
-32787606, -32787606 |
NM_001113569, NM_009295, BC031728 NM_001113569, NM_009295, BC031728 NM_001113569, NM_009295, BC031728 |
20910 |
128 |
SNARE binding platelet degranulation developmental process involved in reproduction protein binding nucleus nucleoplasm cytoplasm mitochondrion cytosol cytoskeleton plasma membrane plasma membrane plasma membrane plasma membrane intracellular protein transport exocytosis vesicle docking involved in exocytosis vesicle docking involved in exocytosis neurotransmitter secretion neurotransmitter secretion neuromuscular synaptic transmission axon target recognition regulation of synaptic vesicle priming protein transport membrane synaptic vesicle priming synaptic vesicle priming synaptic vesicle maturation vesicle-mediated transport syntaxin-1 binding syntaxin-1 binding syntaxin-1 binding syntaxin-1 binding protein kinase binding protein domain specific binding syntaxin binding syntaxin binding secretory granule axon axon platelet alpha granule negative regulation of protein-containing complex assembly regulation of vesicle fusion synaptic vesicle fusion to presynaptic active zone membrane negative regulation of synaptic transmission, GABAergic protein-containing complex SNARE complex assembly identical protein binding myelin sheath phospholipase binding positive regulation of mast cell degranulation negative regulation of neuron apoptotic process phagocytic vesicle positive regulation of exocytosis positive regulation of calcium ion-dependent exocytosis protein N-terminus binding perinuclear region of cytoplasm presynaptic active zone membrane protein stabilization long-term synaptic depression platelet aggregation cellular response to interferon-gamma protein localization to plasma membrane presynapse postsynapse glutamatergic synapse glutamatergic synapse presynaptic dense core vesicle exocytosis positive regulation of vesicle docking positive regulation of glutamate secretion, neurotransmission regulation of acrosomal vesicle exocytosis |
|
| TC0500000170.mm.2 |
Gsap |
gamma-secretase activating protein |
5 |
21176278, 21186266, 21186266 |
NM_175437 |
212167 |
14 |
amyloid-beta binding Golgi apparatus trans-Golgi network trans-Golgi network regulation of proteolysis positive regulation of amyloid-beta formation positive regulation of amyloid-beta formation positive regulation of amyloid-beta formation |
|
| TC1700001744.mm.2 |
Ilrun |
inflammation and lipid regulator with UBA-like and NBR1-like domains |
17 |
-27751231 |
NM_001033279, NM_001044719, NM_001271511, BC132324, BC132326, BC137573, BC137576, BC145403 NM_001033279, NM_001044719, NM_001271511, BC132324, BC132326, BC137573, BC137576, BC145403 NM_001033279, NM_001044719, NM_001271511, BC132324, BC132326, BC137573, BC137576, BC145403 NM_001033279, NM_001044719, NM_001271511, BC132324, BC132326, BC137573, BC137576, BC145403 NM_001033279, NM_001044719, NM_001271511, BC132324, BC132326, BC137573, BC137576, BC145403 NM_001033279, NM_001044719, NM_001271511, BC132324, BC132326, BC137573, BC137576, BC145403 NM_001033279, NM_001044719, NM_001271511, BC132324, BC132326, BC137573, BC137576, BC145403 NM_001033279, NM_001044719, NM_001271511, BC132324, BC132326, BC137573, BC137576, BC145403 |
224647 |
24 |
phagophore assembly site immune system process nucleus cytoplasm centrosome cytosol macroautophagy nuclear speck negative regulation of type I interferon production negative regulation of tumor necrosis factor production ubiquitin binding negative regulation of DNA binding innate immune response negative regulation of defense response to virus negative regulation of protein localization to nucleus |
|
| TC0700002503.mm.2 |
Bcl3 |
B cell leukemia/lymphoma 3 |
7 |
-19808461 |
NM_033601, BC156806 NM_033601, BC156806 |
12051 |
84 |
follicular dendritic cell differentiation marginal zone B cell differentiation humoral immune response mediated by circulating immunoglobulin germinal center formation transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane transcription, DNA-templated cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling transcription factor binding response to virus response to UV-C antimicrobial humoral response extracellular matrix organization DNA damage response, signal transduction by p53 class mediator midbody negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production protein-containing complex Bcl3-Bcl10 complex Bcl3/NF-kappaB2 complex T-helper 1 type immune response defense response to bacterium intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator defense response to protozoan regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle T-helper 2 cell differentiation positive regulation of translation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of receptor signaling pathway via JAK-STAT spleen development |
|
| TC0700003771.mm.2 |
Capn5 |
calpain 5 |
7 |
-98121558, -98121558 |
NM_007602, BC014767 NM_007602, BC014767 |
12337 |
34 |
calcium-dependent cysteine-type endopeptidase activity intracellular anatomical structure cytoplasm proteolysis peptidase activity cysteine-type peptidase activity cell surface hydrolase activity synapse synapse |
|
| TC0600000131.mm.2 |
Met |
met proto-oncogene |
6 |
17463956 |
NM_008591 |
17295 |
399 |
negative regulation of transcription by RNA polymerase II nucleotide binding activation of MAPK activity neuron migration endothelial cell morphogenesis liver development liver development placenta development protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity hepatocyte growth factor-activated receptor activity hepatocyte growth factor-activated receptor activity hepatocyte growth factor-activated receptor activity protein binding ATP binding extracellular space cytoplasm plasma membrane integral component of plasma membrane protein phosphorylation phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway chemical synaptic transmission multicellular organism development nervous system development brain development muscle organ development muscle organ development skeletal muscle tissue development beta-catenin binding basal plasma membrane basal plasma membrane positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation positive regulation of glucose transmembrane transport positive regulation of neuron projection development postsynaptic density muscle cell migration myotube differentiation membrane integral component of membrane kinase activity phosphorylation cell migration transferase activity semaphorin receptor activity protein phosphatase binding neuron differentiation flagellated sperm motility dendrite adult behavior pancreas development positive regulation of microtubule polymerization regulation of interleukin-6 production positive regulation of peptidyl-serine phosphorylation positive regulation of kinase activity negative regulation of Rho protein signal transduction sperm flagellum glucose homeostasis identical protein binding neuron projection neuronal cell body receptor complex phospholipase binding phosphatidylinositol 3-kinase binding protein-containing complex binding postsynaptic membrane positive regulation of DNA replication positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II protein autophosphorylation protein autophosphorylation hepatocyte growth factor receptor signaling pathway branching morphogenesis of an epithelial tube positive regulation of dendrite morphogenesis modulation of chemical synaptic transmission positive chemotaxis positive chemotaxis myoblast proliferation negative regulation of stress fiber assembly positive regulation of protein kinase B signaling cardiac muscle cell development cardiac muscle contraction excitatory synapse excitatory postsynaptic potential regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling establishment of skin barrier negative regulation of thrombin-activated receptor signaling pathway semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway negative regulation of transforming growth factor beta production reactive oxygen species metabolic process regulation of cellular response to oxidative stress positive regulation of p38MAPK cascade negative regulation of hydrogen peroxide-mediated programmed cell death negative regulation of guanyl-nucleotide exchange factor activity positive regulation of endothelial cell chemotaxis |
04060 04144 04360 04510 04520 05100 05144 05200 05211 05218 |
| TC1200002269.mm.2 |
Ifi27l2a |
interferon, alpha-inducible protein 27 like 2A |
12 |
-103433872, -103442165 |
NM_001281830, NM_029803, BC100588 NM_001281830, NM_029803, BC100588 NM_001281830, NM_029803, BC100588 |
76933 |
21 |
molecular_function nucleus mitochondrion aging response to virus membrane integral component of membrane apoptotic signaling pathway |
|
| TC0400002568.mm.2 |
Zbtb5 |
zinc finger and BTB domain containing 5 |
4 |
-44991242 |
NM_001163283, NM_001163284, NM_173399, BC054551, BC057545 NM_001163283, NM_001163284, NM_173399, BC054551, BC057545 NM_001163283, NM_001163284, NM_173399, BC054551, BC057545 NM_001163283, NM_001163284, NM_173399, BC054551, BC057545 NM_001163283, NM_001163284, NM_173399, BC054551, BC057545 |
230119 |
23 |
negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding DNA binding nucleus nucleus regulation of transcription by RNA polymerase II metal ion binding |
|
| TC0300002752.mm.2 |
Stxbp3 |
syntaxin binding protein 3 |
3 |
-108793179 |
NM_011504, BC062901 NM_011504, BC062901 |
20912 |
48 |
cellular glucose homeostasis cellular glucose homeostasis protein binding cytoplasm cytosol cytosol plasma membrane plasma membrane plasma membrane plasma membrane intracellular protein transport exocytosis vesicle docking involved in exocytosis neurotransmitter secretion brain development protein transport membrane vesicle-mediated transport basolateral plasma membrane apical plasma membrane apical plasma membrane syntaxin-1 binding syntaxin-1 binding syntaxin binding syntaxin binding syntaxin binding syntaxin binding protein to membrane docking insulin secretion secretory granule platelet alpha granule response to insulin response to insulin specific granule protein-containing complex binding phagocytic vesicle negative regulation of calcium ion-dependent exocytosis negative regulation of glucose import negative regulation of glucose import platelet aggregation tertiary granule cellular response to interferon-gamma presynapse |
|
| TC0900002269.mm.2 |
Bco2 |
beta-carotene oxygenase 2 |
9 |
-50533086, -50533086 |
NM_133217, BC107006, BC107007 NM_133217, BC107006, BC107007 NM_133217, BC107006, BC107007 |
170752 |
30 |
beta-carotene 15,15'-monooxygenase activity mitochondrion mitochondrion carotenoid dioxygenase activity carotenoid metabolic process carotene metabolic process carotene metabolic process carotene catabolic process carotene catabolic process carotene catabolic process xanthophyll metabolic process oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen retinoic acid metabolic process retinal metabolic process retinal metabolic process retinal metabolic process metal ion binding dioxygenase activity regulation of mitochondrial membrane potential beta,beta-carotene-9',10'-cleaving oxygenase activity regulation of reactive oxygen species metabolic process |
|
| TC1_GL456221_random00000019.mm.2 |
Csprs |
component of Sp100-rs |
1 |
-111557 |
NM_033616 |
114564 |
22 |
DNA-binding transcription factor activity, RNA polymerase II-specific nucleus regulation of transcription by RNA polymerase II |
|
| TC1200002083.mm.2 |
Arel1 |
apoptosis resistant E3 ubiquitin protein ligase 1 |
12 |
-84918140, -84918140 |
NM_178065, BC060658 NM_178065, BC060658 |
68497 |
17 |
protein polyubiquitination ubiquitin-protein transferase activity protein binding cytoplasm cytosol ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process apoptotic process protein ubiquitination protein ubiquitination protein ubiquitination transferase activity negative regulation of apoptotic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process regulation of inflammatory response ubiquitin protein ligase activity |
|
| TC0300002872.mm.2 |
Synpo2 |
synaptopodin 2 |
3 |
-123076518 |
NM_080451, BC158045 NM_080451, BC158045 |
118449 |
19 |
autophagosome assembly stress fiber stress fiber actin binding actin binding protein binding nucleus nucleus nucleus nucleoplasm cytoplasm cytosol focal adhesion actin cytoskeleton actin cytoskeleton Z disc Z disc Z disc cell junction positive regulation of cell migration protein-macromolecule adaptor activity filamin binding positive regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly intracellular membrane-bounded organelle muscle alpha-actinin binding alpha-actinin binding chaperone-mediated autophagy 14-3-3 protein binding vesicle tethering complex regulation of Rho-dependent protein serine/threonine kinase activity |
|
| TC1100003664.mm.2 |
Cacnb1 |
calcium channel, voltage-dependent, beta 1 subunit |
11 |
-98004924, -98004924, -98001507 |
NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 |
12295 |
64 |
voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated calcium channel activity voltage-gated calcium channel activity calcium channel activity protein binding plasma membrane plasma membrane voltage-gated calcium channel complex voltage-gated calcium channel complex protein targeting to membrane ion transport calcium ion transport chemical synaptic transmission neuromuscular junction development high voltage-gated calcium channel activity high voltage-gated calcium channel activity membrane sarcoplasmic reticulum T-tubule regulation of ion transmembrane transport calcium ion transmembrane transport presynapse presynapse regulation of voltage-gated calcium channel activity regulation of calcium ion transmembrane transport via high voltage-gated calcium channel cellular response to amyloid-beta |
04010 04260 05410 05412 05414 |
| TC0500001522.mm.2 |
Tpst1 |
protein-tyrosine sulfotransferase 1 |
5 |
130073325, 130079369 |
NM_001130476, NM_013837, BC012666 NM_001130476, NM_013837, BC012666 NM_001130476, NM_013837, BC012666 |
22021 |
29 |
Golgi apparatus peptidyl-tyrosine sulfation peptidyl-tyrosine sulfation peptidyl-tyrosine sulfation peptidyl-tyrosine sulfation sulfotransferase activity protein-tyrosine sulfotransferase activity protein-tyrosine sulfotransferase activity protein-tyrosine sulfotransferase activity protein-tyrosine sulfotransferase activity membrane integral component of membrane transferase activity integral component of Golgi membrane protein homodimerization activity |
|
| TC0600000236.mm.2 |
Irf5 |
interferon regulatory factor 5 |
6 |
29526624, 29526624, 29529281 |
NM_001252382, NM_012057, BC160276 NM_001252382, NM_012057, BC160276 NM_001252382, NM_012057, BC160276 |
27056 |
120 |
transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific immune system process DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleus cytoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II inflammatory response cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein kinase binding protein kinase binding positive regulation of type I interferon production response to peptidoglycan response to muramyl dipeptide identical protein binding positive regulation of apoptotic process sequence-specific DNA binding innate immune response positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II defense response to virus sequence-specific double-stranded DNA binding |
04620 |
| TC0300001489.mm.2 |
Mcoln2 |
mucolipin 2 |
3 |
146150173, 146149832 |
NM_001005846, NM_026656, BC029847 NM_001005846, NM_026656, BC029847 NM_001005846, NM_026656, BC029847 |
68279 |
23 |
adaptive immune response immune system process cation channel activity calcium channel activity lysosome endosome ion transport calcium ion transport protein transport membrane integral component of membrane positive regulation of chemokine production identical protein binding innate immune response recycling endosome calcium ion transmembrane transport positive regulation of monocyte chemotactic protein-1 production positive regulation of macrophage inflammatory protein 1 alpha production positive regulation of chemokine (C-C motif) ligand 5 production NAADP-sensitive calcium-release channel activity macrophage migration neutrophil migration regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of chemokine (C-X-C motif) ligand 2 production |
|
| TC0200002691.mm.2 |
Rab22a |
RAB22A, member RAS oncogene family |
2 |
173659844 |
NM_024436, BC006596 NM_024436, BC006596 |
19334 |
26 |
nucleotide binding GTPase activity GTPase activity GTPase activity protein binding GTP binding GTP binding endosome early endosome early endosome plasma membrane intracellular protein transport endocytosis endocytosis endomembrane system protein transport actin cytoskeleton membrane GDP binding cytoplasmic vesicle cell projection phagocytic vesicle regulation of vesicle size |
04144 |
| TC0800002634.mm.2 |
N4bp1 |
NEDD4 binding protein 1 |
8 |
-86841138 |
NM_030563 |
80750 |
27 |
RNA binding protein binding nucleus nucleus nucleolus PML body PML body negative regulation of protein ubiquitination negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to UV cellular response to UV |
|
| TC0600001076.mm.2 |
Aldh1l1 |
aldehyde dehydrogenase 1 family, member L1 |
6 |
90550792 |
NM_027406, BC024055, BC025939, BC028817, BC030722, BC030723, BC030727, BC030730 NM_027406, BC024055, BC025939, BC028817, BC030722, BC030723, BC030727, BC030730 NM_027406, BC024055, BC025939, BC028817, BC030722, BC030723, BC030727, BC030730 NM_027406, BC024055, BC025939, BC028817, BC030722, BC030723, BC030727, BC030730 NM_027406, BC024055, BC025939, BC028817, BC030722, BC030723, BC030727, BC030730 NM_027406, BC024055, BC025939, BC028817, BC030722, BC030723, BC030727, BC030730 NM_027406, BC024055, BC025939, BC028817, BC030722, BC030723, BC030727, BC030730 NM_027406, BC024055, BC025939, BC028817, BC030722, BC030723, BC030727, BC030730 |
107747 |
62 |
catalytic activity aldehyde dehydrogenase (NAD+) activity aldehyde dehydrogenase [NAD(P)+] activity protein binding cytoplasm mitochondrion cytosol one-carbon metabolic process biosynthetic process 10-formyltetrahydrofolate catabolic process formyltetrahydrofolate dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor hydroxymethyl-, formyl- and related transferase activity protein-containing complex aldehyde dehydrogenase (NADP+) activity protein-containing complex binding |
00670 |
| TC0700003998.mm.2 |
|
|
|
|
NR_030719, NR_030720 NR_030719, NR_030720 |
|
|
|
|
| TC0700004007.mm.2 |
Gvin-ps5 |
GTPase, very large interferon inducible, pseudogene 5 |
7 |
-106322395, -106075731 |
NR_030720 |
668128 |
7 |
|
|
| TC0800000541.mm.2 |
Casp3 |
caspase 3 |
8 |
46617290 |
NM_001284409, NM_009810, BC038825 NM_001284409, NM_009810, BC038825 NM_001284409, NM_009810, BC038825 |
12367 |
2354 |
B cell homeostasis protease binding aspartic-type endopeptidase activity cysteine-type endopeptidase activity cysteine-type endopeptidase activity cyclin-dependent protein serine/threonine kinase inhibitor activity death receptor binding protein binding nucleus nucleus cytoplasm cytoplasm cytoplasm cytosol cytosol proteolysis proteolysis apoptotic process apoptotic process apoptotic process apoptotic process cellular response to DNA damage stimulus axonal fasciculation heart development sensory perception of sound learning or memory peptidase activity peptidase activity peptidase activity peptidase activity cysteine-type peptidase activity cysteine-type peptidase activity intrinsic apoptotic signaling pathway in response to osmotic stress response to UV response to UV response to wounding response to glucose response to organic substance phospholipase A2 activator activity protein processing hydrolase activity neuron differentiation keratinocyte differentiation keratinocyte differentiation erythrocyte differentiation erythrocyte differentiation negative regulation of B cell proliferation death-inducing signaling complex regulation of protein stability glial cell apoptotic process intracellular signal transduction response to hydrogen peroxide neuronal cell body T cell homeostasis positive regulation of apoptotic process positive regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of neuron apoptotic process protein-containing complex binding membrane raft cell fate commitment negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle negative regulation of activated T cell proliferation neurotrophin TRK receptor signaling pathway neuron apoptotic process neuron apoptotic process neuron apoptotic process anterior neural tube closure intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to organic substance cellular response to staurosporine cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process execution phase of apoptosis execution phase of apoptosis execution phase of apoptosis execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic signaling pathway cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in execution phase of apoptosis positive regulation of amyloid-beta formation |
04010 04115 04210 04650 05010 05012 05014 05016 05145 05146 05200 05210 05416 |
| TC0500001459.mm.2 |
|
|
|
|
XR_104946, XR_104947 XR_104946, XR_104947 |
|
|
|
|
| TC1000001183.mm.2 |
Btg1 |
BTG anti-proliferation factor 1 |
10 |
96617000 |
NM_007569, BC006834, BC018309 NM_007569, BC006834, BC018309 NM_007569, BC006834, BC018309 |
12226 |
44 |
protein binding nucleus nucleus cytoplasm cytoplasm protein methylation negative regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of cell population proliferation enzyme binding positive regulation of catalytic activity positive regulation of endothelial cell differentiation positive regulation of myoblast differentiation positive regulation of angiogenesis negative regulation of mitotic cell cycle positive regulation of fibroblast apoptotic process |
03018 |
| TC0900002283.mm.2 |
Layn |
layilin |
9 |
-51056779 |
NM_001033534, BC139816 NM_001033534, BC139816 |
244864 |
18 |
hyaluronic acid binding hyaluronic acid binding membrane integral component of membrane carbohydrate binding |
|
| TC1300000113.mm.2 |
Inhba |
inhibin beta-A |
13 |
16011850 |
NM_008380, BC053527 NM_008380, BC053527 |
16323 |
200 |
G1/S transition of mitotic cell cycle ovarian follicle development mesoderm formation hair follicle development hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation signaling receptor binding cytokine activity cytokine activity hormone activity extracellular region extracellular region extracellular space extracellular space extracellular space regulation of transcription by RNA polymerase II cell cycle arrest growth factor activity negative regulation of cell population proliferation male gonad development positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation peptide hormone binding striatal medium spiny neuron differentiation negative regulation of cell growth positive regulation of cellular protein metabolic process activin receptor signaling pathway inhibin binding endodermal cell differentiation odontogenesis response to drug hemoglobin biosynthetic process progesterone secretion identical protein binding activin A complex inhibin A complex protein-containing complex binding positive regulation of erythrocyte differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of follicle-stimulating hormone secretion mesodermal cell differentiation perinuclear region of cytoplasm negative regulation of hair follicle development roof of mouth development positive regulation of ovulation SMAD protein signal transduction eyelid development in camera-type eye type II activin receptor binding cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol GABAergic neuron differentiation extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
04060 04350 |
| TC0400004012.mm.2 |
Agtrap |
angiotensin II, type I receptor-associated protein |
4 |
-148077060 |
NM_009642, BC046820, BC057196 NM_009642, BC046820, BC057196 NM_009642, BC046820, BC057196 |
11610 |
98 |
angiotensin type II receptor activity protein binding endoplasmic reticulum Golgi apparatus plasma membrane plasma membrane cell cortex regulation of blood pressure regulation of blood pressure membrane integral component of membrane cytoplasmic vesicle angiotensin-activated signaling pathway identical protein binding intracellular membrane-bounded organelle |
|
| TC1500002243.mm.2 |
Pou6f1 |
POU domain, class 6, transcription factor 1 |
15 |
-100575317 |
NM_010127, BC059830, BC085139 NM_010127, BC059830, BC085139 NM_010127, BC059830, BC085139 |
19009 |
39 |
negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding |
|
| TC1100003914.mm.2 |
Limd2 |
LIM domain containing 2 |
11 |
-106156253, -106156253, -106156253 |
NM_172397, BC068130 NM_172397, BC068130 |
67803 |
21 |
molecular_function nucleus nucleoplasm cytoplasm cytosol biological_process metal ion binding |
|
| TC1300001252.mm.2 |
Mier3 |
MIER family member 3 |
13 |
111686177 |
NM_172593, BC103780, BC138127 NM_172593, BC103780, BC138127 NM_172593, BC103780, BC138127 |
218613 |
18 |
negative regulation of transcription by RNA polymerase II RNA polymerase II repressing transcription factor binding DNA binding transcription corepressor activity nucleus nucleoplasm nucleoplasm protein-containing complex histone deacetylase binding |
|
| TC1400002310.mm.2 |
Slc25a37 |
solute carrier family 25, member 37 |
14 |
-69241850 |
NM_026331, BC040399 NM_026331, BC040399 |
67712 |
35 |
iron ion transmembrane transporter activity iron ion transmembrane transporter activity mitochondrion mitochondrial inner membrane mitochondrial inner membrane iron import into the mitochondrion iron import into the mitochondrion |
|
| MG-1-neg-10341554_st |
|
|
|
|
|
|
|
|
|
| TC0900001391.mm.2 |
Gmppb |
GDP-mannose pyrophosphorylase B |
9 |
108049263 |
NM_177910, BC061207 NM_177910, BC061207 |
331026 |
16 |
nucleotide binding mannose-1-phosphate guanylyltransferase activity GTP binding cytoplasm mitochondrion biosynthetic process transferase activity nucleotidyltransferase activity |
00051 00520 01100 |
| TC0500000992.mm.2 |
Cds1 |
CDP-diacylglycerol synthase 1 |
5 |
101765129 |
NM_173370, BC055292 NM_173370, BC055292 |
74596 |
24 |
phosphatidate cytidylyltransferase activity endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane lipid metabolic process phosphatidylinositol biosynthetic process phospholipid biosynthetic process membrane integral component of membrane CDP-diacylglycerol biosynthetic process transferase activity transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity positive regulation of fat cell differentiation lipid droplet formation lipid droplet formation |
00564 01100 04070 |
| TC1000001744.mm.2 |
Rab32 |
RAB32, member RAS oncogene family |
10 |
-10545038 |
NM_026405, BC016409, BC055945 NM_026405, BC016409, BC055945 NM_026405, BC016409, BC055945 |
67844 |
35 |
nucleotide binding GTPase activity GTPase activity protein binding GTP binding mitochondrion mitochondrion mitochondrion mitochondrial outer membrane early endosome endoplasmic reticulum Golgi apparatus trans-Golgi network intracellular protein transport mitochondrion organization endomembrane system membrane vesicle-mediated transport antigen processing and presentation GTP-dependent protein binding cytoplasmic vesicle vesicle melanosome organization melanosome membrane endosome to melanosome transport AP-1 adaptor complex binding AP-3 adaptor complex binding BLOC-2 complex binding melanosome melanosome melanosome mitochondria-associated endoplasmic reticulum membrane phagocytic vesicle protein localization to membrane phagosome maturation melanosome assembly |
|
| TC1100003496.mm.2 |
Msi2 |
musashi RNA-binding protein 2 |
11 |
-88339381, -88339381, -88685953, -88339381 |
NM_001201341, NM_054043, BC109368, BC111809 NM_001201341, NM_054043, BC109368, BC111809 NM_001201341, NM_054043, BC109368, BC111809 NM_001201341, NM_054043, BC109368, BC111809 |
76626 |
72 |
nucleic acid binding RNA binding single-stranded RNA binding cytoplasm cytoplasm cytosol polysome polysome poly(U) RNA binding identical protein binding intracellular membrane-bounded organelle stem cell development |
03015 |
| TC0800001079.mm.2 |
Capns2 |
calpain, small subunit 2 |
8 |
92901394 |
NM_027112 |
69543 |
8 |
calcium ion binding protein binding cytoplasm plasma membrane plasma membrane membrane metal ion binding |
|
| TC0600001008.mm.2 |
Bmp10 |
bone morphogenetic protein 10 |
6 |
87428993 |
NM_009756, BC145044, BC145983 NM_009756, BC145044, BC145983 NM_009756, BC145044, BC145983 |
12154 |
91 |
kidney development cytokine activity hormone activity extracellular region extracellular space extracellular space cytoplasm cell adhesion multicellular organism development heart development adult heart development growth factor activity cell surface negative regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation Z disc negative regulation of cell growth negative regulation of cell migration BMP signaling pathway telethonin binding activin receptor signaling pathway receptor serine/threonine kinase binding sarcomere organization positive regulation of transcription, DNA-templated atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell development regulation of cardiac muscle contraction cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation positive regulation of sarcomere organization heart trabecula formation pathway-restricted SMAD protein phosphorylation pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction positive regulation of cartilage development regulation of cardiac muscle hypertrophy in response to stress positive regulation of cell proliferation involved in heart morphogenesis |
|
| TC1000002093.mm.2 |
Crybg1 |
crystallin beta-gamma domain containing 1 |
10 |
-43950630, -43950630, -43950306 |
NM_172393 |
11630 |
15 |
molecular_function cellular_component biological_process |
|
| TC1600002062.mm.2 |
4932438H23Rik |
RIKEN cDNA 4932438H23 gene |
16 |
-91055523 |
NM_001163695, NM_028905, BC032975 NM_001163695, NM_028905, BC032975 NM_001163695, NM_028905, BC032975 |
74387 |
14 |
molecular_function cellular_component biological_process |
|
| TC0100000761.mm.2 |
|
|
|
|
|
|
|
|
|
| TC1700001827.mm.2 |
Sik1 |
salt inducible kinase 1 |
17 |
-31844247 |
NM_010831, BC146549 NM_010831, BC146549 |
17691 |
61 |
negative regulation of transcription by RNA polymerase II nucleotide binding magnesium ion binding regulation of sodium ion transport protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleus nucleus cytoplasm cytoplasm cytosol protein phosphorylation protein phosphorylation protein phosphorylation cell cycle multicellular organism development regulation of mitotic cell cycle cAMP response element binding protein binding regulation of myotube differentiation negative regulation of triglyceride biosynthetic process kinase activity phosphorylation transferase activity protein kinase binding protein kinase binding cell differentiation negative regulation of CREB transcription factor activity negative regulation of CREB transcription factor activity intracellular signal transduction intracellular signal transduction cellular response to glucose starvation histone deacetylase binding entrainment of circadian clock by photoperiod anoikis regulation of cell differentiation negative regulation of gluconeogenesis metal ion binding rhythmic process cardiac muscle cell differentiation |
|
| TC0X00000649.mm.2 |
Mtm1 |
X-linked myotubular myopathy gene 1 |
X |
71215073, 71215005, 71210766, 71215005 |
NM_001164190, NM_001164191, NM_001164192, NM_001164193, NM_019926, BC090984 NM_001164190, NM_001164191, NM_001164192, NM_001164193, NM_019926, BC090984 NM_001164190, NM_001164191, NM_001164192, NM_001164193, NM_019926, BC090984 NM_001164190, NM_001164191, NM_001164192, NM_001164193, NM_019926, BC090984 NM_001164190, NM_001164191, NM_001164192, NM_001164193, NM_019926, BC090984 NM_001164190, NM_001164191, NM_001164192, NM_001164193, NM_019926, BC090984 |
17772 |
53 |
ruffle phosphatidylinositol-3-phosphatase activity phosphatidylinositol-3-phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding cytoplasm cytoplasm cytoplasm endosome late endosome cytosol plasma membrane plasma membrane protein dephosphorylation lipid metabolic process endosome to lysosome transport protein transport membrane dephosphorylation hydrolase activity phosphatase activity intermediate filament binding filopodium I band negative regulation of TOR signaling negative regulation of proteasomal ubiquitin-dependent protein catabolic process phosphatidylinositol binding cell projection regulation of vacuole organization intermediate filament organization muscle cell cellular homeostasis muscle cell cellular homeostasis phosphatidylinositol dephosphorylation phosphatidylinositol dephosphorylation mitochondrion distribution mitochondrion distribution mitochondrion distribution positive regulation of skeletal muscle tissue growth negative regulation of protein kinase B signaling phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity mitochondrion morphogenesis mitochondrion morphogenesis mitochondrion morphogenesis negative regulation of autophagosome assembly negative regulation of autophagosome assembly |
|
| TC1800001500.mm.2 |
Mppe1 |
metallophosphoesterase 1 |
18 |
-67225047 |
NM_172630, BC045146, BC086456 NM_172630, BC045146, BC086456 NM_172630, BC045146, BC086456 |
225651 |
13 |
molecular_function nucleoplasm endoplasmic reticulum-Golgi intermediate compartment Golgi apparatus GPI anchor biosynthetic process endoplasmic reticulum to Golgi vesicle-mediated transport phosphoric diester hydrolase activity membrane integral component of membrane vesicle-mediated transport hydrolase activity metal ion binding |
|
| TC0500002480.mm.2 |
Tlr1 |
toll-like receptor 1 |
5 |
-64924679, -64924679 |
NM_001276445, NM_030682, BC141319, BC141321 NM_001276445, NM_030682, BC141319, BC141321 NM_001276445, NM_030682, BC141319, BC141321 NM_001276445, NM_030682, BC141319, BC141321 |
21897 |
87 |
microglial cell activation cell activation regulation of cytokine production toll-like receptor signaling pathway toll-like receptor signaling pathway immune system process MyD88-dependent toll-like receptor signaling pathway transmembrane signaling receptor activity Golgi apparatus plasma membrane integral component of plasma membrane defense response inflammatory response signal transduction activation of NF-kappaB-inducing kinase activity membrane integral component of membrane hydrolase activity cytoplasmic vesicle response to bacterial lipoprotein positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production toll-like receptor 1 signaling pathway positive regulation of toll-like receptor 2 signaling pathway Toll-like receptor 1-Toll-like receptor 2 protein complex Toll-like receptor 1-Toll-like receptor 2 protein complex Toll-like receptor 2 binding Toll-like receptor 2 binding signaling receptor activity macrophage activation detection of triacyl bacterial lipopeptide detection of triacyl bacterial lipopeptide triacyl lipopeptide binding identical protein binding innate immune response membrane raft phagocytic vesicle NAD(P)+ nucleosidase activity NAD+ nucleotidase, cyclic ADP-ribose generating cellular response to bacterial lipopeptide lipopeptide binding lipopeptide binding cellular response to triacyl bacterial lipopeptide cellular response to triacyl bacterial lipopeptide |
04620 |
| TC1400001052.mm.2 |
Rubcnl |
RUN and cysteine rich domain containing beclin 1 interacting protein like |
14 |
75016026, 75016035 |
NM_198642, BC052668 NM_198642, BC052668 |
271221 |
11 |
autophagosome membrane autophagosome membrane lipid metabolic process autophagy lipid binding phosphatidylinositol-5-phosphate binding membrane regulation of lipid metabolic process cytoplasmic vesicle phosphatidylinositol-3-phosphate binding intracellular membrane-bounded organelle autophagosome-lysosome fusion autophagosome-lysosome fusion autophagosome-endosome fusion autophagosome-endosome fusion phosphatidylinositol-4-phosphate binding regulation of glycogen metabolic process autophagosome maturation autophagosome maturation autophagosome maturation phosphatidylinositol phosphate binding |
|
| TC0200000019.mm.2 |
Frmd4a |
FERM domain containing 4A |
2 |
4152862, 4559753, 4017682, 4400975 |
NM_001177843, NM_001177844, NM_172475, BC058672 NM_001177843, NM_001177844, NM_172475, BC058672 NM_001177843, NM_001177844, NM_172475, BC058672 NM_001177843, NM_001177844, NM_172475, BC058672 |
209630 |
26 |
cytoplasm cytoskeleton adherens junction bicellular tight junction bicellular tight junction cell junction protein-macromolecule adaptor activity negative regulation of protein secretion positive regulation of protein secretion establishment of epithelial cell polarity |
|
| TC0600001968.mm.2 |
Lrrc4 |
leucine rich repeat containing 4 |
6 |
-28828125 |
NM_138682, BC117833, BC117834 NM_138682, BC117833, BC117834 NM_138682, BC117833, BC117834 |
192198 |
30 |
protein binding plasma membrane membrane integral component of membrane cell junction dendritic spine neuron spine synapse postsynaptic membrane modulation of chemical synaptic transmission synapse organization excitatory synapse postsynaptic density protein 95 clustering Schaffer collateral - CA1 synapse glutamatergic synapse glutamatergic synapse integral component of postsynaptic density membrane integral component of postsynaptic density membrane synaptic membrane adhesion excitatory synapse assembly |
|
| TC1200002440.mm.2 |
Gpr132 |
G protein-coupled receptor 132 |
12 |
-112850875 |
NM_019925, BC120522, BC120524 NM_019925, BC120522, BC120524 NM_019925, BC120522, BC120524 |
56696 |
46 |
G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle G protein-coupled receptor activity plasma membrane integral component of plasma membrane signal transduction G protein-coupled receptor signaling pathway negative regulation of G2/M transition of mitotic cell cycle negative regulation of G2/M transition of mitotic cell cycle membrane integral component of membrane |
|
| TC1700000765.mm.2 |
H2-M3 |
histocompatibility 2, M region locus 3 |
17 |
37270233 |
NM_013819, BC031984 NM_013819, BC031984 |
14991 |
41 |
negative regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin alpha-beta T cell activation involved in immune response peripheral B cell tolerance induction antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent positive regulation of tolerance induction positive regulation of T cell tolerance induction positive regulation of natural killer cell cytokine production immune response-inhibiting cell surface receptor signaling pathway signaling receptor binding signaling receptor binding extracellular space early endosome plasma membrane immune response external side of plasma membrane external side of plasma membrane negative regulation of angiogenesis MHC class Ib protein complex positive regulation of interferon-gamma production positive regulation of interleukin-12 production cis-Golgi network membrane negative regulation of T cell proliferation protection from natural killer cell mediated cytotoxicity peptide antigen binding peptide antigen binding peptide antigen binding peptide antigen binding CD8 receptor binding defense response to bacterium defense response to bacterium identical protein binding protein homodimerization activity positive regulation of nitric oxide biosynthetic process positive regulation of regulatory T cell differentiation negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity negative regulation of protein kinase B signaling positive regulation of macrophage cytokine production protein homotrimerization negative regulation of G0 to G1 transition positive regulation of endothelial cell apoptotic process positive regulation of cellular senescence negative regulation of dendritic cell differentiation |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| TC1700000773.mm.2 |
Olfr108 |
olfactory receptor 108 |
17 |
37445479 |
NM_146465, BC132008, BC132012 NM_146465, BC132008, BC132012 NM_146465, BC132008, BC132012 |
258457 |
6 |
olfactory receptor activity G protein-coupled receptor signaling pathway sensory perception of smell integral component of membrane |
04740 |
| TC0100001016.mm.2 |
Zcchc2 |
zinc finger, CCHC domain containing 2 |
1 |
105990405 |
NM_001122675, NM_001122676 NM_001122675, NM_001122676 |
227449 |
19 |
molecular_function nucleic acid binding cytoplasm biological_process zinc ion binding phosphatidylinositol binding metal ion binding |
|
| MG-1-neg-10344254_st |
|
|
|
|
|
|
|
|
|
| MG-1-neg-10341222_st |
|
|
|
|
|
|
|
|
|
| TC1100001111.mm.2 |
Slc6a4 |
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 |
11 |
76998596 |
NM_010484, BC108978, BC108979 NM_010484, BC108978, BC108979 NM_010484, BC108978, BC108979 |
15567 |
392 |
neurotransmitter transmembrane transporter activity neurotransmitter:sodium symporter activity serotonin:sodium symporter activity serotonin:sodium symporter activity protein binding endosome plasma membrane integral component of plasma membrane focal adhesion neurotransmitter transport serotonin transport serotonin transport memory circadian rhythm monoamine transmembrane transporter activity monoamine transmembrane transporter activity response to toxic substance positive regulation of gene expression endomembrane system positive regulation of serotonin secretion symporter activity monoamine transport membrane integral component of membrane syntaxin-1 binding cocaine binding negative regulation of cerebellar granule cell precursor proliferation cell junction negative regulation of synaptic transmission, dopaminergic social behavior sodium ion transmembrane transport vasoconstriction sperm ejaculation identical protein binding neuron projection neuron projection membrane raft synapse synapse negative regulation of neuron differentiation positive regulation of cell cycle negative regulation of organ growth metal ion binding brain morphogenesis nitric-oxide synthase binding actin filament binding serotonin binding serotonin uptake serotonin uptake serotonin uptake serotonin uptake cellular response to organic substance cellular response to cGMP regulation of thalamus size neurotransmitter reuptake integral component of postsynaptic membrane integral component of presynaptic membrane serotonergic synapse |
|
| TC0X00002161.mm.2 |
Elf4 |
E74-like factor 4 (ets domain transcription factor) |
X |
-48411048, -48411049 |
NM_019680, BC109160, BC109171, E74-like(ets) NM_019680, BC109160, BC109171, E74-like(ets) NM_019680, BC109160, BC109171, E74-like(ets) NM_019680, BC109160, BC109171, E74-like(ets) |
56501 |
45 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific natural killer cell proliferation NK T cell proliferation DNA binding DNA-binding transcription factor activity nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II nuclear body PML body cell differentiation sequence-specific DNA binding innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II sequence-specific double-stranded DNA binding |
|
| TC1000002164.mm.2 |
Cep85l |
centrosomal protein 85-like |
10 |
-53273442 |
NM_001204983 |
100038725 |
10 |
molecular_function centrosome biological_process |
|
| TC0X00001124.mm.2 |
Apool |
apolipoprotein O-like |
X |
112311351 |
NM_026565, BC024334 NM_026565, BC024334 |
68117 |
21 |
mitochondrion mitochondrion mitochondrial inner membrane membrane integral component of membrane cristae formation MICOS complex MICOS complex |
|
| TC1700000842.mm.2 |
Enpp5 |
ectonucleotide pyrophosphatase/phosphodiesterase 5 |
17 |
44078801 |
NM_001168620, NM_032003, BC138977, BC138978 NM_001168620, NM_032003, BC138977, BC138978 NM_001168620, NM_032003, BC138977, BC138978 NM_001168620, NM_032003, BC138977, BC138978 |
83965 |
22 |
NAD+ diphosphatase activity catalytic activity nucleotide diphosphatase activity extracellular region plasma membrane integral component of plasma membrane cell communication zinc ion binding zinc ion binding nucleotide catabolic process membrane integral component of membrane hydrolase activity metal ion binding |
|
| TC0400001418.mm.2 |
Pou3f1 |
POU domain, class 3, transcription factor 1 |
4 |
124657645 |
NM_011141, BC172733 NM_011141, BC172733 |
18991 |
193 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus transcription regulator complex regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II brain development epidermis development positive regulation of gene expression Schwann cell development myelination in peripheral nervous system keratinocyte differentiation forebrain development myelination sequence-specific DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II |
|
| TC0600003246.mm.2 |
Klri1 |
killer cell lectin-like receptor family I member 1 |
6 |
-129697217 |
NM_001012520 |
503550 |
3 |
plasma membrane integral component of plasma membrane membrane integral component of membrane carbohydrate binding |
|
| TC1200001768.mm.2 |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
12 |
-55489408 |
NM_010907, BC046754 NM_010907, BC046754 |
18035 |
242 |
protein binding nucleus nucleus cytoplasm cytoplasm cytosol cytosol plasma membrane protein import into nucleus I-kappaB kinase/NF-kappaB signaling cytoplasmic sequestering of NF-kappaB nuclear localization sequence binding regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of cholesterol efflux negative regulation of lipid storage enzyme binding heat shock protein binding ubiquitin protein ligase binding lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process response to muramyl dipeptide response to lipopolysaccharide protein-containing complex tumor necrosis factor-mediated signaling pathway toll-like receptor 4 signaling pathway response to muscle stretch regulation of cell population proliferation identical protein binding cytoplasmic sequestering of transcription factor response to exogenous dsRNA protein-containing complex binding negative regulation of myeloid cell differentiation negative regulation of Notch signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of inflammatory response NF-kappaB binding nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to biotic stimulus cellular response to cytokine stimulus cellular response to tumor necrosis factor cellular response to organic cyclic compound |
04062 04210 04380 04620 04621 04622 04623 04660 04662 04722 04920 05140 05142 05145 05160 05200 05215 05220 05222 |
| TC1400002870.mm.2 |
|
|
|
|
NM_001081024, NM_001164289, BC157926, BC172021 NM_001081024, NM_001164289, BC157926, BC172021 NM_001081024, NM_001164289, BC157926, BC172021 NM_001081024, NM_001164289, BC157926, BC172021 |
|
|
mitotic cell cycle molecular_function DNA binding nucleus nucleus nucleoplasm chromosome cytosol chromatin organization cell cycle chromosome segregation multicellular organism development biological_process methyltransferase activity zinc ion binding negative regulation of gene expression transferase activity histone-lysine N-methyltransferase activity nuclear membrane methylation histone lysine methylation metal ion binding histone methyltransferase activity (H3-K9 specific) histone methyltransferase activity (H3-K9 specific) cell division histone H3-K9 methylation histone H3-K9 methylation heterochromatin organization positive regulation of DNA methylation-dependent heterochromatin assembly |
|
| TC1000001830.mm.2 |
Pde7b |
phosphodiesterase 7B |
10 |
-20397051, -20397051 |
NM_013875, BC130267 NM_013875, BC130267 |
29863 |
22 |
3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity signal transduction phosphoric diester hydrolase activity hydrolase activity cAMP-mediated signaling metal ion binding |
00230 |
| MG-1-neg-10343145_st |
|
|
|
|
|
|
|
|
|
| TC1600000861.mm.2 |
Usp25 |
ubiquitin specific peptidase 25 |
16 |
77014068 |
NM_013918, BC048171, BC063059 NM_013918, BC048171, BC063059 NM_013918, BC048171, BC063059 |
30940 |
28 |
proteasome complex cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity nucleus cytoplasm endoplasmic reticulum cytosol cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination protein deubiquitination hydrolase activity ubiquitin protein ligase binding SUMO binding SUMO binding ATPase binding protein K63-linked deubiquitination protein K48-linked deubiquitination negative regulation of ERAD pathway |
|
| TC1700002774.mm.2 |
Cmtr1 |
cap methyltransferase 1 |
17 |
29660594 |
NM_028791, BC024691 NM_028791, BC024691 |
74157 |
25 |
nucleic acid binding mRNA (nucleoside-2'-O-)-methyltransferase activity mRNA (nucleoside-2'-O-)-methyltransferase activity nucleus nucleus nucleoplasm cytoplasm 7-methylguanosine mRNA capping 7-methylguanosine mRNA capping mRNA processing methyltransferase activity transferase activity methylation intracellular membrane-bounded organelle mRNA methylation cap1 mRNA methylation cap1 mRNA methylation |
|
| TC1900000226.mm.2 |
Ms4a4d |
membrane-spanning 4-domains, subfamily A, member 4D |
19 |
11536793 |
NM_025658, BC069842 NM_025658, BC069842 |
66607 |
13 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| MG-1-pos-10341289_st |
|
|
|
|
|
|
|
|
|
| TC1300000904.mm.2 |
Erap1 |
endoplasmic reticulum aminopeptidase 1 |
13 |
74639852 |
NM_030711, BC046610 NM_030711, BC046610 |
80898 |
56 |
adaptive immune response immune system process aminopeptidase activity aminopeptidase activity interleukin-6 receptor binding tumor necrosis factor receptor binding extracellular region cytoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane plasma membrane proteolysis proteolysis proteolysis membrane protein ectodomain proteolysis signal transduction regulation of blood pressure peptidase activity metalloexopeptidase activity metallopeptidase activity zinc ion binding zinc ion binding membrane integral component of membrane hydrolase activity antigen processing and presentation of endogenous peptide antigen via MHC class I peptide binding peptide catabolic process intracellular membrane-bounded organelle positive regulation of angiogenesis metal ion binding metalloaminopeptidase activity |
|
| TC0800002432.mm.2 |
Tmem221 |
transmembrane protein 221 |
8 |
-71554302 |
NM_001100462, BC147816, BC147831 NM_001100462, BC147816, BC147831 NM_001100462, BC147816, BC147831 |
434325 |
2 |
molecular_function cellular_component biological_process membrane integral component of membrane |
|
| TC1700002216.mm.2 |
Foxp4 |
forkhead box P4 |
17 |
-47867132 |
NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 |
74123 |
58 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II heart development identical protein binding sequence-specific DNA binding metal ion binding embryonic foregut morphogenesis lung secretory cell differentiation regulation of lung goblet cell differentiation negative regulation of lung goblet cell differentiation |
|
| TC0300000309.mm.2 |
|
|
|
|
NM_026622, NR_038067, BC092533, BC145212 NM_026622, NR_038067, BC092533, BC145212 NM_026622, NR_038067, BC092533, BC145212 NM_026622, NR_038067, BC092533, BC145212 |
|
|
molecular_function cellular_component extracellular region biological_process |
|
| TC1900000991.mm.2 |
Cdc42ep2 |
CDC42 effector protein (Rho GTPase binding) 2 |
19 |
-5917555 |
NM_026772, BC034884 NM_026772, BC034884 |
104252 |
20 |
opioid peptide activity GTPase activator activity cytoplasm cytoplasm cytosol cytoskeleton plasma membrane plasma membrane Rho protein signal transduction regulation of cell shape regulation of cell shape microtubule cytoskeleton membrane actin cytoskeleton organization positive regulation of actin filament polymerization positive regulation of actin filament polymerization small GTPase binding positive regulation of pseudopodium assembly positive regulation of pseudopodium assembly phagocytic vesicle cellular response to interferon-gamma |
|
| TC0500001359.mm.2 |
Naa25 |
N(alpha)-acetyltransferase 25, NatB auxiliary subunit |
5 |
121397994 |
NM_172722, BC132172, BC138093 NM_172722, BC132172, BC138093 NM_172722, BC132172, BC138093 |
231713 |
22 |
peptide alpha-N-acetyltransferase activity cytoplasm cytoplasm Golgi apparatus cytosol N-terminal peptidyl-methionine acetylation NatB complex |
|
| TC1100004059.mm.2 |
Cd300e |
CD300E molecule |
11 |
-115051916 |
NM_172050, BC034097, BC039971, CD300e NM_172050, BC034097, BC039971, CD300e NM_172050, BC034097, BC039971, CD300e NM_172050, BC034097, BC039971, CD300e |
217306 |
4 |
immune system process transmembrane signaling receptor activity plasma membrane biological_process membrane integral component of membrane |
|
| TC0500003615.mm.2 |
Usp12 |
ubiquitin specific peptidase 12 |
5 |
-146734811 |
NM_011669, BC049274, BC068136 NM_011669, BC049274, BC068136 NM_011669, BC049274, BC068136 |
22217 |
25 |
cysteine-type endopeptidase activity cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitin-specific protease activity nucleus nucleus cytosol cytosol proteolysis ubiquitin-dependent protein catabolic process peptidase activity cysteine-type peptidase activity protein deubiquitination protein deubiquitination protein deubiquitination hydrolase activity metal ion binding positive regulation of T cell receptor signaling pathway ubiquitinyl hydrolase activity ubiquitinyl hydrolase activity |
|
| TC1200000432.mm.2 |
Akap6 |
A kinase (PRKA) anchor protein 6 |
12 |
52699382 |
NM_198111, BC057114 NM_198111, BC057114 |
238161 |
27 |
positive regulation of protein phosphorylation protein binding nucleus nuclear envelope cytoplasm caveola negative regulation of adenylate cyclase activity adenylate cyclase binding adenylate cyclase binding regulation of protein kinase A signaling junctional sarcoplasmic reticulum membrane intercalated disc sarcoplasmic reticulum sarcoplasmic reticulum enzyme binding positive regulation of cell growth T-tubule nuclear membrane nuclear membrane protein-containing complex protein kinase A regulatory subunit binding cellular protein-containing complex localization calcium channel complex sarcolemma protein-membrane adaptor activity ion channel binding ion channel binding positive regulation of translation perinuclear region of cytoplasm perinuclear region of cytoplasm perinuclear region of cytoplasm protein kinase A binding protein kinase A binding positive regulation of release of sequestered calcium ion into cytosol protein phosphatase 2A binding molecular adaptor activity regulation of membrane repolarization positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of cell growth involved in cardiac muscle cell development positive regulation of calcineurin-NFAT signaling cascade cellular response to cAMP cellular response to cytokine stimulus cellular response to epinephrine stimulus regulation of cardiac muscle cell contraction positive regulation of potassium ion transmembrane transport regulation of relaxation of cardiac muscle positive regulation of delayed rectifier potassium channel activity positive regulation of cAMP-dependent protein kinase activity |
|
| TC0900003310.mm.2 |
Lztfl1 |
leucine zipper transcription factor-like 1 |
9 |
-123694405 |
NM_033322, BC026840, BC098224 NM_033322, BC026840, BC098224 NM_033322, BC026840, BC098224 |
93730 |
31 |
protein binding cytoplasm cytosol identical protein binding protein-containing complex binding protein-containing complex binding negative regulation of protein localization to cilium negative regulation of protein localization to cilium negative regulation of protein localization to ciliary membrane |
|
| TC1500000660.mm.2 |
Triobp |
TRIO and F-actin binding protein |
15 |
78983055, 78947723, 78947723 |
NM_001024716, NM_001039155, NM_001039156, NM_138579 NM_001024716, NM_001039155, NM_001039156, NM_138579 NM_001024716, NM_001039155, NM_001039156, NM_138579 NM_001024716, NM_001039155, NM_001039156, NM_138579 |
110253 |
37 |
actin binding protein binding nucleus cytoplasm cytoskeleton actin filament organization cell cycle sensory perception of sound embryo development actin cytoskeleton actin cytoskeleton ubiquitin protein ligase binding stereocilium cuticular plate actin filament binding actin filament binding actin filament binding actin filament bundle assembly cell division auditory receptor cell stereocilium organization stereocilium shaft stereocilium base positive regulation of substrate adhesion-dependent cell spreading positive regulation of substrate adhesion-dependent cell spreading positive regulation of substrate adhesion-dependent cell spreading |
|
| TC1300002001.mm.2 |
|
|
|
|
|
|
|
|
|
| TC0X00003082.mm.2 |
Psmd10 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 |
X |
-140948424 |
NM_001164177, NM_016883, BC026931, BC056196 NM_001164177, NM_016883, BC026931, BC056196 NM_001164177, NM_016883, BC026931, BC056196 NM_001164177, NM_016883, BC026931, BC056196 |
53380 |
25 |
negative regulation of transcription by RNA polymerase II proteasome complex protein binding nucleus cytoplasm cytosol apoptotic process cytoplasmic sequestering of NF-kappaB transcription factor binding proteasome regulatory particle, base subcomplex positive regulation of cell growth positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of apoptotic process negative regulation of MAPK cascade negative regulation of DNA damage response, signal transduction by p53 class mediator intermediate filament cytoskeleton positive regulation of cyclin-dependent protein serine/threonine kinase activity proteasome regulatory particle assembly negative regulation of release of cytochrome c from mitochondria |
|
| TC0200004539.mm.2 |
Hdc |
histidine decarboxylase |
2 |
-126593659 |
NM_008230, BC052833 NM_008230, BC052833 |
15186 |
188 |
histamine metabolic process histamine biosynthetic process histamine biosynthetic process histamine biosynthetic process catalytic activity histidine decarboxylase activity histidine decarboxylase activity histidine decarboxylase activity histidine decarboxylase activity cytoplasm cytosol cellular amino acid metabolic process histidine metabolic process histidine catabolic process histidine catabolic process histidine catabolic process histidine catabolic process amino acid binding lyase activity carboxy-lyase activity carboxylic acid metabolic process pyridoxal phosphate binding dendrite catecholamine biosynthetic process identical protein binding neuronal cell body |
00340 01100 |
| TC0600003125.mm.2 |
Lag3 |
lymphocyte-activation gene 3 |
6 |
-124904358 |
NM_008479, BC120591 NM_008479, BC120591 |
16768 |
61 |
adaptive immune response plasmacytoid dendritic cell activation immune system process transmembrane signaling receptor activity transmembrane signaling receptor activity protein binding extracellular region plasma membrane cell surface receptor signaling pathway external side of plasma membrane membrane integral component of membrane negative regulation of interleukin-2 production MHC class II protein binding MHC class II protein binding MHC class II protein binding negative regulation of regulatory T cell differentiation positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity regulation of immune response negative regulation of T cell activation |
|
| TC1300002013.mm.2 |
Nfil3 |
nuclear factor, interleukin 3, regulated |
13 |
-52967208 |
NM_017373, BC031377, BC100384 NM_017373, BC031377, BC100384 NM_017373, BC031377, BC100384 |
18030 |
116 |
negative regulation of transcription by RNA polymerase II RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding nucleus transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II immune response circadian rhythm positive regulation of gene expression positive regulation of gene expression negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated rhythmic process cellular response to interleukin-4 |
|
| TC1700002558.mm.2 |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
17 |
-78852549 |
NM_011163, BC016422 NM_011163, BC016422 |
19106 |
219 |
nucleotide binding activation of MAPKK activity positive regulation of cytokine production immune system process RNA binding double-stranded RNA binding double-stranded RNA binding protein kinase activity protein kinase activity protein kinase activity protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding nucleus cytoplasm cytosol cytosol translation protein phosphorylation protein phosphorylation response to virus response to toxic substance kinase activity phosphorylation transferase activity negative regulation of translation endoplasmic reticulum unfolded protein response response to lipopolysaccharide positive regulation of chemokine production positive regulation of stress-activated MAPK cascade response to vitamin E negative regulation of osteoblast proliferation cellular response to amino acid starvation response to interferon-alpha identical protein binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of viral genome replication negative regulation of viral genome replication innate immune response protein autophosphorylation protein autophosphorylation perinuclear region of cytoplasm positive regulation of NF-kappaB transcription factor activity defense response to virus regulation of NLRP3 inflammasome complex assembly positive regulation of NIK/NF-kappaB signaling regulation of hematopoietic progenitor cell differentiation regulation of hematopoietic stem cell proliferation regulation of hematopoietic stem cell differentiation |
04141 05160 |
| TC1900000350.mm.2 |
Cemip2 |
cell migration inducing hyaluronidase 2 |
19 |
21778339 |
NM_001033759, NM_031997, BC019745, BC076570, BC089353 NM_001033759, NM_031997, BC019745, BC076570, BC089353 NM_001033759, NM_031997, BC019745, BC076570, BC089353 NM_001033759, NM_031997, BC019745, BC076570, BC089353 NM_001033759, NM_031997, BC019745, BC076570, BC089353 |
83921 |
25 |
angiogenesis hyalurononglucosaminidase activity calcium ion binding plasma membrane integral component of plasma membrane multicellular organism development metabolic process membrane integral component of membrane hydrolase activity hydrolase activity, acting on glycosyl bonds hyaluronan catabolic process intracellular membrane-bounded organelle |
|
| TC1300000481.mm.2 |
Edn1 |
endothelin 1 |
13 |
42301475 |
NM_010104, BC029547 NM_010104, BC029547 |
13614 |
314 |
negative regulation of transcription by RNA polymerase II skeletal system development prostaglandin biosynthetic process branching involved in blood vessel morphogenesis response to hypoxia in utero embryonic development histamine secretion regulation of systemic arterial blood pressure by endothelin regulation of systemic arterial blood pressure by endothelin signaling receptor binding cytokine activity hormone activity hormone activity protein binding extracellular region extracellular space extracellular space extracellular space cytoplasm cellular calcium ion homeostasis regulation of pH cell surface receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G protein-coupled receptor signaling pathway cell-cell signaling heart development respiratory gaseous exchange by respiratory system body fluid secretion regulation of blood pressure regulation of blood pressure positive regulation of cell population proliferation positive regulation of cell population proliferation dorsal/ventral pattern formation positive regulation of heart rate positive regulation of cardiac muscle hypertrophy negative regulation of gene expression regulation of glucose transmembrane transport neural crest cell development phosphatidylinositol 3-kinase signaling artery smooth muscle contraction vein smooth muscle contraction vein smooth muscle contraction regulation of vasoconstriction sensory perception of pain calcium-mediated signaling peptide hormone secretion nitric oxide transport positive regulation of cell migration phospholipase D-activating G protein-coupled receptor signaling pathway endothelin A receptor binding endothelin A receptor binding endothelin A receptor binding endothelin B receptor binding endothelin B receptor binding negative regulation of cellular protein metabolic process positive regulation of prostaglandin secretion Weibel-Palade body negative regulation of smooth muscle cell apoptotic process intracellular signal transduction positive regulation of urine volume positive regulation of urine volume positive regulation of renal sodium excretion epithelial fluid transport vasoconstriction protein kinase C deactivation middle ear morphogenesis positive regulation of odontogenesis superoxide anion generation rhythmic excitation positive regulation of MAP kinase activity positive regulation of JUN kinase activity basal part of cell positive regulation of cell size positive regulation of mitotic nuclear division positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle contraction positive regulation of smooth muscle contraction positive regulation of hormone secretion negative regulation of hormone secretion inositol phosphate-mediated signaling rough endoplasmic reticulum lumen blood vessel morphogenesis positive regulation of smooth muscle cell proliferation positive regulation of DNA-binding transcription factor activity cartilage development positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway negative regulation of nitric-oxide synthase biosynthetic process membrane depolarization regulation of sensory perception of pain positive regulation of sarcomere organization positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of cell growth involved in cardiac muscle cell development positive regulation of chemokine-mediated signaling pathway endothelin receptor signaling pathway positive regulation of neutrophil chemotaxis blood vessel diameter maintenance positive regulation of NIK/NF-kappaB signaling positive regulation of vascular associated smooth muscle cell proliferation positive regulation of signaling receptor activity |
04916 |
| TC1300001526.mm.2 |
Gpr141 |
G protein-coupled receptor 141 |
13 |
-19749681 |
NM_181754, BC125585, BC125587 NM_181754, BC125585, BC125587 NM_181754, BC125585, BC125587 |
353346 |
13 |
G protein-coupled receptor activity cellular_component plasma membrane signal transduction membrane integral component of membrane |
|
| TC0700004604.mm.2 |
Cttn |
cortactin |
7 |
-144435723 |
NM_001252572, NM_007803, BC011434 NM_001252572, NM_007803, BC011434 NM_001252572, NM_007803, BC011434 |
13043 |
132 |
ruffle podosome protein binding profilin binding cytoplasm cytoplasm Golgi apparatus cytosol cytosol cytoskeleton actin filament actin filament plasma membrane plasma membrane clathrin-coated pit focal adhesion cell cortex cell cortex intracellular protein transport intracellular protein transport endocytosis receptor-mediated endocytosis substrate-dependent cell migration, cell extension voltage-gated potassium channel complex voltage-gated potassium channel complex voltage-gated potassium channel complex membrane lamellipodium lamellipodium lamellipodium actin filament polymerization cell junction growth cone site of polarized growth regulation of axon extension regulation of actin filament polymerization positive regulation of actin filament polymerization cortical cytoskeleton cortical actin cytoskeleton actin cytoskeleton reorganization cell projection intracellular membrane-bounded organelle synapse positive regulation of smooth muscle contraction focal adhesion assembly neuron projection morphogenesis cell motility actin filament binding proline-rich region binding Arp2/3 complex binding dendritic spine maintenance lamellipodium organization postsynaptic actin cytoskeleton modification of postsynaptic actin cytoskeleton glutamatergic synapse regulation of autophagy of mitochondrion mitotic spindle midzone negative regulation of extrinsic apoptotic signaling pathway |
04530 05100 |
| TC0X00003436.mm.2 |
Gm614 |
predicted gene 614 |
X |
-101261372 |
NM_001033362, BC147523, BC147537 NM_001033362, BC147523, BC147537 NM_001033362, BC147523, BC147537 |
245536 |
8 |
molecular_function cellular_component biological_process |
|
| TC1200001353.mm.2 |
Ncoa1 |
nuclear receptor coactivator 1 |
12 |
-4247361 |
NM_010881, BC068177, BC080866 NM_010881, BC068177, BC080866 NM_010881, BC068177, BC080866 |
17977 |
152 |
positive regulation of transcription from RNA polymerase II promoter by galactose positive regulation of transcription from RNA polymerase II promoter by galactose chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding regulation of thyroid hormone mediated signaling pathway DNA binding chromatin binding transcription coactivator activity transcription coactivator activity transcription coactivator activity histone acetyltransferase activity protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytosol plasma membrane regulation of transcription, DNA-templated transcription factor binding transcription factor binding transferase activity transferase activity, transferring acyl groups nuclear receptor binding nuclear receptor binding aryl hydrocarbon receptor binding enzyme binding estrogen receptor binding nuclear receptor coactivator activity nuclear receptor coactivator activity response to estradiol response to retinoic acid response to progesterone cellular response to hormone stimulus cellular response to hormone stimulus protein-containing complex progesterone receptor binding nuclear hormone receptor binding retinoic acid receptor binding neuron projection positive regulation of apoptotic process histone H4 acetylation protein-containing complex binding positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II retinoid X receptor binding protein dimerization activity protein N-terminus binding male mating behavior labyrinthine layer morphogenesis cellular response to Thyroglobulin triiodothyronine regulation of cellular response to drug regulation of RNA biosynthetic process |
|
| TC1300000638.mm.2 |
Tspan17 |
tetraspanin 17 |
13 |
54789404 |
NM_028841, BC010346 NM_028841, BC010346 |
74257 |
17 |
integral component of plasma membrane membrane integral component of membrane enzyme binding enzyme binding protein maturation protein maturation establishment of protein localization to organelle protein localization to plasma membrane |
|
| TC1000000529.mm.2 |
Sowahc |
sosondowah ankyrin repeat domain family member C |
10 |
59221921 |
NM_172939 |
268301 |
13 |
molecular_function cellular_component biological_process |
|
| TC1000002383.mm.2 |
Gstt1 |
glutathione S-transferase, theta 1 |
10 |
-75783812, -75783812 |
NM_008185, BC012254, BC055020 NM_008185, BC012254, BC055020 NM_008185, BC012254, BC055020 |
14871 |
32 |
glutathione transferase activity glutathione transferase activity glutathione transferase activity glutathione peroxidase activity nucleus cytoplasm cytosol DNA modification glutathione metabolic process glutathione metabolic process glutathione metabolic process glutathione metabolic process transferase activity dichloromethane metabolic process alkylhalidase activity |
00480 00980 00982 |
| TC0200004423.mm.2 |
Rmdn3 |
regulator of microtubule dynamics 3 |
2 |
-119136997 |
NM_001033136 |
67809 |
30 |
nucleus cytoplasm cytoplasm mitochondrion mitochondrion mitochondrion mitochondrial outer membrane cytoskeleton microtubule spindle microtubule spindle microtubule cellular calcium ion homeostasis apoptotic process microtubule binding microtubule binding membrane integral component of membrane cell differentiation organelle membrane contact site intercellular bridge mitotic spindle pole mitotic spindle pole |
|
| TC0200002308.mm.2 |
Hck |
hemopoietic cell kinase |
2 |
153108467 |
NM_001172117, NM_010407, BC010478 NM_001172117, NM_010407, BC010478 NM_001172117, NM_010407, BC010478 |
15162 |
126 |
nucleotide binding phosphotyrosine residue binding immune system process protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signaling receptor binding protein binding ATP binding nucleus cytoplasm lysosome Golgi apparatus cytoskeleton actin filament plasma membrane caveola focal adhesion protein phosphorylation exocytosis phagocytosis inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell population proliferation regulation of cell shape membrane kinase activity phosphorylation transferase activity peptidyl-tyrosine phosphorylation cell junction cell differentiation extrinsic component of cytoplasmic side of plasma membrane extrinsic component of cytoplasmic side of plasma membrane cytoplasmic vesicle cell projection negative regulation of apoptotic process intracellular membrane-bounded organelle innate immune response protein autophosphorylation regulation of phagocytosis defense response to Gram-positive bacterium regulation of DNA-binding transcription factor activity regulation of podosome assembly positive regulation of actin cytoskeleton reorganization |
04062 04666 |
| TC0200002594.mm.2 |
Cebpb |
CCAAT/enhancer binding protein (C/EBP), beta |
2 |
167688914 |
NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 |
12608 |
535 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II condensed chromosome, centromeric region chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific ovarian follicle development embryonic placenta development granuloma formation DNA binding DNA binding chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription factor binding positive regulation of gene expression nuclear matrix nuclear matrix kinase binding cell differentiation neuron differentiation response to lipopolysaccharide regulation of interleukin-6 production positive regulation of interleukin-4 production mammary gland epithelial cell proliferation response to endoplasmic reticulum stress histone acetyltransferase binding glucocorticoid receptor binding T-helper 1 cell activation CHOP-C/EBP complex negative regulation of T cell proliferation defense response to bacterium identical protein binding protein homodimerization activity histone deacetylase binding negative regulation of neuron apoptotic process sequence-specific DNA binding sequence-specific DNA binding ubiquitin-like protein ligase binding fat cell differentiation fat cell differentiation regulation of cell differentiation positive regulation of fat cell differentiation positive regulation of osteoblast differentiation regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein heterodimerization activity positive regulation of inflammatory response brown fat cell differentiation mammary gland epithelial cell differentiation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of biomineral tissue development cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to interleukin-1 hepatocyte proliferation hepatocyte proliferation RNA polymerase II transcription regulator complex liver regeneration positive regulation of cold-induced thermogenesis regulation of odontoblast differentiation regulation of odontoblast differentiation positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress sequence-specific double-stranded DNA binding positive regulation of sodium-dependent phosphate transport regulation of dendritic cell differentiation |
|
| TC1100003790.mm.2 |
Stat3 |
signal transducer and activator of transcription 3 |
11 |
-100886805 |
NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 |
20848 |
1720 |
chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II repressing transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific temperature homeostasis eye photoreceptor cell differentiation DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex cytoplasm cytoplasm mitochondrion mitochondrial inner membrane cytosol cytosol plasma membrane regulation of transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II protein import into nucleus defense response acute-phase response inflammatory response signal transduction receptor signaling pathway via JAK-STAT receptor signaling pathway via JAK-STAT transcription factor binding cell population proliferation positive regulation of cell population proliferation negative regulation of cell population proliferation negative regulation of autophagy positive regulation of gene expression positive regulation of gene expression negative regulation of hydrogen peroxide biosynthetic process postsynaptic density phosphorylation cytokine-mediated signaling pathway cytokine-mediated signaling pathway stem cell population maintenance protein kinase binding protein phosphatase binding sexual reproduction positive regulation of cell migration intracellular receptor signaling pathway chromatin DNA binding CCR5 chemokine receptor binding response to estradiol positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production cellular response to hormone stimulus leptin-mediated signaling pathway leptin-mediated signaling pathway leptin-mediated signaling pathway leptin-mediated signaling pathway response to cytokine glucocorticoid receptor binding regulation of multicellular organism growth regulation of cell population proliferation glucose homeostasis eating behavior mRNA transcription by RNA polymerase II identical protein binding identical protein binding protein homodimerization activity response to peptide hormone sequence-specific DNA binding sequence-specific DNA binding cellular response to leptin stimulus response to leptin response to leptin response to leptin positive regulation of erythrocyte differentiation positive regulation of Notch signaling pathway positive regulation of angiogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of mitochondrial membrane permeability protein dimerization activity astrocyte differentiation modulation of chemical synaptic transmission positive regulation of NF-kappaB transcription factor activity regulation of cell cycle regulation of cell cycle radial glial cell differentiation regulation of feeding behavior growth hormone receptor signaling pathway growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway via JAK-STAT negative regulation of cell death interleukin-6-mediated signaling pathway primary miRNA binding cellular response to cytokine stimulus cellular response to organic cyclic compound T-helper 17 type immune response T-helper 17 cell lineage commitment RNA polymerase II transcription regulator complex energy homeostasis Schaffer collateral - CA1 synapse glutamatergic synapse postsynapse to nucleus signaling pathway positive regulation of cytokine production involved in inflammatory response negative regulation of neuron death positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of metalloendopeptidase activity positive regulation of vascular endothelial cell proliferation positive regulation of miRNA mediated inhibition of translation negative regulation of primary miRNA processing positive regulation of gene silencing by miRNA negative regulation of stem cell differentiation positive regulation of ATP biosynthetic process negative regulation of neuron migration |
04062 04630 04920 05145 05160 05200 05212 05221 |
| TC1600001203.mm.2 |
Prm1 |
protamine 1 |
16 |
-10796331 |
NM_013637, BC049599, BC059733 NM_013637, BC049599, BC059733 NM_013637, BC049599, BC059733 |
19118 |
110 |
nucleosome DNA binding nucleus nucleus nucleus chromosome nucleus organization multicellular organism development spermatogenesis spermatid development cell differentiation chromosome condensation |
|
| TC1500001658.mm.2 |
St3gal1 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
15 |
-67102874 |
NM_009177, BC084730, BC099670, BC099693 NM_009177, BC084730, BC099670, BC099693 NM_009177, BC084730, BC099670, BC099693 NM_009177, BC084730, BC099670, BC099693 |
20442 |
35 |
memory B cell differentiation beta-galactoside (CMP) alpha-2,3-sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity extracellular region Golgi apparatus protein phosphorylation protein glycosylation protein glycosylation sialyltransferase activity ganglioside biosynthetic process via lactosylceramide ganglioside biosynthetic process via lactosylceramide membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups trans-Golgi network membrane negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process Golgi medial cisterna membrane Golgi trans cisterna membrane protein sialylation protein sialylation protein sialylation |
00512 00533 00603 00604 01100 |
| TC0200001535.mm.2 |
Abtb2 |
ankyrin repeat and BTB (POZ) domain containing 2 |
2 |
103566309 |
NM_178890, BC054399 NM_178890, BC054399 |
99382 |
25 |
protein heterodimerization activity cellular response to toxic substance |
|
| TC0600000007.mm.2 |
Gng11 |
guanine nucleotide binding protein (G protein), gamma 11 |
6 |
4003986 |
NM_025331, BC039062, BC040065 NM_025331, BC039062, BC040065 NM_025331, BC039062, BC040065 |
66066 |
17 |
GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G protein-coupled receptor signaling pathway membrane G-protein beta/gamma-subunit complex G-protein beta-subunit binding |
04062 |
| TC1700002791.mm.2 |
H2-Q1 |
histocompatibility 2, Q region locus 1 |
17 |
35320546 |
NM_010390, BC080812 NM_010390, BC080812 |
15006 |
46 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response external side of plasma membrane cell surface antigen processing and presentation beta-2-microglobulin binding peptide binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding TAP complex binding endoplasmic reticulum exit site |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| TC0600002124.mm.2 |
Dennd2a |
DENN/MADD domain containing 2A |
6 |
-39462377 |
NM_172477, BC145599, BC150799 NM_172477, BC145599, BC150799 NM_172477, BC145599, BC150799 |
209773 |
20 |
guanyl-nucleotide exchange factor activity cytoplasm cytoskeleton protein transport actin cytoskeleton actin cytoskeleton retrograde transport, endosome to Golgi retrograde transport, endosome to Golgi |
|
| TC1700002164.mm.2 |
Rsph9 |
radial spoke head 9 homolog (Chlamydomonas) |
17 |
-46129269 |
NM_029338, BC019423 NM_029338, BC019423 |
75564 |
22 |
cilium movement cilium movement protein binding cytoplasm cytoskeleton cilium axoneme axoneme axoneme axoneme cell projection organization motile cilium motile cilium axoneme assembly axoneme assembly axoneme assembly cell projection motile cilium assembly cilium movement involved in cell motility radial spoke assembly 9+2 motile cilium axonemal central apparatus assembly |
|
| TC0200002018.mm.2 |
Smox |
spermine oxidase |
2 |
131491861 |
NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 NM_001177833, NM_001177834, NM_001177835, NM_001177836, NM_001177837, NM_001177838, NM_001177839, NM_001177840, NM_145533, BC004831 |
228608 |
39 |
nucleus nucleoplasm cytoplasm cytosol polyamine catabolic process oxidoreductase activity nuclear membrane intracellular membrane-bounded organelle spermine catabolic process spermine catabolic process polyamine oxidase activity polyamine oxidase activity polyamine oxidase activity norspermine:oxygen oxidoreductase activity N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity spermine:oxygen oxidoreductase (spermidine-forming) activity |
|
| TC1500000421.mm.2 |
Rnf139 |
ring finger protein 139 |
15 |
58889228 |
NM_175226, BC052901 NM_175226, BC052901 |
75841 |
20 |
protease binding ubiquitin-protein transferase activity endoplasmic reticulum endoplasmic reticulum zinc ion binding negative regulation of cell population proliferation endomembrane system membrane integral component of membrane protein ubiquitination transferase activity negative regulation of translation ubiquitin-like protein transferase activity protein destabilization ERAD pathway ERAD pathway Derlin-1 retrotranslocation complex metal ion binding regulation of ER to Golgi vesicle-mediated transport ubiquitin protein ligase activity regulation of protein processing positive regulation of ubiquitin-dependent protein catabolic process |
|
| TC1900000027.mm.2 |
Pitpnm1 |
phosphatidylinositol transfer protein, membrane-associated 1 |
19 |
4099997, 4100621 |
NM_008851, NR_075078, BC044893, BC048150, NM_001136078 NM_008851, NR_075078, BC044893, BC048150, NM_001136078 NM_008851, NR_075078, BC044893, BC048150, NM_001136078 NM_008851, NR_075078, BC044893, BC048150, NM_001136078 NM_008851, NR_075078, BC044893, BC048150, NM_001136078 |
18739 |
33 |
calcium ion binding phospholipid binding phospholipid transporter activity intracellular anatomical structure cytoplasm endoplasmic reticulum Golgi apparatus lipid droplet cytosol phosphatidylcholine transporter activity phosphatidylinositol transfer activity phosphatidylinositol transfer activity protein transport phospholipid transport membrane receptor tyrosine kinase binding phosphatidylcholine binding phosphatidylcholine binding phosphatidylinositol binding phosphatidylinositol binding intracellular membrane-bounded organelle cell body metal ion binding phosphatidic acid binding |
|
| TC0900001863.mm.2 |
Keap1 |
kelch-like ECH-associated protein 1 |
9 |
-21229729 |
NM_001110305, NM_001110306, NM_001110307, NM_016679, BC055732 NM_001110305, NM_001110306, NM_001110307, NM_016679, BC055732 NM_001110305, NM_001110306, NM_001110307, NM_016679, BC055732 NM_001110305, NM_001110306, NM_001110307, NM_016679, BC055732 NM_001110305, NM_001110306, NM_001110307, NM_016679, BC055732 |
50868 |
232 |
in utero embryonic development protein binding nucleus nucleoplasm cytoplasm cytoplasm cytoplasm endoplasmic reticulum cytosol actin filament adherens junction focal adhesion regulation of transcription, DNA-templated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process transcription factor binding transcription factor binding regulation of autophagy regulation of autophagy negative regulation of gene expression inclusion body inclusion body protein ubiquitination protein ubiquitination midbody Cul3-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex protein-containing complex protein-containing complex centriolar satellite cellular response to oxidative stress cellular response to oxidative stress identical protein binding identical protein binding cytoplasmic sequestering of transcription factor cytoplasmic sequestering of transcription factor regulation of epidermal cell differentiation cellular response to carbohydrate stimulus cellular response to interleukin-4 disordered domain specific binding |
04120 |
| TC0100002203.mm.2 |
Coa5 |
cytochrome C oxidase assembly factor 5 |
1 |
-37417084 |
NM_198006, BC002137 NM_198006, BC002137 |
76178 |
19 |
molecular_function mitochondrion mitochondrion mitochondrial cytochrome c oxidase assembly |
|
| MG-1-neg-10343659_st |
|
|
|
|
|
|
|
|
|
| TC1700000975.mm.2 |
Kat2b |
K(lysine) acetyltransferase 2B |
17 |
53584125, 53566970 |
NM_001190846, NM_020005, BC082581, BC138195, BC145896 NM_001190846, NM_020005, BC082581, BC138195, BC145896 NM_001190846, NM_020005, BC082581, BC138195, BC145896 NM_001190846, NM_020005, BC082581, BC138195, BC145896 NM_001190846, NM_020005, BC082581, BC138195, BC145896 |
18519 |
122 |
histone acetyltransferase complex kinetochore chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding chromatin binding transcription coregulator activity transcription coactivator activity transcription coactivator activity diamine N-acetyltransferase activity histone acetyltransferase activity histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor lysine N-acetyltransferase activity, acting on acetyl phosphate as donor cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding nucleus nucleus nucleoplasm nucleoplasm Ada2/Gcn5/Ada3 transcription activator complex Ada2/Gcn5/Ada3 transcription activator complex cytoplasm centrosome cytosol cytoskeleton chromatin remodeling regulation of transcription, DNA-templated protein acetylation protein acetylation cell cycle transcription factor binding negative regulation of cell population proliferation regulation of protein ADP-ribosylation positive regulation of neuron projection development acetyltransferase activity acetyltransferase activity histone acetylation transferase activity transferase activity, transferring acyl groups N-terminal peptidyl-lysine acetylation internal peptidyl-lysine acetylation internal peptidyl-lysine acetylation peptidyl-lysine acetylation protein kinase binding A band I band cellular response to insulin stimulus protein-containing complex histone acetyltransferase binding positive regulation of chromatin binding actomyosin histone deacetylase binding histone H3 acetylation histone H3-K9 acetylation positive regulation of gluconeogenesis negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of centriole replication rhythmic process peptide-lysine-N-acetyltransferase activity positive regulation of histone H3-K14 acetylation negative regulation of rRNA processing positive regulation of histone H3-K9 acetylation |
04330 |
| TC0900003311.mm.2 |
Fyco1 |
FYVE and coiled-coil domain containing 1 |
9 |
-123789499, -123789499 |
NM_001110253, NM_148925, BC157054 NM_001110253, NM_148925, BC157054 NM_001110253, NM_148925, BC157054 |
17281 |
25 |
lysosome lysosome endosome late endosome late endosome autophagosome autophagosome Golgi apparatus cytoplasmic vesicle intracellular membrane-bounded organelle metal ion binding plus-end-directed vesicle transport along microtubule plus-end-directed vesicle transport along microtubule positive regulation of autophagosome maturation positive regulation of autophagosome maturation |
|
| TC0300000881.mm.2 |
Rfx5 |
regulatory factor X, 5 (influences HLA class II expression) |
3 |
94954107, 94954515 |
NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 |
53970 |
32 |
negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II |
04612 05340 |
| TC0500001888.mm.2 |
Ankib1 |
ankyrin repeat and IBR domain containing 1 |
5 |
-3689998, -3689998 |
NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 |
70797 |
21 |
ubiquitin ligase complex protein polyubiquitination ubiquitin-protein transferase activity cytoplasm ubiquitin-dependent protein catabolic process transferase activity ubiquitin conjugating enzyme binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process metal ion binding ubiquitin protein ligase activity |
|
| TC1700001395.mm.2 |
Tagap1 |
T cell activation GTPase activating protein 1 |
17 |
-6954964 |
NM_147155, BC165956 NM_147155, BC165956 |
380608 |
14 |
GTPase activator activity cellular_component |
|
| TC0600002342.mm.2 |
Nt5c3 |
5'-nucleotidase, cytosolic III |
6 |
-56882400, -56882401, -56882401 |
NM_001252374, NM_026004, BC038029 NM_001252374, NM_026004, BC038029 NM_001252374, NM_026004, BC038029 |
107569 |
23 |
nucleotide binding magnesium ion binding cytoplasm cytoplasm mitochondrion endoplasmic reticulum cytosol CMP catabolic process dCMP catabolic process 5'-nucleotidase activity 5'-nucleotidase activity 5'-nucleotidase activity 5'-nucleotidase activity nucleotide metabolic process transferase activity hydrolase activity UMP catabolic process dTMP catabolic process dUMP catabolic process adenosine metabolic process metal ion binding defense response to virus |
00230 00240 00760 01100 |
| TC0100001600.mm.2 |
Slamf1 |
signaling lymphocytic activation molecule family member 1 |
1 |
171767131, 171767131 |
NM_013730, BC117095, BC117099 NM_013730, BC117095, BC117099 NM_013730, BC117095, BC117099 |
27218 |
74 |
natural killer cell differentiation natural killer cell proliferation leukocyte chemotaxis involved in inflammatory response adaptive immune response myeloid dendritic cell activation involved in immune response immune system process negative regulation of T cell cytokine production protein binding plasma membrane phagocytosis cell adhesion external side of plasma membrane cell surface positive regulation of macrophage chemotaxis membrane integral component of membrane regulation of vesicle fusion negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production T-helper 1 cell cytokine production signaling receptor activity positive regulation of activated T cell proliferation SH2 domain binding identical protein binding identical protein binding innate immune response phagocytic vesicle positive regulation of JNK cascade lymphocyte activation regulation of catalytic activity positive regulation of ERK1 and ERK2 cascade negative regulation of CD40 signaling pathway positive regulation of dendritic cell chemotaxis |
|
| TC1600001048.mm.2 |
Morc3 |
microrchidia 3 |
16 |
93832120 |
NM_001045529, BC098072, BC145705 NM_001045529, BC098072, BC145705 NM_001045529, BC098072, BC145705 |
338467 |
28 |
RNA binding nucleus nucleus nucleoplasm nucleoplasm protein phosphorylation cell aging zinc ion binding post-embryonic development PML body PML body peptidyl-serine phosphorylation methylated histone binding metal ion binding negative regulation of fibroblast proliferation protein stabilization maintenance of protein location in nucleus |
|
| TC0400000496.mm.2 |
Stra6l |
STRA6-like |
4 |
45848815, 45848946 |
NM_028788, BC111889, BC112408 NM_028788, BC111889, BC112408 NM_028788, BC111889, BC112408 |
74152 |
16 |
protein binding plasma membrane plasma membrane membrane integral component of membrane retinol transport vitamin A import vitamin A import |
|
| TC1700002004.mm.2 |
Gm8909 |
predicted gene 8909 |
17 |
-36164443 |
NM_001081032 |
667977 |
2 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding extracellular space immune response external side of plasma membrane peptide antigen binding |
|
| TC1500001491.mm.2 |
|
|
|
|
NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 |
|
|
negative regulation of transcription by RNA polymerase II chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific skeletal system development hair follicle development chondrocyte differentiation nucleic acid binding DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transmembrane receptor protein serine/threonine kinase signaling pathway zinc ion binding protein domain specific binding regulation of chondrocyte differentiation protein-containing complex sequence-specific DNA binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated metal ion binding positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
|
| TC1100003314.mm.2 |
Lgals9 |
lectin, galactose binding, soluble 9 |
11 |
-78962978 |
NM_001159301, NM_010708, BC003754 NM_001159301, NM_010708, BC003754 NM_001159301, NM_010708, BC003754 |
16859 |
104 |
positive regulation of cytokine production immune system process signaling receptor binding protein binding extracellular region extracellular region nucleus nucleus cytoplasm cytosol cytosol chemotaxis heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules female pregnancy positive regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation galactoside binding galactoside binding galactoside binding enzyme binding carbohydrate binding carbohydrate binding carbohydrate binding response to lipopolysaccharide negative regulation of interferon-gamma production negative regulation of interferon-gamma production negative regulation of interferon-gamma production positive regulation of chemokine production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production negative regulation of natural killer cell activation regulation of natural killer cell differentiation toll-like receptor 3 signaling pathway positive regulation of macrophage activation negative regulation of natural killer cell degranulation protein serine/threonine kinase activator activity positive regulation of innate immune response maintenance of protein location positive regulation of regulatory T cell differentiation negative regulation of inflammatory response positive regulation of oxidoreductase activity collagen-containing extracellular matrix cellular response to virus positive regulation of defense response to bacterium positive regulation of T cell migration negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of transcription regulatory region DNA binding |
|
| TC0900001392.mm.2 |
Amigo3 |
adhesion molecule with Ig like domain 3 |
9 |
108053158 |
NM_177275, BC157008 NM_177275, BC157008 |
320844 |
20 |
molecular_function cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nervous system development brain development negative regulation of neuron projection development membrane integral component of membrane integral component of membrane protein-containing complex binding positive regulation of synapse assembly |
|
| TC0200001411.mm.2 |
Pex16 |
peroxisomal biogenesis factor 16 |
2 |
92374675, 92375238 |
NM_145122, NR_028114, BC010822 NM_145122, NR_028114, BC010822 NM_145122, NR_028114, BC010822 |
18633 |
20 |
peroxisome peroxisomal membrane peroxisomal membrane peroxisomal membrane integral component of peroxisomal membrane endoplasmic reticulum endoplasmic reticulum membrane protein targeting to peroxisome peroxisome organization peroxisome organization protein C-terminus binding membrane integral component of membrane peroxisome membrane biogenesis protein import into peroxisome matrix protein to membrane docking ER-dependent peroxisome organization protein import into peroxisome membrane ER-dependent peroxisome localization |
04146 |
| MG-1-neg-10343761_st |
|
|
|
|
|
|
|
|
|
| TC0400000498.mm.2 |
Tdrd7 |
tudor domain containing 7 |
4 |
45965334, 45972296, 45972830 |
NM_146142, BC029689 NM_146142, BC029689 |
100121 |
27 |
lens morphogenesis in camera-type eye lens morphogenesis in camera-type eye RNA binding mRNA binding protein binding cytoplasm mitochondrial matrix multicellular organism development germ cell development spermatogenesis posttranscriptional regulation of gene expression cell differentiation chromatoid body ribonucleoprotein granule P granule protein N-terminus binding lens fiber cell differentiation lens fiber cell differentiation ribonucleoprotein complex |
|
| TC0100001636.mm.2 |
Olfr433 |
olfactory receptor 433 |
1 |
174041932 |
NM_146717, BC119238 NM_146717, BC119238 |
258712 |
12 |
olfactory receptor activity olfactory receptor activity odorant binding G protein-coupled receptor signaling pathway sensory perception of smell integral component of membrane integral component of membrane detection of chemical stimulus involved in sensory perception of smell |
04740 |
| TC0700004636.mm.2 |
Tnni3 |
troponin I, cardiac 3 |
7 |
-4518304 |
NM_009406, BC061171, BC100590 NM_009406, BC061171, BC100590 NM_009406, BC061171, BC100590 |
21954 |
209 |
vasculogenesis regulation of systemic arterial blood pressure by ischemic conditions skeletal muscle contraction actin binding cytoplasm troponin complex troponin complex cellular calcium ion homeostasis cellular calcium ion homeostasis muscle contraction regulation of muscle contraction regulation of smooth muscle contraction striated muscle contraction heart development regulation of cardiac muscle contraction by calcium ion signaling calcium channel inhibitor activity protein kinase binding protein domain specific binding myofibril sarcomere sarcomere troponin C binding troponin T binding negative regulation of ATPase activity contractile fiber metal ion binding calcium-dependent protein binding actin filament binding ventricular cardiac muscle tissue morphogenesis heart contraction cardiac muscle contraction cardiac muscle contraction cardiac myofibril cardiac Troponin complex |
04260 05410 05414 |
| TC1700002766.mm.2 |
|
|
|
|
NM_009341, BC050771, BC141264 NM_009341, BC050771, BC141264 NM_009341, BC050771, BC141264 |
|
|
transcription corepressor activity nucleus centriole biological_process |
|
| TC0500003043.mm.2 |
Cmklr1 |
chemokine-like receptor 1 |
5 |
-113612354, -113612354 |
NM_008153, BC100612 NM_008153, BC100612 |
14747 |
65 |
complement receptor mediated signaling pathway complement receptor activity G protein-coupled receptor activity plasma membrane plasma membrane chemotaxis chemotaxis inflammatory response signal transduction G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of macrophage chemotaxis positive regulation of macrophage chemotaxis membrane integral component of membrane negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-12 production positive regulation of fat cell differentiation regulation of calcium-mediated signaling regulation of calcium-mediated signaling positive regulation of cold-induced thermogenesis |
|
| MG-1-neg-10338367_st |
|
|
|
|
|
|
|
|
|
| TC0700003936.mm.2 |
|
|
|
|
XM_003688838, XM_992714 XM_003688838, XM_992714 |
|
|
|
|
| TC1400002314.mm.2 |
|
|
|
|
XM_003688935, XR_105625 XM_003688935, XR_105625 |
|
|
|
|
| TC0600002554.mm.2 |
Dok1 |
docking protein 1 |
6 |
-83030935 |
NM_010070, BC013066 NM_010070, BC013066 |
13448 |
75 |
protein binding nucleus cytoplasm cytosol transmembrane receptor protein tyrosine kinase signaling pathway Ras protein signal transduction intracellular signal transduction macrophage colony-stimulating factor signaling pathway negative regulation of MAPK cascade |
|
| TC0100001631.mm.2 |
Aim2 |
absent in melanoma 2 |
1 |
173420603 |
NM_001013779, BC009664 NM_001013779, BC009664 |
383619 |
157 |
activation of innate immune response activation of innate immune response activation of innate immune response positive regulation of defense response to virus by host immune system process DNA binding double-stranded DNA binding double-stranded DNA binding double-stranded DNA binding protein binding nucleus nucleoplasm cytoplasm cytoplasm mitochondrion cytosol cytosol apoptotic process inflammatory response negative regulation of NF-kappaB transcription factor activity interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production tumor necrosis factor-mediated signaling pathway cellular response to interferon-beta cellular response to interferon-beta cellular response to drug identical protein binding identical protein binding NLRP3 inflammasome complex assembly innate immune response positive regulation of NF-kappaB transcription factor activity pyroptosis pyroptosis AIM2 inflammasome complex AIM2 inflammasome complex AIM2 inflammasome complex pyroptosome complex assembly positive regulation of cysteine-type endopeptidase activity positive regulation of cysteine-type endopeptidase activity positive regulation of cysteine-type endopeptidase activity |
04623 |
| TC0100000916.mm.2 |
Gpc1 |
glypican 1 |
1 |
92831644 |
NM_016696, BC062902 NM_016696, BC062902 |
14733 |
55 |
copper ion binding nucleoplasm endosome Golgi lumen cytosol plasma membrane regulation of signal transduction cell surface Schwann cell differentiation membrane cell migration fibroblast growth factor binding fibroblast growth factor binding heparan sulfate proteoglycan catabolic process extracellular matrix anchored component of membrane myelin assembly negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway neuronal cell body laminin binding membrane raft membrane raft synapse synapse synapse anchored component of plasma membrane collagen-containing extracellular matrix collagen V binding regulation of protein localization to membrane positive regulation of skeletal muscle cell differentiation |
|
| MG-1-neg-10341263_st |
|
|
|
|
|
|
|
|
|
| MG-1-neg-10338225_st |
|
|
|
|
|
|
|
|
|
| MG-1-neg-10342453_st |
|
|
|
|
|
|
|
|
|
| TC1000001947.mm.2 |
Ncoa7 |
nuclear receptor coactivator 7 |
10 |
-30645581, -30645581 |
NM_001111267, NM_172495, BC141150, BC160294 NM_001111267, NM_172495, BC141150, BC160294 NM_001111267, NM_172495, BC141150, BC160294 NM_001111267, NM_172495, BC141150, BC160294 |
211329 |
27 |
nucleus regulation of transcription by RNA polymerase II response to oxidative stress nuclear receptor coactivator activity nuclear receptor coactivator activity nuclear hormone receptor binding positive regulation of transcription by RNA polymerase II negative regulation of cellular response to oxidative stress negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of oxidative stress-induced neuron death |
|
| TC0900002270.mm.2 |
Tex12 |
testis expressed 12 |
9 |
-50557147 |
NM_025687, BC048458, BC061081 NM_025687, BC048458, BC061081 NM_025687, BC048458, BC061081 |
66654 |
27 |
meiotic DNA repair synthesis meiotic DNA repair synthesis synaptonemal complex synaptonemal complex central element central element protein binding nucleoplasm chromosome synaptonemal complex assembly synaptonemal complex assembly synaptonemal complex assembly |
|
| TC1800000672.mm.2 |
Malt1 |
MALT1 paracaspase |
18 |
65430989 |
NM_172833, BC110487, BC110488 NM_172833, BC110487, BC110488 NM_172833, BC110487, BC110488 |
240354 |
97 |
fibrillar center B-1 B cell differentiation protease binding polkadots positive regulation of T cell cytokine production cysteine-type endopeptidase activity ubiquitin-protein transferase activity protein binding nucleus cytoplasm cytosol cytosol cytosol proteolysis proteolysis apoptotic process I-kappaB kinase/NF-kappaB signaling activation of NF-kappaB-inducing kinase activity peptidase activity response to fungus hydrolase activity kinase activator activity lipopolysaccharide-mediated signaling pathway CBM complex positive regulation of interleukin-1 beta production positive regulation of interleukin-2 production protein-containing complex T cell proliferation B cell activation B cell activation identical protein binding regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein self-association innate immune response innate immune response T cell receptor signaling pathway T cell receptor signaling pathway T cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity nuclear export cellular response to lipopolysaccharide positive regulation of T-helper 17 cell differentiation |
04660 04662 |
| MG-1-neg-10341146_st |
|
|
|
|
|
|
|
|
|
| TC1600001479.mm.2 |
Apod |
apolipoprotein D |
16 |
-31296191 |
NM_007470, BC145907, BC145909 NM_007470, BC145907, BC145909 NM_007470, BC145907, BC145909 |
11815 |
59 |
response to reactive oxygen species response to reactive oxygen species response to reactive oxygen species extracellular region extracellular space intracellular anatomical structure cytoplasm cytoplasm endoplasmic reticulum glucose metabolic process lipid metabolic process lipid metabolic process lipid transport aging lipid binding negative regulation of platelet-derived growth factor receptor signaling pathway cholesterol binding cholesterol binding cytosolic ribosome dendrite negative regulation of protein import into nucleus neuronal cell body perinuclear region of cytoplasm negative regulation of smooth muscle cell proliferation negative regulation of focal adhesion assembly negative regulation of lipoprotein lipid oxidation negative regulation of lipoprotein lipid oxidation negative regulation of monocyte chemotactic protein-1 production negative regulation of cytokine production involved in inflammatory response negative regulation of smooth muscle cell-matrix adhesion negative regulation of T cell migration |
|
| TC0400001147.mm.2 |
Tut4 |
terminal uridylyl transferase 4 |
4 |
108460007, 108459409 |
NM_175472, BC150791 NM_175472, BC150791 |
230594 |
29 |
oocyte maturation cytokine production nucleic acid binding protein binding nucleus nucleolus cytoplasm cytoplasm cytosol zinc ion binding negative regulation of transposition, RNA-mediated miRNA metabolic process miRNA metabolic process miRNA catabolic process transferase activity nucleotidyltransferase activity stem cell population maintenance gene silencing by RNA pre-miRNA processing RNA 3'-end processing RNA 3'-end processing RNA 3'-end processing regulation of lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity positive regulation of interleukin-6 production miRNA binding cytoplasmic ribonucleoprotein granule metal ion binding RNA uridylyltransferase activity RNA uridylyltransferase activity RNA uridylyltransferase activity interleukin-6-mediated signaling pathway uridylyltransferase activity uridylyltransferase activity RNA 3' uridylation RNA 3' uridylation RNA 3' uridylation polyuridylation-dependent mRNA catabolic process |
|
| TC0700002720.mm.2 |
Spint2 |
serine protease inhibitor, Kunitz type 2 |
7 |
-29256329 |
NM_001082548, NM_011464, BC003431, BC026419 NM_001082548, NM_011464, BC003431, BC026419 NM_001082548, NM_011464, BC003431, BC026419 NM_001082548, NM_011464, BC003431, BC026419 |
20733 |
41 |
neural tube closure neural tube closure serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity cytoplasm plasma membrane plasma membrane establishment or maintenance of cell polarity negative regulation of peptidase activity membrane integral component of membrane negative regulation of cell-cell adhesion peptidase inhibitor activity epithelial cell morphogenesis involved in placental branching epithelial cell morphogenesis involved in placental branching basement membrane organization negative regulation of cell motility negative regulation of neural precursor cell proliferation |
|
| TC1000002256.mm.2 |
Hk1 |
hexokinase 1 |
10 |
-62268854, -62268854 |
NM_001146100, NM_010438, BC072628 NM_001146100, NM_010438, BC072628 NM_001146100, NM_010438, BC072628 |
15275 |
90 |
nucleotide binding cellular glucose homeostasis immune system process positive regulation of cytokine production involved in immune response response to ischemia catalytic activity glucokinase activity glucokinase activity glucokinase activity hexokinase activity hexokinase activity hexokinase activity hexokinase activity protein kinase activity protein binding ATP binding glucose binding cytoplasm mitochondrion mitochondrion mitochondrion mitochondrion mitochondrial outer membrane cytosol cytosol cytosol caveola cilium carbohydrate metabolic process fructose 6-phosphate metabolic process mannose metabolic process glycolytic process glycolytic process glycolytic process protein phosphorylation inflammatory response metabolic process fructokinase activity fructokinase activity regulation of anion channel activity membrane kinase activity phosphorylation transferase activity phosphotransferase activity, alcohol group as acceptor peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation mannokinase activity mannokinase activity positive regulation of interleukin-1 beta production protein-containing complex identical protein binding peptidoglycan binding peptidoglycan binding negative regulation of apoptotic process protein-containing complex binding innate immune response membrane raft protein autophosphorylation carbohydrate phosphorylation carbohydrate phosphorylation glucose 6-phosphate metabolic process glucose 6-phosphate metabolic process canonical glycolysis establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion sperm principal piece |
00010 00051 00052 00500 00520 00524 01100 04910 04930 04973 |
| TC0100003866.mm.2 |
Serpinb2 |
serine (or cysteine) peptidase inhibitor, clade B, member 2 |
1 |
107511509, 107511422 |
NM_001174170, NM_011111, BC138815, BC138817 NM_001174170, NM_011111, BC138815, BC138817 NM_001174170, NM_011111, BC138815, BC138817 NM_001174170, NM_011111, BC138815, BC138817 |
18788 |
55 |
serine-type endopeptidase inhibitor activity extracellular region extracellular space cytoplasm negative regulation of peptidase activity negative regulation of endopeptidase activity peptidase inhibitor activity wound healing negative regulation of apoptotic process |
05146 |
| TC0900001720.mm.2 |
Birc2 |
baculoviral IAP repeat-containing 2 |
9 |
-7818225, -7818225 |
NM_007465, BC145985 NM_007465, BC145985 |
11797 |
90 |
protein polyubiquitination response to hypoxia XY body placenta development transcription coactivator activity ubiquitin-protein transferase activity protein binding nucleus nucleus cytoplasm cytoplasm apoptotic process zinc ion binding cytoplasmic side of plasma membrane transferase activity positive regulation of protein ubiquitination protein-containing complex CD40 receptor complex identical protein binding regulation of apoptotic process cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process ubiquitin binding proteasome-mediated ubiquitin-dependent protein catabolic process protein-containing complex binding membrane raft metal ion binding protein N-terminus binding chaperone binding regulation of cell cycle regulation of cell cycle regulation of necroptotic process negative regulation of necroptotic process negative regulation of necroptotic process ubiquitin protein ligase activity necroptotic process cellular response to tumor necrosis factor FBXO family protein binding regulation of NIK/NF-kappaB signaling negative regulation of ripoptosome assembly involved in necroptotic process positive regulation of protein K63-linked ubiquitination positive regulation of protein K48-linked ubiquitination positive regulation of protein monoubiquitination positive regulation of protein polyubiquitination regulation of reactive oxygen species metabolic process |
04120 04210 04510 04621 05145 05200 05222 |
| TC0X00003432.mm.2 |
Mecp2 |
methyl CpG binding protein 2 |
X |
-74026591 |
NM_001081979, NM_010788, BC027153 NM_001081979, NM_010788, BC027153 NM_001081979, NM_010788, BC027153 |
17257 |
618 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II four-way junction DNA binding chromatin heterochromatin heterochromatin heterochromatin behavioral fear response response to hypoxia startle response nervous system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by nervous system process DNA binding DNA binding chromatin binding chromatin binding chromatin binding DNA-binding transcription factor activity DNA-binding transcription factor activity transcription corepressor activity transcription corepressor activity mRNA binding protein binding nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm centrosome cytosol cytosol inositol metabolic process chromatin silencing regulation of gene expression by genetic imprinting regulation of gene expression by genetic imprinting regulation of transcription by RNA polymerase II glutamine metabolic process cellular biogenic amine metabolic process triglyceride metabolic process mitotic spindle organization chemical synaptic transmission synapse assembly brain development respiratory gaseous exchange by respiratory system learning memory long-term memory protein localization transcription factor binding glucocorticoid metabolic process positive regulation of cell population proliferation positive regulation of cell population proliferation methyl-CpG binding methyl-CpG binding methyl-CpG binding adult locomotory behavior visual learning embryo development post-embryonic development double-stranded methylated DNA binding double-stranded methylated DNA binding double-stranded methylated DNA binding double-stranded methylated DNA binding regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle dendrite development negative regulation of angiogenesis histone methylation histone acetylation proprioception sensory perception of pain enzyme binding protein domain specific binding cerebellum development ventricular system development neuron differentiation neuron projection development chromatin DNA binding positive regulation of synaptic plasticity cardiolipin metabolic process negative regulation of protein binding protein-containing complex multicellular organismal response to stress social behavior social behavior siRNA binding cellular response to potassium ion regulation of gene expression, epigenetic response to cocaine neuron maturation histone deacetylase binding negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration regulation of DNA methylation unmethylated CpG binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II phosphatidylcholine metabolic process protein N-terminus binding regulation of synaptic plasticity negative regulation of astrocyte differentiation regulation of synapse organization neuromuscular process controlling posture neuromuscular process negative regulation of smooth muscle cell differentiation regulation of histone H3-K9 methylation response to other organism excitatory postsynaptic potential long-term synaptic potentiation positive regulation of dendritic spine development negative regulation of dendritic spine development cellular response to isoquinoline alkaloid positive regulation of microtubule nucleation glutamatergic synapse positive regulation of histone H3-K9 trimethylation positive regulation of anterograde dense core granule transport positive regulation of retrograde dense core granule transport negative regulation of dendrite extension positive regulation of dendrite extension positive regulation of branching morphogenesis of a nerve positive regulation of DNA methylation promoter-specific chromatin binding promoter-specific chromatin binding negative regulation of primary miRNA processing negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation |
|
| MG-1-neg-10338178_st |
|
|
|
|
|
|
|
|
|
| TC1600000264.mm.2 |
B3gnt5 |
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 |
16 |
19760233 |
NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 |
108105 |
22 |
Golgi apparatus protein glycosylation multicellular organism development central nervous system development brain development acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity galactosyltransferase activity beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity membrane integral component of membrane transferase activity transferase activity, transferring glycosyl groups sphingolipid biosynthetic process lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity |
00601 01100 |
| TC0600001421.mm.2 |
C1rl |
complement component 1, r subcomponent-like |
6 |
124493112 |
NM_181344, BC070472 NM_181344, BC070472 |
232371 |
14 |
immune system process serine-type endopeptidase activity extracellular region extracellular space extracellular space proteolysis complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation innate immune response blood microparticle |
|
| TC0500003585.mm.2 |
Smurf1 |
SMAD specific E3 ubiquitin protein ligase 1 |
5 |
-144876494 |
NM_001038627, NM_029438, BC029097 NM_001038627, NM_029438, BC029097 NM_001038627, NM_029438, BC029097 |
75788 |
84 |
protein polyubiquitination protein polyubiquitination ubiquitin-protein transferase activity ubiquitin-protein transferase activity protein binding cytoplasm cytoplasm mitochondrion cytosol plasma membrane ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process protein export from nucleus membrane protein ubiquitination protein ubiquitination protein ubiquitination transferase activity cell differentiation cell differentiation negative regulation of ossification axon BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway negative regulation of BMP signaling pathway ubiquitin-dependent SMAD protein catabolic process ubiquitin-dependent SMAD protein catabolic process receptor catabolic process protein localization to cell surface neuronal cell body proteasome-mediated ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process ubiquitin protein ligase activity ubiquitin protein ligase activity ubiquitin protein ligase activity parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization engulfment of target by autophagosome substrate localization to autophagosome I-SMAD binding R-SMAD binding protein targeting to vacuole involved in autophagy positive regulation of dendrite extension positive regulation of ubiquitin-dependent protein catabolic process |
04120 04144 04350 |
| TC1300000709.mm.2 |
Idnk |
idnK gluconokinase homolog (E. coli) |
13 |
58157648 |
NM_001048060, NM_198004, BC026742 NM_001048060, NM_198004, BC026742 NM_001048060, NM_198004, BC026742 |
75731 |
12 |
nucleotide binding ATP binding carbohydrate metabolic process kinase activity transferase activity D-gluconate catabolic process gluconokinase activity |
|
| TC1100001242.mm.2 |
Slfn3 |
schlafen 3 |
11 |
83191329 |
NM_011409, BC132627, BC138070, BC145134 NM_011409, BC132627, BC138070, BC145134 NM_011409, BC132627, BC138070, BC145134 NM_011409, BC132627, BC138070, BC145134 |
20557 |
17 |
negative regulation of cell population proliferation |
|
| TC1600002061.mm.2 |
Paxbp1 |
PAX3 and PAX7 binding protein 1 |
16 |
-91014036 |
NM_026110, BC014838 NM_026110, BC014838 |
67367 |
24 |
DNA binding DNA-binding transcription factor activity protein binding nucleus nucleus regulation of transcription, DNA-templated muscle organ development transcription factor binding regulation of skeletal muscle satellite cell proliferation positive regulation of histone methylation positive regulation of histone methylation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of myoblast proliferation |
|
| TC1300002306.mm.2 |
Trip13 |
thyroid hormone receptor interactor 13 |
13 |
-73912461 |
NM_027182, BC126946 NM_027182, BC126946 |
69716 |
42 |
nucleotide binding oocyte maturation oocyte maturation male germ cell nucleus protein binding ATP binding nucleus chromosome double-strand break repair mitotic spindle assembly checkpoint synaptonemal complex assembly reciprocal meiotic recombination reciprocal meiotic recombination male meiosis I female meiosis I spermatogenesis spermatid development cell differentiation identical protein binding identical protein binding oogenesis meiotic cell cycle meiotic recombination checkpoint |
|
| TC1000002916.mm.2 |
Rab3ip |
RAB3A interacting protein |
10 |
-116905779 |
NM_001003950, BC080289 NM_001003950, BC080289 |
216363 |
25 |
guanyl-nucleotide exchange factor activity nucleus cytoplasm Golgi apparatus centrosome cytosol cytoskeleton protein targeting to membrane exocytosis protein transport protein localization to organelle identical protein binding cell projection perinuclear region of cytoplasm GTPase binding negative regulation of filopodium assembly cilium assembly Golgi to plasma membrane transport vesicle proximal dendrite |
|
| TC0600001736.mm.2 |
Stk38l |
serine/threonine kinase 38 like |
6 |
146724929, 146724929 |
NM_172734, BC062170 NM_172734, BC062170 |
232533 |
22 |
nucleotide binding magnesium ion binding actin binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity ATP binding cytoplasm cytoplasm cytosol cytoskeleton protein phosphorylation actin cytoskeleton membrane kinase activity phosphorylation transferase activity peptidyl-serine phosphorylation intracellular signal transduction intracellular signal transduction metal ion binding regulation of cellular component organization |
|
| MG-1-neg-10344406_st |
|
|
|
|
|
|
|
|
|
| TC0600001422.mm.2 |
C1ra |
complement component 1, r subcomponent A |
6 |
124512620 |
NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 |
50909 |
19 |
immune system process serine-type endopeptidase activity serine-type endopeptidase activity calcium ion binding extracellular space extracellular space complement activation, classical pathway peptidase activity serine-type peptidase activity hydrolase activity zymogen activation identical protein binding innate immune response blood microparticle |
04145 04610 05150 05322 |
| TC0100001294.mm.2 |
Dennd1b |
DENN/MADD domain containing 1B |
1 |
138967720, 138963708 |
NM_001166501, NM_181347, BC141388, BC141389 NM_001166501, NM_181347, BC141388, BC141389 NM_001166501, NM_181347, BC141388, BC141389 NM_001166501, NM_181347, BC141388, BC141389 |
329260 |
13 |
guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity cytoplasm cytosol cytosol endocytosis protein transport nuclear speck nuclear speck small GTPase binding cytoplasmic vesicle endocytic recycling endocytic recycling T-helper 2 cell cytokine production T-helper 2 cell cytokine production T-helper 2 cell cytokine production intracellular membrane-bounded organelle positive regulation of GTPase activity regulation of immune response T cell receptor signaling pathway T cell receptor signaling pathway T cell receptor signaling pathway phosphatidylinositol phosphate binding |
|
| TC1000000446.mm.2 |
Ascc3 |
activating signal cointegrator 1 complex subunit 3 |
10 |
50592668 |
NM_198007, BC059917 NM_198007, BC059917 |
77987 |
16 |
nucleotide binding nucleic acid binding RNA binding helicase activity ATP binding nucleus nucleus cytosol DNA repair DNA dealkylation involved in DNA repair cellular response to DNA damage stimulus cell population proliferation hydrolase activity DNA duplex unwinding 3'-5' DNA helicase activity 3'-5' DNA helicase activity activating signal cointegrator 1 complex |
|
| TC1200000359.mm.2 |
Dock4 |
dedicator of cytokinesis 4 |
12 |
40446052 |
NM_172803, BC141138, BC172663 NM_172803, BC141138, BC172663 NM_172803, BC141138, BC172663 |
238130 |
25 |
guanyl-nucleotide exchange factor activity GTPase activator activity nucleolus cytoplasm Golgi apparatus cytosol plasma membrane small GTPase mediated signal transduction membrane SH3 domain binding PDZ domain binding receptor tyrosine kinase binding small GTPase binding stereocilium stereocilium bundle cell chemotaxis negative regulation of vascular associated smooth muscle contraction positive regulation of vascular associated smooth muscle cell migration |
|
| TC1000001988.mm.2 |
Zup1 |
zinc finger containing ubiquitin peptidase 1 |
10 |
-33919141, -33925133 |
NM_028287, BC089514 NM_028287, BC089514 |
72580 |
18 |
nucleic acid binding thiol-dependent ubiquitin-specific protease activity nucleus cytoplasm regulation of gene expression hydrolase activity metal ion binding |
|
| TC1100001474.mm.2 |
Gngt2 |
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 |
11 |
95842667, 95842294, 95843244 |
NM_001038664, NM_001284393, NM_001284397, NM_023121, BC061005 NM_001038664, NM_001284393, NM_001284397, NM_023121, BC061005 NM_001038664, NM_001284393, NM_001284397, NM_023121, BC061005 NM_001038664, NM_001284393, NM_001284397, NM_023121, BC061005 NM_001038664, NM_001284393, NM_001284397, NM_023121, BC061005 |
14710 |
24 |
GTPase activity heterotrimeric G-protein complex plasma membrane signal transduction G protein-coupled receptor signaling pathway membrane G-protein beta/gamma-subunit complex G-protein beta-subunit binding |
04062 |
| TC1300001857.mm.2 |
Mak |
male germ cell-associated kinase |
13 |
-41025119, -41025119 |
NM_001145802, NM_001145803, NM_008547 NM_001145802, NM_001145803, NM_008547 NM_001145802, NM_001145803, NM_008547 |
17152 |
22 |
nucleotide binding photoreceptor outer segment photoreceptor inner segment transcription coactivator activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleus nucleus cytoplasm centrosome cytoskeleton cilium axoneme protein phosphorylation kinase activity phosphorylation transferase activity midbody motile cilium photoreceptor connecting cilium intracellular signal transduction intraciliary transport cell projection photoreceptor cell maintenance protein autophosphorylation metal ion binding cilium assembly mitotic spindle ciliary tip negative regulation of non-motile cilium assembly negative regulation of non-motile cilium assembly negative regulation of non-motile cilium assembly |
|
| TC1200000652.mm.2 |
Hif1a |
hypoxia inducible factor 1, alpha subunit |
12 |
73907866, 73901323, 73907866 |
NM_010431, BC026139 NM_010431, BC026139 |
15251 |
1372 |
negative regulation of transcription by RNA polymerase II response to reactive oxygen species chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific angiogenesis blood vessel development response to hypoxia response to hypoxia response to hypoxia response to hypoxia neural crest cell migration epithelial to mesenchymal transition embryonic placenta development embryonic placenta development B-1 B cell homeostasis vasculature development heart looping p53 binding positive regulation of neuroblast proliferation connective tissue replacement involved in inflammatory response wound healing cytokine production involved in inflammatory response outflow tract morphogenesis cardiac ventricle morphogenesis DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm transcription regulator complex cytoplasm cytosol lactate metabolic process regulation of glycolytic process regulation of glycolytic process regulation of transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II cellular iron ion homeostasis signal transduction lactation transcription factor binding positive regulation of cell population proliferation visual learning regulation of gene expression regulation of gene expression positive regulation of autophagy vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration response to muscle activity positive regulation of macroautophagy nuclear body nuclear speck axonal transport of mitochondrion enzyme binding protein kinase binding protein domain specific binding neural fold elevation formation cerebral cortex development cell differentiation cell differentiation negative regulation of ossification negative regulation of bone mineralization positive regulation of vascular endothelial growth factor receptor signaling pathway motile cilium ubiquitin protein ligase binding negative regulation of TOR signaling oxygen homeostasis oxygen homeostasis regulation of transforming growth factor beta2 production collagen metabolic process protein-containing complex histone acetyltransferase binding embryonic hemopoiesis nuclear hormone receptor binding positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell population proliferation hemoglobin biosynthetic process glucose homeostasis histone deacetylase binding positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration sequence-specific DNA binding sequence-specific DNA binding regulation of transcription from RNA polymerase II promoter in response to oxidative stress regulation of transcription from RNA polymerase II promoter in response to oxidative stress protein-containing complex binding positive regulation of erythrocyte differentiation positive regulation of gluconeogenesis positive regulation of angiogenesis positive regulation of transcription, DNA-templated negative regulation of vasoconstriction negative regulation of growth positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II muscle cell cellular homeostasis positive regulation of hormone biosynthetic process protein heterodimerization activity protein heterodimerization activity protein dimerization activity blood vessel morphogenesis digestive tract morphogenesis camera-type eye morphogenesis positive regulation of smooth muscle cell proliferation regulation of catalytic activity cartilage development elastin metabolic process Hsp90 protein binding intestinal epithelial cell maturation response to fungicide epithelial cell differentiation involved in mammary gland alveolus development iris morphogenesis retina vasculature development in camera-type eye positive regulation of transcription from RNA polymerase II promoter in response to hypoxia positive regulation of chemokine-mediated signaling pathway regulation of thymocyte apoptotic process negative regulation of thymocyte apoptotic process E-box binding cellular response to hypoxia cellular response to hypoxia cellular response to hypoxia dopaminergic neuron differentiation dopaminergic neuron differentiation RNA polymerase II transcription regulator complex hypoxia-inducible factor-1alpha signaling pathway cellular response to virus positive regulation of pri-miRNA transcription by RNA polymerase II negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of autophagy of mitochondrion regulation of aerobic respiration positive regulation of signaling receptor activity negative regulation of reactive oxygen species metabolic process regulation of protein neddylation negative regulation of mesenchymal cell apoptotic process |
04150 05200 05211 |
| MG-1-neg-10338703_st |
|
|
|
|
|
|
|
|
|
| TC0200001935.mm.2 |
Mertk |
MER proto-oncogene tyrosine kinase |
2 |
128698914 |
NM_008587, BC157109 NM_008587, BC157109 |
17289 |
190 |
nucleotide binding photoreceptor outer segment natural killer cell differentiation negative regulation of cytokine production protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding extracellular space cytoplasm integral component of plasma membrane protein phosphorylation phagocytosis phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development spermatogenesis nervous system development membrane integral component of membrane rhabdomere kinase activity phosphorylation cell migration transferase activity platelet activation secretion by cell positive regulation of kinase activity substrate adhesion-dependent cell spreading receptor complex apoptotic cell clearance apoptotic cell clearance apoptotic cell clearance protein kinase B signaling positive regulation of phagocytosis negative regulation of lymphocyte activation retina development in camera-type eye vagina development neutrophil clearance negative regulation of leukocyte apoptotic process |
|
| TC1400002454.mm.2 |
Lacc1 |
laccase domain containing 1 |
14 |
-77024200 |
NM_172488, BC116748, BC119140 NM_172488, BC116748, BC119140 NM_172488, BC116748, BC119140 |
210808 |
18 |
pattern recognition receptor signaling pathway cytokine production involved in immune response immune system process adenosine deaminase activity purine-nucleoside phosphorylase activity copper ion binding nucleus cytoplasm peroxisome endoplasmic reticulum inflammatory response transferase activity hydrolase activity S-methyl-5-thioadenosine phosphorylase activity regulation of cellular pH innate immune response metal ion binding guanosine phosphorylase activity regulation of inflammatory response nucleotide-binding oligomerization domain containing 2 signaling pathway regulation of purine nucleotide metabolic process |
|
| MG-1-neg-10342988_st |
|
|
|
|
|
|
|
|
|
| MG-1-pos-10338779_st |
|
|
|
|
|
|
|
|
|
| TC0100002063.mm.2 |
Ogfrl1 |
opioid growth factor receptor-like 1 |
1 |
-23366423, -23366435 |
NM_001081079 |
70155 |
15 |
opioid receptor activity cellular_component biological_process membrane signaling receptor activity |
|
| TC1900000923.mm.2 |
Syt12 |
synaptotagmin XII |
19 |
-4445907 |
NM_134164, BC116846, BC116848 NM_134164, BC116846, BC116848 NM_134164, BC116846, BC116848 |
171180 |
16 |
SNARE binding phosphatidylserine binding calcium ion binding calcium-dependent phospholipid binding plasma membrane synaptic vesicle synaptic vesicle regulation of dopamine secretion membrane integral component of membrane vesicle-mediated transport calcium-ion regulated exocytosis regulation of calcium ion-dependent exocytosis syntaxin binding cell junction clathrin binding cytoplasmic vesicle synapse regulation of neurotransmitter secretion spontaneous exocytosis of neurotransmitter long-term synaptic potentiation exocytic vesicle cellular response to calcium ion hippocampal mossy fiber to CA3 synapse presynapse |
|
| TC0600003537.mm.2 |
Clec9a |
C-type lectin domain family 9, member a |
6 |
129408861 |
NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 |
232414 |
47 |
positive regulation of cytokine production receptor-mediated endocytosis receptor-mediated endocytosis receptor-mediated endocytosis cell surface cell surface cell surface membrane integral component of membrane carbohydrate binding |
|
| TC0900001204.mm.2 |
Xrn1 |
5'-3' exoribonuclease 1 |
9 |
95954759 |
NM_011916, BC156976 NM_011916, BC156976 |
24127 |
28 |
telomere maintenance telomere maintenance P-body P-body nuclear-transcribed mRNA catabolic process nuclear-transcribed mRNA catabolic process G-quadruplex RNA binding nucleic acid binding DNA binding RNA binding nuclease activity exonuclease activity 5'-3' exoribonuclease activity 5'-3' exoribonuclease activity 5'-3' exoribonuclease activity 5'-3' exoribonuclease activity protein binding nucleus cytoplasm cytosol plasma membrane RNA processing cell aging 5'-3' exonuclease activity rRNA catabolic process rRNA catabolic process hydrolase activity negative regulation of translation dendrite neuronal cell body synapse meiotic cell cycle G-quadruplex DNA binding nuclear mRNA surveillance histone mRNA catabolic process RNA phosphodiester bond hydrolysis, exonucleolytic |
03008 03018 |
| TC1400002406.mm.2 |
Lrch1 |
leucine-rich repeats and calponin homology (CH) domain containing 1 |
14 |
-74754672 |
NM_001033439, NM_001252132 NM_001033439, NM_001252132 |
380916 |
23 |
protein binding cytoplasm cytoplasm negative regulation of GTPase activity negative regulation of GTPase activity cellular response to chemokine cellular response to chemokine cellular response to chemokine negative regulation of T cell migration negative regulation of T cell migration negative regulation of T cell migration |
|
| TC1700000073.mm.2 |
Tcp10a |
t-complex protein 10a |
17 |
7324659 |
NM_011553, NR_046291, BC052353 NM_011553, NR_046291, BC052353 NM_011553, NR_046291, BC052353 |
21461 |
42 |
transcription corepressor activity nucleus centriole biological_process |
|
| TC1600002150.mm.2 |
Fam3b |
FAM3 metabolism regulating signaling molecule B |
16 |
-97470964 |
NM_020622, BC048949 NM_020622, BC048949 |
52793 |
38 |
cytokine activity extracellular region extracellular space nuclear envelope lumen apoptotic process insulin secretion insulin secretion insulin secretion glucose homeostasis |
|
| TC1100000785.mm.2 |
Grap |
GRB2-related adaptor protein |
11 |
61653320 |
NM_027817, BC120674, BC120676 NM_027817, BC120674, BC120676 NM_027817, BC120674, BC120676 |
71520 |
15 |
sensory perception of sound membrane cell junction synapse |
|
| TC0200001036.mm.2 |
Hat1 |
histone aminotransferase 1 |
2 |
71389259 |
NM_026115, BC055460 NM_026115, BC055460 |
107435 |
36 |
chromatin histone acetyltransferase activity nucleus nucleoplasm chromatin organization DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly chromatin silencing at telomere H4 histone acetyltransferase activity H4 histone acetyltransferase activity histone acetylation transferase activity transferase activity, transferring acyl groups protein-containing complex histone binding histone H4 acetylation histone H4 acetylation |
|
| TC1800000105.mm.2 |
Ttc39c |
tetratricopeptide repeat domain 39C |
18 |
12643532 |
NM_028341, BC020021 NM_028341, BC020021 |
72747 |
17 |
molecular_function cellular_component otolith morphogenesis cilium assembly |
|
| MG-1-neg-10342169_st |
|
|
|
|
|
|
|
|
|
| TC0600003307.mm.2 |
Dusp16 |
dual specificity phosphatase 16 |
6 |
-134715467 |
NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 |
70686 |
39 |
inactivation of MAPK activity inactivation of MAPK activity phosphoprotein phosphatase activity protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytosol protein dephosphorylation protein tyrosine/threonine phosphatase activity dephosphorylation phosphatase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity peptidyl-tyrosine dephosphorylation peptidyl-threonine dephosphorylation negative regulation of MAPK cascade mitogen-activated protein kinase binding |
04010 |
| TC0X00000463.mm.2 |
A630012P03Rik |
RIKEN cDNA A630012P03 gene |
X |
52575842 |
NR_045367 |
100504594 |
12 |
|
|
| TC0200003157.mm.2 |
Traf2 |
TNF receptor-associated factor 2 |
2 |
-25517981 |
NM_009422, BC003801 NM_009422, BC003801 |
22030 |
193 |
ubiquitin ligase complex regulation of immunoglobulin production positive regulation of T cell cytokine production tumor necrosis factor receptor superfamily complex ubiquitin-protein transferase activity ubiquitin-protein transferase activity tumor necrosis factor receptor binding tumor necrosis factor receptor binding CD40 receptor binding protein binding cytoplasm cytoplasm cytosol cytosol cell cortex apoptotic process signal transduction activation of NF-kappaB-inducing kinase activity zinc ion binding lipid binding cytoplasmic side of plasma membrane cytoplasmic side of plasma membrane vesicle membrane transferase activity enzyme binding protein kinase binding protein phosphatase binding protein catabolic process protein-macromolecule adaptor activity mitogen-activated protein kinase kinase kinase binding ubiquitin protein ligase binding ubiquitin protein ligase binding thioesterase binding positive regulation of interleukin-2 production protein-containing complex tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway negative regulation of glial cell apoptotic process cellular protein-containing complex assembly CD40 receptor complex identical protein binding regulation of apoptotic process negative regulation of apoptotic process tumor necrosis factor binding regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein-containing complex assembly positive regulation of JUN kinase activity protein-containing complex binding protein-containing complex binding membrane raft membrane raft regulation of JNK cascade positive regulation of JNK cascade sphingolipid binding metal ion binding positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of NF-kappaB transcription factor activity protein autoubiquitination protein K63-linked ubiquitination protein K63-linked ubiquitination cellular response to nitric oxide TRAF2-GSTP1 complex programmed necrotic cell death plasma membrane signaling receptor complex positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of I-kappaB phosphorylation IRE1-TRAF2-ASK1 complex IRE1-TRAF2-ASK1 complex positive regulation of extrinsic apoptotic signaling pathway |
04010 04141 04210 04380 04622 04920 05160 05200 05222 |
| TC1300000514.mm.2 |
Jarid2 |
jumonji, AT rich interactive domain 2 |
13 |
44730773, 44731270 |
NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 |
16468 |
106 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II liver development DNA binding DNA binding chromatin binding protein binding nucleus nucleus nucleus nucleoplasm mitochondrion chromatin organization chromatin remodeling multicellular organism development transcription factor binding negative regulation of cell population proliferation negative regulation of cardiac muscle hypertrophy cell differentiation negative regulation of histone methylation histone methyltransferase complex ESC/E(Z) complex ESC/E(Z) complex regulation of cell population proliferation negative regulation of transcription, DNA-templated spleen development thymus development stem cell differentiation positive regulation of histone H3-K9 methylation negative regulation of cardiac muscle cell proliferation cellular response to leukemia inhibitory factor |
|
| MG-1-pos-10338817_st |
|
|
|
|
|
|
|
|
|
| TC0300000680.mm.2 |
Lrba |
LPS-responsive beige-like anchor |
3 |
86224689, 86224689, 86224689 |
NM_001077687, NM_001077688, NM_030695 NM_001077687, NM_001077688, NM_030695 NM_001077687, NM_001077688, NM_030695 |
80877 |
29 |
lysosome endoplasmic reticulum Golgi apparatus trans-Golgi network cytosol plasma membrane signal transduction protein localization protein localization membrane integral component of membrane endosomal transport protein kinase binding cytoplasmic vesicle protein kinase A binding cellular response to leukemia inhibitory factor |
|
| MG-1-neg-10344520_st |
|
|
|
|
|
|
|
|
|
| MG-1-pos-10340597_st |
|
|
|
|
|
|
|
|
|
| TC0100003207.mm.2 |
Rgs1 |
regulator of G-protein signaling 1 |
1 |
-144244668 |
NM_015811, BC028634 NM_015811, BC028634 |
50778 |
28 |
G-protein alpha-subunit binding GTPase activator activity GTPase activator activity cytoplasm cytosol plasma membrane signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway response to bacterium negative regulation of signal transduction membrane extrinsic component of cytoplasmic side of plasma membrane positive regulation of GTPase activity leukotriene signaling pathway |
|
| MG-1-neg-10341767_st |
|
|
|
|
|
|
|
|
|
| TC1300001654.mm.2 |
Carmil1 |
capping protein regulator and myosin 1 linker 1 |
13 |
-24012483, -24012480, -24012480 |
NM_026825, BC167257 NM_026825, BC167257 |
68732 |
23 |
nucleoplasm cytoplasm cytosol cytoskeleton plasma membrane membrane cell migration nuclear speck lamellipodium lamellipodium lamellipodium assembly positive regulation of cell migration positive regulation of cell migration positive regulation of actin filament polymerization cell leading edge ruffle organization filamentous actin cell projection macropinocytosis macropinosome protein-containing complex binding protein-containing complex binding urate metabolic process positive regulation of stress fiber assembly positive regulation of stress fiber assembly barbed-end actin filament uncapping actin filament network formation positive regulation of substrate adhesion-dependent cell spreading positive regulation of substrate adhesion-dependent cell spreading positive regulation of lamellipodium organization positive regulation of lamellipodium organization negative regulation of barbed-end actin filament capping |
|
| MG-1-neg-10340774_st |
|
|
|
|
|
|
|
|
|
| TC1700000774.mm.2 |
Olfr109 |
olfactory receptor 109 |
17 |
37466207 |
NM_146835, BC130246 NM_146835, BC130246 |
258832 |
6 |
olfactory receptor activity olfactory receptor activity odorant binding G protein-coupled receptor signaling pathway sensory perception of smell integral component of membrane integral component of membrane detection of chemical stimulus involved in sensory perception of smell |
04740 |
| TC0900000769.mm.2 |
Uaca |
uveal autoantigen with coiled-coil domains and ankyrin repeats |
9 |
60794441 |
NM_028283, BC033470, BC042415 NM_028283, BC033470, BC042415 NM_028283, BC033470, BC042415 |
72565 |
32 |
protein binding nucleus nucleus nuclear envelope nucleoplasm cytoplasm cytosol cytosol cytosol cytosol cytoskeleton intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress response to UV membrane positive regulation of protein import into nucleus positive regulation of apoptotic process positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process apoptosome perinuclear region of cytoplasm negative regulation of inflammatory response apoptotic signaling pathway regulation of NIK/NF-kappaB signaling negative regulation of NIK/NF-kappaB signaling negative regulation of NIK/NF-kappaB signaling |
|
| MG-1-neg-10340782_st |
|
|
|
|
|
|
|
|
|
| TC1800000029.mm.2 |
Zeb1 |
zinc finger E-box binding homeobox 1 |
18 |
5591859, 5592646 |
NM_011546, BC139768, BC139769 NM_011546, BC139768, BC139769 NM_011546, BC139768, BC139769 |
21417 |
175 |
negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding DNA binding chromatin binding chromatin binding double-stranded DNA binding protein binding nucleus nucleus nucleoplasm cytosol regulation of transcription by RNA polymerase II pattern specification process nervous system development central nervous system development negative regulation of cell population proliferation regulation of mesenchymal cell proliferation regulation of transforming growth factor beta receptor signaling pathway cell differentiation negative regulation of epithelial cell differentiation regulation of T cell differentiation in thymus sequence-specific DNA binding negative regulation of endothelial cell differentiation positive regulation of neuron differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding animal organ development embryonic camera-type eye morphogenesis embryonic morphogenesis embryonic skeletal system morphogenesis semicircular canal morphogenesis anatomical structure development regulation of smooth muscle cell differentiation cartilage development E-box binding cellular response to amino acid stimulus cochlea morphogenesis |
|
| TC0900001555.mm.2 |
Azi2 |
5-azacytidine induced gene 2 |
9 |
118040521, 118040521, 118040521 |
NM_001048146, NM_001286507, NM_001286508, NM_013727, BC006851 NM_001048146, NM_001286507, NM_001286508, NM_013727, BC006851 NM_001048146, NM_001286507, NM_001286508, NM_013727, BC006851 NM_001048146, NM_001286507, NM_001286508, NM_013727, BC006851 NM_001048146, NM_001286507, NM_001286508, NM_013727, BC006851 |
27215 |
24 |
mitotic cell cycle cytokine production protein binding cytoplasm cytoplasm I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling interferon-alpha production interferon-gamma production interleukin-6 production tumor necrosis factor production T cell activation T cell activation dendritic cell proliferation dendritic cell differentiation |
04622 |
| MG-1-neg-10341353_st |
|
|
|
|
|
|
|
|
|
| TC0200001396.mm.2 |
Phf21a |
PHD finger protein 21A |
2 |
92185482, 92184181, 92221471 |
NM_001109690, NM_001109691, NM_138755, BC019181 NM_001109690, NM_001109691, NM_138755, BC019181 NM_001109690, NM_001109691, NM_138755, BC019181 NM_001109690, NM_001109691, NM_138755, BC019181 |
192285 |
38 |
histone deacetylase complex histone deacetylase complex negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II suckling behavior DNA binding chromatin binding chromatin binding chromatin binding nucleus nucleus chromatin organization metal ion binding DNA repair complex |
|
| TC1100003438.mm.2 |
Med13 |
mediator complex subunit 13 |
11 |
-86267032 |
NM_001080931 |
327987 |
31 |
transcription coregulator activity transcription coregulator activity transcription coactivator activity nucleus nucleoplasm nucleoplasm regulation of transcription by RNA polymerase II mediator complex mediator complex mediator complex cholesterol homeostasis negative regulation of DNA-binding transcription factor activity positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II thyroid hormone receptor binding positive regulation of transcription initiation from RNA polymerase II promoter triglyceride homeostasis |
|
| TC0700003940.mm.2 |
Trim12c |
tripartite motif-containing 12C |
7 |
-104338753, -104338753 |
NM_001146007, NM_175677, BC038937 NM_001146007, NM_175677, BC038937 NM_001146007, NM_175677, BC038937 |
319236 |
13 |
protein polyubiquitination P-body transcription coactivator activity ubiquitin-protein transferase activity nucleoplasm cytoplasm cytoplasm cytosol regulation of gene expression positive regulation of autophagy protein ubiquitination protein kinase binding protein kinase binding protein-macromolecule adaptor activity regulation of protein localization pattern recognition receptor activity identical protein binding protein homodimerization activity protein homodimerization activity positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of viral entry into host cell positive regulation of NF-kappaB transcription factor activity ubiquitin protein ligase activity omegasome |
|
| TC0100002967.mm.2 |
Marco |
macrophage receptor with collagenous structure |
1 |
-120474537 |
NM_010766, BC132338, BC137939 NM_010766, BC132338, BC137939 NM_010766, BC132338, BC137939 |
17167 |
72 |
amyloid-beta binding G protein-coupled receptor binding G protein-coupled receptor binding positive regulation of protein phosphorylation immune system process scavenger receptor activity collagen trimer intracellular anatomical structure cytoplasm plasma membrane plasma membrane plasma membrane endocytosis endocytosis receptor-mediated endocytosis phagocytosis, engulfment adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway membrane integral component of membrane cargo receptor activity apoptotic cell clearance innate immune response positive regulation of ERK1 and ERK2 cascade amyloid-beta clearance |
04145 |
| MG-1-neg-10339990_st |
|
|
|
|
|
|
|
|
|
| MG-1-neg-10344457_st |
|
|
|
|
|
|
|
|
|
| TC0300002959.mm.2 |
Sgms2 |
sphingomyelin synthase 2 |
3 |
-131318985, -131318985, -131318985, -131318985, -131318985, -131318985 |
NM_028943, BC117782 NM_028943, BC117782 |
74442 |
62 |
ceramide phosphoethanolamine synthase activity Golgi apparatus plasma membrane integral component of plasma membrane integral component of plasma membrane integral component of plasma membrane lipid metabolic process sphingolipid metabolic process sphingomyelin biosynthetic process sphingomyelin biosynthetic process sphingomyelin biosynthetic process sphingomyelin biosynthetic process membrane integral component of membrane kinase activity phosphorylation transferase activity integral component of Golgi membrane integral component of Golgi membrane integral component of Golgi membrane integral component of endoplasmic reticulum membrane regulation of bone mineralization sphingomyelin synthase activity sphingomyelin synthase activity sphingomyelin synthase activity sphingomyelin synthase activity ceramide biosynthetic process ceramide biosynthetic process ceramide cholinephosphotransferase activity ceramide cholinephosphotransferase activity ceramide cholinephosphotransferase activity ceramide phosphoethanolamine biosynthetic process |
00600 01100 |
| TC1300001270.mm.2 |
Plpp1 |
phospholipid phosphatase 1 |
13 |
112800776 |
NM_008247, NM_008903, BC061161 NM_008247, NM_008903, BC061161 NM_008247, NM_008903, BC061161 |
19012 |
35 |
diacylglycerol diphosphate phosphatase activity diacylglycerol diphosphate phosphatase activity diacylglycerol diphosphate phosphatase activity plasma membrane plasma membrane integral component of plasma membrane integral component of plasma membrane integral component of plasma membrane caveola lipid metabolic process phospholipid metabolic process phospholipid metabolic process phospholipid metabolic process diacylglycerol biosynthetic process sphingosine metabolic process sphingosine metabolic process sphingosine metabolic process ceramide metabolic process ceramide metabolic process ceramide metabolic process signal transduction signal transduction signal transduction phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity phosphatidate phosphatase activity membrane integral component of membrane hydrolase activity sphingosine-1-phosphate phosphatase activity sphingosine-1-phosphate phosphatase activity lipid phosphatase activity lipid phosphatase activity phospholipid dephosphorylation phospholipid dephosphorylation phospholipid dephosphorylation phospholipid dephosphorylation ceramide-1-phosphate phosphatase activity ceramide-1-phosphate phosphatase activity |
00561 00564 00565 00600 01100 04666 04975 |
| TC0400002668.mm.2 |
Mexis |
macrophage expressed LXRa(NR1H3)-dependent amplifier of Abca1 transcription lncRNA |
4 |
-53261355, -53261355 |
NR_033139, NR_033140, BC147516, BC147547 NR_033139, NR_033140, BC147516, BC147547 NR_033139, NR_033140, BC147516, BC147547 NR_033139, NR_033140, BC147516, BC147547 |
381524 |
10 |
|
|
| TC0100003271.mm.2 |
Smg7 |
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) |
1 |
-152836994, -152836994 |
NM_001005507, NM_001160256, NM_001160257, BC082789, BC086651 NM_001005507, NM_001160256, NM_001160257, BC082789, BC086651 NM_001005507, NM_001160256, NM_001160257, BC082789, BC086651 NM_001005507, NM_001160256, NM_001160257, BC082789, BC086651 NM_001005507, NM_001160256, NM_001160257, BC082789, BC086651 |
226517 |
18 |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleus telomerase holoenzyme complex cytoplasm cytosol telomeric DNA binding telomeric DNA binding intermediate filament cytoskeleton protein phosphatase 2A binding telomerase RNA binding |
03015 |
| MG-1-neg-10338492_st |
|
|
|
|
|
|
|
|
|
| TC0800002012.mm.2 |
Rbpms |
RNA binding protein gene with multiple splicing |
8 |
-33782643, -33803939 |
NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 |
19663 |
48 |
nucleic acid binding transcription coactivator activity RNA binding mRNA binding nucleus nucleoplasm cytoplasm cytosol response to oxidative stress poly(A) binding cytoplasmic stress granule positive regulation of pathway-restricted SMAD protein phosphorylation protein homodimerization activity positive regulation of SMAD protein signal transduction |
|
| MG-1-neg-10340044_st |
|
|
|
|
|
|
|
|
|
| TC0200005425.mm.2 |
Ythdf1 |
YTH N6-methyladenosine RNA binding protein 1 |
2 |
-180904376 |
NM_173761, BC061479, BC065050 NM_173761, BC061479, BC065050 NM_173761, BC061479, BC065050 |
228994 |
24 |
immune system process regulation of antigen processing and presentation RNA binding mRNA binding cytoplasm learning memory ribosome binding positive regulation of translation positive regulation of translation positive regulation of translational initiation mRNA destabilization regulation of long-term synaptic potentiation regulation of axon guidance N6-methyladenosine-containing RNA binding N6-methyladenosine-containing RNA binding N6-methyladenosine-containing RNA binding |
|
| TC1700000682.mm.2 |
H2-Q2 |
histocompatibility 2, Q region locus 2 |
17 |
35342306 |
NM_010392, BC138688, BC138689 NM_010392, BC138688, BC138689 NM_010392, BC138688, BC138689 |
15013 |
31 |
positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent signaling receptor binding signaling receptor binding extracellular space endoplasmic reticulum Golgi apparatus Golgi medial cisterna plasma membrane immune response female pregnancy external side of plasma membrane cell surface beta-2-microglobulin binding multicellular organism growth peptide binding peptide antigen binding peptide antigen binding T cell receptor binding CD8 receptor binding MHC class I protein complex MHC class I peptide loading complex protein-containing complex binding TAP binding TAP complex binding endoplasmic reticulum exit site |
04144 04145 04514 04612 04940 05320 05330 05332 05416 |
| MG-1-neg-10340437_st |
|
|
|
|
|
|
|
|
|
| TC0400001726.mm.2 |
Mul1 |
mitochondrial ubiquitin ligase activator of NFKB 1 |
4 |
138434671 |
NM_026689, BC019516 NM_026689, BC019516 |
68350 |
25 |
protein polyubiquitination mitochondrial fission p53 binding ubiquitin-protein transferase activity mitochondrion mitochondrion mitochondrion mitochondrial outer membrane peroxisome apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process organelle organization activation of JUN kinase activity negative regulation of mitochondrial fusion regulation of mitochondrion organization membrane integral component of membrane protein ubiquitination protein ubiquitination transferase activity SUMO transferase activity negative regulation of cell growth axon integral component of mitochondrial outer membrane ubiquitin protein ligase binding regulation of protein stability protein destabilization positive regulation of protein sumoylation identical protein binding neuronal cell body negative regulation of innate immune response metal ion binding negative regulation of defense response to virus by host protein stabilization mitochondrion localization regulation of mitochondrial membrane potential negative regulation of protein kinase B signaling negative regulation of type I interferon-mediated signaling pathway ubiquitin protein ligase activity cellular response to exogenous dsRNA negative regulation of chemokine (C-C motif) ligand 5 production positive regulation of mitochondrial fission regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of dendrite extension positive regulation of dendrite extension positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization |
|
| MG-1-neg-10340298_st |
|
|
|
|
|
|
|
|
|
| MG-1-neg-10343442_st |
|
|
|
|
|
|
|
|
|
| TC0500000057.mm.2 |
Tmem243 |
transmembrane protein 243, mitochondrial |
5 |
9100736 |
NM_001081029, BC147127, BC147128, BC147812, BC147813 NM_001081029, BC147127, BC147128, BC147812, BC147813 NM_001081029, BC147127, BC147128, BC147812, BC147813 NM_001081029, BC147127, BC147128, BC147812, BC147813 NM_001081029, BC147127, BC147128, BC147812, BC147813 |
652925 |
11 |
molecular_function cellular_component biological_process |
|
| MG-1-neg-10339929_st |
|
|
|
|
|
|
|
|
|
| MG-1-neg-10341322_st |
|
|
|
|
|
|
|
|
|
| TC0100001577.mm.2 |
Cfap126 |
cilia and flagella associated protein 126 |
1 |
171121660, 171122043, 171113985, 171123044 |
NM_001081275, BC061017 NM_001081275, BC061017 |
75472 |
19 |
protein binding cytoplasm cytoskeleton plasma membrane cilium membrane apical plasma membrane cell projection organization ciliary basal body ciliary basal body cell projection cilium organization cilium organization |
|
| MG-1-neg-10338889_st |
|
|
|
|
|
|
|
|
|
| TC0400002809.mm.2 |
Tnfsf8 |
tumor necrosis factor (ligand) superfamily, member 8 |
4 |
-63832823 |
NM_009403, BC117093, BC117097 NM_009403, BC117093, BC117097 NM_009403, BC117093, BC117097 |
21949 |
40 |
cytokine activity tumor necrosis factor receptor binding extracellular space immune response membrane integral component of membrane CD8-positive, alpha-beta T cell differentiation CD8-positive, alpha-beta T cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II defense response to Gram-positive bacterium |
04060 |
| TC0200004251.mm.2 |
Prrg4 |
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) |
2 |
-104830740 |
NM_178695, BC099390, BC115470, BC151011, BC151019 NM_178695, BC099390, BC115470, BC151011, BC151019 NM_178695, BC099390, BC115470, BC151011, BC151019 NM_178695, BC099390, BC115470, BC151011, BC151019 NM_178695, BC099390, BC115470, BC151011, BC151019 |
228413 |
13 |
calcium ion binding extracellular region plasma membrane biological_process membrane integral component of membrane WW domain binding |
|
| TC0600001787.mm.2 |
Samd9l |
sterile alpha motif domain containing 9-like |
6 |
-3372257 |
NM_010156 |
209086 |
18 |
hematopoietic progenitor cell differentiation protein binding cytoplasm early endosome stem cell division endosomal vesicle fusion common myeloid progenitor cell proliferation regulation of protein catabolic process spleen development |
|
| TC0900000181.mm.2 |
Shfl |
shiftless antiviral inhibitor of ribosomal frameshifting |
9 |
20868641 |
NM_175687, BC031510, BC043448 NM_175687, BC031510, BC043448 NM_175687, BC031510, BC043448 |
319278 |
12 |
P-body RNA binding nucleus nucleoplasm cytoplasm cytosol regulation of translational termination response to type I interferon response to interferon-gamma response to type III interferon response to interferon-beta identical protein binding ribosome binding ribosome binding negative regulation of viral genome replication innate immune response defense response to virus viral translational frameshifting viral translational frameshifting sequence-specific mRNA binding sequence-specific mRNA binding negative regulation of translational frameshifting |
|
| TC0100003233.mm.2 |
Pla2g4a |
phospholipase A2, group IVA (cytosolic, calcium-dependent) |
1 |
-149829618, -149829618 |
NM_008869, BC003816 NM_008869, BC003816 |
18783 |
208 |
Golgi membrane prostaglandin biosynthetic process prostaglandin biosynthetic process ovulation from ovarian follicle positive regulation of T-helper 1 type immune response phospholipase activity lysophospholipase activity phospholipase A2 activity phospholipase A2 activity phospholipase A2 activity calcium ion binding calcium ion binding calcium-dependent phospholipid binding calcium-dependent phospholipid binding nucleus nucleus nuclear envelope cytoplasm endoplasmic reticulum endoplasmic reticulum Golgi apparatus Golgi apparatus cytosol cytosol cytosol glycerol metabolic process lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process monoacylglycerol biosynthetic process platelet activating factor biosynthetic process prostaglandin metabolic process positive regulation of cell population proliferation lipid binding O-acyltransferase activity phospholipid catabolic process response to organic substance phosphatidylinositol-5-phosphate binding positive regulation of platelet activation membrane lipid catabolic process hydrolase activity arachidonic acid metabolic process leukotriene biosynthetic process leukotriene biosynthetic process positive regulation of vesicle fusion positive regulation of prostaglandin biosynthetic process phosphatidylinositol-3-phosphate binding positive regulation of prostaglandin secretion phosphatidylglycerol catabolic process phosphatidylcholine catabolic process phosphatidylcholine catabolic process histone acetyltransferase binding phosphatidylcholine acyl-chain remodeling regulation of cell population proliferation zymogen granule positive regulation of macrophage activation positive regulation of apoptotic process surfactant homeostasis intracellular membrane-bounded organelle icosanoid biosynthetic process glycerophospholipid catabolic process decidualization metal ion binding calcium-dependent phospholipase A2 activity calcium-dependent phospholipase A2 activity calcium-dependent phospholipase A2 activity calcium-independent phospholipase A2 activity perinuclear region of cytoplasm arachidonic acid secretion arachidonic acid secretion positive regulation of inflammatory response response to calcium ion phosphatidylinositol-4-phosphate binding cellular response to antibiotic ceramide 1-phosphate binding |
00564 00565 00590 00591 00592 01100 04010 04270 04370 04664 04666 04730 04912 04972 04975 05145 |
| MG-1-neg-10339892_st |
|
|
|
|
|
|
|
|
|
| TC0800000975.mm.2 |
Hook2 |
hook microtubule tethering protein 2 |
8 |
84990622, 84990006 |
NM_001167991, NM_133255, BC019486, BC055881, BC080744 NM_001167991, NM_133255, BC019486, BC055881, BC080744 NM_001167991, NM_133255, BC019486, BC055881, BC080744 NM_001167991, NM_133255, BC019486, BC055881, BC080744 NM_001167991, NM_133255, BC019486, BC055881, BC080744 |
170833 |
20 |
protein binding cytoplasm centrosome centrosome cytosol cytoskeleton microtubule endosome organization lysosome organization microtubule binding endosome to lysosome transport protein transport cytoskeleton-dependent intracellular transport HOPS complex cytoplasmic microtubule organization identical protein binding intracellular membrane-bounded organelle early endosome to late endosome transport dynein light intermediate chain binding FHF complex |
|
| TC0600000240.mm.2 |
Tspan33 |
tetraspanin 33 |
6 |
29694213 |
NM_146173, BC024685 NM_146173, BC024685 |
232670 |
18 |
cytoplasm plasma membrane integral component of plasma membrane cell surface membrane integral component of membrane enzyme binding enzyme binding cell junction pore complex pore complex pore complex assembly pore complex assembly protein maturation protein maturation protein maturation protein localization to plasma membrane protein localization to plasma membrane protein localization to plasma membrane tetraspanin-enriched microdomain |
|